Details for: SERPINA4

Gene ID: 5267

Symbol: SERPINA4

Ensembl ID: ENSG00000100665

Description: serpin family A member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.8870
    Cell Significance Index: 96.9300
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.0067
    Cell Significance Index: 1.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.9912
    Cell Significance Index: 49.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8349
    Cell Significance Index: 58.7700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.6143
    Cell Significance Index: 6.0800
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.0718
    Cell Significance Index: 8.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8495
    Cell Significance Index: 21.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7942
    Cell Significance Index: 135.6100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.6729
    Cell Significance Index: 6.2500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3039
    Cell Significance Index: 1.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2653
    Cell Significance Index: 50.4800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2351
    Cell Significance Index: 3.4700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1779
    Cell Significance Index: 1.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0172
    Cell Significance Index: 1.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0161
    Cell Significance Index: 11.7700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0040
    Cell Significance Index: 0.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0113
    Cell Significance Index: -1.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0119
    Cell Significance Index: -10.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0184
    Cell Significance Index: -2.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0202
    Cell Significance Index: -0.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0250
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0265
    Cell Significance Index: -19.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0314
    Cell Significance Index: -0.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0370
    Cell Significance Index: -2.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0380
    Cell Significance Index: -4.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0417
    Cell Significance Index: -0.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0440
    Cell Significance Index: -0.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0462
    Cell Significance Index: -1.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0472
    Cell Significance Index: -1.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0567
    Cell Significance Index: -3.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0641
    Cell Significance Index: -11.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0655
    Cell Significance Index: -18.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0679
    Cell Significance Index: -13.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0855
    Cell Significance Index: -8.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0945
    Cell Significance Index: -11.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0977
    Cell Significance Index: -9.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1065
    Cell Significance Index: -22.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1094
    Cell Significance Index: -1.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1248
    Cell Significance Index: -25.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1299
    Cell Significance Index: -5.8900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1337
    Cell Significance Index: -1.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1405
    Cell Significance Index: -3.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1458
    Cell Significance Index: -18.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1519
    Cell Significance Index: -20.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1579
    Cell Significance Index: -12.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1653
    Cell Significance Index: -10.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1944
    Cell Significance Index: -4.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2337
    Cell Significance Index: -17.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2827
    Cell Significance Index: -4.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3273
    Cell Significance Index: -15.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3634
    Cell Significance Index: -5.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3929
    Cell Significance Index: -18.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4702
    Cell Significance Index: -12.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4729
    Cell Significance Index: -13.9300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4944
    Cell Significance Index: -5.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5148
    Cell Significance Index: -26.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5172
    Cell Significance Index: -11.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5468
    Cell Significance Index: -19.1600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.5480
    Cell Significance Index: -5.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5483
    Cell Significance Index: -13.9700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.6143
    Cell Significance Index: -4.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6170
    Cell Significance Index: -13.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6271
    Cell Significance Index: -16.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6441
    Cell Significance Index: -18.4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.7336
    Cell Significance Index: -8.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7623
    Cell Significance Index: -18.4700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.7627
    Cell Significance Index: -7.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7746
    Cell Significance Index: -25.3600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.8072
    Cell Significance Index: -11.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8091
    Cell Significance Index: -25.7700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.8161
    Cell Significance Index: -13.9500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8576
    Cell Significance Index: -13.8900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.8764
    Cell Significance Index: -14.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8790
    Cell Significance Index: -14.7100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.9226
    Cell Significance Index: -9.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.9268
    Cell Significance Index: -18.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9530
    Cell Significance Index: -14.0700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.9577
    Cell Significance Index: -10.5600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.9605
    Cell Significance Index: -13.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.9650
    Cell Significance Index: -14.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9651
    Cell Significance Index: -13.8800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.9714
    Cell Significance Index: -8.8900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.9900
    Cell Significance Index: -11.0100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.9947
    Cell Significance Index: -13.9700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.0016
    Cell Significance Index: -13.7400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0024
    Cell Significance Index: -14.2700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -1.0059
    Cell Significance Index: -12.0000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.0070
    Cell Significance Index: -12.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -1.0115
    Cell Significance Index: -9.5900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -1.0139
    Cell Significance Index: -12.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0171
    Cell Significance Index: -25.3700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -1.0225
    Cell Significance Index: -13.6300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -1.0255
    Cell Significance Index: -12.1900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.0260
    Cell Significance Index: -14.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.0312
    Cell Significance Index: -13.5700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -1.0315
    Cell Significance Index: -13.2100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.0322
    Cell Significance Index: -13.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine Protease Inhibitor:** SERPINA4 encodes for a protein that inhibits serine proteases, which are involved in various biological processes, including inflammation, coagulation, and immune response. 2. **Hemostasis Regulation:** SERPINA4 plays a critical role in regulating hemostasis by inhibiting platelet activation, aggregation, and degranulation, thereby preventing excessive bleeding. 3. **Immune Response:** SERPINA4 is expressed in immune cells, such as B cells and plasma cells, and is involved in the regulation of immune responses, including inflammation and immune cell activation. 4. **Tissue-Specific Expression:** SERPINA4 is highly expressed in multiple tissues, including the colon, liver, pancreas, and epithelial cells, suggesting a diverse range of physiological functions. **Pathways and Functions:** SERPINA4 is involved in several signaling pathways, including: 1. **Hemostasis:** SERPINA4 inhibits platelet activation, aggregation, and degranulation, thereby regulating hemostasis. 2. **Immune Response:** SERPINA4 is involved in the regulation of immune responses, including inflammation and immune cell activation. 3. **Extracellular Space:** SERPINA4 regulates the extracellular space by inhibiting serine proteases, which are involved in various biological processes. 4. **Negative Regulation of Endopeptidase Activity:** SERPINA4 inhibits endopeptidase activity, which is involved in the degradation of peptides and proteins. **Clinical Significance:** Dysregulation of SERPINA4 has been implicated in various diseases, including: 1. **Thrombosis:** SERPINA4 deficiency has been associated with an increased risk of thrombosis and cardiovascular disease. 2. **Inflammatory Diseases:** SERPINA4 is involved in the regulation of inflammation and immune responses, and its dysregulation has been implicated in various inflammatory diseases, including arthritis and asthma. 3. **Cancer:** SERPINA4 has been shown to have anti-tumor properties, and its dysregulation has been implicated in various types of cancer. 4. **Neurological Diseases:** SERPINA4 has been implicated in the regulation of neuroinflammation and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, SERPINA4 is a critical component of the serpin family, regulating hemostasis, immune response, and inflammation. Its dysregulation has been implicated in various diseases, highlighting the importance of SERPINA4 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the functions of SERPINA4 and its role in human disease.

