No CSI details found for gene ID: 6753
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2398521989
Symbol: SSR3_HUMAN
Name: Somatostatin receptor type 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1337145
Title: Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.
PubMed ID: 1337145
PubMed ID: 8097479
Title: A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.
PubMed ID: 8097479
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 418
- Mass: 45847
- Checksum: 1227095F801190C4
- Sequence:
MDMLHPSSVS TTSEPENASS AWPPDATLGN VSAGPSPAGL AVSGVLIPLV YLVVCVVGLL GNSLVIYVVL RHTASPSVTN VYILNLALAD ELFMLGLPFL AAQNALSYWP FGSLMCRLVM AVDGINQFTS IFCLTVMSVD RYLAVVHPTR SARWRTAPVA RTVSAAVWVA SAVVVLPVVV FSGVPRGMST CHMQWPEPAA AWRAGFIIYT AALGFFGPLL VICLCYLLIV VKVRSAGRRV WAPSCQRRRR SERRVTRMVV AVVALFVLCW MPFYVLNIVN VVCPLPEEPA FFGLYFLVVA LPYANSCANP ILYGFLSYRF KQGFRRVLLR PSRRVRSQEP TVGPPEKTEE EDEEEEDGEE SREGGKGKEM NGRVSQITQP GTSGQERPPS RVASKEQQLL PQEASTGEKS STMRISYL
Details Unavailable
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{
"geneID": 6753,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"CP068256.2"
]
},
"genePos": {
"start": 37204237,
"end": 37220548
},
"orientation": false,
"symbol": "SSTR3",
"created": {
"$date": {
"$numberLong": "1738333349190"
}
},
"crossReference": {
"enseGeneID": "ENSG00000278195",
"enseRnaID": [
"ENST00000610913.2"
],
"enseProtID": [
"ENSP00000480971.1"
]
},
"chrom": {
"pos": "22",
"type": 1,
"loc": "22q13.1"
},
"desc": "somatostatin receptor 3",
"geneType": 5,
"mim": [
{
"id": 182453,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-1852241",
"term": "Organelle biogenesis and maintenance",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-5617833",
"term": "Cilium Assembly",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-5620920",
"term": "Cargo trafficking to the periciliary membrane",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A\/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418594",
"term": "G alpha (i) signalling events",
"cat": 13
},
{
"id": "R-HSA-5620922",
"term": "BBSome-mediated cargo-targeting to cilium",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"cat": 0
},
{
"id": "GO:0004994",
"term": "somatostatin receptor activity",
"cat": 0
},
{
"id": "GO:0005102",
"term": "signaling receptor binding",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
19071123,
22651821,
32814053
],
"cat": 0
},
{
"id": "GO:0042923",
"term": "neuropeptide binding",
"cat": 0
},
{
"id": "GO:0007187",
"term": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",
"cat": 1
},
{
"id": "GO:0007218",
"term": "neuropeptide signaling pathway",
"cat": 1
},
{
"id": "GO:0007267",
"term": "cell-cell signaling",
"pubMed": [
1337145
],
"cat": 1
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"cat": 1
},
{
"id": "GO:0008285",
"term": "negative regulation of cell population proliferation",
"cat": 1
},
{
"id": "GO:0008628",
"term": "hormone-mediated apoptotic signaling pathway",
"pubMed": [
8961277
],
"cat": 1
},
{
"id": "GO:0021549",
"term": "cerebellum development",
"cat": 1
},
{
"id": "GO:0030900",
"term": "forebrain development",
"cat": 1
},
{
"id": "GO:0038170",
"term": "somatostatin signaling pathway",
"cat": 1
},
{
"id": "GO:0042594",
"term": "response to starvation",
"cat": 1
},
{
"id": "GO:0071385",
"term": "cellular response to glucocorticoid stimulus",
"cat": 1
},
{
"id": "GO:0071392",
"term": "cellular response to estradiol stimulus",
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005929",
"term": "cilium",
"pubMed": [
28154160
],
"cat": 2
},
{
"id": "GO:0043005",
"term": "neuron projection",
"cat": 2
},
{
"id": "GO:0060170",
"term": "ciliary membrane",
"cat": 2
},
{
"id": "GO:0097730",
"term": "non-motile cilium",
"cat": 2
}
],
"protein": [
{
"symbol": "SSR3_HUMAN",
