Details for: VAMP7

Gene ID: 6845

Symbol: VAMP7

Ensembl ID: ENSG00000124333

Description: vesicle associated membrane protein 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.2885
    Cell Significance Index: -17.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.8959
    Cell Significance Index: -19.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.1232
    Cell Significance Index: -19.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.6861
    Cell Significance Index: -19.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.1096
    Cell Significance Index: -17.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.8084
    Cell Significance Index: -15.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6395
    Cell Significance Index: -14.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 4.2325
    Cell Significance Index: 87.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6508
    Cell Significance Index: -7.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.5611
    Cell Significance Index: 53.3600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.6477
    Cell Significance Index: 33.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6299
    Cell Significance Index: 119.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1814
    Cell Significance Index: 62.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.6871
    Cell Significance Index: 35.9300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.2606
    Cell Significance Index: 15.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0765
    Cell Significance Index: 64.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9878
    Cell Significance Index: 34.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9495
    Cell Significance Index: 103.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7637
    Cell Significance Index: 124.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5880
    Cell Significance Index: 15.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5306
    Cell Significance Index: 106.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5237
    Cell Significance Index: 472.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4947
    Cell Significance Index: 13.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3425
    Cell Significance Index: 47.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3309
    Cell Significance Index: 22.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3293
    Cell Significance Index: 59.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3124
    Cell Significance Index: 20.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2884
    Cell Significance Index: 103.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2814
    Cell Significance Index: 34.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2532
    Cell Significance Index: 50.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2415
    Cell Significance Index: 3.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2273
    Cell Significance Index: 124.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2241
    Cell Significance Index: 11.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2213
    Cell Significance Index: 153.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2180
    Cell Significance Index: 25.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1930
    Cell Significance Index: 1.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1928
    Cell Significance Index: 19.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1869
    Cell Significance Index: 4.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1855
    Cell Significance Index: 5.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1839
    Cell Significance Index: 5.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1806
    Cell Significance Index: 79.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1747
    Cell Significance Index: 25.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1739
    Cell Significance Index: 12.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1735
    Cell Significance Index: 29.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1709
    Cell Significance Index: 32.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1481
    Cell Significance Index: 18.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1357
    Cell Significance Index: 6.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1121
    Cell Significance Index: 14.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0841
    Cell Significance Index: 2.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0668
    Cell Significance Index: 3.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0667
    Cell Significance Index: 3.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0665
    Cell Significance Index: 5.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0477
    Cell Significance Index: 1.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0417
    Cell Significance Index: 2.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0416
    Cell Significance Index: 2.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0226
    Cell Significance Index: 42.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0152
    Cell Significance Index: 0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0025
    Cell Significance Index: 1.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0023
    Cell Significance Index: 4.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0003
    Cell Significance Index: 0.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0048
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -7.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0265
    Cell Significance Index: -0.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0358
    Cell Significance Index: -22.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0474
    Cell Significance Index: -13.6300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0711
    Cell Significance Index: -0.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0737
    Cell Significance Index: -3.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0811
    Cell Significance Index: -3.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0863
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0882
    Cell Significance Index: -10.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0951
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0955
    Cell Significance Index: -20.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1159
    Cell Significance Index: -0.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1185
    Cell Significance Index: -2.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1386
    Cell Significance Index: -8.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1469
    Cell Significance Index: -15.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1515
    Cell Significance Index: -3.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1538
    Cell Significance Index: -4.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1734
    Cell Significance Index: -3.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1755
    Cell Significance Index: -2.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1811
    Cell Significance Index: -5.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1967
    Cell Significance Index: -15.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2785
    Cell Significance Index: -5.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2801
    Cell Significance Index: -8.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2819
    Cell Significance Index: -9.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2862
    Cell Significance Index: -4.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3055
    Cell Significance Index: -6.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3085
    Cell Significance Index: -5.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3086
    Cell Significance Index: -10.8100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.3106
    Cell Significance Index: -1.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3647
    Cell Significance Index: -14.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3677
    Cell Significance Index: -7.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3758
    Cell Significance Index: -6.6400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3812
    Cell Significance Index: -3.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VAMP7 is a small, membrane-associated protein that belongs to the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) family. SNARE proteins are essential for the regulation of membrane fusion and vesicle-mediated transport. VAMP7 is specifically localized to the plasma membrane and is involved in the formation and fusion of vesicles with the plasma membrane. The protein contains a characteristic SNARE motif and is capable of interacting with other SNARE proteins, such as Syntaxin and SNAP-25, to facilitate membrane fusion. **Pathways and Functions** VAMP7 is involved in various cellular processes, including: 1. **Autophagosome maturation**: VAMP7 plays a crucial role in the maturation of autophagosomes, which are double-membraned structures involved in the degradation and recycling of cellular components. 2. **Exocytosis**: VAMP7 is involved in the regulation of exocytosis, a process by which cells release molecules, such as neurotransmitters and hormones, into the extracellular environment. 3. **Cargo recognition for clathrin-mediated endocytosis**: VAMP7 interacts with clathrin, a protein involved in the formation of clathrin-coated vesicles, to facilitate the recognition and internalization of cargo molecules. 4. **Cytokine signaling in the immune system**: VAMP7 is expressed in immune cells, such as dendritic cells and macrophages, and is involved in the regulation of cytokine signaling pathways, which are essential for the activation of immune responses. **Clinical Significance** Dysregulation of VAMP7 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Alterations in VAMP7 expression and function have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Inflammatory disorders**: VAMP7 is involved in the regulation of cytokine signaling pathways, and its dysregulation has been implicated in inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: VAMP7 has been identified as a potential biomarker for cancer diagnosis and prognosis, as its expression levels are altered in various types of cancer. In conclusion, VAMP7 is a critical protein involved in various cellular processes, including vesicle formation, trafficking, and exocytosis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of VAMP7 function and its role in human disease.

Genular Protein ID: 3259361753

Symbol: VAMP7_HUMAN

Name: Vesicle-associated membrane protein 7

UniProtKB Accession Codes:

P51809 Q53GY7 Q7Z409 Q9H4A7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8640232

Title: A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation.

PubMed ID: 8640232

DOI: 10.1038/ng0696-227

PubMed ID: 10655549

Title: Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region.

PubMed ID: 10655549

DOI: 10.1093/hmg/9.3.395

PubMed ID: 12853575

Title: A dual mechanism controlling the localization and function of exocytic v-SNARE.

PubMed ID: 12853575

DOI: 10.1073/pnas.1431910100

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10888671

Title: Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages.

PubMed ID: 10888671

DOI: 10.1091/mbc.11.7.2327

PubMed ID: 16677249

Title: A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils.

PubMed ID: 16677249

DOI: 10.1111/j.1398-9995.2006.01089.x

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18042464

Title: Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line.

PubMed ID: 18042464

DOI: 10.1016/j.bbrc.2007.11.079

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23741335

Title: Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.

PubMed ID: 23741335

DOI: 10.1371/journal.pone.0064514

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25648148

Title: Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.

PubMed ID: 25648148

DOI: 10.15252/embr.201439464

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 220
  • Mass: 24935
  • Checksum: 9C1AA5C590375CEF
  • Sequence:
    • MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY LFHYICQDRI 
VYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY AMNSEFSSVL AAQLKHHSEN 
KGLDKVMETQ AQVDELKGIM VRNIDLVAQR GERLELLIDK TENLVDSSVT FKTTSRNLAR 
AMCMKNLKLT IIIIIVSIVF IYIIVSPLCG GFTWPSCVKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.