Details for: PLG

Gene ID: 5340

Symbol: PLG

Ensembl ID: ENSG00000122194

Description: plasminogen

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 8.45
    Marker Score: 27081
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.48
    Marker Score: 14681
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.58
    Marker Score: 4965
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.82
    Marker Score: 15159
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.58
    Marker Score: 7647
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1
    Marker Score: 13497
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.04
    Marker Score: 8797
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 2.02
    Marker Score: 5884
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.96
    Marker Score: 6967
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.9
    Marker Score: 16102.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.82
    Marker Score: 1749
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.6
    Marker Score: 1717
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.28
    Marker Score: 484
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7359
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.1
    Marker Score: 341.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2574
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.03
    Marker Score: 704
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.86
    Marker Score: 857
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1616
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1504
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.76
    Marker Score: 209
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9114
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 456
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 334
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 367
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.54
    Marker Score: 546
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.34
    Marker Score: 210
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.32
    Marker Score: 71
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 153
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 315
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.29
    Marker Score: 109
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 171
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 115
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 120
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2
    Marker Score: 193
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.16
    Marker Score: 553
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 148
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.15
    Marker Score: 285
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 152
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.13
    Marker Score: 99.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.13
    Marker Score: 134
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.13
    Marker Score: 210
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.12
    Marker Score: 221
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.12
    Marker Score: 178
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.11
    Marker Score: 124
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.11
    Marker Score: 157
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.11
    Marker Score: 942
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.1
    Marker Score: 267.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.1
    Marker Score: 147
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 82
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.09
    Marker Score: 846
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.09
    Marker Score: 106
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 75
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.08
    Marker Score: 5028

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Other Information

**Key characteristics:** - PLG is a secreted protein that is synthesized by endothelial cells and some other cell types. - It is a large protein with a molecular weight of approximately 140 kDa. - It is a key regulator of blood coagulation and inflammation. **Pathways and functions:** - PLG is a key activator of matrix metalloproteinases, enzymes that break down the ECM. - It is involved in the degradation of the ECM in blood vessels, where it helps to regulate blood flow and inflammation. - In inflammation, PLG is released from damaged blood vessels and deposited in the site of injury. - It then activates matrix metalloproteinases, which break down the ECM and promote the formation of new blood vessels. - PLG also plays a role in the regulation of platelet aggregation and degranulation. **Clinical significance:** - Mutations in the PLG gene have been linked to a number of human diseases, including vascular disease, cancer, and inflammation. - In vascular disease, mutations in PLG can lead to the formation of blood clots, which can block blood flow and cause heart attack and stroke. - In cancer, mutations in PLG can promote tumor growth and metastasis. - In inflammation, mutations in PLG can lead to the release of inflammatory cytokines and chemokines, which can contribute to the development of chronic inflammation. **Additional notes:** - PLG is a highly conserved protein, with similar genes found in other vertebrates. - It is a promising target for the treatment of vascular disease and cancer. - There are a number of drugs that are currently used to inhibit PLG and treat disease.

Genular Protein ID: 607072704

Symbol: PLMN_HUMAN

Name: Plasmin heavy chain A

UniProtKB Accession Codes:

P00747 Q15146 Q5TEH4 Q6PA00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EC 1 EMBL 25 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 69 PDBsum 47 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2318848

Title: Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.

PubMed ID: 2318848

DOI: 10.1016/s0021-9258(19)39298-1

PubMed ID: 3030813

Title: Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.

PubMed ID: 3030813

DOI: 10.1016/0014-5793(87)81501-6

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 122932

Title: Structural relationship between 'glutamic acid' and 'lysine' forms of human plasminogen and their interaction with the NH2-terminal activation peptide as studied by affinity chromatography.

PubMed ID: 122932

DOI: 10.1111/j.1432-1033.1975.tb09887.x

PubMed ID: 6148961

Title: Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen.

PubMed ID: 6148961

DOI: 10.1021/bi00313a035

PubMed ID: 126863

Title: Amino-acid sequence of the cyanogen-bromide fragment from human plasminogen that forms the linkage between the plasmin chains.

PubMed ID: 126863

DOI: 10.1111/j.1432-1033.1975.tb02403.x

PubMed ID: 142009

Title: Primary structure of the B-chain of human plasmin.

PubMed ID: 142009

DOI: 10.1111/j.1432-1033.1977.tb11578.x

PubMed ID: 4694729

Title: The primary structure of human plasminogen. II. The histidine loop of human plasmin: light (B) chain active center histidine sequence.

PubMed ID: 4694729

DOI: 10.1016/s0021-9258(19)44237-3

PubMed ID: 4240117

Title: Studies on the active center of human plasmin. Partial amino acid sequence of a peptide containing the active center serine residue.

PubMed ID: 4240117

DOI: 10.1016/s0021-9258(18)83410-x

PubMed ID: 6919539

Title: Structure of the omega-aminocarboxylic acid-binding sites of human plasminogen. Arginine 70 and aspartic acid 56 are essential for binding of ligand by kringle 4.

