Details for: CALY

Gene ID: 50632

Symbol: CALY

Ensembl ID: ENSG00000130643

Description: calcyon neuron specific vesicular protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.1251
    Cell Significance Index: -24.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.1481
    Cell Significance Index: -24.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.5320
    Cell Significance Index: 277.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.9661
    Cell Significance Index: 64.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7739
    Cell Significance Index: 88.8500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.6852
    Cell Significance Index: 20.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.1446
    Cell Significance Index: 112.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9052
    Cell Significance Index: 382.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6767
    Cell Significance Index: 601.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.6754
    Cell Significance Index: 20.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4003
    Cell Significance Index: 39.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8671
    Cell Significance Index: 58.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7190
    Cell Significance Index: 71.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6861
    Cell Significance Index: 619.5400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.5317
    Cell Significance Index: 6.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4669
    Cell Significance Index: 28.7000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.4414
    Cell Significance Index: 5.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4159
    Cell Significance Index: 15.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4011
    Cell Significance Index: 17.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3906
    Cell Significance Index: 63.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3581
    Cell Significance Index: 68.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.2997
    Cell Significance Index: 6.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2982
    Cell Significance Index: 32.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2410
    Cell Significance Index: 166.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1530
    Cell Significance Index: 3.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0894
    Cell Significance Index: 6.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0635
    Cell Significance Index: 3.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0108
    Cell Significance Index: 0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0031
    Cell Significance Index: 2.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0070
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0091
    Cell Significance Index: -5.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0105
    Cell Significance Index: -19.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0111
    Cell Significance Index: -0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0134
    Cell Significance Index: -24.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0164
    Cell Significance Index: -3.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0195
    Cell Significance Index: -26.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0195
    Cell Significance Index: -0.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0370
    Cell Significance Index: -27.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0401
    Cell Significance Index: -25.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0427
    Cell Significance Index: -23.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0516
    Cell Significance Index: -2.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0526
    Cell Significance Index: -23.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0540
    Cell Significance Index: -9.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0587
    Cell Significance Index: -1.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0652
    Cell Significance Index: -1.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0726
    Cell Significance Index: -20.8800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0922
    Cell Significance Index: -1.1500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0927
    Cell Significance Index: -0.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0929
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0952
    Cell Significance Index: -10.9100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1020
    Cell Significance Index: -1.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1151
    Cell Significance Index: -2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1298
    Cell Significance Index: -23.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1342
    Cell Significance Index: -3.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1370
    Cell Significance Index: -27.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1455
    Cell Significance Index: -3.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1646
    Cell Significance Index: -5.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1674
    Cell Significance Index: -24.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1876
    Cell Significance Index: -25.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1906
    Cell Significance Index: -6.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1946
    Cell Significance Index: -23.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1952
    Cell Significance Index: -25.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1979
    Cell Significance Index: -4.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2094
    Cell Significance Index: -27.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2103
    Cell Significance Index: -24.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2108
    Cell Significance Index: -24.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2574
    Cell Significance Index: -2.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2605
    Cell Significance Index: -27.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2628
    Cell Significance Index: -26.8400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2696
    Cell Significance Index: -2.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2884
    Cell Significance Index: -7.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3004
    Cell Significance Index: -6.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3037
    Cell Significance Index: -19.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3466
    Cell Significance Index: -25.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3555
    Cell Significance Index: -12.4600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3689
    Cell Significance Index: -3.5100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3708
    Cell Significance Index: -2.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3779
    Cell Significance Index: -4.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3805
    Cell Significance Index: -6.5200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3969
    Cell Significance Index: -6.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4213
    Cell Significance Index: -4.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4223
    Cell Significance Index: -23.7000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4419
    Cell Significance Index: -5.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4456
    Cell Significance Index: -28.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4598
    Cell Significance Index: -23.9500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4638
    Cell Significance Index: -5.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4686
    Cell Significance Index: -8.0100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5081
    Cell Significance Index: -10.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5113
    Cell Significance Index: -24.0300
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.5264
    Cell Significance Index: -4.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5359
    Cell Significance Index: -27.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5535
    Cell Significance Index: -3.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5559
    Cell Significance Index: -7.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5720
    Cell Significance Index: -26.6700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.6106
    Cell Significance Index: -5.5200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6173
    Cell Significance Index: -12.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6653
    Cell Significance Index: -14.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Neuronal specificity:** CALY is highly expressed in neuronal populations, particularly in glutamatergic and glycinergic neurons. 2. **Vesicular transport:** CALY facilitates the movement of vesicles along axons, contributing to the regulation of neurotransmitter release. 3. **Regulation of endocytosis and exocytosis:** CALY plays a role in the positive regulation of clathrin coat assembly, endocytosis, and retrograde axon cargo transport. 4. **Expression in non-neuronal cells:** CALY is also expressed in certain non-neuronal cell types, including mast cells, ciliated cells, and epithelial cells. **Pathways and Functions:** 1. **Anterograde axonal transport:** CALY is involved in the transport of vesicles from the cell body to the synapse, facilitating the release of neurotransmitters. 2. **Clathrin coat assembly:** CALY regulates the assembly of clathrin coats, which are essential for the formation and scission of vesicles. 3. **Endosomal transport:** CALY contributes to the transport of endosomes along axons, influencing the regulation of endocytosis and exocytosis. 4. **Postsynaptic endocytic zone:** CALY is involved in the regulation of postsynaptic endocytic zones, where neurotransmitters are internalized and recycled. 5. **Synaptic plasticity:** CALY plays a role in the regulation of synaptic plasticity, which is essential for learning and memory. **Clinical Significance:** 1. **Neurodevelopmental disorders:** Alterations in CALY expression or function may contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative diseases:** CALY dysfunction may be involved in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Mast cell disorders:** CALY expression in mast cells may be involved in the regulation of allergic responses and mast cell-mediated diseases. 4. **Cancer:** CALY expression in certain epithelial cells may be involved in the regulation of cancer cell behavior and metastasis. In conclusion, CALY is a crucial component of the neuronal transport machinery, playing a pivotal role in the regulation of neurotransmitter release and synaptic plasticity. Its dysregulation may contribute to various neurological and non-neuronal disorders, highlighting the need for further research into the clinical significance of CALY.

