Details for: GP6

Gene ID: 51206

Symbol: GP6

Ensembl ID: ENSG00000088053

Description: glycoprotein VI platelet

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.1380
    Cell Significance Index: -5.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.1715
    Cell Significance Index: -5.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 10.1480
    Cell Significance Index: -5.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0381
    Cell Significance Index: 9.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7453
    Cell Significance Index: 23.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5863
    Cell Significance Index: 117.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3923
    Cell Significance Index: 20.3800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.3343
    Cell Significance Index: 5.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3195
    Cell Significance Index: 114.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2964
    Cell Significance Index: 22.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2746
    Cell Significance Index: 10.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2636
    Cell Significance Index: 11.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2175
    Cell Significance Index: 5.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2153
    Cell Significance Index: 35.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1802
    Cell Significance Index: 3.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1622
    Cell Significance Index: 9.7400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1189
    Cell Significance Index: 1.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0929
    Cell Significance Index: 9.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0887
    Cell Significance Index: 2.4800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0872
    Cell Significance Index: 1.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0746
    Cell Significance Index: 1.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0707
    Cell Significance Index: 1.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0645
    Cell Significance Index: 12.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0601
    Cell Significance Index: 0.8200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0594
    Cell Significance Index: 0.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0325
    Cell Significance Index: 3.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0200
    Cell Significance Index: 1.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0187
    Cell Significance Index: 35.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0163
    Cell Significance Index: 30.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0132
    Cell Significance Index: 0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0120
    Cell Significance Index: 18.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0083
    Cell Significance Index: 1.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0051
    Cell Significance Index: 0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0042
    Cell Significance Index: 0.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0028
    Cell Significance Index: 3.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0016
    Cell Significance Index: 1.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0006
    Cell Significance Index: 0.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0044
    Cell Significance Index: -2.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0051
    Cell Significance Index: -0.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0059
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0076
    Cell Significance Index: -0.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0102
    Cell Significance Index: -5.7700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0115
    Cell Significance Index: -0.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0119
    Cell Significance Index: -5.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0163
    Cell Significance Index: -0.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0163
    Cell Significance Index: -1.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0216
    Cell Significance Index: -0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0256
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0271
    Cell Significance Index: -4.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0276
    Cell Significance Index: -1.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0287
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0295
    Cell Significance Index: -6.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0297
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0303
    Cell Significance Index: -3.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0342
    Cell Significance Index: -0.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0344
    Cell Significance Index: -0.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0347
    Cell Significance Index: -4.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0355
    Cell Significance Index: -1.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0356
    Cell Significance Index: -1.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0360
    Cell Significance Index: -4.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0385
    Cell Significance Index: -0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0391
    Cell Significance Index: -5.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0401
    Cell Significance Index: -0.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0407
    Cell Significance Index: -4.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0434
    Cell Significance Index: -1.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0465
    Cell Significance Index: -5.9600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0475
    Cell Significance Index: -0.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0489
    Cell Significance Index: -5.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0490
    Cell Significance Index: -1.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0491
    Cell Significance Index: -0.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0492
    Cell Significance Index: -1.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0500
    Cell Significance Index: -1.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0526
    Cell Significance Index: -0.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0540
    Cell Significance Index: -1.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0578
    Cell Significance Index: -1.1600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0602
    Cell Significance Index: -0.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0686
    Cell Significance Index: -5.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0711
    Cell Significance Index: -2.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0745
    Cell Significance Index: -1.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0746
    Cell Significance Index: -1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0764
    Cell Significance Index: -3.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0775
    Cell Significance Index: -1.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0789
    Cell Significance Index: -5.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0844
    Cell Significance Index: -0.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0860
    Cell Significance Index: -6.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0876
    Cell Significance Index: -3.5900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1072
    Cell Significance Index: -1.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1160
    Cell Significance Index: -2.3600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1238
    Cell Significance Index: -1.4800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1240
    Cell Significance Index: -2.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1253
    Cell Significance Index: -4.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1261
    Cell Significance Index: -2.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1272
    Cell Significance Index: -4.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPVI is a type of integrin receptor that exhibits specificity for collagen, allowing it to bind to collagen fibrils at the site of vascular injury. Its unique structure, comprising four immunoglobulin-like domains, enables it to interact with collagen and initiate a signaling cascade that activates platelet signaling pathways. Notably, GPVI is expressed on the surface of platelets and is significantly upregulated in response to collagen exposure, highlighting its crucial role in platelet activation and hemostasis. **Pathways and Functions** GPVI's primary function is to facilitate platelet adhesion to exposed collagen, which is a critical step in the hemostatic process. Upon binding to collagen, GPVI triggers a signaling cascade that activates platelet signaling pathways, including the collagen-activated tyrosine kinase receptor signaling pathway. This pathway ultimately leads to the activation of platelet aggregation, a key event in thrombus formation. The GPVI-mediated activation cascade involves the recruitment of signaling molecules, such as the adaptor protein FERM (4.1 protein, Ezrin, Radixin, Moesin), which interacts with GPVI and facilitates the activation of downstream signaling pathways. Additionally, GPVI interacts with other platelet receptors, including integrin αIIbβ3, to coordinate platelet activation and aggregation. **Clinical Significance** Dysregulation of GPVI has been implicated in various cardiovascular disorders, including thrombotic thrombocytopenic purpura (TTP) and thrombotic microangiopathy (TMA). In TTP, mutations in the GPVI gene have been associated with impaired platelet adhesion to collagen, leading to a deficiency in platelet activation and thrombus formation. Furthermore, GPVI has been shown to play a role in the pathogenesis of atherosclerosis, where impaired platelet activation and aggregation contribute to the formation of atherosclerotic plaques. In addition to its role in cardiovascular disorders, GPVI has also been implicated in other diseases, including cancer and inflammatory conditions. The expression of GPVI on the surface of cancer cells has been associated with increased metastatic potential, suggesting a potential role for GPVI in the progression of cancer. In conclusion, GPVI is a critical component of platelet activation and hemostasis, playing a pivotal role in the recruitment of platelets to the site of vascular injury. Its dysregulation has been implicated in various cardiovascular disorders, and further research is needed to fully elucidate its role in disease pathogenesis.

