Details for: PLG

Gene ID: 5340

Symbol: PLG

Ensembl ID: ENSG00000122194

Description: plasminogen

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.1633
    Cell Significance Index: 137.5100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.1363
    Cell Significance Index: 23.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7067
    Cell Significance Index: 537.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1447
    Cell Significance Index: 46.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3537
    Cell Significance Index: 19.9800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2789
    Cell Significance Index: 7.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2736
    Cell Significance Index: 242.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2273
    Cell Significance Index: 39.3100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.1199
    Cell Significance Index: 3.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8575
    Cell Significance Index: 84.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7821
    Cell Significance Index: 706.2000
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.6729
    Cell Significance Index: 5.1700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.4940
    Cell Significance Index: 3.9000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.4858
    Cell Significance Index: 1.6900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4713
    Cell Significance Index: 4.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4537
    Cell Significance Index: 73.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4423
    Cell Significance Index: 48.1100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3478
    Cell Significance Index: 1.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2832
    Cell Significance Index: 6.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2632
    Cell Significance Index: 18.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2405
    Cell Significance Index: 14.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2324
    Cell Significance Index: 4.9500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1915
    Cell Significance Index: 1.8200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1556
    Cell Significance Index: 1.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1512
    Cell Significance Index: 2.2000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1208
    Cell Significance Index: 1.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0745
    Cell Significance Index: 5.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0613
    Cell Significance Index: 1.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0594
    Cell Significance Index: 1.5300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.0507
    Cell Significance Index: 0.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0501
    Cell Significance Index: 3.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0486
    Cell Significance Index: 1.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0399
    Cell Significance Index: 8.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0378
    Cell Significance Index: 1.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0366
    Cell Significance Index: 20.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0322
    Cell Significance Index: 0.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0317
    Cell Significance Index: 0.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0309
    Cell Significance Index: 0.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0257
    Cell Significance Index: 1.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0172
    Cell Significance Index: 0.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0155
    Cell Significance Index: 5.5700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0097
    Cell Significance Index: 0.1000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0087
    Cell Significance Index: 0.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0019
    Cell Significance Index: 2.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0012
    Cell Significance Index: 0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0007
    Cell Significance Index: 0.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0021
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0024
    Cell Significance Index: -0.4100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0025
    Cell Significance Index: -0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0038
    Cell Significance Index: -2.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0040
    Cell Significance Index: -0.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0046
    Cell Significance Index: -1.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0051
    Cell Significance Index: -0.2300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0063
    Cell Significance Index: -1.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0068
    Cell Significance Index: -1.4300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0088
    Cell Significance Index: -1.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0095
    Cell Significance Index: -1.1200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0112
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0130
    Cell Significance Index: -1.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0134
    Cell Significance Index: -1.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0135
    Cell Significance Index: -1.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0139
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0142
    Cell Significance Index: -1.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0142
    Cell Significance Index: -0.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0161
    Cell Significance Index: -0.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0162
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0179
    Cell Significance Index: -1.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0181
    Cell Significance Index: -0.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0182
    Cell Significance Index: -0.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0208
    Cell Significance Index: -0.6800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0210
    Cell Significance Index: -0.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0218
    Cell Significance Index: -0.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0219
    Cell Significance Index: -1.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0219
    Cell Significance Index: -1.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0221
    Cell Significance Index: -0.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0231
    Cell Significance Index: -0.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0233
    Cell Significance Index: -0.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0246
    Cell Significance Index: -0.6700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0249
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0252
    Cell Significance Index: -2.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0253
    Cell Significance Index: -1.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0260
    Cell Significance Index: -0.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0263
    Cell Significance Index: -1.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0263
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The PLG gene encodes for a precursor protein that undergoes proteolytic processing to produce the active enzyme plasmin. 2. **Function:** Plasmin plays a critical role in fibrinolysis, the degradation of the extracellular matrix, and tissue remodeling. 3. **Expression:** PLG is expressed in various cell types, including hepatocytes, retinal bipolar neurons, and immune cells. 4. **Regulation:** PLG expression is regulated by various factors, including proteolytic processing, post-translational modifications, and transcriptional control. **Pathways and Functions:** 1. **Fibrinolysis:** Plasminogen is converted to plasmin, which then degrades fibrin clots, regulating blood coagulation. 2. **Matrix Metalloproteinases (MMPs):** Plasminogen activation is linked to the activation of MMPs, which degrade the extracellular matrix and regulate tissue remodeling. 3. **Cell-Cell Adhesion:** Plasminogen and plasmin regulate cell-cell adhesion by modulating the activity of cadherins and other adhesion molecules. 4. **Immune Response:** Plasminogen and plasmin play roles in immune response, including the regulation of leukocyte migration and the degradation of extracellular matrix. 5. **Tissue Remodeling:** Plasminogen and plasmin regulate tissue remodeling by degrading the extracellular matrix and modulating the activity of growth factors. **Clinical Significance:** 1. **Cardiovascular Disorders:** Alterations in PLG expression have been implicated in cardiovascular disorders, including atherosclerosis and thrombosis. 2. **Cancer:** PLG expression is altered in various cancers, including breast cancer and lung cancer, where it regulates tumor growth and metastasis. 3. **Neurodegenerative Diseases:** PLG expression is altered in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it regulates synaptic transmission and tissue remodeling. 4. **Inflammatory Diseases:** PLG expression is altered in inflammatory diseases, including rheumatoid arthritis and multiple sclerosis, where it regulates immune response and tissue remodeling. In conclusion, the plasminogen gene plays a critical role in regulating fibrinolysis, tissue remodeling, and immune response. Alterations in PLG expression have been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 607072704

