Details for: PTGFR

Gene ID: 5737

Symbol: PTGFR

Ensembl ID: ENSG00000122420

Description: prostaglandin F receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 12.6929
    Cell Significance Index: 174.0600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.8894
    Cell Significance Index: 19.4900
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.4545
    Cell Significance Index: 8.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1302
    Cell Significance Index: 17.9300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.7645
    Cell Significance Index: 5.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6726
    Cell Significance Index: 33.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6641
    Cell Significance Index: 13.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5806
    Cell Significance Index: 12.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5744
    Cell Significance Index: 11.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5015
    Cell Significance Index: 33.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3624
    Cell Significance Index: 46.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3613
    Cell Significance Index: 9.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3270
    Cell Significance Index: 117.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2170
    Cell Significance Index: 6.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1461
    Cell Significance Index: 16.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0636
    Cell Significance Index: 3.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0539
    Cell Significance Index: 3.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0425
    Cell Significance Index: 8.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0087
    Cell Significance Index: 6.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0071
    Cell Significance Index: 0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0068
    Cell Significance Index: 3.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0031
    Cell Significance Index: 2.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0020
    Cell Significance Index: -1.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0057
    Cell Significance Index: -1.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0062
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0068
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0099
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0105
    Cell Significance Index: -1.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0111
    Cell Significance Index: -4.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0134
    Cell Significance Index: -2.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0138
    Cell Significance Index: -3.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0192
    Cell Significance Index: -3.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0219
    Cell Significance Index: -0.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0338
    Cell Significance Index: -0.8100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0378
    Cell Significance Index: -0.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0391
    Cell Significance Index: -3.9900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0407
    Cell Significance Index: -0.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0415
    Cell Significance Index: -5.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0429
    Cell Significance Index: -5.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0442
    Cell Significance Index: -1.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0522
    Cell Significance Index: -5.4400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0550
    Cell Significance Index: -0.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0575
    Cell Significance Index: -4.4100
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.0606
    Cell Significance Index: -0.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0607
    Cell Significance Index: -2.8600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0657
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0669
    Cell Significance Index: -5.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0688
    Cell Significance Index: -0.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0763
    Cell Significance Index: -5.6900
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0767
    Cell Significance Index: -0.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0785
    Cell Significance Index: -1.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0931
    Cell Significance Index: -5.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0937
    Cell Significance Index: -2.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0970
    Cell Significance Index: -5.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1004
    Cell Significance Index: -1.6800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1041
    Cell Significance Index: -0.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1072
    Cell Significance Index: -4.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1076
    Cell Significance Index: -5.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1110
    Cell Significance Index: -5.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1151
    Cell Significance Index: -5.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1190
    Cell Significance Index: -3.7900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1223
    Cell Significance Index: -1.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1249
    Cell Significance Index: -3.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1297
    Cell Significance Index: -4.9100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1312
    Cell Significance Index: -1.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1350
    Cell Significance Index: -4.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1387
    Cell Significance Index: -4.5400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1404
    Cell Significance Index: -1.2800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1457
    Cell Significance Index: -2.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1496
    Cell Significance Index: -5.4900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.1568
    Cell Significance Index: -1.6600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1575
    Cell Significance Index: -3.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1599
    Cell Significance Index: -4.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1631
    Cell Significance Index: -4.4400
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1638
    Cell Significance Index: -1.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1645
    Cell Significance Index: -3.2800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.1671
    Cell Significance Index: -0.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1676
    Cell Significance Index: -5.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1726
    Cell Significance Index: -3.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1846
    Cell Significance Index: -2.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1873
    Cell Significance Index: -3.1500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1908
    Cell Significance Index: -2.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1914
    Cell Significance Index: -4.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1944
    Cell Significance Index: -4.9500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1970
    Cell Significance Index: -1.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2017
    Cell Significance Index: -5.8100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2114
    Cell Significance Index: -1.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2120
    Cell Significance Index: -3.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2126
    Cell Significance Index: -5.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2131
    Cell Significance Index: -5.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2137
    Cell Significance Index: -5.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** PTGFR belongs to the class A/1 (rhodopsin-like receptors) and is characterized by its seven transmembrane alpha-helices. 2. **Ligand Binding:** PTGFR is activated by prostaglandin F2-alpha, a naturally occurring prostaglandin that plays a role in various physiological and pathological processes. 3. **Signaling Pathways:** PTGFR is involved in several signaling pathways, including adenylate cyclase-activating G protein-coupled receptor signaling and calcium-mediated signaling. 4. **Cellular Expression:** PTGFR is significantly expressed in megakaryocytes, skeletal muscle cells, cardiac endothelial cells, and tracheal goblet cells, among others. **Pathways and Functions:** 1. **Adenylate Cyclase-Activating G Protein-Coupled Receptor Signaling Pathway:** Activation of PTGFR leads to the activation of adenylate cyclase, resulting in increased cAMP levels and subsequent activation of protein kinase A (PKA). 2. **Calcium-Mediated Signaling:** PTGFR activation also leads to the release of intracellular calcium, which activates various downstream signaling pathways, including the calcineurin/NFAT pathway. 3. **Cell Proliferation and Apoptosis:** PTGFR activation has been shown to regulate cell proliferation and apoptosis in various cell types, including megakaryocytes and skeletal muscle cells. 4. **Inflammatory Response:** PTGFR activation has been implicated in the regulation of inflammatory responses, particularly in the context of immune responses to lipopolysaccharide. 5. **Gene Expression:** PTGFR activation has been shown to regulate gene expression in various cell types, including the regulation of inflammatory genes. **Clinical Significance:** The Prostaglandin F Receptor plays a crucial role in various physiological and pathological processes, including: 1. **Parturition:** PTGFR has been implicated in the regulation of parturition, particularly in the context of preterm labor. 2. **Inflammatory Response:** PTGFR activation has been shown to regulate inflammatory responses, which is relevant in the context of various diseases, including inflammatory bowel disease and asthma. 3. **Cellular Proliferation and Apoptosis:** PTGFR activation has been shown to regulate cell proliferation and apoptosis in various cell types, which is relevant in the context of cancer and other diseases. 4. **Immune Response:** PTGFR activation has been implicated in the regulation of immune responses, particularly in the context of immune responses to lipopolysaccharide. Overall, the Prostaglandin F Receptor is a key player in regulating various cellular processes and immune responses. Further studies are needed to fully elucidate the role of PTGFR in various physiological and pathological processes.

