Details for: SSTR5

Gene ID: 6755

Symbol: SSTR5

Ensembl ID: ENSG00000162009

Description: somatostatin receptor 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53056
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8273
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.62
    Marker Score: 2636
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.26
    Marker Score: 4116
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2547
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 522
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9811
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.56
    Marker Score: 554
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.55
    Marker Score: 3656
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.54
    Marker Score: 596.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.44
    Marker Score: 259
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.44
    Marker Score: 232.5
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.41
    Marker Score: 1303
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.38
    Marker Score: 146
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.37
    Marker Score: 390
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.35
    Marker Score: 413
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.35
    Marker Score: 357
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.29
    Marker Score: 80
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.26
    Marker Score: 494
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 95
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.17
    Marker Score: 162.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 333
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 655
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1
    Marker Score: 132
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 21.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 170
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 37.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 181
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 109
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 101
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 99
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.03
    Marker Score: 117
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 23.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.02
    Marker Score: 28.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.02
    Marker Score: 82
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 97
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 28

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Other Information

**Key characteristics:** - SSTR5 is a single transmembrane protein with a molecular weight of approximately 140 kDa. - It is a member of the somatostatin receptor family, which are a group of receptors that are involved in a variety of cellular processes, including cell growth, differentiation, and metabolism. - SSTR5 is a negative regulator of cell population proliferation. - It is a key regulator of insulin secretion by binding to the hormone somatostatin and triggering its release. **Pathways and functions:** - SSTR5 is a GPCR that binds to the hormone somatostatin. - Upon binding to somatostatin, SSTR5 undergoes a conformational change that activates its intracellular signaling cascade. - This cascade leads to the inhibition of the MAPK pathway, which is a major signaling pathway involved in cell growth and differentiation. - As a result of this inhibition, SSTR5 promotes cell cycle arrest and apoptosis in proliferating cells. **Clinical significance:** - Mutations in SSTR5 have been linked to several human diseases, including diabetes, obesity, and cancer. - In diabetes, mutations in SSTR5 lead to an increase in somatostatin production, which can lead to hyperglycemia. - In cancer, mutations in SSTR5 can lead to the activation of the MAPK pathway, which can promote cell growth and survival. SSTR5 is a key regulator of cell growth, differentiation, and metabolism, and its mutations can have significant clinical implications for human health.

Genular Protein ID: 1760088671

Symbol: SSR5_HUMAN

Name: Somatostatin receptor type 5

UniProtKB Accession Codes:

P35346 P34988 Q541E0 Q9UJI5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 6 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7908405

Title: Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.

PubMed ID: 7908405

PubMed ID: 8373420

Title: Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.

PubMed ID: 8373420

DOI: 10.1006/bbrc.1993.2122

PubMed ID: 8078491

Title: Characterization of cloned human somatostatin receptor SSTR5.

PubMed ID: 8078491

PubMed ID: 12072395

Title: Identification of an upstream pituitary-active promoter of human somatostatin receptor subtype 5.

PubMed ID: 12072395

DOI: 10.1210/endo.143.7.8883

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 18653781

Title: Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization.

PubMed ID: 18653781

DOI: 10.1210/me.2007-0334

PubMed ID: 21820437

Title: Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase.

PubMed ID: 21820437

DOI: 10.1016/j.febslet.2011.07.028

Sequence Information:

  • Length: 364
  • Mass: 39202
  • Checksum: 905744715F31121C
  • Sequence:
    • MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV CAAGLGGNTL 
VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN AASFWPFGPV LCRLVMTLDG 
VNQFTSVFCL TVMSVDRYLA VVHPLSSARW RRPRVAKLAS AAAWVLSLCM SLPLLVFADV 
QEGGTCNASW PEPVGLWGAV FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR 
RSERKVTRMV LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN 
PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA HRAAANGLMQ 
TSKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.