Details for: SSTR3

Gene ID: 6753

Symbol: SSTR3

Ensembl ID: ENSG00000278195

Description: somatostatin receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9496
    Cell Significance Index: 51.2700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.5544
    Cell Significance Index: 7.5600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.4319
    Cell Significance Index: 14.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3514
    Cell Significance Index: 4.5000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2752
    Cell Significance Index: 3.8600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2158
    Cell Significance Index: 2.5500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.1536
    Cell Significance Index: 1.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1444
    Cell Significance Index: 2.3800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.1213
    Cell Significance Index: 1.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1178
    Cell Significance Index: 23.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0559
    Cell Significance Index: 3.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0361
    Cell Significance Index: 0.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0300
    Cell Significance Index: 0.4300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0240
    Cell Significance Index: 0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0209
    Cell Significance Index: 7.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0190
    Cell Significance Index: 1.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0051
    Cell Significance Index: -1.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0070
    Cell Significance Index: -2.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0071
    Cell Significance Index: -0.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0074
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0082
    Cell Significance Index: -1.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0105
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0115
    Cell Significance Index: -1.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0127
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0143
    Cell Significance Index: -1.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0171
    Cell Significance Index: -0.5600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0179
    Cell Significance Index: -0.5700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0257
    Cell Significance Index: -0.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0264
    Cell Significance Index: -0.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0310
    Cell Significance Index: -2.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0324
    Cell Significance Index: -1.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0326
    Cell Significance Index: -1.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0340
    Cell Significance Index: -1.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0341
    Cell Significance Index: -0.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0367
    Cell Significance Index: -0.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0369
    Cell Significance Index: -0.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0377
    Cell Significance Index: -1.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0416
    Cell Significance Index: -1.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0421
    Cell Significance Index: -1.9800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0422
    Cell Significance Index: -0.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0470
    Cell Significance Index: -1.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0485
    Cell Significance Index: -1.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0493
    Cell Significance Index: -0.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0531
    Cell Significance Index: -1.4200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0533
    Cell Significance Index: -0.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0548
    Cell Significance Index: -0.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0598
    Cell Significance Index: -1.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0629
    Cell Significance Index: -1.9900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0662
    Cell Significance Index: -0.7300
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0679
    Cell Significance Index: -0.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0689
    Cell Significance Index: -1.8400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0693
    Cell Significance Index: -1.2000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0707
    Cell Significance Index: -0.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0710
    Cell Significance Index: -3.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0744
    Cell Significance Index: -0.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0755
    Cell Significance Index: -1.8100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0759
    Cell Significance Index: -1.2300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0766
    Cell Significance Index: -0.8400
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0767
    Cell Significance Index: -0.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0771
    Cell Significance Index: -1.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0793
    Cell Significance Index: -2.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0828
    Cell Significance Index: -1.7900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0848
    Cell Significance Index: -1.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0850
    Cell Significance Index: -1.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0851
    Cell Significance Index: -1.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0858
    Cell Significance Index: -1.8200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0878
    Cell Significance Index: -1.7500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0911
    Cell Significance Index: -1.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0914
    Cell Significance Index: -1.1400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0916
    Cell Significance Index: -1.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0925
    Cell Significance Index: -3.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0926
    Cell Significance Index: -1.5500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0937
    Cell Significance Index: -0.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0949
    Cell Significance Index: -1.9300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0949
    Cell Significance Index: -1.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0951
    Cell Significance Index: -0.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0982
    Cell Significance Index: -1.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1006
    Cell Significance Index: -1.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1043
    Cell Significance Index: -1.5200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1055
    Cell Significance Index: -1.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1070
    Cell Significance Index: -1.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1089
    Cell Significance Index: -2.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1112
    Cell Significance Index: -1.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1135
    Cell Significance Index: -1.9400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1146
    Cell Significance Index: -1.3700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1168
    Cell Significance Index: -1.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1181
    Cell Significance Index: -1.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1192
    Cell Significance Index: -1.7600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1229
    Cell Significance Index: -1.6900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1249
    Cell Significance Index: -1.4700
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.1256
    Cell Significance Index: -0.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SSTR3 is widely expressed in various cell types, including neuroendocrine cells, immune cells, granulosa cells, goblet cells, and intestinal crypt stem cells. 2. **Receptor Type:** SSTR3 belongs to the class A/1 GPCR family, which is characterized by the presence of a rhodopsin-like extracellular domain. 3. **Ligand Binding:** SSTR3 is activated by somatostatin, a peptide hormone that regulates various physiological processes, including growth, differentiation, and hormone secretion. 4. **Signaling Pathways:** SSTR3 is involved in regulating multiple signaling pathways, including Gαi signaling, cyclic nucleotide second messenger signaling, and apoptosis. **Pathways and Functions:** 1. **Cell Growth and Differentiation:** SSTR3 regulates cell growth and differentiation by modulating the expression of genes involved in cell cycle progression and apoptosis. 2. **Hormone-Mediated Signaling:** SSTR3 is involved in regulating hormone-mediated signaling pathways, including the regulation of somatostatin secretion and the modulation of hormone receptor expression. 3. **Apoptosis:** SSTR3 regulates apoptosis by modulating the expression of pro-apoptotic and anti-apoptotic genes. 4. **Immune Response:** SSTR3 is involved in regulating the immune response by modulating the expression of genes involved in immune cell function and cytokine production. 5. **Neuroendocrine Function:** SSTR3 regulates neuroendocrine function by modulating the expression of genes involved in hormone secretion and cell growth. **Clinical Significance:** Dysregulation of SSTR3 has been implicated in various diseases, including: 1. **Cancer:** SSTR3 overexpression has been observed in various types of cancer, including neuroendocrine tumors and colon cancer. 2. **Neurodegenerative Diseases:** SSTR3 has been implicated in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Immune System Disorders:** SSTR3 has been implicated in the regulation of immune system disorders, including autoimmune diseases and immunodeficiency disorders. 4. **Reproductive Disorders:** SSTR3 has been implicated in the regulation of reproductive disorders, including infertility and reproductive cancer. In conclusion, SSTR3 is a multifaceted gene involved in regulating cell growth, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its function.

