Details for: SLC18A1

Gene ID: 6570

Symbol: SLC18A1

Ensembl ID: ENSG00000036565

Description: solute carrier family 18 member A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.2134
    Cell Significance Index: 19.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6182
    Cell Significance Index: 51.8300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.4381
    Cell Significance Index: 20.9600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.9437
    Cell Significance Index: 9.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8802
    Cell Significance Index: 18.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8719
    Cell Significance Index: 86.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8153
    Cell Significance Index: 736.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5835
    Cell Significance Index: 63.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5553
    Cell Significance Index: 33.3400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.5047
    Cell Significance Index: 5.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4838
    Cell Significance Index: 78.6900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.4518
    Cell Significance Index: 5.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3630
    Cell Significance Index: 5.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3382
    Cell Significance Index: 23.3900
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.2915
    Cell Significance Index: 2.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2740
    Cell Significance Index: 52.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2315
    Cell Significance Index: 6.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1425
    Cell Significance Index: 1.4800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.1160
    Cell Significance Index: 0.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0945
    Cell Significance Index: 2.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0704
    Cell Significance Index: 1.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0436
    Cell Significance Index: 30.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0236
    Cell Significance Index: 0.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0134
    Cell Significance Index: 0.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0024
    Cell Significance Index: 0.1100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0005
    Cell Significance Index: -0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0018
    Cell Significance Index: -0.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0035
    Cell Significance Index: -1.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0051
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0059
    Cell Significance Index: -1.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0065
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0067
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0083
    Cell Significance Index: -1.6700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0090
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0117
    Cell Significance Index: -1.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0131
    Cell Significance Index: -0.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0146
    Cell Significance Index: -2.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0161
    Cell Significance Index: -2.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0173
    Cell Significance Index: -0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0182
    Cell Significance Index: -2.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0196
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0202
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0221
    Cell Significance Index: -2.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0237
    Cell Significance Index: -0.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0253
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0268
    Cell Significance Index: -3.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0276
    Cell Significance Index: -0.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0280
    Cell Significance Index: -0.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0321
    Cell Significance Index: -0.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0322
    Cell Significance Index: -2.4700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0325
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0365
    Cell Significance Index: -0.3400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0375
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0392
    Cell Significance Index: -0.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0396
    Cell Significance Index: -2.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0403
    Cell Significance Index: -1.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0406
    Cell Significance Index: -2.1300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0408
    Cell Significance Index: -0.3500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0416
    Cell Significance Index: -0.4900
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0428
    Cell Significance Index: -0.3400
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0430
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0448
    Cell Significance Index: -3.0100
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0504
    Cell Significance Index: -0.4800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0508
    Cell Significance Index: -0.6900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0536
    Cell Significance Index: -0.5400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0544
    Cell Significance Index: -1.7200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0546
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0549
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0552
    Cell Significance Index: -3.3900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0562
    Cell Significance Index: -0.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0565
    Cell Significance Index: -1.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0567
    Cell Significance Index: -2.6700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0619
    Cell Significance Index: -1.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0651
    Cell Significance Index: -2.8800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0674
    Cell Significance Index: -0.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0678
    Cell Significance Index: -2.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0699
    Cell Significance Index: -2.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0711
    Cell Significance Index: -0.8300
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0736
    Cell Significance Index: -0.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0743
    Cell Significance Index: -1.4500
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: -0.0755
    Cell Significance Index: -0.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0758
    Cell Significance Index: -2.8700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0759
    Cell Significance Index: -1.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0790
    Cell Significance Index: -1.9700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0840
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SLC18A1 is widely expressed in various cell types, including sympathetic neurons, endothelial cells, and chromaffin cells, highlighting its importance in the regulation of monoamine neurotransmission. 2. **Protein Structure:** The SLC18A1 protein belongs to the VMAT complex, consisting of two subunits: VMAT1 and VMAT2. This complex is responsible for the uptake of monoamines into synaptic vesicles. 3. **Function:** SLC18A1 mediates the loading of monoamines, such as serotonin, into synaptic vesicles, regulating neurotransmission and modulating various physiological processes. **Pathways and Functions:** 1. **Aminergic Neurotransmitter Loading into Synaptic Vesicle:** SLC18A1 is involved in the loading of monoamines, such as serotonin, into synaptic vesicles, regulating neurotransmission and synaptic plasticity. 2. **Clathrin-sculpted Monoamine Transport Vesicle Membrane:** The SLC18A1 protein contributes to the formation of clathrin-coated vesicles, which are essential for the transport of monoamines across the neuronal membrane. 3. **Endoplasmic Reticulum Membrane:** SLC18A1 is also expressed in the endoplasmic reticulum, where it regulates the transport of monoamines and other small molecules. 4. **Monoamine:Proton Antiporter Activity:** The SLC18A1 protein exhibits antiporter activity, facilitating the exchange of monoamines and protons across the neuronal membrane. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of SLC18A1 has been implicated in various neurological disorders, including depression, anxiety, and Parkinson's disease. 2. **Cardiovascular Disease:** Abnormal expression of SLC18A1 has been linked to cardiovascular disease, including hypertension and atherosclerosis. 3. **Cancer:** The SLC18A1 protein has been identified as a potential biomarker for cancer diagnosis and treatment, given its overexpression in various types of cancer. 4. **Immunological Disorders:** SLC18A1 has been shown to play a role in the regulation of immune responses, including the modulation of inflammation and immune cell function. In conclusion, SLC18A1 is a critical gene involved in the regulation of monoamine neurotransmission and has significant implications for various physiological and pathological processes. Further research is needed to fully elucidate the function and significance of SLC18A1, particularly in the context of immunological disorders.

