Details for: VCX2

Gene ID: 51480

Symbol: VCX2

Ensembl ID: ENSG00000177504

Description: variable charge X-linked 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.4181
    Cell Significance Index: 2.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1459
    Cell Significance Index: 1.5100
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0606
    Cell Significance Index: 0.6600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0503
    Cell Significance Index: 0.3800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0160
    Cell Significance Index: 0.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0084
    Cell Significance Index: 1.0800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0083
    Cell Significance Index: -0.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0093
    Cell Significance Index: -0.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0112
    Cell Significance Index: -0.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0126
    Cell Significance Index: -0.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0146
    Cell Significance Index: -0.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0163
    Cell Significance Index: -0.5200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0175
    Cell Significance Index: -0.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0183
    Cell Significance Index: -0.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0198
    Cell Significance Index: -0.5200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0234
    Cell Significance Index: -0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0245
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0248
    Cell Significance Index: -0.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0274
    Cell Significance Index: -0.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0284
    Cell Significance Index: -0.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0289
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0290
    Cell Significance Index: -0.8300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0330
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0332
    Cell Significance Index: -0.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0332
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0344
    Cell Significance Index: -0.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0395
    Cell Significance Index: -0.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0398
    Cell Significance Index: -0.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0414
    Cell Significance Index: -0.5800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0429
    Cell Significance Index: -0.5100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0433
    Cell Significance Index: -0.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0445
    Cell Significance Index: -0.5700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0456
    Cell Significance Index: -0.5600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0473
    Cell Significance Index: -0.5300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0480
    Cell Significance Index: -0.6200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0480
    Cell Significance Index: -0.5100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0480
    Cell Significance Index: -0.5200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0491
    Cell Significance Index: -0.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0520
    Cell Significance Index: -0.6200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0522
    Cell Significance Index: -0.5900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0531
    Cell Significance Index: -0.6700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0550
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0554
    Cell Significance Index: -0.5200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0554
    Cell Significance Index: -0.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0564
    Cell Significance Index: -0.7000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0569
    Cell Significance Index: -0.7100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0569
    Cell Significance Index: -0.5900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0578
    Cell Significance Index: -0.6100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0588
    Cell Significance Index: -0.6000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0588
    Cell Significance Index: -0.6000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0592
    Cell Significance Index: -0.4900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0602
    Cell Significance Index: -0.3600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0607
    Cell Significance Index: -0.7800
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0638
    Cell Significance Index: -0.6000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0642
    Cell Significance Index: -0.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0648
    Cell Significance Index: -0.6900
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0690
    Cell Significance Index: -0.5700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0701
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0711
    Cell Significance Index: -0.7400
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0728
    Cell Significance Index: -0.7400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0768
    Cell Significance Index: -0.7300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0790
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0794
    Cell Significance Index: -0.4800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0826
    Cell Significance Index: -0.6000
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0832
    Cell Significance Index: -0.7200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0879
    Cell Significance Index: -0.7700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0922
    Cell Significance Index: -0.6000
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: -0.0938
    Cell Significance Index: -0.5400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1045
    Cell Significance Index: -0.5500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1095
    Cell Significance Index: -0.6900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1155
    Cell Significance Index: -0.6200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1191
    Cell Significance Index: -0.5500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1193
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable Charge X-Linked Protein**: VCX2 is a variable charge X-linked protein, suggesting its involvement in protein-protein interactions and potential regulatory functions. 2. **Widespread Expression**: VCX2 is expressed in a diverse range of cell types, including primordial germ cells, intestinal epithelial cells, glial cells, and neural progenitor cells, highlighting its potential role in various biological processes. 3. **Pathway Significance**: VCX2 is implicated in several biological pathways, including brain development, cellular component, and molecular function, underscoring its multifaceted role in cellular regulation. 4. **Protein Structure**: The specific structure and organization of VCX2 remain unknown, requiring further investigation to elucidate its functional mechanisms. **Pathways and Functions:** 1. **Brain Development**: VCX2's involvement in brain development suggests its role in regulating neural cell fate decisions, neuronal differentiation, and synaptic plasticity. 2. **Cellular Component**: VCX2's expression in various cell types implies its involvement in cellular differentiation, migration, and survival, highlighting its potential role in tissue homeostasis. 3. **Molecular Function**: The variable charge X-linked nature of VCX2 suggests its involvement in protein-protein interactions, protein-ligand binding, and signal transduction pathways. 4. **Immune Regulation**: VCX2's expression in immune cells, such as glial cells and neural progenitor cells, implies its role in regulating immune responses, inflammation, and tissue repair. **Clinical Significance:** 1. **Neurological Disorders**: VCX2's involvement in brain development and neural function suggests its potential role in the pathogenesis of neurological disorders, such as autism, schizophrenia, and neurodegenerative diseases. 2. **Immunological Diseases**: VCX2's expression in immune cells implies its role in regulating immune responses, inflammation, and tissue repair, highlighting its potential as a therapeutic target in immunological diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: VCX2's expression in various cell types and its involvement in cellular differentiation and survival suggest its potential role in cancer development and progression, highlighting the need for further investigation into its functional mechanisms. In conclusion, VCX2 is a complex gene with far-reaching implications in immune regulation, brain development, and cellular differentiation. Further research is necessary to elucidate its functional mechanisms, uncover its therapeutic potential, and unravel the mysteries surrounding this enigmatic gene.

Genular Protein ID: 2863946389

Symbol: VCX2_HUMAN

Name: Variable charge X-linked protein 2

UniProtKB Accession Codes:

Q9H322 A3KPB6 Q4V9T2 Q9P0H5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 1 STRING 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10903929

Title: A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.

PubMed ID: 10903929

DOI: 10.1086/303047

PubMed ID: 10607842

Title: A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.

PubMed ID: 10607842

DOI: 10.1093/hmg/9.2.311

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 139
  • Mass: 14661
  • Checksum: 0AE8B40CF2A3B739
  • Sequence:
    • MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA 
AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEV EEPLSQESEV 
EEPLTVWMAS FSPVSESTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.