Details for: MEP1A

Gene ID: 4224

Symbol: MEP1A

Ensembl ID: ENSG00000112818

Description: meprin A subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 5.9534
    Cell Significance Index: 45.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 5.0049
    Cell Significance Index: 108.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.2886
    Cell Significance Index: 64.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 3.8598
    Cell Significance Index: -2.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.1131
    Cell Significance Index: 51.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8963
    Cell Significance Index: -5.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8439
    Cell Significance Index: 83.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.4810
    Cell Significance Index: 24.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4784
    Cell Significance Index: 240.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3433
    Cell Significance Index: 146.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2253
    Cell Significance Index: 1106.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1894
    Cell Significance Index: 25.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.0837
    Cell Significance Index: 22.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0142
    Cell Significance Index: 29.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.9218
    Cell Significance Index: 11.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8540
    Cell Significance Index: 59.0600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4862
    Cell Significance Index: 4.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4349
    Cell Significance Index: 43.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3880
    Cell Significance Index: 9.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3748
    Cell Significance Index: 3.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3547
    Cell Significance Index: 12.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3437
    Cell Significance Index: 5.0100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2842
    Cell Significance Index: 3.0800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2205
    Cell Significance Index: 2.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2092
    Cell Significance Index: 41.5200
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.2078
    Cell Significance Index: 1.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1841
    Cell Significance Index: 3.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1717
    Cell Significance Index: 5.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0958
    Cell Significance Index: 11.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0914
    Cell Significance Index: 17.4000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0806
    Cell Significance Index: 0.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0279
    Cell Significance Index: 0.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0265
    Cell Significance Index: 0.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0005
    Cell Significance Index: 0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0004
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0029
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0037
    Cell Significance Index: -2.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0106
    Cell Significance Index: -2.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0107
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0148
    Cell Significance Index: -4.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0153
    Cell Significance Index: -0.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0159
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0161
    Cell Significance Index: -0.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0166
    Cell Significance Index: -0.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0186
    Cell Significance Index: -1.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0204
    Cell Significance Index: -1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0205
    Cell Significance Index: -3.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0206
    Cell Significance Index: -0.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0226
    Cell Significance Index: -2.3100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0262
    Cell Significance Index: -1.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0275
    Cell Significance Index: -0.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0280
    Cell Significance Index: -4.0700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0282
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0287
    Cell Significance Index: -0.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0302
    Cell Significance Index: -2.0300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0310
    Cell Significance Index: -0.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0340
    Cell Significance Index: -2.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0344
    Cell Significance Index: -4.2300
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0445
    Cell Significance Index: -0.3100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0476
    Cell Significance Index: -0.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0509
    Cell Significance Index: -1.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0526
    Cell Significance Index: -2.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0528
    Cell Significance Index: -1.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0533
    Cell Significance Index: -1.0400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0537
    Cell Significance Index: -0.5900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0541
    Cell Significance Index: -1.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0589
    Cell Significance Index: -0.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0592
    Cell Significance Index: -3.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0602
    Cell Significance Index: -1.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0606
    Cell Significance Index: -1.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0610
    Cell Significance Index: -2.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0612
    Cell Significance Index: -1.6400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0614
    Cell Significance Index: -0.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0614
    Cell Significance Index: -1.0400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0633
    Cell Significance Index: -0.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0642
    Cell Significance Index: -1.8900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0652
    Cell Significance Index: -0.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0652
    Cell Significance Index: -1.5900
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0653
    Cell Significance Index: -0.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0661
    Cell Significance Index: -1.3500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0662
    Cell Significance Index: -0.5700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0671
    Cell Significance Index: -0.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0708
    Cell Significance Index: -2.6800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0737
    Cell Significance Index: -0.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0738
    Cell Significance Index: -1.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Meprin A complex**: MEP1A is a subunit of the Meprin A complex, a heterodimeric enzyme composed of two subunits, alpha and beta. 2. **Metalloendopeptidase activity**: Meprin A exhibits metalloendopeptidase activity, which involves the cleavage of peptide bonds in proteins. 3. **Zinc ion binding**: MEP1A binds to zinc ions, which are essential for the catalytic activity of Meprin A. 4. **Expression in various tissues**: MEP1A is expressed in enterocytes, blood vessel endothelial cells, colon epithelial cells, and other cell types, suggesting its involvement in multiple physiological processes. **Pathways and Functions:** 1. **Epidermal growth factor receptor ligand maturation**: Meprin A is involved in the maturation of epidermal growth factor receptor (EGFR) ligands, which regulates cell signaling and proliferation. 2. **Extracellular exosome**: Meprin A contributes to the formation and regulation of extracellular exosomes, which are small vesicles involved in intercellular communication. 3. **Extracellular space**: Meprin A regulates the extracellular space by modulating the activity of other metalloproteases and influencing the structure of the extracellular matrix. 4. **Signaling receptor ligand precursor processing**: Meprin A is involved in the processing of signaling receptor ligands, which regulates cell signaling and response to external stimuli. **Clinical Significance:** 1. **Cancer**: Meprin A has been implicated in cancer progression, as it regulates the activity of other metalloproteases involved in tumor growth and metastasis. 2. **Cardiovascular disease**: Meprin A is involved in the regulation of blood vessel endothelial function, which is critical in cardiovascular disease. 3. **Neurological disorders**: Meprin A has been linked to neurological disorders, such as Alzheimer's disease, where it regulates the processing of signaling receptor ligands. 4. **Inflammatory diseases**: Meprin A is involved in the regulation of inflammation, as it modulates the activity of other metalloproteases involved in the inflammatory response. In conclusion, the MEP1A gene plays a critical role in regulating various physiological processes, including cell signaling, extracellular matrix formation, and inflammation. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is needed to fully elucidate the functions and clinical significance of Meprin A and its subunits, including MEP1A.

