TUBA8 | ENSG00000183785 | NCBI 51807

Details for: TUBA8

Gene ID: 51807

Symbol: TUBA8

Ensembl ID: ENSG00000183785

Description: tubulin alpha 8

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Carboxyterminal post-translational modifications of tubulin
(R-HSA-8955332)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
G2/m transition
(R-HSA-69275)
Gap junction assembly
(R-HSA-190861)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon signaling
(R-HSA-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-HSA-190840)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pkr-mediated signaling
(R-HSA-9833482)
Post-chaperonin tubulin folding pathway
(R-HSA-389977)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Protein folding
(R-HSA-391251)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Recycling pathway of l1
(R-HSA-437239)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-HSA-9668328)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of connexons to the plasma membrane
(R-HSA-190872)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Acrosomal vesicle
(GO:0001669)
Cytoplasm
(GO:0005737)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Protein binding
(GO:0005515)
Spermatid development
(GO:0007286)
Structural constituent of cytoskeleton
(GO:0005200)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 41.8528
Cell Significance Index: -6.5100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 25.7448
Cell Significance Index: -6.5300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 12.1844
Cell Significance Index: -4.9500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 12.1796
Cell Significance Index: -6.2700
Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.1022
Cell Significance Index: 46.0300
Cell Name: keratocyte (CL0002363)
Fold Change: 0.9461
Cell Significance Index: 15.0100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.5476
Cell Significance Index: 14.0800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5072
Cell Significance Index: 101.7500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.4200
Cell Significance Index: 28.2400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4082
Cell Significance Index: 13.0800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2153
Cell Significance Index: 42.7200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2064
Cell Significance Index: 9.1300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1909
Cell Significance Index: 7.2300
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.1668
Cell Significance Index: 1.1300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1026
Cell Significance Index: 2.7500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0896
Cell Significance Index: 32.1300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0686
Cell Significance Index: 5.2700
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.0652
Cell Significance Index: 1.5900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0566
Cell Significance Index: 9.2100
Cell Name: helper T cell (CL0000912)
Fold Change: 0.0324
Cell Significance Index: 0.4600
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0300
Cell Significance Index: 0.5900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0294
Cell Significance Index: 20.3300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0263
Cell Significance Index: 0.4500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0239
Cell Significance Index: 4.5600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0093
Cell Significance Index: 0.9200
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0082
Cell Significance Index: 15.2100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0044
Cell Significance Index: 0.2000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0036
Cell Significance Index: 5.5200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0030
Cell Significance Index: 0.1800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0028
Cell Significance Index: 5.3300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0008
Cell Significance Index: -0.1400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0039
Cell Significance Index: -5.2700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0056
Cell Significance Index: -3.5700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0075
Cell Significance Index: -5.4900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0087
Cell Significance Index: -6.5800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0090
Cell Significance Index: -6.6400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0097
Cell Significance Index: -1.4100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0106
Cell Significance Index: -0.4600
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0114
Cell Significance Index: -6.2300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0115
Cell Significance Index: -5.2100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0117
Cell Significance Index: -6.5800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0126
Cell Significance Index: -0.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0140
Cell Significance Index: -0.9000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0173
Cell Significance Index: -4.9900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0208
Cell Significance Index: -0.6000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0229
Cell Significance Index: -2.8200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0234
Cell Significance Index: -1.4400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0242
Cell Significance Index: -4.1300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0283
Cell Significance Index: -3.0800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0330
Cell Significance Index: -6.9500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0360
Cell Significance Index: -2.0200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0368
Cell Significance Index: -1.0500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0404
Cell Significance Index: -2.1200
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0431
Cell Significance Index: -0.6500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0435
Cell Significance Index: -5.9800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0449
Cell Significance Index: -5.8000
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.0452
Cell Significance Index: -0.4300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0453
Cell Significance Index: -5.3500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0474
Cell Significance Index: -3.2800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0544
Cell Significance Index: -5.5600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0546
Cell Significance Index: -1.7400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0558
Cell Significance Index: -6.5000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0575
Cell Significance Index: -1.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0577
Cell Significance Index: -6.6100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0578
Cell Significance Index: -1.4500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0603
Cell Significance Index: -1.2100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0622
Cell Significance Index: -6.4800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0660
Cell Significance Index: -3.4300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0774
Cell Significance Index: -4.8800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0831
Cell Significance Index: -6.1900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0835
Cell Significance Index: -1.7300
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.0843
Cell Significance Index: -1.3600
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0880
Cell Significance Index: -2.1100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0901
Cell Significance Index: -2.9500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0922
Cell Significance Index: -4.8100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0937
Cell Significance Index: -2.0300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0938
Cell Significance Index: -2.3400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0985
Cell Significance Index: -3.4500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0994
Cell Significance Index: -4.6700
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1035
Cell Significance Index: -2.1600
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1037
Cell Significance Index: -2.2400
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1074
Cell Significance Index: -1.1700
Cell Name: osteoclast (CL0000092)
Fold Change: -0.1175
Cell Significance Index: -1.2000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1190
Cell Significance Index: -5.5500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1234
Cell Significance Index: -2.4400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1299
Cell Significance Index: -3.4800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1346
Cell Significance Index: -3.5400
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1372
Cell Significance Index: -1.9700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1382
Cell Significance Index: -6.9800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1390
Cell Significance Index: -2.9600
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1395
Cell Significance Index: -2.0600
Cell Name: neuron (CL0000540)
Fold Change: -0.1403
Cell Significance Index: -1.3300
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.1498
Cell Significance Index: -2.0200
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.1514
Cell Significance Index: -1.2500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1560
Cell Significance Index: -5.4200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1597
Cell Significance Index: -5.6100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1599
Cell Significance Index: -4.4700
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1640
Cell Significance Index: -2.0700
Cell Name: neural cell (CL0002319)
Fold Change: -0.1663
Cell Significance Index: -1.9400
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1669
Cell Significance Index: -2.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** TUBA8 is a highly conserved protein, with high sequence homology across species. It is a constituent of microtubules, which are essential for maintaining cellular structure, regulating intracellular trafficking, and facilitating cell division. TUBA8 is also involved in the assembly and presentation of NMDA receptors on the cell surface, a process critical for synaptic transmission and neuronal development. **Pathways and Functions:** TUBA8 plays a pivotal role in various cellular processes, including: 1. **Microtubule formation and stabilization**: TUBA8 contributes to the formation and stabilization of microtubules, which are essential for maintaining cellular structure and regulating intracellular trafficking. 2. **NMDA receptor assembly and presentation**: TUBA8 is involved in the assembly and presentation of NMDA receptors on the cell surface, a process critical for synaptic transmission and neuronal development. 3. **Autophagy and selective autophagy**: TUBA8 is implicated in the regulation of autophagy, a process essential for maintaining cellular homeostasis and eliminating damaged organelles. 4. **Immune system regulation**: TUBA8 is expressed in various immune cells, including hematopoietic oligopotent progenitor cells and peripheral blood mononuclear cells, suggesting its involvement in immune system regulation. 5. **Cell cycle regulation**: TUBA8 is involved in the regulation of the cell cycle, particularly during the G2/M transition, a critical phase in cell division. **Clinical Significance:** TUBA8 has been implicated in various immune-related diseases, including: 1. **Neurological disorders**: TUBA8 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where microtubule dysfunction is a key pathogenic mechanism. 2. **Autoimmune diseases**: TUBA8 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where microtubule dysfunction can contribute to immune system dysregulation. 3. **Cancer**: TUBA8 has been linked to cancer, particularly in the context of microtubule-dependent cell division and survival. 4. **Infectious diseases**: TUBA8 has been implicated in the regulation of immune responses to viral infections, such as HIV-1. In conclusion, TUBA8 is a multifaceted protein with a wide range of functions, from microtubule formation and NMDA receptor assembly to autophagy and immune system regulation. Its dysregulation has been implicated in various immune-related diseases, highlighting the need for further research into the molecular mechanisms underlying TUBA8's role in immune system function and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tubulin alpha-8 chain

