Details for: MUC2

Gene ID: 4583

Symbol: MUC2

Ensembl ID: ENSG00000198788

Description: mucin 2, oligomeric mucus/gel-forming

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 11.6058
    Cell Significance Index: 125.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8155
    Cell Significance Index: -12.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.4005
    Cell Significance Index: 647.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.8591
    Cell Significance Index: 100.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3820
    Cell Significance Index: 107.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7745
    Cell Significance Index: 1602.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5042
    Cell Significance Index: 163.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3192
    Cell Significance Index: 79.2000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.2371
    Cell Significance Index: 12.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0707
    Cell Significance Index: 30.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8802
    Cell Significance Index: 60.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8056
    Cell Significance Index: 12.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4424
    Cell Significance Index: 11.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4360
    Cell Significance Index: 10.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4285
    Cell Significance Index: 6.4200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.3969
    Cell Significance Index: 3.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3072
    Cell Significance Index: 3.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2737
    Cell Significance Index: 5.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2116
    Cell Significance Index: 4.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1362
    Cell Significance Index: 2.9000
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.0692
    Cell Significance Index: 0.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0299
    Cell Significance Index: 4.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0209
    Cell Significance Index: 0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0037
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.9400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0105
    Cell Significance Index: -1.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0119
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0131
    Cell Significance Index: -5.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0142
    Cell Significance Index: -2.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0147
    Cell Significance Index: -8.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0297
    Cell Significance Index: -5.8900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0332
    Cell Significance Index: -0.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0418
    Cell Significance Index: -8.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0543
    Cell Significance Index: -0.7100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0633
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0699
    Cell Significance Index: -8.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0747
    Cell Significance Index: -8.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0865
    Cell Significance Index: -9.0100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0886
    Cell Significance Index: -1.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1017
    Cell Significance Index: -4.7400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1046
    Cell Significance Index: -1.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1068
    Cell Significance Index: -15.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1113
    Cell Significance Index: -3.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1117
    Cell Significance Index: -5.2500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1136
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1365
    Cell Significance Index: -1.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1386
    Cell Significance Index: -2.3900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1407
    Cell Significance Index: -1.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1411
    Cell Significance Index: -7.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1561
    Cell Significance Index: -5.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1702
    Cell Significance Index: -9.5500
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1799
    Cell Significance Index: -1.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2132
    Cell Significance Index: -9.4300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2168
    Cell Significance Index: -2.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2266
    Cell Significance Index: -6.0500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2412
    Cell Significance Index: -3.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2430
    Cell Significance Index: -3.6900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2469
    Cell Significance Index: -1.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2493
    Cell Significance Index: -9.4400
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.2574
    Cell Significance Index: -2.6500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2618
    Cell Significance Index: -1.6200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2677
    Cell Significance Index: -2.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2686
    Cell Significance Index: -9.8600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2707
