Details for: OPN1LW

Gene ID: 5956

Symbol: OPN1LW

Ensembl ID: ENSG00000102076

Description: opsin 1, long wave sensitive

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9423
    Cell Significance Index: 22.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3599
    Cell Significance Index: 4.2900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1478
    Cell Significance Index: 1.4300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.1354
    Cell Significance Index: 1.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1231
    Cell Significance Index: 7.7600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.1169
    Cell Significance Index: 1.0300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0965
    Cell Significance Index: 1.0900
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.0963
    Cell Significance Index: 0.7600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0957
    Cell Significance Index: 1.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0584
    Cell Significance Index: 1.0000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0416
    Cell Significance Index: 0.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.0391
    Cell Significance Index: 0.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0270
    Cell Significance Index: 0.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0208
    Cell Significance Index: 1.0900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0170
    Cell Significance Index: 0.1400
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.0161
    Cell Significance Index: 0.1900
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: 0.0159
    Cell Significance Index: 0.2000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0115
    Cell Significance Index: 0.1500
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: 0.0073
    Cell Significance Index: 0.0900
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.0065
    Cell Significance Index: 0.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0016
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0049
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0054
    Cell Significance Index: -1.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0069
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0087
    Cell Significance Index: -1.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0090
    Cell Significance Index: -0.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0108
    Cell Significance Index: -0.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0108
    Cell Significance Index: -0.2800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0135
    Cell Significance Index: -0.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0137
    Cell Significance Index: -0.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0146
    Cell Significance Index: -0.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0149
    Cell Significance Index: -0.4200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0154
    Cell Significance Index: -0.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0161
    Cell Significance Index: -0.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0165
    Cell Significance Index: -0.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0168
    Cell Significance Index: -0.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0171
    Cell Significance Index: -0.9600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0172
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0173
    Cell Significance Index: -0.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0178
    Cell Significance Index: -0.3000
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0180
    Cell Significance Index: -0.2100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0186
    Cell Significance Index: -0.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0202
    Cell Significance Index: -0.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0207
    Cell Significance Index: -0.6600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0210
    Cell Significance Index: -0.2700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0214
    Cell Significance Index: -0.2400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0218
    Cell Significance Index: -0.2900
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0219
    Cell Significance Index: -0.2600
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0224
    Cell Significance Index: -0.2800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0238
    Cell Significance Index: -0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0239
    Cell Significance Index: -1.2100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0249
    Cell Significance Index: -0.4000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0250
    Cell Significance Index: -0.3200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0256
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0257
    Cell Significance Index: -0.3900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0260
    Cell Significance Index: -0.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0261
    Cell Significance Index: -0.6500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0261
    Cell Significance Index: -0.3300
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0261
    Cell Significance Index: -0.2600
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0263
    Cell Significance Index: -0.3200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0278
    Cell Significance Index: -0.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0288
    Cell Significance Index: -1.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0295
    Cell Significance Index: -0.4200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0296
    Cell Significance Index: -0.1600
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0302
    Cell Significance Index: -0.3700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0306
    Cell Significance Index: -0.4600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0307
    Cell Significance Index: -0.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0314
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0316
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0323
    Cell Significance Index: -0.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0327
    Cell Significance Index: -0.5300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0331
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0333
    Cell Significance Index: -0.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0333
    Cell Significance Index: -0.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0340
    Cell Significance Index: -1.0000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0345
    Cell Significance Index: -0.6800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0346
    Cell Significance Index: -0.4200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0349
    Cell Significance Index: -0.5100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0353
    Cell Significance Index: -0.4400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0353
    Cell Significance Index: -0.3700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0355
    Cell Significance Index: -0.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** OPN1LW is a rhodopsin-like receptor, a family of G protein-coupled receptors (GPCRs) that play a pivotal role in photoreception. 2. **Function:** As a long-wave sensitive opsin, OPN1LW is responsible for detecting visible light in the blue-violet spectrum, enabling cone cells to perceive daylight and color. 3. **Expression:** OPN1LW is highly expressed in various cell types, including glial cells, immune cells (e.g., T cells, B cells), and epithelial cells of the colon. **Pathways and Functions:** 1. **Photoreceptor Activity:** OPN1LW is integral to the visual phototransduction pathway, where it interacts with other photopigments to initiate a signaling cascade that ultimately leads to neural transmission of visual information. 2. **G Protein-Coupled Receptor Signaling:** OPN1LW is a member of the GPCR family, which responds to ligand binding by activating G proteins, leading to various downstream effects, including modulating cellular processes such as cytokinesis and cell cycle progression. 3. **Immune System:** OPN1LW is also expressed in immune cells, where it may play a role in modulating immune responses, potentially influencing the development of autoimmune diseases or immune-related disorders. **Clinical Significance:** Dysfunction or mutations in OPN1LW have been implicated in various retinal disorders, including color vision deficiency and age-related macular degeneration. Additionally, the expression of OPN1LW in immune cells may have implications for the development of immunotherapies or treatments for immune-related diseases. **Implications Beyond Visual Perception:** The discovery of OPN1LW's role in the immune system and other cellular processes highlights the complexity and interconnectedness of the human body. Further research into the functions and regulatory mechanisms of OPN1LW may uncover new avenues for understanding and treating a range of diseases, from immune disorders to neurodegenerative conditions. In conclusion, OPN1LW is a vital component of the visual transduction pathway and plays a significant role in the immune system. Further investigation into the structure, function, and clinical significance of OPN1LW will undoubtedly shed light on the intricate mechanisms underlying human health and disease.

Genular Protein ID: 2426902577

Symbol: OPSR_HUMAN

Name: Long-wave-sensitive opsin 1

UniProtKB Accession Codes:

P04000

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2937147

Title: Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

PubMed ID: 2937147

DOI: 10.1126/science.2937147

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 3303660

Title: Molecular biology of the visual pigments.

PubMed ID: 3303660

DOI: 10.1016/0042-6989(86)90115-x

PubMed ID: 1557123

Title: Polymorphism in red photopigment underlies variation in colour matching.

PubMed ID: 1557123

DOI: 10.1038/356431a0

PubMed ID: 8213841

Title: Genetic heterogeneity among blue-cone monochromats.

PubMed ID: 8213841

PubMed ID: 8666378

Title: Gene conversion between red and defective green opsin gene in blue cone monochromacy.

PubMed ID: 8666378

DOI: 10.1006/geno.1995.9998

PubMed ID: 12051694

Title: Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies.

PubMed ID: 12051694

DOI: 10.1016/s0006-291x(02)00458-8

Sequence Information:

  • Length: 364
  • Mass: 40574
  • Checksum: 730367A9CA3AB7D0
  • Sequence:
    • MAQQWSLQRL AGRHPQDSYE DSTQSSIFTY TNSNSTRGPF EGPNYHIAPR WVYHLTSVWM 
IFVVTASVFT NGLVLAATMK FKKLRHPLNW ILVNLAVADL AETVIASTIS IVNQVSGYFV 
LGHPMCVLEG YTVSLCGITG LWSLAIISWE RWMVVCKPFG NVRFDAKLAI VGIAFSWIWA 
AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMVTCCII PLAIIMLCYL 
QVWLAIRAVA KQQKESESTQ KAEKEVTRMV VVMIFAYCVC WGPYTFFACF AAANPGYAFH 
PLMAALPAYF AKSATIYNPV IYVFMNRQFR NCILQLFGKK VDDGSELSSA SKTEVSSVSS 
VSPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.