Genular Protein ID: 1536731567

Symbol: MEP1A_HUMAN

Name: Meprin A subunit alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8262185

Title: Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.

PubMed ID: 8262185

DOI: 10.1016/0014-5793(93)80421-p

PubMed ID: 17976009

Title: Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.

PubMed ID: 17976009

DOI: 10.1515/bc.2007.156

PubMed ID: 27399812

Title: SweetNET: A Bioinformatics Workflow for Glycopeptide MS/MS Spectral Analysis.

PubMed ID: 27399812

DOI: 10.1021/acs.jproteome.6b00417

Sequence Information:

  • Length: 746
  • Mass: 84419
  • Checksum: B5F0812F2850F958
  • Sequence:
  • MAWIRSTCIL FFTLLFAHIA AVPIKYLPEE NVHDADFGEQ KDISEINLAA GLDLFQGDIL 
    LQKSRNGLRD PNTRWTFPIP YILADNLGLN AKGAILYAFE MFRLKSCVDF KPYEGESSYI 
    IFQQFDGCWS EVGDQHVGQN ISIGQGCAYK AIIEHEILHA LGFYHEQSRT DRDDYVNIWW 
    DQILSGYQHN FDTYDDSLIT DLNTPYDYES LMHYQPFSFN KNASVPTITA KIPEFNSIIG 
    QRLDFSAIDL ERLNRMYNCT TTHTLLDHCT FEKANICGMI QGTRDDTDWA HQDSAQAGEV 
    DHTLLGQCTG AGYFMQFSTS SGSAEEAALL ESRILYPKRK QQCLQFFYKM TGSPSDRLVV 
    WVRRDDSTGN VRKLVKVQTF QGDDDHNWKI AHVVLKEEQK FRYLFQGTKG DPQNSTGGIY 
    LDDITLTETP CPTGVWTVRN FSQVLENTSK GDKLQSPRFY NSEGYGFGVT LYPNSRESSG 
    YLRLAFHVCS GENDAILEWP VENRQVIITI LDQEPDVRNR MSSSMVFTTS KSHTSPAIND 
    TVIWDRPSRV GTYHTDCNCF RSIDLGWSGF ISHQMLKRRS FLKNDDLIIF VDFEDITHLS 
    QTEVPTKGKR LSPQGLILQG QEQQVSEEGS GKAMLEEALP VSLSQGQPSR QKRSVENTGP 
    LEDHNWPQYF RDPCDPNPCQ NDGICVNVKG MASCRCISGH AFFYTGERCQ AVQVHGSVLG 
    MVIGGTAGVI FLTFSIIAIL SQRPRK

Genular Protein ID: 404183028

Symbol: B7ZL91_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 774
  • Mass: 87897
  • Checksum: 3BF8DE8342E89C99
  • Sequence:
  • MAWIRSTCIL FFTLLFAHIA AVPVSRVLLF GYLEILILVY IIHFLYIYFF QIKYLPEENV 
    HDADFGEQKD ISEINLAAGL DLFQGDILLQ KSRNGLRDPN TRWTFPIPYI LADNLGLNAK 
    GAILYAFEMF RLKSCVDFKP YEGESSYIIF QQFDGCWSEV GDQHVGQNIS IGQGCAYKAI 
    IEHEILHALG FYHEQSRTDR DDYVNIWWDQ ILSGYQHNFD TYDDSLITDL NTPYDYESLM 
    HYQPFSFNKN ASVPTITAKI PEFNSIIGQR LDFSAIDLER LNRMYNCTTT HTLLDHCTFE 
    KANICGMIQG TRDDTDWAHQ DSAQAGEVDH TLLGQCTGAG YFMQFSTSSG SAEEAALLES 
    RILYPKRKQQ CLQFFYKMTG SPSDRLVVWV RRDDSTGNVR KLVKVQTFQG DDDHNWKIAH 
    VVLKEEQKFR YLFQGTKGDP QNSTGGIYLD DITLTETPCP TGVWTVRNFS QVLENTSKGD 
    KLQSPRFYNS EGYGFGVTLY PNSRESSGYL RLAFHVCSGE NDAILEWPVE NRQVIITILD 
    QEPDVRNRMS SSMVFTTSKS HTSPAINDTV IWDRPSRVGT YHTDCNCFRS IDLGWSGFIS 
    HQMLKRRSFL KNDDLIIFVD FEDITHLSQT EVPTKGKRLS PQGLILQGQE QQVSEEGSGK 
    AMLEEALPVS LSQGQPSRQK RSVENTGPLE DHNWPQYFRD PCDPNPCQND GICVNVKGMA 
    SCRCISGHAF FYTGERCQAV QVHGSVLGMV IGGTAGVIFL TFSIIAILSQ RPRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.