    Cell Significance Index: -2.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2709
    Cell Significance Index: -8.8700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2777
    Cell Significance Index: -2.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2798
    Cell Significance Index: -3.8800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2820
    Cell Significance Index: -2.6100
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.2824
    Cell Significance Index: -2.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2848
    Cell Significance Index: -4.5800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.2881
    Cell Significance Index: -3.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2900
    Cell Significance Index: -9.2400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2971
    Cell Significance Index: -3.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2975
    Cell Significance Index: -7.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3077
    Cell Significance Index: -7.8400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.3081
    Cell Significance Index: -2.2200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.3085
    Cell Significance Index: -2.5500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3146
    Cell Significance Index: -4.4100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3151
    Cell Significance Index: -2.8100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3255
    Cell Significance Index: -4.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3367
    Cell Significance Index: -8.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3412
    Cell Significance Index: -4.6600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3523
    Cell Significance Index: -2.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3613
    Cell Significance Index: -9.6800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3706
    Cell Significance Index: -4.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3738
    Cell Significance Index: -9.8300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.3809
    Cell Significance Index: -4.3900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3859
    Cell Significance Index: -4.9700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.3866
    Cell Significance Index: -4.1400
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.3877
    Cell Significance Index: -3.2700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3882
    Cell Significance Index: -5.2400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3891
    Cell Significance Index: -4.9900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3931
    Cell Significance Index: -5.2400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3933
    Cell Significance Index: -2.6100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3957
    Cell Significance Index: -6.0200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.3992
    Cell Significance Index: -3.9100
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.4006
    Cell Significance Index: -3.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mucin structure and function**: MUC2 is an oligomeric glycoprotein that forms a gel-like matrix, providing a barrier against luminal contents and pathogens. 2. **Expression pattern**: MUC2 is predominantly expressed in goblet cells of the trachea, intestine, and colon, as well as in plasma cells, T cells, and other immune cells. 3. **Diversity of functions**: MUC2 plays a role in maintaining the integrity of the epithelial surface, regulating the intestinal microbiota, and modulating immune responses. **Pathways and Functions:** 1. **Extracellular matrix and mucus secretion**: MUC2 is involved in the formation of the extracellular matrix and the secretion of mucus, which protects the epithelial surface from pathogens and toxins. 2. **Host-mediated regulation of intestinal microbiota**: MUC2 helps regulate the composition of the intestinal microbiota by modulating the adhesion and invasion of pathogens. 3. **Golgi lumen and protein binding**: MUC2 is synthesized and secreted from the Golgi lumen, where it interacts with other proteins and molecules to form a functional mucous barrier. 4. **Copper ion binding and detoxification**: MUC2 has been shown to bind copper ions, which may play a role in detoxifying these ions and maintaining the redox balance in the epithelial surface. **Clinical Significance:** 1. **Gastrointestinal disorders**: Abnormalities in MUC2 expression or function have been implicated in various gastrointestinal disorders, including inflammatory bowel disease (IBD), celiac disease, and gastroesophageal reflux disease (GERD). 2. **Cancer**: MUC2 overexpression has been observed in various cancers, including colorectal cancer, and may contribute to tumor progression and metastasis. 3. **Immunological disorders**: MUC2 plays a role in regulating immune responses, and abnormalities in its expression or function may contribute to immunological disorders, such as atopic dermatitis and asthma. 4. **Infectious diseases**: MUC2 helps regulate the adhesion and invasion of pathogens, and abnormalities in its function may contribute to the development of infectious diseases. In conclusion, MUC2 is a critical component of the mucous barrier and plays a multifaceted role in maintaining the integrity of the gastrointestinal epithelium, regulating the intestinal microbiota, and modulating immune responses. Abnormalities in MUC2 expression or function have significant implications for various diseases, highlighting the importance of further research into the mechanisms of MUC2 and its potential therapeutic applications.

