Details for: RBP3

Gene ID: 5949

Symbol: RBP3

Ensembl ID: ENSG00000265203

Description: retinol binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 9.9520
    Cell Significance Index: 627.2400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.5300
    Cell Significance Index: 52.4500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.7009
    Cell Significance Index: 13.1100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.2289
    Cell Significance Index: 10.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8077
    Cell Significance Index: 11.0200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.5263
    Cell Significance Index: 6.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2047
    Cell Significance Index: 23.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1216
    Cell Significance Index: 1.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0577
    Cell Significance Index: 0.9700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0096
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0092
    Cell Significance Index: 1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0086
    Cell Significance Index: -5.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0120
    Cell Significance Index: -0.2000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0208
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0281
    Cell Significance Index: -15.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0313
    Cell Significance Index: -6.2800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0327
    Cell Significance Index: -0.3000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0371
    Cell Significance Index: -0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0378
    Cell Significance Index: -5.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0380
    Cell Significance Index: -2.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0533
    Cell Significance Index: -2.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0544
    Cell Significance Index: -2.8600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0673
    Cell Significance Index: -0.7600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0766
    Cell Significance Index: -0.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0808
    Cell Significance Index: -5.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0903
    Cell Significance Index: -5.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0961
    Cell Significance Index: -4.2500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1029
    Cell Significance Index: -1.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1074
    Cell Significance Index: -6.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1105
    Cell Significance Index: -5.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1125
    Cell Significance Index: -4.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1198
    Cell Significance Index: -3.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1504
    Cell Significance Index: -3.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1604
    Cell Significance Index: -1.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1696
    Cell Significance Index: -4.3200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1706
    Cell Significance Index: -1.6700
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1770
    Cell Significance Index: -2.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1790
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1840
    Cell Significance Index: -1.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1868
    Cell Significance Index: -6.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1948
    Cell Significance Index: -2.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2019
    Cell Significance Index: -6.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2036
    Cell Significance Index: -5.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2055
    Cell Significance Index: -6.5500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2235
    Cell Significance Index: -3.1000
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.2320
    Cell Significance Index: -2.8500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2336
    Cell Significance Index: -3.1500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2363
    Cell Significance Index: -3.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2454
    Cell Significance Index: -5.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2499
    Cell Significance Index: -4.2100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2565
    Cell Significance Index: -3.1200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2582
    Cell Significance Index: -3.2400
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.2593
    Cell Significance Index: -3.2000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2630
    Cell Significance Index: -3.4400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2678
    Cell Significance Index: -3.2600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2723
    Cell Significance Index: -3.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2726
    Cell Significance Index: -6.8000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2738
    Cell Significance Index: -2.2600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2756
    Cell Significance Index: -3.1600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.2799
    Cell Significance Index: -3.2500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2840
    Cell Significance Index: -4.3200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.2842
    Cell Significance Index: -3.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2922
    Cell Significance Index: -4.1600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.2998
    Cell Significance Index: -3.1500
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.3058
    Cell Significance Index: -3.6900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3073
    Cell Significance Index: -3.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3096
    Cell Significance Index: -6.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3097
    Cell Significance Index: -5.7300
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.3099
    Cell Significance Index: -3.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3138
    Cell Significance Index: -6.6600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.3138
    Cell Significance Index: -3.9000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3238
    Cell Significance Index: -6.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3240
    Cell Significance Index: -6.5100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3243
    Cell Significance Index: -4.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3301
    Cell Significance Index: -6.8900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3334
    Cell Significance Index: -4.0300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3339
    Cell Significance Index: -4.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3351
    Cell Significance Index: -6.6300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3365
    Cell Significance Index: -3.2100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3430
    Cell Significance Index: -6.7500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.3521
    Cell Significance Index: -4.4100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.3635
    Cell Significance Index: -3.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3673
    Cell Significance Index: -4.5800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3716
    Cell Significance Index: -4.6900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3721
    Cell Significance Index: -4.1200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3732
    Cell Significance Index: -4.4100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3739
    Cell Significance Index: -4.0200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3776
    Cell Significance Index: -3.8600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3818
    Cell Significance Index: -4.1600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3873
    Cell Significance Index: -4.0600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3885
    Cell Significance Index: -4.2500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.3968
    Cell Significance Index: -4.2400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3984
    Cell Significance Index: -4.1100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3985
    Cell Significance Index: -6.8900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4015
    Cell Significance Index: -4.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4016
    Cell Significance Index: -3.8600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4025
    Cell Significance Index: -4.7900
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.4086
    Cell Significance Index: -3.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4116
    Cell Significance Index: -5.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RBP3 is a small, secreted protein that binds to retinoids, facilitating their transport across cell membranes. It is primarily expressed in photoreceptor cells of the retina, as well as in immune cells such as T cells and plasma cells. RBP3 has a high affinity for all-trans retinol (ATR), the primary retinoid metabolite in the visual cycle, and plays a crucial role in maintaining retinoid homeostasis. **Pathways and Functions:** RBP3 is integral to the retinoid cycle, which involves the conversion of 11-cis retinal to all-trans retinal in photoreceptor cells. This process is essential for visual perception, as it allows for the regeneration of rhodopsin, the light-sensitive pigment in rod cells. Beyond its role in visual perception, RBP3 is involved in various other cellular processes, including: 1. **Lipid metabolism:** RBP3 regulates the transport of retinoids, which are essential lipid metabolites involved in cellular signaling pathways. 2. **Protein binding:** RBP3 interacts with various proteins, including serine proteases and lipases, influencing their activity and cellular behavior. 3. **Immune regulation:** RBP3 modulates immune responses by regulating the activity of immune cells, such as T cells and plasma cells. **Clinical Significance:** RBP3 has been implicated in various diseases, including: 1. **Visual impairment:** Mutations in the RBP3 gene have been associated with visual impairments, such as night blindness and cone-rod dystrophy. 2. **Immune-related disorders:** Abnormalities in RBP3 expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** RBP3 has been shown to play a role in cancer progression, particularly in the development of retinal cancer. 4. **Neurodegenerative diseases:** RBP3 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, RBP3 is a multifunctional protein that plays a critical role in both visual perception and immune regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying RBP3 function and its clinical significance.

