Details for: LGSN

Gene ID: 51557

Symbol: LGSN

Ensembl ID: ENSG00000146166

Description: lengsin, lens protein with glutamine synthetase domain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.9101
    Cell Significance Index: -2.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 3.0488
    Cell Significance Index: 107.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.4238
    Cell Significance Index: 50.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1646
    Cell Significance Index: 62.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9494
    Cell Significance Index: 48.7300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.8804
    Cell Significance Index: 59.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3049
    Cell Significance Index: 80.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1971
    Cell Significance Index: 18.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1018
    Cell Significance Index: 35.2900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.7523
    Cell Significance Index: 9.7200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5135
    Cell Significance Index: 7.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4701
    Cell Significance Index: 89.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3994
    Cell Significance Index: 5.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3094
    Cell Significance Index: 6.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2723
    Cell Significance Index: 16.3500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2428
    Cell Significance Index: 3.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2258
    Cell Significance Index: 6.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2109
    Cell Significance Index: 20.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1982
    Cell Significance Index: 21.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1868
    Cell Significance Index: 168.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1788
    Cell Significance Index: 4.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1414
    Cell Significance Index: 6.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1171
    Cell Significance Index: 19.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1006
    Cell Significance Index: 6.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0634
    Cell Significance Index: 97.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0508
    Cell Significance Index: 93.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0492
    Cell Significance Index: 66.9000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0353
    Cell Significance Index: 0.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0198
    Cell Significance Index: 1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0179
    Cell Significance Index: 6.4200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0177
    Cell Significance Index: 0.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0175
    Cell Significance Index: 0.3800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0145
    Cell Significance Index: 0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0085
    Cell Significance Index: 1.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0077
    Cell Significance Index: 4.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0027
    Cell Significance Index: 0.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0026
    Cell Significance Index: 0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0019
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0027
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0034
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0047
    Cell Significance Index: -0.8000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0064
    Cell Significance Index: -0.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0085
    Cell Significance Index: -1.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0102
    Cell Significance Index: -1.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0114
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0118
    Cell Significance Index: -1.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0124
    Cell Significance Index: -0.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0154
    Cell Significance Index: -0.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0157
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0157
    Cell Significance Index: -2.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0172
    Cell Significance Index: -2.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0186
    Cell Significance Index: -0.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0195
    Cell Significance Index: -0.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0206
    Cell Significance Index: -1.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0209
    Cell Significance Index: -0.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0223
    Cell Significance Index: -1.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0271
    Cell Significance Index: -1.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0274
    Cell Significance Index: -0.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0289
    Cell Significance Index: -0.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0297
    Cell Significance Index: -0.4100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0319
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0323
    Cell Significance Index: -0.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0327
    Cell Significance Index: -0.5500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0338
    Cell Significance Index: -0.4300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0347
    Cell Significance Index: -0.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0361
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0361
    Cell Significance Index: -0.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0368
    Cell Significance Index: -0.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0374
    Cell Significance Index: -2.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0378
    Cell Significance Index: -2.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0400
    Cell Significance Index: -0.7900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0431
    Cell Significance Index: -0.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0444
    Cell Significance Index: -0.8700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0447
    Cell Significance Index: -0.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0452
    Cell Significance Index: -0.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0457
    Cell Significance Index: -2.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0469
    Cell Significance Index: -0.6500
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0478
    Cell Significance Index: -0.5000
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0480
    Cell Significance Index: -0.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0481
    Cell Significance Index: -0.3300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0483
    Cell Significance Index: -0.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0484
    Cell Significance Index: -1.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0489
    Cell Significance Index: -1.8500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0491
    Cell Significance Index: -1.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0511
    Cell Significance Index: -1.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0531
    Cell Significance Index: -1.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0548
    Cell Significance Index: -2.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0551
    Cell Significance Index: -0.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lens Protein with Glutamine Synthetase Domain:** Lengsin's unique structure, comprising a lens protein and a glutamine synthetase domain, sets it apart from other known proteins. This domain is crucial for its function, as it enables the protein to interact with glutamine and other amino acids, regulating their synthesis and utilization. 2. **Significant Expression in Various Cell Types:** Lengsin's expression in hematopoietic oligopotent progenitor cells, small intestine goblet cells, and lens fiber cells highlights its potential role in multiple cellular processes, including cell proliferation, differentiation, and maintenance of cellular homeostasis. 3. **Cytoplasmic and Membrane Localization:** The localization of Lengsin in the cytoplasm and plasma membrane of various cells suggests its involvement in intracellular signaling pathways, membrane trafficking, and cellular communication. **Pathways and Functions:** 1. **Glutamine Biosynthetic Process:** Lengsin's glutamine synthetase domain enables it to participate in the regulation of glutamine synthesis, a critical process for cellular energy metabolism and nitrogen utilization. 2. **Glutamine Synthetase Activity:** The glutamine synthetase activity of Lengsin allows it to interact with glutamine and other amino acids, regulating their synthesis and utilization. 3. **Nitrogen Utilization:** Lengsin's role in nitrogen utilization is essential for maintaining cellular homeostasis and supporting various cellular processes, including protein synthesis and energy metabolism. 4. **Cell Proliferation and Differentiation:** The expression of Lengsin in hematopoietic oligopotent progenitor cells and small intestine goblet cells suggests its involvement in cell proliferation and differentiation. **Clinical Significance:** 1. **Lens Disorders:** The expression of Lengsin in lens fiber cells highlights its potential role in maintaining lens transparency and structure. Abnormal expression of Lengsin may contribute to lens disorders, such as cataracts and age-related macular degeneration. 2. **Gastrointestinal Disorders:** The expression of Lengsin in small intestine goblet cells and intestinal tuft cells suggests its involvement in maintaining intestinal homeostasis and regulating gut function. Abnormal expression of Lengsin may contribute to gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome. 3. **Cancer Research:** The expression of Lengsin in hematopoietic oligopotent progenitor cells and transit amplifying cells of small intestine and colon suggests its potential role in cancer development and progression. Further investigation is required to understand the involvement of Lengsin in cancer biology. In conclusion, Lengsin is a multifunctional protein with a glutamine synthetase domain, exhibiting a unique combination of characteristics that warrant further investigation. Its expression in various cell types and involvement in multiple biological processes make it an attractive candidate for further study, particularly in the context of lens disorders, gastrointestinal disorders, and cancer research.