Symbol: PLMN_HUMAN

Name: Plasmin heavy chain A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2318848

Title: Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.

PubMed ID: 2318848

DOI: 10.1016/s0021-9258(19)39298-1

PubMed ID: 3030813

Title: Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.

PubMed ID: 3030813

DOI: 10.1016/0014-5793(87)81501-6

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 122932

Title: Structural relationship between 'glutamic acid' and 'lysine' forms of human plasminogen and their interaction with the NH2-terminal activation peptide as studied by affinity chromatography.

PubMed ID: 122932

DOI: 10.1111/j.1432-1033.1975.tb09887.x

PubMed ID: 6148961

Title: Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen.

PubMed ID: 6148961

DOI: 10.1021/bi00313a035

PubMed ID: 126863

Title: Amino-acid sequence of the cyanogen-bromide fragment from human plasminogen that forms the linkage between the plasmin chains.

PubMed ID: 126863

DOI: 10.1111/j.1432-1033.1975.tb02403.x

PubMed ID: 142009

Title: Primary structure of the B-chain of human plasmin.

PubMed ID: 142009

DOI: 10.1111/j.1432-1033.1977.tb11578.x

PubMed ID: 4694729

Title: The primary structure of human plasminogen. II. The histidine loop of human plasmin: light (B) chain active center histidine sequence.

PubMed ID: 4694729

DOI: 10.1016/s0021-9258(19)44237-3

PubMed ID: 4240117

Title: Studies on the active center of human plasmin. Partial amino acid sequence of a peptide containing the active center serine residue.

PubMed ID: 4240117

DOI: 10.1016/s0021-9258(18)83410-x

PubMed ID: 6919539

Title: Structure of the omega-aminocarboxylic acid-binding sites of human plasminogen. Arginine 70 and aspartic acid 56 are essential for binding of ligand by kringle 4.

PubMed ID: 6919539

DOI: 10.1016/s0021-9258(18)34391-6

PubMed ID: 6094526

Title: The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain.

PubMed ID: 6094526

DOI: 10.1016/s0021-9258(18)89800-3

PubMed ID: 9201958

Title: Serine-578 is a major phosphorylation locus in human plasma plasminogen.

PubMed ID: 9201958

DOI: 10.1021/bi970328d

PubMed ID: 3356193

Title: The N- and O-linked carbohydrate chains of human, bovine and porcine plasminogen. Species specificity in relation to sialylation and fucosylation patterns.

PubMed ID: 3356193

DOI: 10.1111/j.1432-1033.1988.tb13966.x

PubMed ID: 9102401

Title: Acceleration of plasminogen activation by tissue plasminogen activator on surface-bound histidine-proline-rich glycoprotein.

PubMed ID: 9102401

DOI: 10.1074/jbc.272.9.5718

PubMed ID: 9054441

Title: Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.

PubMed ID: 9054441

DOI: 10.1074/jbc.272.11.7408

PubMed ID: 7525077

Title: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

PubMed ID: 7525077

DOI: 10.1016/0092-8674(94)90200-3

PubMed ID: 9102221

Title: A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer.

PubMed ID: 9102221

PubMed ID: 9548733

Title: Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).

PubMed ID: 9548733

DOI: 10.1021/bi9731798

PubMed ID: 10077593

Title: Angiostatin binds ATP synthase on the surface of human endothelial cells.

