Details for: PCP4

Gene ID: 5121

Symbol: PCP4

Ensembl ID: ENSG00000183036

Description: Purkinje cell protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.7036
    Cell Significance Index: -22.6300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 45.0463
    Cell Significance Index: 478.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.7960
    Cell Significance Index: 409.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.4892
    Cell Significance Index: 142.0900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.8197
    Cell Significance Index: 51.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.6977
    Cell Significance Index: 207.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.4525
    Cell Significance Index: 168.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.0978
    Cell Significance Index: 31.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.2286
    Cell Significance Index: 40.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6364
    Cell Significance Index: -5.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.7928
    Cell Significance Index: 813.6800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.4391
    Cell Significance Index: 24.6000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2868
    Cell Significance Index: 15.3400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.1104
    Cell Significance Index: 13.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0363
    Cell Significance Index: 205.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9566
    Cell Significance Index: 1801.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9243
    Cell Significance Index: 91.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9234
    Cell Significance Index: 833.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.8241
    Cell Significance Index: 85.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5934
    Cell Significance Index: 19.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4800
    Cell Significance Index: 78.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3976
    Cell Significance Index: 252.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3733
    Cell Significance Index: 23.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3175
    Cell Significance Index: 34.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3089
    Cell Significance Index: 58.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2962
    Cell Significance Index: 6.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2833
    Cell Significance Index: 56.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2470
    Cell Significance Index: 3.0800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2049
    Cell Significance Index: 2.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1927
    Cell Significance Index: 69.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1318
    Cell Significance Index: 96.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0790
    Cell Significance Index: 5.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0674
    Cell Significance Index: 5.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0468
    Cell Significance Index: 25.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0309
    Cell Significance Index: 2.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0168
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0074
    Cell Significance Index: 13.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0053
    Cell Significance Index: 7.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0017
    Cell Significance Index: 1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0004
    Cell Significance Index: 0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0050
    Cell Significance Index: -3.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0106
    Cell Significance Index: -1.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0129
    Cell Significance Index: -2.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0168
    Cell Significance Index: -7.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0172
    Cell Significance Index: -11.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0277
    Cell Significance Index: -20.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0368
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0394
    Cell Significance Index: -6.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0402
    Cell Significance Index: -2.0300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0425
    Cell Significance Index: -0.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0531
    Cell Significance Index: -2.1800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0602
    Cell Significance Index: -0.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0614
    Cell Significance Index: -17.6600
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0633
    Cell Significance Index: -0.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0684
    Cell Significance Index: -8.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0761
    Cell Significance Index: -3.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0803
    Cell Significance Index: -4.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0808
    Cell Significance Index: -1.7500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0970
    Cell Significance Index: -2.4200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0990
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1061
    Cell Significance Index: -10.8400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1139
    Cell Significance Index: -0.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1235
    Cell Significance Index: -1.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1239
    Cell Significance Index: -17.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1359
    Cell Significance Index: -15.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1387
    Cell Significance Index: -17.0500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1618
    Cell Significance Index: -1.7400
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1684
    Cell Significance Index: -1.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1804
    Cell Significance Index: -9.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1892
