Details for: NEUROG1

Gene ID: 4762

Symbol: NEUROG1

Ensembl ID: ENSG00000181965

Description: neurogenin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 9.8827
    Cell Significance Index: 56.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0220
    Cell Significance Index: -0.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0416
    Cell Significance Index: -8.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1199
    Cell Significance Index: -1.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1335
    Cell Significance Index: -5.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1399
    Cell Significance Index: -7.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1526
    Cell Significance Index: -3.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1656
    Cell Significance Index: -10.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1717
    Cell Significance Index: -23.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1872
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.2181
    Cell Significance Index: -2.0200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2184
    Cell Significance Index: -2.1400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2267
    Cell Significance Index: -1.3500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2365
    Cell Significance Index: -3.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2383
    Cell Significance Index: -4.1200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2492
    Cell Significance Index: -3.5000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2578
    Cell Significance Index: -3.1300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.2591
    Cell Significance Index: -2.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2635
    Cell Significance Index: -7.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2646
    Cell Significance Index: -9.2700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2682
    Cell Significance Index: -3.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2828
    Cell Significance Index: -10.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2831
    Cell Significance Index: -9.2700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2958
    Cell Significance Index: -3.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3060
    Cell Significance Index: -8.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3094
    Cell Significance Index: -8.2900
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.3122
    Cell Significance Index: -2.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3143
    Cell Significance Index: -10.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3288
    Cell Significance Index: -4.0000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.3347
    Cell Significance Index: -3.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3431
    Cell Significance Index: -4.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3465
    Cell Significance Index: -9.1100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3591
    Cell Significance Index: -8.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3593
    Cell Significance Index: -10.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3704
    Cell Significance Index: -8.1100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3731
    Cell Significance Index: -4.2000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3786
    Cell Significance Index: -3.3400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3888
    Cell Significance Index: -4.0800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.3997
    Cell Significance Index: -4.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4078
    Cell Significance Index: -10.3900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.4177
    Cell Significance Index: -4.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4289
    Cell Significance Index: -10.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4311
    Cell Significance Index: -10.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4337
    Cell Significance Index: -9.3700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.4400
    Cell Significance Index: -2.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4415
    Cell Significance Index: -9.3700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4517
    Cell Significance Index: -5.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4861
    Cell Significance Index: -8.3300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4869
    Cell Significance Index: -8.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4921
    Cell Significance Index: -8.2900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.4965
    Cell Significance Index: -3.0800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5057
    Cell Significance Index: -3.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5057
    Cell Significance Index: -10.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5111
    Cell Significance Index: -10.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5283
    Cell Significance Index: -10.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5354
    Cell Significance Index: -8.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5581
    Cell Significance Index: -8.2400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.5690
    Cell Significance Index: -5.6300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.5720
    Cell Significance Index: -3.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5767
    Cell Significance Index: -11.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5877
    Cell Significance Index: -4.5300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5987
    Cell Significance Index: -6.5600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6489
    Cell Significance Index: -9.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6522
    Cell Significance Index: -7.8000
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.6678
    Cell Significance Index: -5.1900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.6813
    Cell Significance Index: -7.9200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6857
    Cell Significance Index: -9.1400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.6878
    Cell Significance Index: -8.6300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.6896
    Cell Significance Index: -9.4700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6907
    Cell Significance Index: -8.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6962
    Cell Significance Index: -9.9100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.7057
    Cell Significance Index: -9.2100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.7083