PubMed ID: 10077593

DOI: 10.1073/pnas.96.6.2811

PubMed ID: 10889192

Title: Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen).

PubMed ID: 10889192

DOI: 10.1074/jbc.m002290200

PubMed ID: 14699093

Title: Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells.

PubMed ID: 14699093

DOI: 10.1074/jbc.m310964200

PubMed ID: 15016824

Title: Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.

PubMed ID: 15016824

DOI: 10.1074/jbc.m401023200

PubMed ID: 16043488

Title: Angiomotin regulates endothelial cell-cell junctions and cell motility.

PubMed ID: 16043488

DOI: 10.1074/jbc.m503915200

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 2143188

Title: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.

PubMed ID: 2143188

DOI: 10.1016/s0021-9258(18)77401-2

PubMed ID: 19712047

Title: Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage.

PubMed ID: 19712047

DOI: 10.1042/bj20090794

PubMed ID: 21949403

Title: Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut.

PubMed ID: 21949403

DOI: 10.1073/pnas.1103657108

PubMed ID: 22433849

Title: OspC is potent plasminogen receptor on surface of Borrelia burgdorferi.

PubMed ID: 22433849

DOI: 10.1074/jbc.m111.290775

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27387503

Title: Molecular Interactions of human plasminogen with fibronectin-binding Protein B (FnBPB), a fibrinogen/fibronectin-binding protein from Staphylococcus aureus.

PubMed ID: 27387503

DOI: 10.1074/jbc.m116.731125

PubMed ID: 34502392

Title: Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.

PubMed ID: 34502392

DOI: 10.3390/ijms22179480

PubMed ID: 36756125

Title: Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment <i>in vivo</i> while altering the levels of chemokines and adhesion molecules.

PubMed ID: 36756125

DOI: 10.3389/fimmu.2023.1116324

PubMed ID: 1657148

Title: Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution.

PubMed ID: 1657148

DOI: 10.1021/bi00107a029

PubMed ID: 1657149

Title: The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.

PubMed ID: 1657149

DOI: 10.1021/bi00107a030

PubMed ID: 8054447

Title: The structure of recombinant plasminogen kringle 1 and the fibrin binding site.

PubMed ID: 8054447

DOI: 10.1097/00001721-199404000-00001

PubMed ID: 8611560

Title: Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.

PubMed ID: 8611560

DOI: 10.1021/bi9521351

PubMed ID: 15299951

Title: Structure of human plasminogen kringle 4 at 1.68 Angstrom and 277 K. A possible structural role of disordered residues.

PubMed ID: 15299951

DOI: 10.1107/s0907444996012267

PubMed ID: 9783753

Title: The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action.

PubMed ID: 9783753

DOI: 10.1038/2359

PubMed ID: 9521645

Title: Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.

PubMed ID: 9521645

DOI: 10.1021/bi972284e

PubMed ID: 10656799

Title: Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.

PubMed ID: 10656799

DOI: 10.1006/jmbi.1999.3397

PubMed ID: 11350170

Title: Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein.

PubMed ID: 11350170

DOI: 10.1006/jmbi.2001.4646

PubMed ID: 12054798

Title: The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.

PubMed ID: 12054798

DOI: 10.1016/s0022-2836(02)00211-5

PubMed ID: 12456874

Title: Effects of deletion of streptokinase residues 48-59 on plasminogen activation.

PubMed ID: 12456874

DOI: 10.1093/protein/15.9.753

PubMed ID: 15211511

Title: Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain.

PubMed ID: 15211511

DOI: 10.1002/prot.20070

PubMed ID: 23335990

Title: The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake.

PubMed ID: 23335990

DOI: 10.1371/journal.pone.0054104

PubMed ID: 2157850

Title: Solution structure of the kringle 4 domain from human plasminogen by 1H nuclear magnetic resonance spectroscopy and distance geometry.

PubMed ID: 2157850

DOI: 10.1016/0022-2836(90)90330-o

PubMed ID: 8181475

Title: 1H-NMR assignments and secondary structure of human plasminogen kringle 1.

PubMed ID: 8181475

DOI: 10.1111/j.1432-1033.1994.tb18808.x

PubMed ID: 8181476

Title: Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1.

PubMed ID: 8181476

DOI: 10.1111/j.1432-1033.1994.tb18809.x

PubMed ID: 8652577

Title: Recombinant gene expression and 1H NMR characteristics of the kringle (2 + 3) supermodule: spectroscopic/functional individuality of plasminogen kringle domains.