"name": "Somatostatin receptor type 3",
"accession": [
"P32745",
"A8K550",
"Q53ZR7"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"M96738",
"AY277678",
"AY322541",
"CR456585",
"AK291165",
"Z82188",
"BC096829"
],
"CCDS": [
"CCDS13944.1"
],
"PIR": [
"A46226"
],
"RefSeq": [
"NP_001042.1",
"NP_001265616.1",
"XP_005261778.1",
"XP_006724374.1",
"XP_011528651.1",
"XP_016884412.1",
"XP_016884413.1"
],
"AlphaFoldDB": [
"P32745"
],
"SMR": [
"P32745"
],
"BioGRID": [
"112631"
],
"CORUM": [
"P32745"
],
"IntAct": [
"P32745"
],
"MINT": [
"P32745"
],
"STRING": [
"9606.ENSP00000480971"
],
"BindingDB": [
"P32745"
],
"ChEMBL": [
"CHEMBL2028"
],
"DrugBank": [
"DB15494",
"DB13985",
"DB06663",
"DB09099"
],
"DrugCentral": [
"P32745"
],
"GuidetoPHARMACOLOGY": [
"357"
],
"TCDB": [
"9.A.14.13.23"
],
"GlyCosmos": [
"P32745"
],
"GlyGen": [
"P32745"
],
"iPTMnet": [
"P32745"
],
"PhosphoSitePlus": [
"P32745"
],
"BioMuta": [
"SSTR3"
],
"DMDM": [
"417815"
],
"MassIVE": [
"P32745"
],
"PaxDb": [
"9606-ENSP00000480971"
],
"PeptideAtlas": [
"P32745"
],
"ProteomicsDB": [
"54880"
],
"Antibodypedia": [
"74216"
],
"DNASU": [
"6753"
],
"Ensembl": [
"ENST00000610913.2",
"ENST00000617123.1"
],
"KEGG": [
"hsa:6753"
],
"MANE-Select": [
"ENST00000610913.2"
],
"UCSC": [
"uc021wos.3"
],
"AGR": [
"HGNC:11332"
],
"CTD": [
"6753"
],
"DisGeNET": [
"6753"
],
"GeneCards": [
"SSTR3"
],
"HGNC": [
"HGNC:11332"
],
"HPA": [
"ENSG00000278195"
],
"MIM": [
"182453"
],
"neXtProt": [
"NX_P32745"
],
"OpenTargets": [
"ENSG00000278195"
],
"PharmGKB": [
"PA36156"
],
"VEuPathDB": [
"HostDB:ENSG00000278195"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT00940000162038"
],
"HOGENOM": [
"CLU_009579_8_1_1"
],
"InParanoid": [
"P32745"
],
"OMA": [
"NTSSAWP"
],
"OrthoDB": [
"5393360at2759"
],
"PhylomeDB": [
"P32745"
],
"TreeFam": [
"TF315737"
],
"PathwayCommons": [
"P32745"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-418594",
"R-HSA-5620922"
],
"SignaLink": [
"P32745"
],
"SIGNOR": [
"P32745"
],
"BioGRID-ORCS": [
"6753"
],
"GeneWiki": [
"Somatostatin_receptor_3"
],
"GenomeRNAi": [
"6753"
],
"Pharos": [
"P32745"
],
"PRO": [
"PR:P32745"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P32745"
],
"Bgee": [
"ENSG00000278195"
],
"GO": [
"GO:0060170",
"GO:0005929",
"GO:0043005",
"GO:0097730",
"GO:0005886",
"GO:0004930",
"GO:0042923",
"GO:0005102",
"GO:0004994",
"GO:0007267",
"GO:0071392",
"GO:0071385",
"GO:0021549",
"GO:0030900",
"GO:0007187",
"GO:0008628",
"GO:0008285",
"GO:0007218",
"GO:0042594",
"GO:0007283"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000276",
"IPR017452",
"IPR000586",
"IPR001856"
],
"PANTHER": [
"PTHR24229",
"PTHR24229:SF42"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR00237",
"PR00246",
"PR00589"
],
"SMART": [
"SM01381"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.",
"pubmedID": "1337145",
"doi": "10.1210\/mend.6.12.1337145"
},
{
"title": "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.",
"pubmedID": "8097479",
"doi": "10.1016\/0014-5793(93)80124-d"
},
{
"title": "A genome annotation-driven approach to cloning the human ORFeome.",
"pubmedID": "15461802",
"doi": "10.1186\/gb-2004-5-10-r84"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038\/ng1285"
},
{
"title": "The DNA sequence of human chromosome 22.",
"pubmedID": "10591208",
"doi": "10.1038\/990031"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
}
],
"sequence": {
"length": 418,
"mass": 45847,
"checksum": "1227095F801190C4",
"modified": {
"$date": {
"$numberLong": "749433600000"
}
},
"version": 1,
"sequence": "MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL"
},
"existence": 0,
"relevance": 1,
"proteinID": 2398521989
}
],
"mRNAExpressions": {
"proteinAtlas": [
{
"l": "T-cells",
"c": "naive CD4 T-cell",
"e": 1.1
}
]
},
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}