Details for: SSTR5

Gene ID: 6755

Symbol: SSTR5

Ensembl ID: ENSG00000162009

Description: somatostatin receptor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.3918
    Cell Significance Index: 41.0000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.0788
    Cell Significance Index: 13.5500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.8412
    Cell Significance Index: 11.8200
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.3767
    Cell Significance Index: 4.1500
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.2891
    Cell Significance Index: 2.6500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2777
    Cell Significance Index: 2.3600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.2154
    Cell Significance Index: 2.6200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1725
    Cell Significance Index: 2.0100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1227
    Cell Significance Index: 0.8000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0276
    Cell Significance Index: 0.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0220
    Cell Significance Index: 0.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0192
    Cell Significance Index: 2.2000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.0142
    Cell Significance Index: 0.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0133
    Cell Significance Index: 0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0011
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -1.0000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0039
    Cell Significance Index: -0.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0056
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0062
    Cell Significance Index: -1.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0081
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0097
    Cell Significance Index: -1.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0098
    Cell Significance Index: -0.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0103
    Cell Significance Index: -0.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0106
    Cell Significance Index: -0.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0119
    Cell Significance Index: -0.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0141
    Cell Significance Index: -0.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0165
    Cell Significance Index: -0.3300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0172
    Cell Significance Index: -0.2900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0193
    Cell Significance Index: -0.2500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0193
    Cell Significance Index: -0.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0197
    Cell Significance Index: -0.5800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0199
    Cell Significance Index: -0.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0235
    Cell Significance Index: -0.2500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0245
    Cell Significance Index: -0.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0246
    Cell Significance Index: -0.6700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0247
    Cell Significance Index: -0.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0264
    Cell Significance Index: -0.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0300
    Cell Significance Index: -0.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0300
    Cell Significance Index: -1.0500
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.0307
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0312
    Cell Significance Index: -1.0200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0316
    Cell Significance Index: -0.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0343
    Cell Significance Index: -0.9200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0359
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0367
    Cell Significance Index: -0.2600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0369
    Cell Significance Index: -0.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0379
    Cell Significance Index: -0.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0411
    Cell Significance Index: -1.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0417
    Cell Significance Index: -1.0400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0417
    Cell Significance Index: -0.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0437
    Cell Significance Index: -0.8600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0445
    Cell Significance Index: -0.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0448
    Cell Significance Index: -0.9500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0452
    Cell Significance Index: -0.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0460
    Cell Significance Index: -0.6700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0473
    Cell Significance Index: -0.7200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0485
    Cell Significance Index: -0.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0486
    Cell Significance Index: -0.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0492
    Cell Significance Index: -0.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0496
    Cell Significance Index: -0.9800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0498
    Cell Significance Index: -1.0400
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0501
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0507
    Cell Significance Index: -0.5800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0507
    Cell Significance Index: -0.8200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0508
    Cell Significance Index: -0.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0513
    Cell Significance Index: -0.7000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0515
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0520
    Cell Significance Index: -0.7900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0523
    Cell Significance Index: -0.6100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0523
    Cell Significance Index: -0.6700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0527
    Cell Significance Index: -0.6200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0527
    Cell Significance Index: -0.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0528
    Cell Significance Index: -1.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0535
    Cell Significance Index: -0.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0549
    Cell Significance Index: -0.8100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0559
    Cell Significance Index: -0.7200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0561
    Cell Significance Index: -0.3600
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.0562
    Cell Significance Index: -0.4600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0563
    Cell Significance Index: -0.6800
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0579
    Cell Significance Index: -0.5700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0581
    Cell Significance Index: -0.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0582
    Cell Significance Index: -1.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0584
    Cell Significance Index: -0.6900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0585
    Cell Significance Index: -0.7800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0585
    Cell Significance Index: -0.5600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0594
    Cell Significance Index: -0.7800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0595
    Cell Significance Index: -0.7400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0597
    Cell Significance Index: -0.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0601
    Cell Significance Index: -1.0400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0602
    Cell Significance Index: -0.4000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0607
    Cell Significance Index: -0.7000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0607
    Cell Significance Index: -0.8100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0608
    Cell Significance Index: -0.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor structure:** SSTR5 is a GPCR with seven transmembrane helices, characteristic of the rhodopsin-like receptor family. 2. **Ligand binding:** SSTR5 binds to somatostatin, a neuropeptide hormone that inhibits the release of various hormones, including insulin and growth hormone. 3. **Signaling pathways:** SSTR5 activates Gαi proteins, leading to the inhibition of adenylate cyclase and subsequent decrease in cAMP levels, which in turn modulates downstream signaling pathways. 4. **Cellular localization:** SSTR5 is expressed in progenitor cells, oligodendrocyte precursor cells, and other cell types involved in the central nervous system, immune system, and gastrointestinal tract. 5. **Clinical significance:** SSTR5 is implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. **Pathways and Functions:** 1. **Gαi signaling events:** SSTR5 activates Gαi proteins, which inhibit adenylate cyclase and decrease cAMP levels, modulating downstream signaling pathways. 2. **Neuropeptide signaling pathway:** SSTR5 binds to somatostatin, leading to the inhibition of hormone release and modulation of cellular responses. 3. **Regulation of cell population proliferation:** SSTR5 modulates cell proliferation and differentiation by regulating the expression of cyclin-dependent kinases and other cell cycle regulators. 4. **Regulation of insulin secretion:** SSTR5 inhibits insulin secretion in pancreatic β-cells, highlighting its role in glucose homeostasis. 5. **Negative regulation of cytokinesis:** SSTR5 modulates the process of cytokinesis, ensuring proper cell division and preventing aberrant cell growth. **Clinical Significance:** 1. **Neurodegenerative disorders:** SSTR5 has been implicated in neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, where somatostatin signaling is disrupted. 2. **Cancer:** SSTR5 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 3. **Inflammatory conditions:** SSTR5 is involved in the regulation of immune responses, and its dysregulation has been linked to inflammatory conditions, such as multiple sclerosis and rheumatoid arthritis. 4. **Gastrointestinal disorders:** SSTR5 is expressed in absorptive cells and transit amplifying cells, and its dysregulation has been implicated in gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. 5. **Immunological disorders:** SSTR5 is involved in the regulation of immune responses, and its dysregulation has been linked to immunological disorders, such as autoimmune diseases and transplant rejection. In conclusion, SSTR5 is a key player in G protein-coupled receptor signaling, and its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, inflammatory conditions, gastrointestinal disorders, and immunological disorders. Further research is necessary to fully understand the complex role of SSTR5 in modulating cellular responses and its implications in human disease.

