Details for: RFPL1

Gene ID: 5988

Symbol: RFPL1

Ensembl ID: ENSG00000128250

Description: ret finger protein like 1

Associated with

  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Innate immune response
    (GO:0045087)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of cell division
    (GO:0051782)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of g2/m transition of mitotic cell cycle
    (GO:0010972)
  • Negative regulation of mitotic cell cycle
    (GO:0045930)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
    (GO:2001272)
  • Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032436)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of viral entry into host cell
    (GO:0046596)
  • Ubiquitin protein ligase activity
    (GO:0061630)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.8597
    Cell Significance Index: -1.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3782
    Cell Significance Index: 3.0200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3378
    Cell Significance Index: 4.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1516
    Cell Significance Index: 3.3200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0676
    Cell Significance Index: 0.8500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0595
    Cell Significance Index: 0.4700
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.0510
    Cell Significance Index: 0.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0483
    Cell Significance Index: 1.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0304
    Cell Significance Index: 1.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0213
    Cell Significance Index: 0.3100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0205
    Cell Significance Index: 0.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0194
    Cell Significance Index: 0.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0143
    Cell Significance Index: 0.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0135
    Cell Significance Index: 2.7100
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.0123
    Cell Significance Index: 0.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0096
    Cell Significance Index: 2.7500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0084
    Cell Significance Index: 0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0054
    Cell Significance Index: 1.9400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0045
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0011
    Cell Significance Index: 0.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -0.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0057
    Cell Significance Index: -0.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0058
    Cell Significance Index: -0.1400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0060
    Cell Significance Index: -1.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0067
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0070
    Cell Significance Index: -1.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0079
    Cell Significance Index: -1.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0084
    Cell Significance Index: -1.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0095
    Cell Significance Index: -1.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0097
    Cell Significance Index: -0.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0099
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0107
    Cell Significance Index: -1.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0108
    Cell Significance Index: -0.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0120
    Cell Significance Index: -1.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0128
    Cell Significance Index: -0.4500
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0130
    Cell Significance Index: -0.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0133
    Cell Significance Index: -0.7000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0135
    Cell Significance Index: -0.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0139
    Cell Significance Index: -0.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0152
    Cell Significance Index: -0.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0168
    Cell Significance Index: -0.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0171
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0172
    Cell Significance Index: -0.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0172
    Cell Significance Index: -0.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0176
    Cell Significance Index: -0.9900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0189
    Cell Significance Index: -0.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0193
    Cell Significance Index: -0.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0199
    Cell Significance Index: -0.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0209
    Cell Significance Index: -0.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0224
    Cell Significance Index: -0.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0231
    Cell Significance Index: -0.2800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0231
    Cell Significance Index: -0.1600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0233
    Cell Significance Index: -0.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0255
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0266
    Cell Significance Index: -0.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0268
    Cell Significance Index: -0.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0274
    Cell Significance Index: -1.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0302
    Cell Significance Index: -0.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0316
    Cell Significance Index: -0.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0329
    Cell Significance Index: -0.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0329
    Cell Significance Index: -1.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0331
    Cell Significance Index: -0.6900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0357
    Cell Significance Index: -0.4500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0364
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0394
    Cell Significance Index: -1.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0400
    Cell Significance Index: -1.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0414
    Cell Significance Index: -1.0100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0422
    Cell Significance Index: -0.8300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0426
    Cell Significance Index: -0.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0432
    Cell Significance Index: -0.5900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0456
    Cell Significance Index: -0.5900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0465
    Cell Significance Index: -0.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0469
    Cell Significance Index: -0.6000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0471
    Cell Significance Index: -0.6200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0481
    Cell Significance Index: -0.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0503
    Cell Significance Index: -2.5400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0513
    Cell Significance Index: -0.6200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0524
    Cell Significance Index: -0.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0532
    Cell Significance Index: -1.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0545
    Cell Significance Index: -1.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0565
    Cell Significance Index: -0.9500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0583
    Cell Significance Index: -0.9800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0592
    Cell Significance Index: -0.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0593
    Cell Significance Index: -0.9600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0593
    Cell Significance Index: -0.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RFPL1 is a member of the ret finger protein family, characterized by the presence of a ret finger domain. This domain is responsible for protein-protein interactions and protein binding. RFPL1 has been shown to interact with various proteins, including kinases, phosphatases, and transcription factors, which regulate cellular processes such as cell cycle, apoptosis, and immune responses. RFPL1 is also involved in protein polyubiquitination, a post-translational modification that regulates protein degradation and protein activity. **Pathways and Functions** RFPL1 is involved in various cellular pathways, including: 1. **Cell Cycle Regulation**: RFPL1 negatively regulates the G2/M transition of the mitotic cell cycle, preventing excessive cell proliferation and ensuring proper cell division. 2. **Apoptosis**: RFPL1 positively regulates the apoptotic process, promoting programmed cell death in response to cellular stress or damage. 3. **Autophagy**: RFPL1 positively regulates autophagy, a process by which cells recycle damaged or dysfunctional cellular components. 4. **Immune Response**: RFPL1 is involved in the regulation of immune responses, including the positive regulation of NF-κB signaling and the activation of canonical NF-κB transcription factors. 5. **Viral Entry**: RFPL1 regulates viral entry into host cells, preventing the spread of viral infections. 6. **Protein Degradation**: RFPL1 is involved in protein polyubiquitination, a process that regulates protein degradation and protein activity. **Clinical Significance** RFPL1 has been implicated in various diseases, including: 1. **Cancer**: RFPL1 has been shown to be downregulated in various types of cancer, suggesting its role in tumor suppression. 2. **Neurodegenerative Diseases**: RFPL1 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it may play a role in regulating cellular stress and apoptosis. 3. **Immune Disorders**: RFPL1 has been shown to be involved in immune disorders, including autoimmune diseases and immunodeficiency disorders, where it may play a role in regulating immune responses. 4. **Viral Infections**: RFPL1 has been implicated in viral infections, including HIV and influenza, where it may play a role in regulating viral entry and replication. In conclusion, RFPL1 is a multifunctional protein that plays a crucial role in regulating cellular processes, including cell cycle, apoptosis, autophagy, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of RFPL1 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 2165872911

Symbol: RFPL1_HUMAN

Name: Ret finger protein-like 1

UniProtKB Accession Codes:

O75677 Q6IC06 Q9UJ97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10508838

Title: Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts.

PubMed ID: 10508838

DOI: 10.1101/gr.9.9.803

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20725088

Title: Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.

PubMed ID: 20725088

DOI: 10.1038/cdd.2010.102

Sequence Information:

  • Length: 317
  • Mass: 35491
  • Checksum: 75FDDED7BF51B8CA
  • Sequence:
    • MKRLSLVTTN RLSPHGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP MSLECGCAVC 
FKCINSLQKE PHGEDLLCCC CSMVSQKNKI RPSWQLERLA SHIKELEPKL KKILQMNPRM 
RKFQVDMTLD ADTANNFLLI SDDLRSVRSG CITQNRQDLA ERFDVSICIL GSPRFTCGRH 
YWEVDVGTST EWDLGVCRES VHRKGRIHLT TERGFWTVSL RDGSRLSAST VPLTFLFVDR 
KLQRVGIFLD MGMQNVSFFD AEGGSHVYTF RSVSAEEPLH LFFAPPSPPN GDKSVLSICP 
VINPGTTDAP VHPGEAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.