Genular Protein ID: 605132852

Symbol: RET3_HUMAN

Name: Retinol-binding protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2542268

Title: Human interstitial retinoid-binding protein. Gene structure and primary structure.

PubMed ID: 2542268

DOI: 10.1016/s0021-9258(18)83169-6

PubMed ID: 2303470

Title: Characterization and comparative structural features of the gene for human interstitial retinol-binding protein.

PubMed ID: 2303470

DOI: 10.1016/s0021-9258(19)39642-5

PubMed ID: 2792773

Title: Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences.

PubMed ID: 2792773

DOI: 10.1016/0378-1119(89)90254-0

PubMed ID: 3170584

Title: Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA.

PubMed ID: 3170584

DOI: 10.1016/s0021-9258(19)37592-1

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3455009

Title: Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization.

PubMed ID: 3455009

DOI: 10.1007/bf01534925

PubMed ID: 2402443

Title: Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene.

PubMed ID: 2402443

DOI: 10.1093/nar/18.17.5181

PubMed ID: 17286855

Title: Mapping of transcription start sites of human retina expressed genes.

PubMed ID: 17286855

DOI: 10.1186/1471-2164-8-42

PubMed ID: 3827838

Title: Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing.

PubMed ID: 3827838

DOI: 10.1042/bj2400019

PubMed ID: 3743780

Title: N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species.

PubMed ID: 3743780

DOI: 10.1016/0014-5793(86)80918-8

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19074801

Title: A homozygous missense mutation in the IRBP gene (RBP3) associated with autosomal recessive retinitis pigmentosa.

PubMed ID: 19074801

DOI: 10.1167/iovs.08-2497

PubMed ID: 23486466

Title: Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).

PubMed ID: 23486466

DOI: 10.1074/jbc.m112.418251

Sequence Information:

  • Length: 1247
  • Mass: 135363
  • Checksum: 6C1841411E012E0F
  • Sequence:
  • MMREWVLLMS VLLCGLAGPT HLFQPSLVLD MAKVLLDNYC FPENLLGMQE AIQQAIKSHE 
    ILSISDPQTL ASVLTAGVQS SLNDPRLVIS YEPSTPEPPP QVPALTSLSE EELLAWLQRG 
    LRHEVLEGNV GYLRVDSVPG QEVLSMMGEF LVAHVWGNLM GTSALVLDLR HCTGGQVSGI 
    PYIISYLHPG NTILHVDTIY NRPSNTTTEI WTLPQVLGER YGADKDVVVL TSSQTRGVAE 
    DIAHILKQMR RAIVVGERTG GGALDLRKLR IGESDFFFTV PVSRSLGPLG GGSQTWEGSG 
    VLPCVGTPAE QALEKALAIL TLRSALPGVV HCLQEVLKDY YTLVDRVPTL LQHLASMDFS 
    TVVSEEDLVT KLNAGLQAAS EDPRLLVRAI GPTETPSWPA PDAAAEDSPG VAPELPEDEA 
    IRQALVDSVF QVSVLPGNVG YLRFDSFADA SVLGVLAPYV LRQVWEPLQD TEHLIMDLRH 
    NPGGPSSAVP LLLSYFQGPE AGPVHLFTTY DRRTNITQEH FSHMELPGPR YSTQRGVYLL 
    TSHRTATAAE EFAFLMQSLG WATLVGEITA GNLLHTRTVP LLDTPEGSLA LTVPVLTFID 
    NHGEAWLGGG VVPDAIVLAE EALDKAQEVL EFHQSLGALV EGTGHLLEAH YARPEVVGQT 
    SALLRAKLAQ GAYRTAVDLE SLASQLTADL QEVSGDHRLL VFHSPGELVV EEAPPPPPAV 
    PSPEELTYLI EALFKTEVLP GQLGYLRFDA MAELETVKAV GPQLVRLVWQ QLVDTAALVI 
    DLRYNPGSYS TAIPLLCSYF FEAEPRQHLY SVFDRATSKV TEVWTLPQVA GQRYGSHKDL 
    YILMSHTSGS AAEAFAHTMQ DLQRATVIGE PTAGGALSVG IYQVGSSPLY ASMPTQMAMS 
    ATTGKAWDLA GVEPDITVPM SEALSIAQDI VALRAKVPTV LQTAGKLVAD NYASAELGAK 
    MATKLSGLQS RYSRVTSEVA LAEILGADLQ MLSGDPHLKA AHIPENAKDR IPGIVPMQIP 
    SPEVFEELIK FSFHTNVLED NIGYLRFDMF GDGELLTQVS RLLVEHIWKK IMHTDAMIID 
    MRFNIGGPTS SIPILCSYFF DEGPPVLLDK IYSRPDDSVS ELWTHAQVVG ERYGSKKSMV 
    ILTSSVTAGT AEEFTYIMKR LGRALVIGEV TSGGCQPPQT YHVDDTNLYL TIPTARSVGA 
    SDGSSWEGVG VTPHVVVPAE EALARAKEML QHNQLRVKRS PGLQDHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.