Details for: PON3

Gene ID: 5446

Symbol: PON3

Ensembl ID: ENSG00000105852

Description: paraoxonase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.6029
    Cell Significance Index: -5.1200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 7.4513
    Cell Significance Index: -5.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.3418
    Cell Significance Index: -5.1000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.8982
    Cell Significance Index: 65.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5764
    Cell Significance Index: -3.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2726
    Cell Significance Index: 242.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1966
    Cell Significance Index: 28.9900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.1488
    Cell Significance Index: 23.9600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.0528
    Cell Significance Index: 3.9700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.9864
    Cell Significance Index: 10.1800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8887
    Cell Significance Index: 6.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7815
    Cell Significance Index: 155.1000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7363
    Cell Significance Index: 4.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6442
    Cell Significance Index: 63.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5922
    Cell Significance Index: 534.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5797
    Cell Significance Index: 34.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5144
    Cell Significance Index: 10.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5011
    Cell Significance Index: 35.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4895
    Cell Significance Index: 7.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4887
    Cell Significance Index: 53.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3829
    Cell Significance Index: 6.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3668
    Cell Significance Index: 229.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3622
    Cell Significance Index: 58.9100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3381
    Cell Significance Index: 4.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3022
    Cell Significance Index: 15.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2816
    Cell Significance Index: 13.1300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.2628
    Cell Significance Index: 1.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2396
    Cell Significance Index: 16.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1778
    Cell Significance Index: 2.6800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1758
    Cell Significance Index: 1.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1308
    Cell Significance Index: 5.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1229
    Cell Significance Index: 3.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1209
    Cell Significance Index: 53.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1131
    Cell Significance Index: 2.4500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0851
    Cell Significance Index: 1.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0571
    Cell Significance Index: 6.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0553
    Cell Significance Index: 41.8400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0528
    Cell Significance Index: 0.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0514
    Cell Significance Index: 8.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0502
    Cell Significance Index: 1.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0468
    Cell Significance Index: 1.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0462
    Cell Significance Index: 3.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0159
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0144
    Cell Significance Index: 27.0900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0071
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0060
    Cell Significance Index: 1.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0059
    Cell Significance Index: 0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0057
    Cell Significance Index: 0.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0029
    Cell Significance Index: 0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0017
    Cell Significance Index: 0.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0006
    Cell Significance Index: 0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0024
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0038
    Cell Significance Index: -0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0042
    Cell Significance Index: -5.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0054
    Cell Significance Index: -0.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0081
    Cell Significance Index: -4.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0120
    Cell Significance Index: -1.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0121
    Cell Significance Index: -4.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0136
    Cell Significance Index: -1.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0156
    Cell Significance Index: -4.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0179
    Cell Significance Index: -2.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0196
    Cell Significance Index: -1.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0199
    Cell Significance Index: -3.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0199
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0237
    Cell Significance Index: -2.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0253
    Cell Significance Index: -0.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0293
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0298
    Cell Significance Index: -1.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0364
    Cell Significance Index: -4.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0410
    Cell Significance Index: -4.1900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0451
    Cell Significance Index: -0.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0474
    Cell Significance Index: -5.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0499
    Cell Significance Index: -5.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0580
    Cell Significance Index: -1.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0587
    Cell Significance Index: -3.0500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0653
    Cell Significance Index: -0.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0656
    Cell Significance Index: -5.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0695
    Cell Significance Index: -5.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0748
    Cell Significance Index: -5.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0749
    Cell Significance Index: -3.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0754
    Cell Significance Index: -4.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0786
    Cell Significance Index: -4.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0929
    Cell Significance Index: -2.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0995
    Cell Significance Index: -4.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0998
    Cell Significance Index: -2.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1086
    Cell Significance Index: -5.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1142
    Cell Significance Index: -5.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1167
    Cell Significance Index: -4.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1218
    Cell Significance Index: -1.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1222
    Cell Significance Index: -1.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1296
    Cell Significance Index: -4.5400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1307
    Cell Significance Index: -1.0800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1329
    Cell Significance Index: -1.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1343
    Cell Significance Index: -2.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PON3 is a serine protease that exhibits lactonase activity, capable of hydrolyzing lactones and esters. It is primarily expressed in various tissues, including germ cells, epithelial cells of the lung, granulocyte monocyte progenitor cells, and hepatocytes, particularly in the midzonal and centrilobular regions. PON3 is also found in the extracellular space and is associated with exosomes, suggesting its role in intercellular communication. **Pathways and Functions:** PON3 is involved in several metabolic pathways, including: 1. **Acyl-l-homoserine-lactone lactonohydrolase activity**: PON3 hydrolyzes lactones, which are key players in the regulation of various cellular processes, including cell signaling and redox homeostasis. 2. **Arachidonic acid metabolism**: PON3 modulates the metabolism of arachidonic acid, a polyunsaturated fatty acid involved in inflammation and immune responses. 3. **Aromatic compound catabolic process**: PON3 catalyzes the degradation of aromatic compounds, which are essential for the metabolism of xenobiotics and endogenous compounds. 4. **Aryldialkylphosphatase activity**: PON3 exhibits phosphatase activity, which is involved in the regulation of various cellular processes, including cell signaling and protein function. 5. **Atorvastatin adme**: PON3 is involved in the metabolism of atorvastatin, a statin medication used to lower cholesterol levels. **Clinical Significance:** PON3's function in protecting against oxidative stress and inflammation makes it an attractive target for the treatment of various diseases, including: 1. **Atherosclerosis**: PON3's ability to hydrolyze lactones and esters may contribute to the development of atherosclerosis. Inhibiting PON3 activity may lead to increased lactone levels, exacerbating atherosclerosis. 2. **Neurodegenerative diseases**: PON3's role in regulating arachidonic acid metabolism and antioxidant defenses may be critical in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cancer**: PON3's involvement in the degradation of aromatic compounds and its potential role in cell signaling may contribute to cancer development and progression. In conclusion, PON3 is a multifunctional enzyme that plays a critical role in various cellular processes, including metabolism, cell signaling, and antioxidant defenses. Further research is needed to fully elucidate the function and clinical significance of PON3, but its potential implications in various diseases make it an exciting area of study for immunologists and clinicians alike.

Genular Protein ID: 479259831

Symbol: PON3_HUMAN

Name: Serum paraoxonase/lactonase 3

UniProtKB Accession Codes:

Q15166 A4D1H8 O75855 O76060 Q6IRU9 Q8IX97 Q9BZH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChEBI 18 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 6 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661009

Title: The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.

PubMed ID: 8661009

DOI: 10.1006/geno.1996.0225

PubMed ID: 15772423

Title: Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.

PubMed ID: 15772423

DOI: 10.1194/jlr.m400511-jlr200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 354
  • Mass: 39607
  • Checksum: 1B861B35E8533921
  • Sequence:
    • MGKLVALVLL GVGLSLVGEM FLAFRERVNA SREVEPVEPE NCHLIEELES GSEDIDILPS 
GLAFISSGLK YPGMPNFAPD EPGKIFLMDL NEQNPRAQAL EISGGFDKEL FNPHGISIFI 
DKDNTVYLYV VNHPHMKSTV EIFKFEEQQR SLVYLKTIKH ELLKSVNDIV VLGPEQFYAT 
RDHYFTNSLL SFFEMILDLR WTYVLFYSPR EVKVVAKGFC SANGITVSAD QKYVYVADVA 
AKNIHIMEKH DNWDLTQLKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LNYNPEDPPG 
SEVLRIQNVL SEKPRVSTVY ANNGSVLQGT SVASVYHGKI LIGTVFHKTL YCEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.