Genular Protein ID: 1006443456

Symbol: VMAT1_HUMAN

Name: Chromaffin granule amine transporter

UniProtKB Accession Codes:

P54219 E9PDJ5 Q9BRE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 3 EMDB 8 Ensembl 6 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 6 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8643547

Title: Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.

PubMed ID: 8643547

DOI: 10.1073/pnas.93.10.5166

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16326835

Title: Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1.

PubMed ID: 16326835

DOI: 10.1677/jme.1.01875

PubMed ID: 23337945

Title: Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing.

PubMed ID: 23337945

DOI: 10.1038/mp.2012.193

Sequence Information:

  • Length: 525
  • Mass: 56257
  • Checksum: 041F2959F4F2BFBC
  • Sequence:
    • MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY DMEFKEVNSS 
LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI AWMNDTASTI PPPATEAISA 
HKNNCLQGTG FLEEEITRVG VLFASKAVMQ LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS 
TVMFAFSGTY TLLFVARTLQ GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL 
LVGAPFGSVM YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP 
YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL IGTNLFGVLA 
NKMGRWLCSL IGMLVVGTSL LCVPLAHNIF GLIGPNAGLG LAIGMVDSSM MPIMGHLVDL 
RHTSVYGSVY AIADVAFCMG FAIGPSTGGA IVKAIGFPWL MVITGVINIV YAPLCYYLRS 
PPAKEEKLAI LSQDCPMETR MYATQKPTKE FPLGEDSDEE PDHEE

Genular Protein ID: 994851519

Symbol: Q96GL6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96GL6

Database IDs:

ARBA 12 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 4 Rhea 4 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 385
  • Mass: 41172
  • Checksum: DF4240D7F4CBC2BA
  • Sequence:
    • MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY DMEFKEVNSS 
LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI AWMNDTASTI PPPATEAISA 
HKNNCLQGTG FLEEEITRVG VLFASKAVMQ LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS 
TVMFAFSGTY TLLFVARTLQ GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL 
LVGAPFGSVM YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP 
YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL IGTNLFGVLA 
NKMGRWLCSL IGMLVVGTSL LCLPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.