Genular Protein ID: 2942035564

Symbol: MUC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q02817 Q14878

Database IDs:

AGR 1 BioGRID 1 BioMuta 1 CDD 1 CPTAC 1 CTD 1 ChEBI 35 ChiTaRS 1 DIP 1 DMDM 1 DrugBank 2 EMBL 7 EMDB 7 GO 13 Gene3D 1 GeneCards 1 GeneWiki 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8300571

Title: Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.

PubMed ID: 8300571

DOI: 10.1016/s0021-9258(17)41965-x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 1400449

Title: The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region.

PubMed ID: 1400449

DOI: 10.1016/s0021-9258(19)36620-7

PubMed ID: 1885763

Title: MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism.

PubMed ID: 1885763

DOI: 10.1172/jci115360

PubMed ID: 2703501

Title: Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism.

PubMed ID: 2703501

DOI: 10.1016/s0021-9258(18)83373-7

PubMed ID: 1550588

Title: Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5.

PubMed ID: 1550588

DOI: 10.1016/0006-291x(92)90557-2

PubMed ID: 11445551

Title: In vivo glycosylation of mucin tandem repeats.

PubMed ID: 11445551

DOI: 10.1093/glycob/11.6.459

PubMed ID: 12374796

Title: The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

PubMed ID: 12374796

DOI: 10.1074/jbc.m208483200

PubMed ID: 12582180

Title: An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

PubMed ID: 12582180

DOI: 10.1074/jbc.m210069200

PubMed ID: 17058067

Title: Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease.