Genular Protein ID: 3586419318

Symbol: KAIN_HUMAN

Name: Kallistatin

UniProtKB Accession Codes:

P29622 Q53XB5 Q86TR9 Q96BZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8227002

Title: Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli.

PubMed ID: 8227002

DOI: 10.1016/s0021-9258(20)80553-5

PubMed ID: 7835886

Title: Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4).

PubMed ID: 7835886

DOI: 10.1006/geno.1994.1513

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1334488

Title: Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence.

PubMed ID: 1334488

DOI: 10.1016/s0021-9258(18)35690-4

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

Sequence Information:

  • Length: 427
  • Mass: 48542
  • Checksum: 68EBE7AF956BFB77
  • Sequence:
    • MHLIDYLLLL LVGLLALSHG QLHVEHDGES CSNSSHQQIL ETGEGSPSLK IAPANADFAF 
RFYYLIASET PGKNIFFSPL SISAAYAMLS LGACSHSRSQ ILEGLGFNLT ELSESDVHRG 
FQHLLHTLNL PGHGLETRVG SALFLSHNLK FLAKFLNDTM AVYEAKLFHT NFYDTVGTIQ 
LINDHVKKET RGKIVDLVSE LKKDVLMVLV NYIYFKALWE KPFISSRTTP KDFYVDENTT 
VRVPMMLQDQ EHHWYLHDRY LPCSVLRMDY KGDATVFFIL PNQGKMREIE EVLTPEMLMR 
WNNLLRKRNF YKKLELHLPK FSISGSYVLD QILPRLGFTD LFSKWADLSG ITKQQKLEAS 
KSFHKATLDV DEAGTEAAAA TSFAIKFFSA QTNRHILRFN RPFLVVIFST STQSVLFLGK 
VVDPTKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.