Details for: RPS6KA1

Gene ID: 6195

Symbol: RPS6KA1

Ensembl ID: ENSG00000117676

Description: ribosomal protein S6 kinase A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.7039
    Cell Significance Index: -16.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.0321
    Cell Significance Index: -18.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.5702
    Cell Significance Index: -16.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4683
    Cell Significance Index: -11.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5349
    Cell Significance Index: 99.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4763
    Cell Significance Index: 160.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4100
    Cell Significance Index: 26.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1732
    Cell Significance Index: 34.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1515
    Cell Significance Index: 1039.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9853
    Cell Significance Index: 160.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9297
    Cell Significance Index: 23.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9127
    Cell Significance Index: 42.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9085
    Cell Significance Index: 41.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8804
    Cell Significance Index: 25.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8756
    Cell Significance Index: 23.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8487
    Cell Significance Index: 11.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8179
    Cell Significance Index: 17.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6864
    Cell Significance Index: 47.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4770
    Cell Significance Index: 56.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4306
    Cell Significance Index: 22.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4106
    Cell Significance Index: 19.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2956
    Cell Significance Index: 161.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2920
    Cell Significance Index: 52.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2623
    Cell Significance Index: 32.2500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2488
    Cell Significance Index: 2.1200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2444
    Cell Significance Index: 3.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2019
    Cell Significance Index: 89.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2015
    Cell Significance Index: 5.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1512
    Cell Significance Index: 3.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1372
    Cell Significance Index: 4.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1280
    Cell Significance Index: 25.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1201
    Cell Significance Index: 1.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1131
    Cell Significance Index: 11.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1021
    Cell Significance Index: 70.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0631
    Cell Significance Index: 3.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0621
    Cell Significance Index: 12.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0562
    Cell Significance Index: 20.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0368
    Cell Significance Index: 7.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0292
    Cell Significance Index: 0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0109
    Cell Significance Index: 1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0108
    Cell Significance Index: 1.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0022
    Cell Significance Index: 1.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0122
    Cell Significance Index: -1.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -16.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0273
    Cell Significance Index: -3.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0281
    Cell Significance Index: -15.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0319
    Cell Significance Index: -19.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0336
    Cell Significance Index: -15.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0344
    Cell Significance Index: -2.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0443
    Cell Significance Index: -12.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0490
    Cell Significance Index: -5.6200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0546
    Cell Significance Index: -0.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0633
    Cell Significance Index: -4.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0668
    Cell Significance Index: -1.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0719
    Cell Significance Index: -1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0733
    Cell Significance Index: -10.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0849
    Cell Significance Index: -4.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0902
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0924
    Cell Significance Index: -19.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1375
    Cell Significance Index: -14.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1423
    Cell Significance Index: -18.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1804
    Cell Significance Index: -11.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1845
    Cell Significance Index: -14.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1961
    Cell Significance Index: -8.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2043
    Cell Significance Index: -2.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2091
    Cell Significance Index: -16.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2247
    Cell Significance Index: -12.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2425
    Cell Significance Index: -12.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2447
    Cell Significance Index: -15.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2461
    Cell Significance Index: -8.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2630
    Cell Significance Index: -8.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2935
    Cell Significance Index: -6.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3156
    Cell Significance Index: -4.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3171
    Cell Significance Index: -10.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3275
    Cell Significance Index: -10.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3337
    Cell Significance Index: -14.7600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3385
    Cell Significance Index: -2.1000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.3658
    Cell Significance Index: -0.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3710
    Cell Significance Index: -16.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3735
    Cell Significance Index: -13.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3833
    Cell Significance Index: -9.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3885
    Cell Significance Index: -14.7100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.4102
    Cell Significance Index: -2.5400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4119
    Cell Significance Index: -7.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4207
    Cell Significance Index: -8.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4263
    Cell Significance Index: -14.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4298
    Cell Significance Index: -6.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4409
    Cell Significance Index: -8.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4439
    Cell Significance Index: -9.7200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.4549
    Cell Significance Index: -3.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4575
    Cell Significance Index: -9.8900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4715
    Cell Significance Index: -9.8400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4734
    Cell Significance Index: -3.8600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4777
    Cell Significance Index: -9.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPS6KA1 is a serine/threonine kinase that belongs to the RSK family of kinases. It is highly expressed in cells with high protein synthesis rates, such as myeloid leukocytes and enterocytes. This gene is involved in the regulation of cell growth, differentiation, and survival, and its activity is modulated by various signaling pathways, including the MAPK/ERK pathway, PI3K/Akt pathway, and p38 MAPK pathway. RPS6KA1 is also involved in the regulation of protein synthesis, particularly in response to stress and inflammation. **Pathways and Functions:** RPS6KA1 is involved in various signaling pathways, including: 1. **MAPK/ERK pathway:** RPS6KA1 is activated by the MAPK/ERK pathway, which regulates cell growth, differentiation, and survival. This pathway is also involved in the regulation of protein synthesis and translation. 2. **PI3K/Akt pathway:** RPS6KA1 is activated by the PI3K/Akt pathway, which regulates cell survival, growth, and metabolism. 3. **p38 MAPK pathway:** RPS6KA1 is activated by the p38 MAPK pathway, which regulates cell differentiation, survival, and stress response. 4. **Transcriptional regulation:** RPS6KA1 regulates transcription by phosphorylating transcription factors, such as CREB and NF-κB, which are involved in the regulation of gene expression. 5. **Protein synthesis regulation:** RPS6KA1 regulates protein synthesis by phosphorylating ribosomal proteins, which are involved in the regulation of translation. **Clinical Significance:** RPS6KA1's involvement in various cellular processes makes it a potential therapeutic target in diseases such as: 1. **Cancer:** RPS6KA1 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is involved in cancer cell growth, differentiation, and survival. 2. **Autoimmune disorders:** RPS6KA1 is involved in the regulation of immune responses and is implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurodegenerative diseases:** RPS6KA1 is involved in the regulation of protein synthesis and is implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory disorders:** RPS6KA1 is involved in the regulation of inflammation and is implicated in inflammatory disorders, such as atherosclerosis and inflammatory bowel disease. In conclusion, RPS6KA1 is a multifaceted gene involved in various cellular processes, including cell growth, differentiation, and survival. Its involvement in immune responses, cancer development, and neurodegenerative diseases highlights its importance as a therapeutic target in these diseases. Further research is needed to fully understand the mechanisms of RPS6KA1 and its potential as a therapeutic target.