PubMed ID: 17058067

DOI: 10.1007/s00109-006-0100-2

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18327567

Title: Listeria monocytogenes internalins bind to the human intestinal mucin MUC2.

PubMed ID: 18327567

DOI: 10.1007/s00203-008-0358-6

PubMed ID: 19359471

Title: The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.

PubMed ID: 19359471

DOI: 10.1073/pnas.0808722106

PubMed ID: 19432394

Title: Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.

PubMed ID: 19432394

DOI: 10.1021/pr9002504

PubMed ID: 31310764

Title: Intestinal gel-forming Mucins polymerize by disulfide-mediated dimerization of D3 domains.

PubMed ID: 31310764

DOI: 10.1016/j.jmb.2019.07.018

PubMed ID: 33031746

Title: Assembly Mechanism of Mucin and von Willebrand Factor Polymers.

PubMed ID: 33031746

DOI: 10.1016/j.cell.2020.09.021

PubMed ID: 35377815

Title: Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.

PubMed ID: 35377815

DOI: 10.1073/pnas.2116790119

PubMed ID: 36206754

Title: Intestinal mucin is a chaperone of multivalent copper.

PubMed ID: 36206754

DOI: 10.1016/j.cell.2022.09.021

Sequence Information:

  • Length: 5289
  • Mass: 550850
  • Checksum: 7AFBC09DA626F0A5
  • Sequence:
    • MGLPLARLAA VCLALSLAGG SELQTEGRTR NHGHNVCSTW GNFHYKTFDG DVFRFPGLCD 
YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD DTIYLTRHLA VLNGAVVSTP 
HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE DALMLELDTK FRNHTCGLCG DYNGLQSYSE 
FLSDGVLFSP LEFGNMQKIN QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL 
VPLEPYLRAC QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV 
YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ CHCRLHGHLY 
TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT TFDGKTYTFH GDCYYVLAKG 
DHNDSYALLG ELAPCGSTDK QTCLKTVVLL ADKKKNVVVF KSDGSVLLNE LQVNLPHVTA 
SFSVFRPSSY HIMVSMAIGV RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK 
TASGLVEATG AGFANTWKAQ SSCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR 
CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR EHVCNKDVGS 
CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC PDHTFLDEKG RCVPLAKCSC 
YHRGLYLEAG DVVVRQEERC VCRDGRLHCR QIRLIGQSCT APKIHMDCSN LTALATSKPR 
ALSCQTLAAG YYHTECVSGC VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN 
TCTCKRGRWV CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF 
SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT TREVGQYLVV 
ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN NDFTTRDHMV VSSELDFGNS 
WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ CSILKSSVFS ICHSKVDPKP FYEACVHDSC 
SCDTGGDCEC FCSAVASYAQ ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR 
SFETCRTING IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA 
SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE KHFNICSITT 
RPSTLTTFTT ITLPTTPTTF TTTTTTTTPT SSTVLSTTPK LCCLWSDWIN EDHPSSGSDD 
GDRETFDGVC GAPEDIECRS VKDPHLSLEQ LGQKVQCDVS VGFICKNEDQ FGNGPFGLCY 
DYKIRVNCCW PMDKCITTPS PPTTTPSPPP TSTTTLPPTT TPSPPTTTTT TPPPTTTPSP 
PITTTTTPPP TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP 
SPPTTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP TSTTTLPPTT 
TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT TPSPPTTTTT TPPPTTTPSP 
PTTTPITPPT STTTLPPTTT PSPPPTTTTT PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT 
PSSPITTTPS PPTTTMTTPS PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP 
TTTMTTLPPT TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH 
KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC KNEDQKPGGV 
IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPTPITT TTTVTPTPTP TSTQSTTPTP 
ITTTNTVTPT PTPTGTQTPT PTPITTTTTM VTPTPTITST QTPTPTPITT TTVTPTPTPT 
STQRTTPTSI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPISTTT 
MVTPTPTPTG TQTLTPTPIT TTTTVTPTPT PTGTQTPTST PISTTTTVTP TPTPTGTQTP 
TLTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTKSTTPTS ITTTTMVTPT 
PPPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTPTPITTT TTVTPTPTPT GTQTPTSTPI 
TTNTTVTPTP TPTGTPSTTL TPITTTTMVT PTPTPTGTQT PTSTPISTTT TVTPTPTPTG 
TQTPTPTPIS TTTTVTPTPT PTSTQTPTTT PITTTTTVTP NPTPTGTQTP TTTPITTTTT 
VTPTPTPTGT QTPTTTPIST TTTVTPTPTP TGTQTPTTTA ITTTTTVTPT PTPTGTQTPT 
STPITTTTTV TPTPTPTGTQ TPTSTPISNT TTVTPTPTPT GTQTPTVTPI TTTTTVTPTR 
TPTGTKSTTP TSITTTTMVT PTPTPTGTHT PTTTPITTTT TVTPTPTPTG TQTPTPTPIT 
TTTTVTPTPT PTGTQTPTST PITTTTTVTP TPTPTGTQTP TTTPITTNTT VTPTPTPTGT 
QTPTTVLITT TTTMTPTPTP TSTKSTTVTP ITTTTTVTPT PTPTGTQSTT LTPITTTTTV 
TPTPTPTGTQ TPTTTPISTT TTVIPTPTPT GTQTPTSTPI TTTTTVTPTP TPTGTQTPTS 
TPISTTTTVT PTATPTGTQT PTLTPITTTT TVTSTPTPTG TQTPTPTPIT TTTTVTPTPT 
PTSTQTPTST PITTTTTVTP TPTPTGTQTP TTTHITTTTT VTPTPTPTGT QAPTPTAITT 
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQSPT PTAITTTTTV TPTPTPTGTQ 
TPTTTPITTT TTVTPTPTPT GTQSTTLTPI TTTTTVTPIP TPTGTQTPTS TPITTTITVT 
PTPTPTGTQT PTPTPISTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT 
PISTTTTVTP TPTPTGTQTP TSTPITTTTT VTPTPTPTGT QTPTPTPITT TTTVTPTPTP 
TGTQTPTSTP ITTTTTVTPT PTPTGTQTPT PTPITTTTTV TPTPTPTGTQ TPTSTPITTT 
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQSTTL TPITTTTTVT PTPTPTGTQT 
PTSTPITTTT TVTPTPTGTQ TPTPTPISTT TTVTPTPTPT GTQTPTMTPI TTTTTVTPTP 
TPTGTQTPTT TPISTTTTVT PTPTPTGTQT PTSTPITTTT TVTPTPTPTG TQTPTTTPIT 
TTTTVTPTPT PTGTQSTTLT PITTTTTVTP TPTPTGTQTP TPTPISTTTT VTPTPTPTGT 
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ISTTTTVTPT PTPTGTQTPT STPITTTTTV 
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQAPTPTAI TTTTTVTPTP TPTGTQTPTT 
TPITTTTMVT PTPTPTGTQT PTSTPITTTT TVTPTPTPTG TQTPTPTPIS TTTTVTPTPT 
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPISTTTT VTPTPTPTGT QTPTSTPITT 
TTTVTPTPTP TGTQTPTPTP ITTTTTVTPT PTPTGTQTPT STPITTTTTV TPTPTPTGTQ 
TPTTTPITTT TTVTPTPTPT GTQSTTLTPI TTTTTVTPTP TPTGTQTPTS TPITTTTTVT 
PTPTPTGTQT PTPTPISTTS TVTPTPTPTG TQTPTMTPIT TTTTVTPTPT PTGTQTPTST 
PITTTTTVTP TPTPTGTQTP TMTPITTTTT VTPTPTPTGT QAPTPTAITT TTTVTPTPTP 
TGTQTPTTTP ITTTTTVTPT PTPTGTQSTT LTPITTTTTV TPTPTPTGTQ TPTPTPISTT 
TTVTPTPTPT GTQTPTMTPI TTTTTVTPTP TPTGTQTPTT TPISTTTTVT PTPTPTGTQT 
PTTTPITTTT TVTPTPTPTG TQTPTTTPIS TTTTVTPTPT PTGTQTPTTT PITTTTTVTP 
TPTPTGTQTP TTTPISTTTT VTPTPTPTGT QTPTSTPITT TTTVTPTPTP TGTQTPTTTP 
ITTTTTVTPT PTPTGTQAPT PTAITTTSTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT 
GTQSPTPTAI TTTTTVTPTP TPTGTQTPTL TPITTTTTVT PTPTPTGTQT PTPTPISTTT 
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTV LITTTTTMTP TPTPTSTKST 
TVTPITTTTT VTATPTPTGT QTPTMIPIST TTTVTPTPTP TTGSTGPPTH TSTAPIAELT 
TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST APPSTPTAPT TTSGGHTLSP 
PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ TTTTSAWTPT PTPLSTPSII RTTGLRPYPS 
SVLICCVLND TYYAPGEEVY NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP SPTPTPSKST 
PTPSKPSSTP SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT VEIVKVECEP 
PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ GNCTYVLVEE 
ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI KTVHMMPMQV QVQVNRQAVA 
LPYKKYGLEV YQSGINYVVD IPELGVLVSY NGLSFSVRLP YHRFGNNTKG QCGTCTNTTS 
DDCILPSGEI VSNCEAAADQ WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK TTPHKDCTPS 
PLCQLIKDSL FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL CAQQNICLDW 
RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG TMNYAPGFDV 
CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ PKRCSQKPVT HCVEDGTYLA 
TEVNPADTCC NITVCKCNTS LCKEKPSVCP LGFEVKSKMV PGRCCPFYWC ESKGVCVHGN 
AEYQPGSPVY SSKCQDCVCT DKVDNNTLLN VIACTHVPCN TSCSPGFELM EAPGECCKKC 
EQTHCIIKRP DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT CPNFDASICI 
PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG SCGTFVMYSA 
KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE SCQCQDTVCG LPTGTSRRAR 
RSPRHLGSG

