Details for: NEUROG1

Gene ID: 4762

Symbol: NEUROG1

Ensembl ID: ENSG00000181965

Description: neurogenin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53039
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6834.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3176
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.4
    Marker Score: 815
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.15
    Marker Score: 1418.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1948.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1808
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1477
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11806
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.72
    Marker Score: 1142
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 543
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.49
    Marker Score: 2925.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 272
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 194
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 175
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.31
    Marker Score: 885
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.26
    Marker Score: 749
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 699
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.19
    Marker Score: 1620
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 212
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 50.5
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 149.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.14
    Marker Score: 1424
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.09
    Marker Score: 173
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.09
    Marker Score: 153
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.09
    Marker Score: 257
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.07
    Marker Score: 115
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.06
    Marker Score: 85
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.06
    Marker Score: 162
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 141
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 31.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 217
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 35.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.03
    Marker Score: 50
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.03
    Marker Score: 31.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.03
    Marker Score: 46
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 50
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 47
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.03
    Marker Score: 72
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 46
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.02
    Marker Score: 47
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.02
    Marker Score: 93
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.02
    Marker Score: 48

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - It is a transmembrane protein with a predicted molecular weight of approximately 120 kDa. - It is a member of the neurogenin family of transcription factors. - It is a key regulator of the cell cycle, as it is expressed in cells that are dividing or differentiating. - It is also involved in the development of the nervous system, as it is expressed in neurons, glial cells, and blood vessels. - It is involved in the regulation of transcription, as it is a key target for the transcription factor E2F1. **Pathways and functions:** - Neurogenin 1 is involved in a variety of cellular processes, including cell cycle progression, proliferation, and differentiation. - It is required for the maintenance of neural progenitor cells and the survival of adult neurons. - It is also involved in the development of the nervous system, as it is expressed in neurons, glial cells, and blood vessels. - It is involved in the regulation of transcription, as it is a key target for the transcription factor E2F1. - It is also involved in the regulation of apoptosis, as it is a pro-apoptotic protein. **Clinical significance:** - Mutations in NEUROG1 have been linked to a number of human diseases, including autism, schizophrenia, and epilepsy. - Neurogenin 1 is a promising target for the treatment of these disorders, as it is expressed in cells that are affected in these diseases. - Studies of neurogenin 1 have shown that it can be used to treat neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Genular Protein ID: 2679569121

Symbol: NGN1_HUMAN

Name: Neurogenin-1

UniProtKB Accession Codes:

Q92886 Q5U0Q9 Q96HE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8816493

Title: NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.

PubMed ID: 8816493

DOI: 10.1128/mcb.16.10.5792

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 237
  • Mass: 25718
  • Checksum: E3702A0B3408D567
  • Sequence:
    • MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE 
VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP 
SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA 
SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.