PubMed ID: 6919539

DOI: 10.1016/s0021-9258(18)34391-6

PubMed ID: 6094526

Title: The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain.

PubMed ID: 6094526

DOI: 10.1016/s0021-9258(18)89800-3

PubMed ID: 9201958

Title: Serine-578 is a major phosphorylation locus in human plasma plasminogen.

PubMed ID: 9201958

DOI: 10.1021/bi970328d

PubMed ID: 3356193

Title: The N- and O-linked carbohydrate chains of human, bovine and porcine plasminogen. Species specificity in relation to sialylation and fucosylation patterns.

PubMed ID: 3356193

DOI: 10.1111/j.1432-1033.1988.tb13966.x

PubMed ID: 9102401

Title: Acceleration of plasminogen activation by tissue plasminogen activator on surface-bound histidine-proline-rich glycoprotein.

PubMed ID: 9102401

DOI: 10.1074/jbc.272.9.5718

PubMed ID: 9054441

Title: Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.

PubMed ID: 9054441

DOI: 10.1074/jbc.272.11.7408

PubMed ID: 7525077

Title: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

PubMed ID: 7525077

DOI: 10.1016/0092-8674(94)90200-3

PubMed ID: 9102221

Title: A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer.

PubMed ID: 9102221

PubMed ID: 9548733

Title: Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).

PubMed ID: 9548733

DOI: 10.1021/bi9731798

PubMed ID: 10077593

Title: Angiostatin binds ATP synthase on the surface of human endothelial cells.

PubMed ID: 10077593

DOI: 10.1073/pnas.96.6.2811

PubMed ID: 10889192

Title: Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen).

PubMed ID: 10889192

DOI: 10.1074/jbc.m002290200

PubMed ID: 14699093

Title: Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells.

PubMed ID: 14699093

DOI: 10.1074/jbc.m310964200

PubMed ID: 15016824

Title: Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.

PubMed ID: 15016824

DOI: 10.1074/jbc.m401023200

PubMed ID: 16043488

Title: Angiomotin regulates endothelial cell-cell junctions and cell motility.

PubMed ID: 16043488

DOI: 10.1074/jbc.m503915200

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 2143188

Title: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.

PubMed ID: 2143188

DOI: 10.1016/s0021-9258(18)77401-2

PubMed ID: 19712047

Title: Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage.

PubMed ID: 19712047

DOI: 10.1042/bj20090794

PubMed ID: 21949403

Title: Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut.

PubMed ID: 21949403

DOI: 10.1073/pnas.1103657108

PubMed ID: 22433849

Title: OspC is potent plasminogen receptor on surface of Borrelia burgdorferi.

PubMed ID: 22433849

DOI: 10.1074/jbc.m111.290775

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27387503

Title: Molecular Interactions of human plasminogen with fibronectin-binding Protein B (FnBPB), a fibrinogen/fibronectin-binding protein from Staphylococcus aureus.

PubMed ID: 27387503

DOI: 10.1074/jbc.m116.731125

PubMed ID: 1657148

Title: Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution.

PubMed ID: 1657148

DOI: 10.1021/bi00107a029

PubMed ID: 1657149

Title: The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.

PubMed ID: 1657149

DOI: 10.1021/bi00107a030

PubMed ID: 8054447

Title: The structure of recombinant plasminogen kringle 1 and the fibrin binding site.

PubMed ID: 8054447

DOI: 10.1097/00001721-199404000-00001

PubMed ID: 8611560

Title: Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.

PubMed ID: 8611560

DOI: 10.1021/bi9521351

PubMed ID: 15299951

Title: Structure of human plasminogen kringle 4 at 1.68 Angstrom and 277 K. A possible structural role of disordered residues.

PubMed ID: 15299951

DOI: 10.1107/s0907444996012267

PubMed ID: 9783753

Title: The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action.

PubMed ID: 9783753

DOI: 10.1038/2359

PubMed ID: 9521645

Title: Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.

PubMed ID: 9521645

DOI: 10.1021/bi972284e

PubMed ID: 10656799

Title: Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.

PubMed ID: 10656799

DOI: 10.1006/jmbi.1999.3397

PubMed ID: 11350170

Title: Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein.

PubMed ID: 11350170

DOI: 10.1006/jmbi.2001.4646

PubMed ID: 12054798

Title: The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.

PubMed ID: 12054798

DOI: 10.1016/s0022-2836(02)00211-5

PubMed ID: 12456874

Title: Effects of deletion of streptokinase residues 48-59 on plasminogen activation.

PubMed ID: 12456874

DOI: 10.1093/protein/15.9.753

PubMed ID: 15211511

Title: Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain.

PubMed ID: 15211511

DOI: 10.1002/prot.20070

PubMed ID: 23335990

Title: The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake.