Genular Protein ID: 2398521989

Symbol: SSR3_HUMAN

Name: Somatostatin receptor type 3

UniProtKB Accession Codes:

P32745 A8K550 Q53ZR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 7 Ensembl 2 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1337145

Title: Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.

PubMed ID: 1337145

DOI: 10.1210/mend.6.12.1337145

PubMed ID: 8097479

Title: A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.

PubMed ID: 8097479

DOI: 10.1016/0014-5793(93)80124-d

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 418
  • Mass: 45847
  • Checksum: 1227095F801190C4
  • Sequence:
    • MDMLHPSSVS TTSEPENASS AWPPDATLGN VSAGPSPAGL AVSGVLIPLV YLVVCVVGLL 
GNSLVIYVVL RHTASPSVTN VYILNLALAD ELFMLGLPFL AAQNALSYWP FGSLMCRLVM 
AVDGINQFTS IFCLTVMSVD RYLAVVHPTR SARWRTAPVA RTVSAAVWVA SAVVVLPVVV 
FSGVPRGMST CHMQWPEPAA AWRAGFIIYT AALGFFGPLL VICLCYLLIV VKVRSAGRRV 
WAPSCQRRRR SERRVTRMVV AVVALFVLCW MPFYVLNIVN VVCPLPEEPA FFGLYFLVVA 
LPYANSCANP ILYGFLSYRF KQGFRRVLLR PSRRVRSQEP TVGPPEKTEE EDEEEEDGEE 
SREGGKGKEM NGRVSQITQP GTSGQERPPS RVASKEQQLL PQEASTGEKS STMRISYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.