    Cell Significance Index: -21.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1915
    Cell Significance Index: -24.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1923
    Cell Significance Index: -22.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1997
    Cell Significance Index: -5.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2002
    Cell Significance Index: -4.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2247
    Cell Significance Index: -6.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2524
    Cell Significance Index: -5.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2674
    Cell Significance Index: -5.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2819
    Cell Significance Index: -15.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2977
    Cell Significance Index: -18.2500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.2988
    Cell Significance Index: -2.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3017
    Cell Significance Index: -10.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3375
    Cell Significance Index: -25.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3387
    Cell Significance Index: -15.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3454
    Cell Significance Index: -11.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4115
    Cell Significance Index: -13.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4178
    Cell Significance Index: -5.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4366
    Cell Significance Index: -22.7400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4382
    Cell Significance Index: -5.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4508
    Cell Significance Index: -19.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4803
    Cell Significance Index: -16.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4921
    Cell Significance Index: -8.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4939
    Cell Significance Index: -12.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4942
    Cell Significance Index: -18.1400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4957
    Cell Significance Index: -6.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4975
    Cell Significance Index: -23.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4981
    Cell Significance Index: -13.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** PCP4 is primarily found in the cytoplasm, nucleus, and cytosol, suggesting its involvement in both nuclear and cytoplasmic processes. 2. **Protein binding:** PCP4 interacts with calmodulin, a calcium-binding protein, and other proteins, indicating a regulatory function in calcium-dependent signaling pathways. 3. **Neuron differentiation:** PCP4 is highly expressed in neurons, particularly in Purkinje cells, glycinergic neurons, and GABAergic amacrine cells, suggesting its role in regulating neuronal development and function. 4. **Thyroid follicular cell expression:** PCP4 is also expressed in thyroid follicular cells, which may indicate its involvement in thyroid function and regulation. **Pathways and Functions:** 1. **Calmodulin-dependent kinase signaling pathway:** PCP4 interacts with calmodulin, which is a key regulator of calcium-dependent signaling pathways. This interaction may modulate the activity of calmodulin-dependent kinases, influencing various cellular processes. 2. **Calcium ion binding:** PCP4's ability to bind calcium ions suggests its involvement in regulating calcium-dependent signaling pathways, which are crucial for cellular processes such as muscle contraction, neuronal transmission, and cell proliferation. 3. **Protein-containing complex formation:** PCP4's interaction with other proteins may form protein-containing complexes that regulate cellular processes, including protein degradation, cell signaling, and transcription. **Clinical Significance:** 1. **Neurological disorders:** Alterations in PCP4 expression or function may contribute to neurological disorders, such as epilepsy, Parkinson's disease, and Alzheimer's disease, where neuronal dysfunction and regulation are key pathophysiological features. 2. **Thyroid diseases:** PCP4's expression in thyroid follicular cells suggests its potential involvement in thyroid function and regulation. Abnormalities in PCP4 expression may contribute to thyroid disorders, such as hypothyroidism or hyperthyroidism. 3. **Cancer:** PCP4's role in regulating cellular signaling pathways and protein binding may also be relevant to cancer development and progression. Further studies are needed to elucidate the potential involvement of PCP4 in cancer. In conclusion, PCP4 is a multifunctional protein that plays a crucial role in regulating cellular processes, including calcium ion binding, calmodulin binding, and neuron differentiation. Its involvement in various cellular processes and disease implications highlight the need for further research on the functions and clinical significance of PCP4.

Genular Protein ID: 1444103196

Symbol: PCP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P48539 A6NDJ9 Q6ICS4 Q93059

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8931698

Title: Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3.

PubMed ID: 8931698

DOI: 10.1007/s004390050282

PubMed ID: 8914602

Title: Molecular genetic characterization and comparative mapping of the human PCP4 gene.

PubMed ID: 8914602

DOI: 10.1007/bf02369907

PubMed ID: 21491429

Title: PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-o activation in mouse models of Down syndrome.

PubMed ID: 21491429

DOI: 10.1002/cne.22651

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19106096

Title: PEP-19, an intrinsically disordered regulator of calmodulin signaling.

PubMed ID: 19106096

DOI: 10.1074/jbc.m808067200

PubMed ID: 23204517

Title: The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release.

PubMed ID: 23204517

DOI: 10.1074/jbc.m112.411314

PubMed ID: 27876793

Title: PEP-19 modulates calcium binding to calmodulin by electrostatic steering.

PubMed ID: 27876793

DOI: 10.1038/ncomms13583

Sequence Information:

  • Length: 62
  • Mass: 6791
  • Checksum: 99ED306DE41BF29D
  • Sequence:
    • MSERQGAGAT NGKDKTSGEN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF RKFQKKKAGS 
QS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.