Details for: ATXN8OS

Gene ID: 6315

Symbol: ATXN8OS

Ensembl ID: ENSG00000230223

Description: ATXN8 opposite strand lncRNA

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 7.3922
    Cell Significance Index: 62.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 5.3800
    Cell Significance Index: -2.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7410
    Cell Significance Index: 500.9400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.5894
    Cell Significance Index: 3.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1029
    Cell Significance Index: 35.3300
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.2843
    Cell Significance Index: 2.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2442
    Cell Significance Index: 1.9500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.2270
    Cell Significance Index: 0.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1941
    Cell Significance Index: 4.2500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1776
    Cell Significance Index: 2.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1295
    Cell Significance Index: 5.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0952
    Cell Significance Index: 1.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0722
    Cell Significance Index: 0.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0398
    Cell Significance Index: 2.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0377
    Cell Significance Index: 1.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0301
    Cell Significance Index: 1.5800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0231
    Cell Significance Index: 0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0186
    Cell Significance Index: 6.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0086
    Cell Significance Index: 1.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0082
    Cell Significance Index: 0.1400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0048
    Cell Significance Index: 0.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0046
    Cell Significance Index: -2.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0137
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0138
    Cell Significance Index: -2.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0151
    Cell Significance Index: -2.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0158
    Cell Significance Index: -0.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0168
    Cell Significance Index: -2.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0185
    Cell Significance Index: -0.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0196
    Cell Significance Index: -0.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0205
    Cell Significance Index: -0.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0221
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0237
    Cell Significance Index: -2.7100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0260
    Cell Significance Index: -0.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0265
    Cell Significance Index: -2.7600
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.0280
    Cell Significance Index: -0.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0312
    Cell Significance Index: -0.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0370
    Cell Significance Index: -1.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0373
    Cell Significance Index: -2.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0407
    Cell Significance Index: -2.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0469
    Cell Significance Index: -2.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0505
    Cell Significance Index: -1.7700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0538
    Cell Significance Index: -0.5100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0558
    Cell Significance Index: -0.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0563
    Cell Significance Index: -1.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0580
    Cell Significance Index: -0.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0598
    Cell Significance Index: -2.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0641
    Cell Significance Index: -2.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0681
    Cell Significance Index: -2.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0709
    Cell Significance Index: -1.8100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0710
    Cell Significance Index: -0.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0729
    Cell Significance Index: -1.1800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0733
    Cell Significance Index: -0.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0753
    Cell Significance Index: -2.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0770
    Cell Significance Index: -1.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0774
    Cell Significance Index: -2.6900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0775
    Cell Significance Index: -0.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0847
    Cell Significance Index: -4.2800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0851
    Cell Significance Index: -1.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0866
    Cell Significance Index: -2.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0869
    Cell Significance Index: -2.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0869
    Cell Significance Index: -1.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0896
    Cell Significance Index: -2.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0896
    Cell Significance Index: -3.6700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0911
    Cell Significance Index: -0.9800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0919
    Cell Significance Index: -1.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0933
    Cell Significance Index: -2.4900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0970
    Cell Significance Index: -1.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0971
    Cell Significance Index: -2.7700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0975
    Cell Significance Index: -1.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1001
    Cell Significance Index: -2.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1011
    Cell Significance Index: -2.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1018
    Cell Significance Index: -2.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1028
    Cell Significance Index: -2.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1031
    Cell Significance Index: -2.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1051
    Cell Significance Index: -2.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1056
    Cell Significance Index: -2.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1092
    Cell Significance Index: -2.1500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1097
    Cell Significance Index: -2.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1108
    Cell Significance Index: -1.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1111
    Cell Significance Index: -2.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1126
    Cell Significance Index: -2.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1130
    Cell Significance Index: -1.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1135
    Cell Significance Index: -2.7500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1151
    Cell Significance Index: -1.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1161
    Cell Significance Index: -1.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1163
    Cell Significance Index: -1.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1183
    Cell Significance Index: -1.9800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1199
    Cell Significance Index: -1.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1200
    Cell Significance Index: -2.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Opposite strand lncRNA:** ATXN8OS is a long non-coding RNA that is transcribed from the opposite strand of the ATXN8 gene, which is known for its involvement in neurodegenerative diseases. 2. **Widespread tissue expression:** ATXN8OS is significantly expressed in various cell types, including transit amplifying cells of the colon, alpha-beta T cells, T cells, blood vessel endothelial cells, dopaminergic neurons, goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and intestinal crypt stem cells of the colon. 3. **Lack of coding potential:** ATXN8OS does not possess any coding potential, suggesting that it may play a regulatory role in gene expression. 4. **No known homologues:** ATXN8OS has no known homologues in other species, which raises questions about its evolutionary origins and functional significance. **Pathways and Functions:** 1. **Regulation of gene expression:** ATXN8OS may play a role in regulating gene expression by influencing the activity of nearby genes, potentially through epigenetic mechanisms. 2. **Cell differentiation and proliferation:** ATXN8OS may be involved in regulating cell differentiation and proliferation, particularly in the context of immune cell development and function. 3. **Neurotransmission and synaptic plasticity:** ATXN8OS may also play a role in regulating neurotransmission and synaptic plasticity, given its expression in dopaminergic neurons and GABAergic interneurons. 4. **Epigenetic regulation:** ATXN8OS may interact with epigenetic regulators to modify chromatin structure and influence gene expression. **Clinical Significance:** 1. **Neurodegenerative diseases:** The expression of ATXN8OS in dopaminergic neurons and GABAergic interneurons raises the possibility that it may be involved in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. 2. **Immune system disorders:** ATXN8OS expression in alpha-beta T cells and other immune cells suggests that it may play a role in the regulation of immune responses and the development of immune-related disorders. 3. **Cancer:** The expression of ATXN8OS in absorptive cells and intestinal crypt stem cells of the colon raises the possibility that it may be involved in the development and progression of colon cancer. 4. **Neurological disorders:** ATXN8OS expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells suggests that it may be involved in the regulation of neuronal function and the development of neurological disorders, such as epilepsy and autism spectrum disorder. In conclusion, ATXN8OS is a mysterious lncRNA with widespread tissue expression and potential regulatory functions in various biological processes. Further studies are needed to elucidate the functional significance of ATXN8OS and its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.