Details for: MMP15

Gene ID: 4324

Symbol: MMP15

Ensembl ID: ENSG00000102996

Description: matrix metallopeptidase 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.8912
    Cell Significance Index: -11.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.9934
    Cell Significance Index: -10.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.0501
    Cell Significance Index: -10.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7035
    Cell Significance Index: -12.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9556
    Cell Significance Index: -4.2800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.9057
    Cell Significance Index: 26.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.8256
    Cell Significance Index: 44.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1894
    Cell Significance Index: 53.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0268
    Cell Significance Index: 111.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9918
    Cell Significance Index: 895.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9601
    Cell Significance Index: 20.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8370
    Cell Significance Index: 22.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8280
    Cell Significance Index: 23.8600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7548
    Cell Significance Index: 8.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6966
    Cell Significance Index: 68.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6254
    Cell Significance Index: 32.4900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.5722
    Cell Significance Index: 2.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4888
    Cell Significance Index: 33.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4696
    Cell Significance Index: 24.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3944
    Cell Significance Index: 5.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2963
    Cell Significance Index: 6.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2777
    Cell Significance Index: 5.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2133
    Cell Significance Index: 116.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1898
    Cell Significance Index: 4.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1884
    Cell Significance Index: 37.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1772
    Cell Significance Index: 4.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1625
    Cell Significance Index: 4.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1457
    Cell Significance Index: 3.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1184
    Cell Significance Index: 1.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1144
    Cell Significance Index: 1.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1099
    Cell Significance Index: 3.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0870
    Cell Significance Index: 16.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0807
    Cell Significance Index: 14.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0692
    Cell Significance Index: 2.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0568
    Cell Significance Index: 2.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0348
    Cell Significance Index: 4.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0220
    Cell Significance Index: 1.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0219
    Cell Significance Index: 7.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0184
    Cell Significance Index: 12.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0166
    Cell Significance Index: 7.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0154
    Cell Significance Index: 0.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0026
    Cell Significance Index: 2.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0040
    Cell Significance Index: -0.8100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0080
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0104
    Cell Significance Index: -15.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0162
    Cell Significance Index: -10.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0200
    Cell Significance Index: -5.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0208
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0209
    Cell Significance Index: -13.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0228
    Cell Significance Index: -3.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0261
    Cell Significance Index: -11.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0346
    Cell Significance Index: -4.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0349
    Cell Significance Index: -4.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0431
    Cell Significance Index: -6.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0520
    Cell Significance Index: -3.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0529
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0588
    Cell Significance Index: -6.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0615
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0631
    Cell Significance Index: -13.3000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0727
    Cell Significance Index: -0.6000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0748
    Cell Significance Index: -0.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0775
    Cell Significance Index: -10.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0826
    Cell Significance Index: -0.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0874
    Cell Significance Index: -0.9100
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.0892
    Cell Significance Index: -0.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0916
    Cell Significance Index: -2.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1071
    Cell Significance Index: -12.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1090
    Cell Significance Index: -6.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1114
    Cell Significance Index: -11.6000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1190
    Cell Significance Index: -1.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1376
    Cell Significance Index: -8.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1472
    Cell Significance Index: -10.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1481
    Cell Significance Index: -11.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1549
    Cell Significance Index: -9.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1576
    Cell Significance Index: -3.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1641
    Cell Significance Index: -9.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1669
    Cell Significance Index: -5.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1695
    Cell Significance Index: -11.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1712
    Cell Significance Index: -4.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1882
    Cell Significance Index: -5.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1890
    Cell Significance Index: -2.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1893
    Cell Significance Index: -8.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1924
    Cell Significance Index: -12.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1986
    Cell Significance Index: -1.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2000
    Cell Significance Index: -5.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2073
    Cell Significance Index: -6.1100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2405
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2441
    Cell Significance Index: -5.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2445
    Cell Significance Index: -4.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2447
    Cell Significance Index: -2.6600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2482
    Cell Significance Index: -1.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2534
    Cell Significance Index: -3.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2584
    Cell Significance Index: -11.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2851
    Cell Significance Index: -9.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MMP15 is a type II transmembrane protein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. Its extracellular domain contains a catalytic site, which is responsible for the degradation of various substrates, including collagens, elastin, and proteoglycans. The transmembrane domain allows MMP15 to interact with other cell surface proteins, modulating its activity and localization. The intracellular domain contains a prodomain, which is essential for the protein's activation and stability. **Pathways and Functions:** MMP15 plays a crucial role in various cellular processes, including: 1. **Extracellular matrix remodeling**: MMP15 degrades collagens and elastin, which are essential components of the extracellular matrix. This process is critical in tissue development, repair, and remodeling. 2. **Immune regulation**: MMP15 has been implicated in the regulation of immune responses, including the activation of immune cells, such as macrophages and neutrophils. 3. **Endodermal cell differentiation**: MMP15 is expressed in endodermal cells, where it plays a role in the differentiation and migration of these cells during embryonic development. 4. **Neuroregulation**: MMP15 has been found in the nervous system, where it is involved in the regulation of neural cell migration and axon outgrowth. **Clinical Significance:** MMP15 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of MMP15 has been observed in various types of cancer, including breast, lung, and colon cancer. Its role in tumor invasion and metastasis is still unclear. 2. **Inflammatory diseases**: MMP15 has been found in the synovial fluid of patients with rheumatoid arthritis, suggesting its involvement in the pathogenesis of this disease. 3. **Neurodegenerative diseases**: MMP15 has been implicated in the regulation of neuroinflammation and neurodegeneration in diseases such as Alzheimer's and Parkinson's. In conclusion, MMP15 is a multifunctional protein that plays a critical role in immune regulation, tissue remodeling, and disease pathogenesis. Its expression and activity are tightly regulated by various cellular processes, and its dysregulation has been implicated in various diseases. Further studies are needed to fully understand the functions and clinical significance of MMP15. **References:** * [Insert references to relevant studies on MMP15] Note: The references provided should be based on actual studies and not fictional ones.

Genular Protein ID: 2786059125

Symbol: MMP15_HUMAN

Name: Matrix metalloproteinase-15

UniProtKB Accession Codes:

P51511 A0A2U6 Q14111

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 6 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7649159

Title: cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment.

PubMed ID: 7649159

DOI: 10.1111/j.1432-1033.1995.tb20738.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9119382

Title: Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.

PubMed ID: 9119382

DOI: 10.1006/geno.1996.4496

PubMed ID: 9461298

Title: Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.

PubMed ID: 9461298

DOI: 10.1111/j.1432-1033.1997.00751.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 669
  • Mass: 75807
  • Checksum: FE875EC0674B297F
  • Sequence:
    • MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE VHAENWLRLY 
GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE ETKEWMKRPR CGVPDQFGVR 
VKANLRRRRK RYALTGRKWN NHHLTFSIQN YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ 
EVPYEDIRLR RQKEADIMVL FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP 
WTFSSTDLHG NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ 
QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP GPPVQPRATE 
RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV LDNYPMPIGH FWRGLPGDIS 
AAYERQDGRF VFFKGDRYWL FREANLEPGY PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF 
FQEDRYWRFN EETQRGDPGY PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE 
RLRMEPGYPK SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD 
FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ RKGAPRVLLY 
CKRSLQEWV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.