Genular Protein ID: 593002320

Symbol: GPVI_HUMAN

Name: Glycoprotein 6

UniProtKB Accession Codes:

Q9HCN6 Q9HCN7 Q9UIF2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 7 Ensembl 22 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11027634

Title: Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI.

PubMed ID: 11027634

DOI: 10.1006/bbrc.2000.3624

PubMed ID: 10961879

Title: Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.

PubMed ID: 10961879

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9295288

Title: A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.

PubMed ID: 9295288

DOI: 10.1074/jbc.272.38.23528

PubMed ID: 16014566

Title: The influence of N-linked glycosylation on the function of platelet glycoprotein VI.

PubMed ID: 16014566

DOI: 10.1182/blood-2005-04-1454

PubMed ID: 16405521

Title: Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen.

PubMed ID: 16405521

DOI: 10.1111/j.1538-7836.2005.01764.x

PubMed ID: 18955485

Title: G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.

PubMed ID: 18955485

DOI: 10.1074/jbc.m806895200

PubMed ID: 20946164

Title: TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.

PubMed ID: 20946164

DOI: 10.1111/j.1538-7836.2010.04091.x

PubMed ID: 21552524

Title: GPVI and GPIbalpha mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors.

PubMed ID: 21552524

DOI: 10.1371/journal.pone.0019190

PubMed ID: 16861347

Title: Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI.

PubMed ID: 16861347

DOI: 10.1182/blood-2006-01-010215

PubMed ID: 19549989

Title: Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.

PubMed ID: 19549989

DOI: 10.1182/blood-2009-03-213504

PubMed ID: 19552682

Title: A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder.

PubMed ID: 19552682

DOI: 10.1111/j.1538-7836.2009.03520.x

Sequence Information:

  • Length: 339
  • Mass: 36866
  • Checksum: 3EFE2DD0E1676BA8
  • Sequence:
    • MSPSPTALFC LGLCLGRVPA QSGPLPKPSL QALPSSLVPL EKPVTLRCQG PPGVDLYRLE 
KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS DQLELVATGV FAKPSLSAQP 
GPAVSSGGDV TLQCQTRYGF DQFALYKEGD PAPYKNPERW YRASFPIITV TAAHSGTYRC 
YSFSSRDPYL WSAPSDPLEL VVTGTSVTPS RLPTEPPSPV AEFSEATAEL TVSFTNEVFT 
TETSRSITAS PKESDSPAGP ARQYYTKGNL VRICLGAVIL IILAGFLAED WHSRRKRLRH 
RGRAVQRPLP PLPPLPLTRK SNGGQDGGRQ DVHSRGLCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.