PubMed ID: 8652577

DOI: 10.1021/bi9520949

PubMed ID: 9305949

Title: Ligand preferences of kringle 2 and homologous domains of human plasminogen: canvassing weak, intermediate, and high-affinity binding sites by 1H-NMR.

PubMed ID: 9305949

DOI: 10.1021/bi971316v

PubMed ID: 22645135

Title: Structural basis for activation of an integral membrane protease by lipopolysaccharide.

PubMed ID: 22645135

DOI: 10.1074/jbc.m112.376418

PubMed ID: 1986355

Title: Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.

PubMed ID: 1986355

DOI: 10.1073/pnas.88.1.115

PubMed ID: 8392398

Title: Congenital plasminogen deficiency caused by a Ser-572 to Pro mutation.

PubMed ID: 8392398

PubMed ID: 6216475

Title: Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

PubMed ID: 6216475

DOI: 10.1073/pnas.79.20.6132

PubMed ID: 6238949

Title: Plasminogens Tochigi II and Nagoya: two additional molecular defects with Ala-600-->Thr replacement found in plasmin light chain variants.

PubMed ID: 6238949

DOI: 10.1093/oxfordjournals.jbchem.a134836

PubMed ID: 1427790

Title: Plasminogen with type-I mutation is polymorphic in the Japanese population.

PubMed ID: 1427790

DOI: 10.1007/bf00210737

PubMed ID: 9242524

Title: Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

PubMed ID: 9242524

PubMed ID: 9858247

Title: Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.

PubMed ID: 9858247

DOI: 10.1046/j.1365-2141.1998.01074.x

PubMed ID: 10233898

Title: Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

PubMed ID: 10233898

PubMed ID: 23204165

Title: Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.

PubMed ID: 23204165

DOI: 10.1093/infdis/jis718

PubMed ID: 28795768

Title: Hereditary angioedema with a mutation in the plasminogen gene.

PubMed ID: 28795768

DOI: 10.1111/all.13270

PubMed ID: 29952006

Title: Plasminogen gene mutation with normal C1 inhibitor hereditary angioedema: Three additional French families.

PubMed ID: 29952006

DOI: 10.1111/all.13543

PubMed ID: 29987869

Title: A missense mutation of the plasminogen gene in hereditary angioedema with normal C1 inhibitor in Japan.

PubMed ID: 29987869

DOI: 10.1111/all.13550

PubMed ID: 29548426

Title: A missense mutation in the plasminogen gene, within the plasminogen kringle 3 domain, in hereditary angioedema with normal C1 inhibitor.

PubMed ID: 29548426

DOI: 10.1016/j.bbrc.2017.12.060

PubMed ID: 33114181

Title: Deciphering the genetics of primary angioedema with normal levels of C1 inhibitor.

PubMed ID: 33114181

DOI: 10.3390/jcm9113402

PubMed ID: 33799813

Title: Screening for plasminogen mutations in hereditary angioedema patients.

PubMed ID: 33799813

DOI: 10.3390/genes12030402

Sequence Information:

  • Length: 810
  • Mass: 90569
  • Checksum: 8B31CB877CCB3AB6
  • Sequence:
  • MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA AKCEEDEEFT 
    CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL SECKTGNGKN YRGTMSKTKN 
    GITCQKWSST SPHRPRFSPA THPSEGLEEN YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE 
    CEEECMHCSG ENYDGKISKT MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE 
    LRPWCFTTDP NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS 
    AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP SCDSSPVSTE 
    QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS WSSMTPHRHQ KTPENYPNAG 
    LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN LKKCSGTEAS VVAPPPVVLL PDVETPSEED 
    CMFGNGKGYR GKRATTVTGT PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG 
    PWCYTTNPRK LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT 
    RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ EIEVSRLFLE 
    PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF ITGWGETQGT FGAGLLKEAQ 
    LPVIENKVCN RYEFLNGRVQ STELCAGHLA GGTDSCQGDS GGPLVCFEKD KYILQGVTSW 
    GLGCARPNKP GVYVRVSRFV TWIEGVMRNN

Genular Protein ID: 3170429502

Symbol: Q5TEH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 136
  • Mass: 15444
  • Checksum: 617124AAABBD2A4B
  • Sequence:
  • MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA AKCEEDEEFT 
    CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL SECKTGNGKN YRGTMSKTKN 
    GITCQKWSST SPHRPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.