Genular Protein ID: 3719428857

Symbol: A0A3S8TMF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3S8TMF2

Database IDs:

ARBA 3 CDD 1 CTD 1 ChiTaRS 1 EMBL 2 Ensembl 2 Gene3D 1 HGNC 1 InterPro 8 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 5 SUPFAM 2

Citations:

PubMed ID: 30504806

Title: The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals.

PubMed ID: 30504806

DOI: 10.1038/s41598-018-35499-w

Sequence Information:

  • Length: 5130
  • Mass: 534832
  • Checksum: 8E3889BC5BD9C2EC
  • Sequence:
    • MGLPLARLAA VCLALSLAGG SELQTEGRTR NHGHNVCSTW GNFHYKTFDG DVFRFPGLCD 
YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD DTIYLTRHLA VLNGAVVSTP 
HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE DALMLELDTK FRNHTCGLCG DYNGLQSYSE 
FLSDGVLFSP LEFGNMQKIN QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL 
VPLEPYLRAC QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV 
YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ CHCRLHGHLY 
TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT TFDGKTYTFH GDCYYVLAKG 
DHNDSYALLG ELAPCGSTDK QTCLKTVVLL ADKKKNVVVF KSDGSVLLNE LQVNLPHVTA 
SFSVFRPSSY HIMVSMAIGV RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK 
TASGLVEATG AGFANTWKAQ SSCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR 
CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR EHVCNKDVGS 
CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC PDHTFLDEKG RCVPLAKCSC 
YHRGLYLEAG DVVVRQEERC VCRDGRLHCR QIRLIGQSCT APKIHMDCSN LTALATSKPR 
ALSCQTLAAG YYHTECVSGC VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN 
TCTCKRGRWV CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF 
SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT TREVGQYLVV 
ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN NDFTTRDHMV VSSELDFGNS 
WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ CSILKSSVFS ICHSKVDPKP FYEACVHDSC 
SCDTGGDCEC FCSAVASYAQ ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR 
SFETCRTING IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA 
SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE KHFNICSITT 
RPSTLTTFTT ITLPTTPTTF TTTTTTTTPT SSTVLSTTPK LCCLWSDWIN EDHPSSGSDD 
GDRETFDGVC GAPEDIECRS VKDPHLSLEQ LGQKVQCDVS VGFICKNEDQ FGNGPFGLCY 
DYKIRVNCCW PMDKCITTPS PPTTTPSPPP TSTTTLPPTT TPSPPTTTTT TPPPTTTPSP 
PITTTTTPPP TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP 
SPPTTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP TSTTTLPPTT 
TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT TPSPPTTTTT TPPPTTTPSP 
PTTTPITPPT STTTLPPTTT PSPPPTTTTT PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT 
PSSPITTTPS PPTTTMTTPS PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP 
TTTTTTLPPT TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH 
KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC KNEDQKPGGV 
IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPTPITT TTTVTPTPTP TSTQSTTPTP 
ITTTNTVTPT PTPTGTQTPT PTPITTTTTM VTPTPTITST QTPTPTPITT TTVTPTPTPT 
STQRTTPTSI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPISTTT 
TVTPTPTPTG TQTLTPTPIT TTTTVTPTPT PTGTQTPTST PITTTTTVTP TPTPTGTQTP 
TLTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTKSTTPTS ITTTTMVTPT 
PPPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTPTPITTT TTVTPTPTPT GTQTPTSTPI 
TTNTTVTPTP TPTGTPSTTL TPITTTTTVT PTPTPTGTQT PTSTPISTTT MVTPTPTPTG 