Genular Protein ID: 3160925532

Symbol: CALY_HUMAN

Name: Neuron-specific vesicular protein calcyon

UniProtKB Accession Codes:

Q9NYX4 Q5VWX3 Q5VWY5 Q5VWY6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 4 Ensembl 3 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10698743

Title: Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.

PubMed ID: 10698743

DOI: 10.1126/science.287.5458.1660

PubMed ID: 17170272

Title:

PubMed ID: 17170272

DOI: 10.1126/science.314.5806.1681b

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12622665

Title: Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia.

PubMed ID: 12622665

DOI: 10.1001/archpsyc.60.3.311

PubMed ID: 14534309

Title: Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane.

PubMed ID: 14534309

DOI: 10.1074/jbc.m305803200

PubMed ID: 16595675

Title: Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis.

PubMed ID: 16595675

DOI: 10.1074/jbc.m600265200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 217
  • Mass: 23434
  • Checksum: 7B3ACA9042819F58
  • Sequence:
    • MVKLGCSFSG KPGKDPGDQD GAAMDSVPLI SPLDISQLQP PLPDQVVIKT QTEYQLSSPD 
QQNFPDLEGQ RLNCSHPEEG RRLPTARMIA FAMALLGCVL IMYKAIWYDQ FTCPDGFLLR 
HKICTPLTLE MYYTEMDPER HRSILAAIGA YPLSRKHGTE TPAAWGDGYR AAKEERKGPT 
QAGAAAAATE PPGKPSAKAE KEAARKAAGS AAPPPAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.