    Cell Significance Index: -8.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7129
    Cell Significance Index: -9.1300
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.7224
    Cell Significance Index: -7.8400
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.7232
    Cell Significance Index: -8.7200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.7247
    Cell Significance Index: -8.2500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.7250
    Cell Significance Index: -9.0800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.7300
    Cell Significance Index: -8.2900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.7345
    Cell Significance Index: -7.9600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.7346
    Cell Significance Index: -9.1700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.7377
    Cell Significance Index: -8.1900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.7427
    Cell Significance Index: -8.1400
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.7452
    Cell Significance Index: -8.7100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.7506
    Cell Significance Index: -8.2400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.7514
    Cell Significance Index: -8.7300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.7519
    Cell Significance Index: -12.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7525
    Cell Significance Index: -8.9700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.7713
    Cell Significance Index: -8.9300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.7732
    Cell Significance Index: -7.9000
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.7798
    Cell Significance Index: -8.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7970
    Cell Significance Index: -12.1100
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.7996
    Cell Significance Index: -9.7300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.8006
    Cell Significance Index: -10.3100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.8038
    Cell Significance Index: -7.6400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.8079
    Cell Significance Index: -7.6000
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.8080
    Cell Significance Index: -10.1600
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.8092
    Cell Significance Index: -10.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8139
    Cell Significance Index: -10.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NGN1 is a transcription factor that belongs to the basic helix-loop-helix (bHLH) family of proteins. It is a dimeric protein that binds to specific DNA sequences, known as E-boxes, which are located in the promoter regions of target genes. NGN1 is highly expressed in progenitor cells, which are characterized by their ability to differentiate into multiple cell types. The expression of NGN1 is tightly regulated by various signaling pathways, including the Notch and Wnt/β-catenin pathways, which are critical for the proper development and differentiation of cells. NGN1 is also involved in the regulation of cell survival and apoptosis, and has been shown to interact with other transcription factors, such as Myc and Nfia, to regulate the expression of target genes. The expression of NGN1 is highly dynamic and is regulated by various transcriptional and post-transcriptional mechanisms, including alternative splicing and microRNA-mediated regulation. **Pathways and Functions** NGN1 is involved in several signaling pathways that regulate the development and differentiation of cells, including: 1. **Notch signaling pathway**: NGN1 interacts with the Notch transcription factor to regulate the expression of target genes involved in cell fate commitment and differentiation. 2. **Wnt/β-catenin pathway**: NGN1 interacts with β-catenin to regulate the expression of target genes involved in cell proliferation and differentiation. 3. **E-box binding**: NGN1 binds to specific DNA sequences, known as E-boxes, which are located in the promoter regions of target genes. 4. **Chromatin remodeling**: NGN1 interacts with chromatin-modifying enzymes to regulate the expression of target genes. NGN1 plays a crucial role in the development and differentiation of various cell types, including: 1. **Neurons**: NGN1 regulates the expression of genes involved in neuronal differentiation and survival. 2. **Glial cells**: NGN1 regulates the expression of genes involved in glial cell differentiation and function. 3. **Immune cells**: NGN1 regulates the expression of genes involved in immune cell differentiation and function. 4. **Muscle cells**: NGN1 regulates the expression of genes involved in muscle cell differentiation and function. **Clinical Significance** NGN1 has been implicated in various neurological and developmental disorders, including: 1. **Neurodevelopmental disorders**: NGN1 has been implicated in disorders such as autism spectrum disorder, schizophrenia, and intellectual disability. 2. **Cancer**: NGN1 has been implicated in the development and progression of various types of cancer, including leukemia and lymphoma. 3. **Neurodegenerative diseases**: NGN1 has been implicated in the development and progression of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In summary, NGN1 is a critical transcription factor that plays a crucial role in the development and differentiation of various cell types, particularly in the nervous system. Its dysregulation has been implicated in various neurological and developmental disorders, and has significant implications for the development of novel therapeutic strategies.

Genular Protein ID: 2679569121

Symbol: NGN1_HUMAN

Name: Neurogenin-1

UniProtKB Accession Codes:

Q92886 Q5U0Q9 Q96HE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8816493

Title: NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.

PubMed ID: 8816493

DOI: 10.1128/mcb.16.10.5792

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26077850

Title: High diagnostic yield of clinical exome sequencing in Middle Eastern patients with Mendelian disorders.

PubMed ID: 26077850

DOI: 10.1007/s00439-015-1575-0

PubMed ID: 33439489

Title: Adding evidence to the role of NEUROG1 in congenital cranial dysinnervation disorders.

PubMed ID: 33439489

DOI: 10.1111/cge.13922

Sequence Information:

  • Length: 237
  • Mass: 25718
  • Checksum: E3702A0B3408D567
  • Sequence:
    • MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE 
VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP 
SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA 
SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.