Genular Protein ID: 1828926603

Symbol: KS6A1_HUMAN

Name: Ribosomal protein S6 kinase alpha-1

UniProtKB Accession Codes:

Q15418 A6NGG4 A8K9K7 B2RDY8 B7Z5J0 E9PRI4 Q5SVM5 Q5SVM8 Q5SVM9 Q96C05 Q9BQK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CPTAC 4 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 EC 3 ELM 1 EMBL 8 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8141249

Title: Human rsk isoforms: cloning and characterization of tissue-specific expression.

PubMed ID: 8141249

DOI: 10.1152/ajpcell.1994.266.2.c351

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9687510

Title: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

PubMed ID: 9687510

DOI: 10.1093/emboj/17.15.4426

PubMed ID: 9430688

Title: Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.

PubMed ID: 9430688

DOI: 10.1074/jbc.273.3.1496

PubMed ID: 10679322

Title: Rsk1 mediates a MEK-MAP kinase cell survival signal.

PubMed ID: 10679322

DOI: 10.1016/s0960-9822(00)00310-9

PubMed ID: 11684016

Title: C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.

PubMed ID: 11684016

DOI: 10.1016/s1097-2765(01)00374-4

PubMed ID: 12213813

Title: Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A.

PubMed ID: 12213813

DOI: 10.1074/jbc.m205501200

PubMed ID: 12832467

Title: Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.

PubMed ID: 12832467

DOI: 10.1128/mcb.23.14.4796-4804.2003

PubMed ID: 15117958

Title: 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.

PubMed ID: 15117958

DOI: 10.1074/jbc.m311144200

PubMed ID: 15342917

Title: Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

PubMed ID: 15342917

DOI: 10.1073/pnas.0405659101

PubMed ID: 16213824

Title: The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.

PubMed ID: 16213824

DOI: 10.1016/j.cub.2005.08.050

PubMed ID: 16223362

Title: Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.

PubMed ID: 16223362

DOI: 10.1042/bj20050967

PubMed ID: 16763566

Title: The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

PubMed ID: 16763566

DOI: 10.1038/sj.emboj.7601166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17360704

Title: RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.

PubMed ID: 17360704

DOI: 10.1074/jbc.m700906200

PubMed ID: 18722121

Title: Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.

PubMed ID: 18722121

DOI: 10.1016/j.cub.2008.07.078

PubMed ID: 18508509

Title: The RSK factors of activating the Ras/MAPK signaling cascade.

PubMed ID: 18508509

DOI: 10.2741/3003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18813292

Title: The RSK family of kinases: emerging roles in cellular signalling.

PubMed ID: 18813292

DOI: 10.1038/nrm2509

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22017876

Title: DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

PubMed ID: 22017876

DOI: 10.1016/j.molcel.2011.08.029

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26158630

Title: Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.

PubMed ID: 26158630

DOI: 10.1038/ncomms8679

PubMed ID: 30842327

Title: Development of an ORF45-Derived Peptide To Inhibit the Sustained RSK Activation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.

PubMed ID: 30842327

DOI: 10.1128/jvi.02154-18

PubMed ID: 35772404

Title: The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.

PubMed ID: 35772404

DOI: 10.1016/j.molcel.2022.06.008

PubMed ID: 17965187

Title: Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.

PubMed ID: 17965187

DOI: 10.1110/ps.073123707

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 735
  • Mass: 82723
  • Checksum: 765731A4442A53DF
  • Sequence:
    • MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS 
HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 
HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 
LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS 
HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 
PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 
KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL HSVVQQLHGK NLVFSDGYVV 
KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD 
DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIG KTVEYLHSQG VVHRDLKPSN 
ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 
GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP 
HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS 
ILAQRRVRKL PSTTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.