TQTPTPTPIS TTTTVTPTPT PTGTQTPTPT PITTTTTVTP TPTPTGTQTP TSTPITTTTT 
VTPTPTPTGT QTPTTTPITT NTTVTPTPTP TGTQTPTTVL ITTTTTMTPT PTPTSTKSTT 
VTPITTTTTV TPTPTPTGTQ STTLTPITTT TTVTPTPTPT GIQTPTTTPI STTTTVTPTP 
TPTGTQTPTS TPITTTTTVT PTPTPTGTQT PTSTPISTTT TVTPTATPTG TQTPTLTPIT 
TTTTVTPTPT PTGTKSTTPT SITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT 
QTPTPTPITT TTTVTPTPTP TSTQTPTSTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV 
TPTPTPTGTQ APTPTAITTT TTGTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQSPTP 
TAITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQSTTLTPIT TTTTVTPTPT 
PTGTQTPTST PITTTITVTP TPTPTGTQTP TPTPISTTTT VTPTPTPTGT QTPTSTPITT 
TTTVTPTPTP TGTQTPTTTP ISTTTTVTPT PTPTGTQTPT STPITTTTTV TPTPTPTGTQ 
TPTTTPISTT TTVTPTPTPT GTQTPTSTPI TTTTTVTPTP TPTGTQTPTP TPITTTTTVT 
PTPTPTGTQT PTSTPITTTT TVTPTPTPTG TQTPTPTPIT TTTTVTPTPT PTGTQTPTPT 
PITTTTTVTP TPTPTGTQTP TSTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP 
TGTQSTTLTP ITTTTTVTPT PTPTGTQTPT STPITTITTV TPTPTPTGTQ TPTPTPISTT 
TTVTPTPTPT GTQTPTMTPI TTTTTVTPTP TPTGTQTPTT TPISTTTTVT PTPTPTGTQT 
PTSTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQSTTLT PITTTTTVTP 
TPTPTGTQTP TPTPISTTTT VTPTPTPTGT QTPTMTPITT TTTVTPTPTP TGTQTPTTTP 
ISTTTTVTPT PTPTGTQTPR STPITTTTKV TPTPTPTGTQ TPTPTPITTT TTVTPTPTPT 
GTQAPTPAAI TTTSTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQS TTLTPITTTT 
TVTPTPTPTG TQTPTSTPIT TTTTVTPTPT PTGTQTPTPT PISTTSTVTP TPTPTGTQTP 
TMTPITTTTT VTPTPTPTGT QTPTTTPIST TTTVTPTPTP TGTQNPTSTP ITTTTTVTPT 
PTPTGTQTPT MTPITTTTTV TPTPTPTGTQ APTPTAITTT TTVTPTPTPT GTQTPTTTPI 
TTTTTVTPTP IPTGTQSTTL TPITTTTTVT PTPTPTGTQT PTPIPISTTT TVTPTPTPTG 
TQTPTMTPIT TTTTVTPTPT PTGTQTPTTT PISTTTTVTP TPTPTGTQTP TSTPITTTTT 
VTPTPIPTGT QTPTTTPITT TTTVTPTPTP TGTQAPTPTA ITTTTTVTPT PTPTGTQTPT 
TTPITTTTTV TPTPIPTGTQ STTLTPITTT TTVTPTPTPT STQTPTPTPI STTTTVTPTP 
TPTGTQTPTM TPITTTTTVT PTPTPTGTQT PTTTPISTTT TVTPTPTPTG TQTPTSTPIT 
TTTTVTPTPT STGTQTPTTT PITTTTTVTP TPTPTGTQAP TPTAITTTST VTPTPTPTGT 
QTPTTTPITT TTTVTPTPTP TGTQSPTPTA ITTTTTVTPT PTPTGTQTPT STPITTTTTV 
TPTPTPTGTQ TPTPTPISTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT 
VLITTTTTMT PTPTPTSTKS TTVTPITTTT TVTATPTPTG TQTPTMIPIS TTTTVTPTPT 
PTTGSTGPPT HTSTAPIAEL TTSNPPPESS TPQTSRSTSS PLTESTTLLS TLPPAIEMTS 
TAPPSTPTAP TTTSGGHTLS PPPSTTTSPP GTPTRGTTTG SSSAPTPSTV QTTTTSAWTP 
TPTPLSTPSI IRTTGLRPYP SSVLICCVLN DTYYAPGEEV YNGTYGDTCY FVNCSLSCTL 
EFYNWSCPST PSPTPTPSKS TPTPSKPSST PSKPTPGTKP PECPDFDPPR QENETWWLCD 
CFMATCKYNN TVEIVKVECE PPPMPTCSNG LQPVRVEDPD GCCWHWECDC YCTGWGDPHY 
VTFDGLYYSY QGNCTYVLVE EISPSVDNFG VYIDNYHCDP NDKVSCPRTL IVRHETQEVL 
IKTVHMMPMQ VQVQVNRQAV ALPYKKYGLE VYQSGINYVV DIPELGVLVS YNGLSFSVRL 
PYHRFGNNTK GQCGTCTNTT SDDCILPSGE IVSNCEAAAD QWLVNDPSKP HCPHSSSTTK 
RPAVTVPGGG KTTPHKDCTP SPLCQLIKDS LFAQCHALVP PQHYYDACVF DSCFMPGSSL 
ECASLQAYAA LCAQQNICLD WRNHTHGACL VECPSHREYQ ACGPAEEPTC KSSSSQQNNT 
VLVEGCFCPE GTMNYAPGFD VCVKTCGCVG PDNVPREFGE HFEFDCKNCV CLEGGSGIIC 
QPKRCSQKPV THCVEDGTYL ATEVNPADTC CNITVCKCNT SLCKEKPSVC PLGFEVKSKM 
VPGRCCPFYW CESKGVCVHG NAEYQPGSPV YSSKCQDCVC TDKVDNNTLL NVIACTHVPC 
NTSCSPGFEL MEAPGECCKK CEQTHCIIKR PDNQHVILKP GDFKSDPKNN CTFFSCVKIH 
NQLISSVSNI TCPNFDASIC IPGSITFMPN GCCKTCTPRN ETRVPCSTVP VTTEVSYAGC 
TKTVLMNHCS GSCGTFVMYS AKAQALDHSC SCCKEEKTSQ REVVLSCPNG GSLTHTYTHI 
ESCQCQDTVC GLPTGTSRRA RRSPRHLGSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.