Details for: TAS2R3

Gene ID: 50831

Symbol: TAS2R3

Ensembl ID: ENSG00000127362

Description: taste 2 receptor member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7914
    Cell Significance Index: 10.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.3301
    Cell Significance Index: 8.2500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2438
    Cell Significance Index: 2.7600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1564
    Cell Significance Index: 1.8400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.1469
    Cell Significance Index: 0.8800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.0670
    Cell Significance Index: 0.6800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0655
    Cell Significance Index: 0.9800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0563
    Cell Significance Index: 0.6800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0561
    Cell Significance Index: 0.8200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0477
    Cell Significance Index: 0.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0416
    Cell Significance Index: 0.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0351
    Cell Significance Index: 1.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0275
    Cell Significance Index: 0.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0261
    Cell Significance Index: 0.3900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0249
    Cell Significance Index: 0.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0222
    Cell Significance Index: 0.3800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0193
    Cell Significance Index: 0.2500
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.0188
    Cell Significance Index: 0.2000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0187
    Cell Significance Index: 0.2300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.0148
    Cell Significance Index: 0.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0106
    Cell Significance Index: 0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0071
    Cell Significance Index: 2.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0053
    Cell Significance Index: 0.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0052
    Cell Significance Index: 0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0039
    Cell Significance Index: 0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0037
    Cell Significance Index: 0.6300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0009
    Cell Significance Index: 0.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0009
    Cell Significance Index: 0.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0004
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0007
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0008
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0016
    Cell Significance Index: -0.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0017
    Cell Significance Index: -0.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0023
    Cell Significance Index: -0.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0031
    Cell Significance Index: -0.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0031
    Cell Significance Index: -0.1900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0041
    Cell Significance Index: -0.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0048
    Cell Significance Index: -0.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0054
    Cell Significance Index: -0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0055
    Cell Significance Index: -0.1400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0066
    Cell Significance Index: -0.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0072
    Cell Significance Index: -0.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0076
    Cell Significance Index: -0.1500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0091
    Cell Significance Index: -0.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0092
    Cell Significance Index: -0.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0100
    Cell Significance Index: -0.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0106
    Cell Significance Index: -0.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0111
    Cell Significance Index: -0.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0115
    Cell Significance Index: -0.2300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0123
    Cell Significance Index: -0.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0144
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0153
    Cell Significance Index: -0.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0156
    Cell Significance Index: -0.4100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0156
    Cell Significance Index: -0.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0163
    Cell Significance Index: -0.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0165
    Cell Significance Index: -0.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0168
    Cell Significance Index: -0.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0182
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0188
    Cell Significance Index: -0.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0196
    Cell Significance Index: -0.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0199
    Cell Significance Index: -0.4600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0203
    Cell Significance Index: -0.4000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0203
    Cell Significance Index: -0.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0204
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0206
    Cell Significance Index: -0.3400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0211
    Cell Significance Index: -0.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0226
    Cell Significance Index: -0.2600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0233
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0235
    Cell Significance Index: -0.4600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0236
    Cell Significance Index: -0.3100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0236
    Cell Significance Index: -0.4800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0259
    Cell Significance Index: -0.3100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0259
    Cell Significance Index: -0.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0260
    Cell Significance Index: -0.4800
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0278
    Cell Significance Index: -0.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0282
    Cell Significance Index: -0.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0282
    Cell Significance Index: -0.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0298
    Cell Significance Index: -0.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0303
    Cell Significance Index: -0.4000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0305
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TAS2R3 gene is a member of the taste 2 receptor family, which is a subset of G protein-coupled receptors (GPCRs). These receptors are characterized by their ability to bind to specific ligands, including bitter compounds, and trigger a signaling cascade that ultimately leads to the perception of taste. The TAS2R3 receptor is specifically sensitive to a wide range of bitter compounds, including those found in certain vegetables, coffee, and some medications. Its expression is widespread in various tissues, including the taste buds on the tongue and elsewhere in the oral cavity. **Pathways and Functions:** The TAS2R3 receptor is part of the GPCR signaling pathway, which is a complex cascade of molecular events that ultimately leads to the activation of various cellular responses. When the TAS2R3 receptor binds to a bitter compound, it triggers the activation of Gα(i) proteins, which in turn activate downstream signaling pathways. These pathways include the activation of phospholipase C, phosphodiesterase, and other enzymes that ultimately lead to changes in cellular function. The TAS2R3 receptor plays a critical role in maintaining our sense of taste and is involved in the detection of chemical stimuli involved in sensory perception. **Clinical Significance:** The TAS2R3 gene has been implicated in various diseases, including cancer and autoimmune disorders. For example, polymorphisms in the TAS2R3 gene have been associated with an increased risk of certain types of cancer, such as colorectal cancer. Additionally, the TAS2R3 receptor has been shown to play a role in the modulation of the immune response, with dysregulation of the receptor leading to impaired immune function. Furthermore, the TAS2R3 gene has been linked to the development of autoimmune disorders, such as rheumatoid arthritis and lupus. Understanding the role of the TAS2R3 gene in these diseases can provide valuable insights into the development of new therapeutic strategies. In conclusion, the TAS2R3 gene is a crucial component of the human sense of taste, and its dysregulation has been linked to various diseases. Further research into the function and regulation of the TAS2R3 receptor is necessary to fully understand its role in maintaining our overall health and to develop effective treatments for diseases associated with its dysregulation.

Genular Protein ID: 3990604400

Symbol: TA2R3_HUMAN

Name: Taste receptor type 2 member 3

UniProtKB Accession Codes:

Q9NYW6 A4D1U2 Q645W2 Q75MV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 7 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10761934

Title: A novel family of mammalian taste receptors.

PubMed ID: 10761934

DOI: 10.1016/s0092-8674(00)80705-9

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10761935

Title: T2Rs function as bitter taste receptors.

PubMed ID: 10761935

DOI: 10.1016/s0092-8674(00)80706-0

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

Sequence Information:

  • Length: 316
  • Mass: 35915
  • Checksum: 6A7BA3C6497ABC5B
  • Sequence:
    • MMGLTEGVFL ILSGTQFTLG ILVNCFIELV NGSSWFKTKR MSLSDFIITT LALLRIILLC 
IILTDSFLIE FSPNTHDSGI IMQIIDVSWT FTNHLSIWLA TCLGVLYCLK IASFSHPTFL 
WLKWRVSRVM VWMLLGALLL SCGSTASLIN EFKLYSVFRG IEATRNVTEH FRKKRSEYYL 
IHVLGTLWYL PPLIVSLASY SLLIFSLGRH TRQMLQNGTS SRDPTTEAHK RAIRIILSFF 
FLFLLYFLAF LIASFGNFLP KTKMAKMIGE VMTMFYPAGH SFILILGNSK LKQTFVVMLR 
CESGHLKPGS KGPIFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.