Genular Protein ID: 102490521

Symbol: LGSN_HUMAN

Name: Lengsin

UniProtKB Accession Codes:

Q5TDP6 A1L421 Q0PVN9 Q0PVP0 Q9NYJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17010935

Title: Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens.

PubMed ID: 17010935

DOI: 10.1016/j.bbrc.2006.09.062

PubMed ID: 12107413

Title: Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants.

PubMed ID: 12107413

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 509
  • Mass: 57278
  • Checksum: 86ACAC50866121BB
  • Sequence:
    • MNNEEDLLQE DSTRDEGNET EANSMNTLRR TRKKVTKPYV CSTEVGETDM SNSNDCMRDS 
SQILTPPQLS SRMKHIRQAM AKNRLQFVRF EATDLHGVSR SKTIPAHFFQ EKVSHGVCMP 
RGYLEVIPNP KDNEMNNIRA TCFNSDIVLM PELSTFRVLP WADRTARVIC DTFTVTGEPL 
LTSPRYIAKR QLSHLQASGF SLLSAFIYDF CIFGVPEILN SKIISFPALT FLNNHDQPFM 
QELVDGLYHT GANVESFSSS TRPGQMEISF LPEFGISSAD NAFTLRTGVK EVARKYNYIA 
SFFIETGFCD SGILSHSLWD VDRKKNMFCS TSGTEQLTIT GKKWLAGLLK HSAALSCLMA 
PSVSCRKRYS KDRKDLKKSV PTTWGYNDNS CIFNIKCHGE KGTRIENKLG SATANPYLVL 
AATVAAGLDG LHSSNEVLAG PDESTDFYQV EPSEIPLKLE DALVALEEDQ CLRQALGETF 
IRYFVAMKKY ELENEEIAAE RNKFLEYFI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.