Genular Protein ID: 2440009385

Symbol: PF2R_HUMAN

Name: Prostaglandin F2-alpha receptor

UniProtKB Accession Codes:

P43088 A8K9Y0 Q2KHP3 Q6RYQ6 Q9P1X4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 11 EMDB 8 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8300593

Title: Cloning and expression of a cDNA for the human prostanoid FP receptor.

PubMed ID: 8300593

DOI: 10.1016/s0021-9258(17)41991-0

PubMed ID: 9341156

Title: Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha.

PubMed ID: 9341156

DOI: 10.1074/jbc.272.43.27147

PubMed ID: 14984197

Title: Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor.

PubMed ID: 14984197

DOI: 10.1016/j.abb.2003.10.021

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18587449

Title: Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes.

PubMed ID: 18587449

DOI: 10.1038/bjp.2008.142

Sequence Information:

  • Length: 359
  • Mass: 40055
  • Checksum: 08077045C0B20BCA
  • Sequence:
    • MSMNNSKQLV SPAAALLSNT TCQTENRLSV FFSVIFMTVG ILSNSLAIAI LMKAYQRFRQ 
KSKASFLLLA SGLVITDFFG HLINGAIAVF VYASDKEWIR FDQSNVLCSI FGICMVFSGL 
CPLLLGSVMA IERCIGVTKP IFHSTKITSK HVKMMLSGVC LFAVFIALLP ILGHRDYKIQ 
ASRTWCFYNT EDIKDWEDRF YLLLFSFLGL LALGVSLLCN AITGITLLRV KFKSQQHRQG 
RSHHLEMVIQ LLAIMCVSCI CWSPFLVTMA NIGINGNHSL ETCETTLFAL RMATWNQILD 
PWVYILLRKA VLKNLYKLAS QCCGVHVISL HIWELSSIKN SLKVAAISES PVAEKSAST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.