Details for: SPMAP2

Gene ID: 51298

Symbol: SPMAP2

Ensembl ID: ENSG00000105549

Description: sperm microtubule associated protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.8466
    Cell Significance Index: 235.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0894
    Cell Significance Index: 66.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.6086
    Cell Significance Index: 83.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.8647
    Cell Significance Index: 28.1000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.4047
    Cell Significance Index: 17.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3814
    Cell Significance Index: 33.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1430
    Cell Significance Index: 217.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7301
    Cell Significance Index: 15.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7097
    Cell Significance Index: 70.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6057
    Cell Significance Index: 546.8700
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.5386
    Cell Significance Index: 0.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4804
    Cell Significance Index: 52.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4546
    Cell Significance Index: 27.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4470
    Cell Significance Index: 6.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3885
    Cell Significance Index: 63.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2615
    Cell Significance Index: 18.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2382
    Cell Significance Index: 3.0100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2093
    Cell Significance Index: 2.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1262
    Cell Significance Index: 3.1500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.1170
    Cell Significance Index: 1.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0824
    Cell Significance Index: 2.0600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0729
    Cell Significance Index: 0.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0706
    Cell Significance Index: 4.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0673
    Cell Significance Index: 1.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0594
    Cell Significance Index: 1.3000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0423
    Cell Significance Index: 0.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0264
    Cell Significance Index: 11.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0263
    Cell Significance Index: 1.3700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0239
    Cell Significance Index: 0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0199
    Cell Significance Index: 0.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0185
    Cell Significance Index: 3.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0141
    Cell Significance Index: 0.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0104
    Cell Significance Index: 0.3000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0095
    Cell Significance Index: 0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0085
    Cell Significance Index: 0.3000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0059
    Cell Significance Index: 0.0900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.0054
    Cell Significance Index: 0.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0042
    Cell Significance Index: 0.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0026
    Cell Significance Index: 0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0024
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0005
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0016
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0018
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0020
    Cell Significance Index: -0.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0024
    Cell Significance Index: -0.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0051
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0051
    Cell Significance Index: -1.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0074
    Cell Significance Index: -1.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0074
    Cell Significance Index: -0.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0084
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0090
    Cell Significance Index: -0.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0097
    Cell Significance Index: -1.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0101
    Cell Significance Index: -0.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0163
    Cell Significance Index: -1.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0163
    Cell Significance Index: -0.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0168
    Cell Significance Index: -0.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0184
    Cell Significance Index: -1.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0191
    Cell Significance Index: -0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0200
    Cell Significance Index: -1.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0211
    Cell Significance Index: -0.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0214
    Cell Significance Index: -0.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0216
    Cell Significance Index: -0.5500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0217
    Cell Significance Index: -0.2900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0223
    Cell Significance Index: -0.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0227
    Cell Significance Index: -0.4700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0231
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0252
    Cell Significance Index: -0.7200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0253
    Cell Significance Index: -0.8000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0260
    Cell Significance Index: -0.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0270
    Cell Significance Index: -0.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0272
    Cell Significance Index: -1.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0278
    Cell Significance Index: -0.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0280
    Cell Significance Index: -0.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0281
    Cell Significance Index: -0.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0283
    Cell Significance Index: -1.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0283
    Cell Significance Index: -0.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0285
    Cell Significance Index: -0.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0285
    Cell Significance Index: -0.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0298
    Cell Significance Index: -1.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0301
    Cell Significance Index: -0.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0327
    Cell Significance Index: -0.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0328
    Cell Significance Index: -0.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0339
    Cell Significance Index: -0.6700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0349
    Cell Significance Index: -0.7000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0351
    Cell Significance Index: -0.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0352
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SPMAP2 is significantly expressed in intestinal tuft cells, Paneth cells, and various types of immune cells, including CD14-low, CD16-positive monocytes. This suggests that SPMAP2 plays a crucial role in maintaining the integrity of the intestinal epithelium and immune system. 2. **Cellular Localization:** SPMAP2 is primarily associated with microtubules, which are essential for maintaining cell shape and facilitating cellular processes such as migration and division. 3. **Protein Binding:** SPMAP2 interacts with various proteins, including chaperone-mediated protein complex, which is essential for protein folding and stability. **Pathways and Functions:** 1. **Cell Differentiation:** SPMAP2 is involved in the regulation of cellular differentiation, particularly in the development of intestinal tuft cells and Paneth cells. 2. **Chaperone-Mediated Protein Complex Assembly:** SPMAP2 plays a crucial role in the assembly of chaperone-mediated protein complexes, which are essential for protein folding and stability. 3. **Spermatogenesis:** SPMAP2 is expressed in the testes and is involved in the regulation of spermatogenesis, a complex process involving the development of sperm cells. **Clinical Significance:** 1. **Cancer:** SPMAP2 has been identified as a cancer/testis antigen, which is a type of protein that is expressed in both cancerous and normal testicular cells. This suggests that SPMAP2 may play a role in the development of testicular cancer. 2. **Immunological Disorders:** The expression of SPMAP2 in immune cells suggests that it may play a role in the regulation of immune responses and the development of immunological disorders such as autoimmune diseases. 3. **Intestinal Disorders:** The expression of SPMAP2 in intestinal tuft cells and Paneth cells suggests that it may play a role in the regulation of intestinal homeostasis and the development of intestinal disorders such as inflammatory bowel disease. In conclusion, SPMAP2 is a multifaceted gene that plays a crucial role in various cellular processes, including cell differentiation, chaperone-mediated protein complex assembly, and spermatogenesis. Its expression in immune cells and intestinal tuft cells suggests that it may play a role in the regulation of immune responses and the development of immunological disorders. Further studies are needed to fully elucidate the role of SPMAP2 in human health and disease.

Genular Protein ID: 4055688558

Symbol: SPMA2_HUMAN

Name: Cancer/testis antigen 56

UniProtKB Accession Codes:

Q9P2T0 A6NMJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11173852

Title: Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG).

PubMed ID: 11173852

DOI: 10.1159/000056840

PubMed ID: 10747865

Title: Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis.

PubMed ID: 10747865

DOI: 10.1074/jbc.c901047199

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 379
  • Mass: 43444
  • Checksum: DE1B6397A4FAA875
  • Sequence:
    • MGDSRRRSLG NQPSSEAAGR SEREQDGDPR GLQSSVYESR RVTDPERQDL DNAELGPEDP 
EEELPPEEVA GEEFPETLDP KEALSELERV LDKDLEEDIP EISRLSISQK LPSTTMTKAR 
KRRRRRRLME LAEPKINWQV LKDRKGRCGK GYAWISPCKM SLHFCLCWPS VYWTERFLED 
TTLTITVPAV SRRVEELSRP KRFYLEYYNN NRTTPVWPIP RSSLEYRASS RLKELAAPKI 
RDNFWSMPMS EVSQVSRAAQ MAVPSSRILQ LSKPKAPATL LEEWDPVPKP KPHVSDHNRL 
LHLARPKAQS DKCVPDRDPR WEVLDVTKKV VASPRIISLA KPKVRKGLNE GYDRRPLASM 
SLPPPKASPE KCDQPRPGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.