Genular Protein ID: 3836569525

Symbol: TBA8_HUMAN

Name: Tubulin alpha-8 chain

UniProtKB Accession Codes:

Q9NY65 B2RCX2 B3KPW9 B4DWG3 Q2M3N4

Database IDs:

Citations:

PubMed ID: 10772959

Title: TUBA8: a new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse.

PubMed ID: 10772959

DOI: 10.1006/bbrc.2000.2571

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 20466094

Title: Tuba8 is expressed at low levels in the developing mouse and human brain.

PubMed ID: 20466094

DOI: 10.1016/j.ajhg.2010.03.019

PubMed ID: 26875866

Title: Graded control of microtubule severing by tubulin glutamylation.

PubMed ID: 26875866

DOI: 10.1016/j.cell.2016.01.019

PubMed ID: 35482892

Title: Posttranslational modification of microtubules by the MATCAP detyrosinase.

PubMed ID: 35482892

DOI: 10.1126/science.abn6020

PubMed ID: 34704371

Title: Mutations in the most divergent alpha-tubulin isotype, alpha8-tubulin, cause defective platelet biogenesis.

PubMed ID: 34704371

DOI: 10.1111/jth.15573

Sequence Information:

Length: 449
Mass: 50094
Checksum: 8D1AFB9D131529BD
Sequence:

MRECISVHVG QAGVQIGNAC WELFCLEHGI QADGTFDAQA SKINDDDSFT TFFSETGNGK 
HVPRAVMIDL EPTVVDEVRA GTYRQLFHPE QLITGKEDAA NNYARGHYTV GKESIDLVLD 
RIRKLTDACS GLQGFLIFHS FGGGTGSGFT SLLMERLSLD YGKKSKLEFA IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLV TYAPIISAEK AYHEQLSVAE ITSSCFEPNS 
QMVKCDPRHG KYMACCMLYR GDVVPKDVNV AIAAIKTKRT IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDLAALEK DYEEVGTDSF EEENEGEEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TUBA8

Associated with

Cells (max top 100)

Other Information

TUBA8: a new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. PubMed ID: 10772959

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Tuba8 is expressed at low levels in the developing mouse and human brain. PubMed ID: 20466094

Graded control of microtubule severing by tubulin glutamylation. PubMed ID: 26875866

Posttranslational modification of microtubules by the MATCAP detyrosinase. PubMed ID: 35482892

Mutations in the most divergent alpha-tubulin isotype, alpha8-tubulin, cause defective platelet biogenesis. PubMed ID: 34704371