PubMed ID: 23335990

DOI: 10.1371/journal.pone.0054104

PubMed ID: 2157850

Title: Solution structure of the kringle 4 domain from human plasminogen by 1H nuclear magnetic resonance spectroscopy and distance geometry.

PubMed ID: 2157850

DOI: 10.1016/0022-2836(90)90330-o

PubMed ID: 8181475

Title: 1H-NMR assignments and secondary structure of human plasminogen kringle 1.

PubMed ID: 8181475

DOI: 10.1111/j.1432-1033.1994.tb18808.x

PubMed ID: 8181476

Title: Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1.

PubMed ID: 8181476

DOI: 10.1111/j.1432-1033.1994.tb18809.x

PubMed ID: 8652577

Title: Recombinant gene expression and 1H NMR characteristics of the kringle (2 + 3) supermodule: spectroscopic/functional individuality of plasminogen kringle domains.

PubMed ID: 8652577

DOI: 10.1021/bi9520949

PubMed ID: 9305949

Title: Ligand preferences of kringle 2 and homologous domains of human plasminogen: canvassing weak, intermediate, and high-affinity binding sites by 1H-NMR.

PubMed ID: 9305949

DOI: 10.1021/bi971316v

PubMed ID: 1986355

Title: Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.

PubMed ID: 1986355

DOI: 10.1073/pnas.88.1.115

PubMed ID: 8392398

Title: Congenital plasminogen deficiency caused by a Ser-572 to Pro mutation.

PubMed ID: 8392398

PubMed ID: 6216475

Title: Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

PubMed ID: 6216475

DOI: 10.1073/pnas.79.20.6132

PubMed ID: 6238949

Title: Plasminogens Tochigi II and Nagoya: two additional molecular defects with Ala-600-->Thr replacement found in plasmin light chain variants.

PubMed ID: 6238949

DOI: 10.1093/oxfordjournals.jbchem.a134836

PubMed ID: 1427790

Title: Plasminogen with type-I mutation is polymorphic in the Japanese population.

PubMed ID: 1427790

DOI: 10.1007/bf00210737

PubMed ID: 9242524

Title: Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

PubMed ID: 9242524

PubMed ID: 9858247

Title: Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.

PubMed ID: 9858247

DOI: 10.1046/j.1365-2141.1998.01074.x

PubMed ID: 10233898

Title: Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

PubMed ID: 10233898

PubMed ID: 23204165

Title: Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.

PubMed ID: 23204165

DOI: 10.1093/infdis/jis718

PubMed ID: 28795768

Title: Hereditary angioedema with a mutation in the plasminogen gene.

PubMed ID: 28795768

DOI: 10.1111/all.13270

PubMed ID: 29952006

Title: Plasminogen gene mutation with normal C1 inhibitor hereditary angioedema: Three additional French families.

PubMed ID: 29952006

DOI: 10.1111/all.13543

PubMed ID: 29987869

Title: A missense mutation of the plasminogen gene in hereditary angioedema with normal C1 inhibitor in Japan.

PubMed ID: 29987869

DOI: 10.1111/all.13550

PubMed ID: 29548426

Title: A missense mutation in the plasminogen gene, within the plasminogen kringle 3 domain, in hereditary angioedema with normal C1 inhibitor.

PubMed ID: 29548426

DOI: 10.1016/j.bbrc.2017.12.060

PubMed ID: 33114181

Title: Deciphering the genetics of primary angioedema with normal levels of C1 inhibitor.

PubMed ID: 33114181

DOI: 10.3390/jcm9113402

PubMed ID: 33799813

Title: Screening for plasminogen mutations in hereditary angioedema patients.

PubMed ID: 33799813

DOI: 10.3390/genes12030402

Sequence Information:

  • Length: 810
  • Mass: 90569
  • Checksum: 8B31CB877CCB3AB6
  • Sequence:
    • MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA AKCEEDEEFT 
CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL SECKTGNGKN YRGTMSKTKN 
GITCQKWSST SPHRPRFSPA THPSEGLEEN YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE 
CEEECMHCSG ENYDGKISKT MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE 
LRPWCFTTDP NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS 
AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP SCDSSPVSTE 
QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS WSSMTPHRHQ KTPENYPNAG 
LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN LKKCSGTEAS VVAPPPVVLL PDVETPSEED 
CMFGNGKGYR GKRATTVTGT PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG 
PWCYTTNPRK LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT 
RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ EIEVSRLFLE 
PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF ITGWGETQGT FGAGLLKEAQ 
LPVIENKVCN RYEFLNGRVQ STELCAGHLA GGTDSCQGDS GGPLVCFEKD KYILQGVTSW 
GLGCARPNKP GVYVRVSRFV TWIEGVMRNN

Genular Protein ID: 3170429502

Symbol: Q5TEH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TEH5

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 136
  • Mass: 15444
  • Checksum: 617124AAABBD2A4B
  • Sequence:
    • MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA AKCEEDEEFT 
CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL SECKTGNGKN YRGTMSKTKN 
GITCQKWSST SPHRPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.