Genular Protein ID: 1760088671

Symbol: SSR5_HUMAN

Name: Somatostatin receptor type 5

UniProtKB Accession Codes:

P35346 P34988 Q541E0 Q9UJI5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 6 EMDB 2 Ensembl 3 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7908405

Title: Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.

PubMed ID: 7908405

PubMed ID: 8373420

Title: Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.

PubMed ID: 8373420

DOI: 10.1006/bbrc.1993.2122

PubMed ID: 8078491

Title: Characterization of cloned human somatostatin receptor SSTR5.

PubMed ID: 8078491

PubMed ID: 12072395

Title: Identification of an upstream pituitary-active promoter of human somatostatin receptor subtype 5.

PubMed ID: 12072395

DOI: 10.1210/endo.143.7.8883

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 18653781

Title: Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization.

PubMed ID: 18653781

DOI: 10.1210/me.2007-0334

PubMed ID: 21820437

Title: Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase.

PubMed ID: 21820437

DOI: 10.1016/j.febslet.2011.07.028

Sequence Information:

  • Length: 364
  • Mass: 39202
  • Checksum: 905744715F31121C
  • Sequence:
    • MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV CAAGLGGNTL 
VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN AASFWPFGPV LCRLVMTLDG 
VNQFTSVFCL TVMSVDRYLA VVHPLSSARW RRPRVAKLAS AAAWVLSLCM SLPLLVFADV 
QEGGTCNASW PEPVGLWGAV FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR 
RSERKVTRMV LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN 
PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA HRAAANGLMQ 
TSKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.