Details for: TRGV3

Gene ID: 6976

Symbol: TRGV3

Ensembl ID: ENSG00000211699

Description: T cell receptor gamma variable 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 5.9129
    Cell Significance Index: 15.8400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.0617
    Cell Significance Index: 8.6000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6584
    Cell Significance Index: 3.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3110
    Cell Significance Index: 8.3200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.0163
    Cell Significance Index: 0.1300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0150
    Cell Significance Index: 0.1900
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.0122
    Cell Significance Index: 0.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0045
    Cell Significance Index: 0.2100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0039
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0065
    Cell Significance Index: -0.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0107
    Cell Significance Index: -2.1600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0170
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0192
    Cell Significance Index: -2.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0254
    Cell Significance Index: -2.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0300
    Cell Significance Index: -2.0200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0348
    Cell Significance Index: -0.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0360
    Cell Significance Index: -2.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0394
    Cell Significance Index: -0.6700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0417
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0434
    Cell Significance Index: -0.6400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0492
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0544
    Cell Significance Index: -1.7800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0576
    Cell Significance Index: -0.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0579
    Cell Significance Index: -0.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0597
    Cell Significance Index: -1.9000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0601
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0664
    Cell Significance Index: -0.5600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0668
    Cell Significance Index: -0.5200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0716
    Cell Significance Index: -0.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0717
    Cell Significance Index: -1.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0770
    Cell Significance Index: -1.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0795
    Cell Significance Index: -2.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0810
    Cell Significance Index: -2.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0810
    Cell Significance Index: -2.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0883
    Cell Significance Index: -2.2500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0903
    Cell Significance Index: -0.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0905
    Cell Significance Index: -1.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0915
    Cell Significance Index: -2.2900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0924
    Cell Significance Index: -1.1200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0950
    Cell Significance Index: -0.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0981
    Cell Significance Index: -2.6200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0982
    Cell Significance Index: -1.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1009
    Cell Significance Index: -2.1800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1012
    Cell Significance Index: -1.0100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1014
    Cell Significance Index: -0.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1015
    Cell Significance Index: -2.1600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1034
    Cell Significance Index: -1.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1051
    Cell Significance Index: -1.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1056
    Cell Significance Index: -2.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1060
    Cell Significance Index: -1.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1078
    Cell Significance Index: -2.6100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1104
    Cell Significance Index: -1.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1118
    Cell Significance Index: -2.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1137
    Cell Significance Index: -2.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1138
    Cell Significance Index: -2.6300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1148
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1173
    Cell Significance Index: -0.9500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1193
    Cell Significance Index: -1.4900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1197
    Cell Significance Index: -1.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1233
    Cell Significance Index: -1.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1238
    Cell Significance Index: -3.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1261
    Cell Significance Index: -2.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1267
    Cell Significance Index: -1.8700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1269
    Cell Significance Index: -1.5000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1282
    Cell Significance Index: -1.3300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1321
    Cell Significance Index: -2.1400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1352
    Cell Significance Index: -1.1300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1363
    Cell Significance Index: -2.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1368
    Cell Significance Index: -1.2800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1371
    Cell Significance Index: -1.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1386
    Cell Significance Index: -2.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1389
    Cell Significance Index: -2.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1391
    Cell Significance Index: -1.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1431
    Cell Significance Index: -1.3800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1451
    Cell Significance Index: -1.9900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1499
    Cell Significance Index: -1.5300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1513
    Cell Significance Index: -1.7800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1545
    Cell Significance Index: -1.9600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1550
    Cell Significance Index: -2.1500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1559
    Cell Significance Index: -1.1600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1565
    Cell Significance Index: -1.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1572
    Cell Significance Index: -2.7100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1573
    Cell Significance Index: -1.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1578
    Cell Significance Index: -3.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1594
    Cell Significance Index: -1.6500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1604
    Cell Significance Index: -2.2500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1629
    Cell Significance Index: -2.1300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1633
    Cell Significance Index: -1.8400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1653
    Cell Significance Index: -2.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1654
    Cell Significance Index: -2.3500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1680
    Cell Significance Index: -1.4500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1684
    Cell Significance Index: -1.9800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1687
    Cell Significance Index: -2.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1694
    Cell Significance Index: -2.1700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1704
    Cell Significance Index: -1.7300
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.1705
    Cell Significance Index: -1.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1708
    Cell Significance Index: -2.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGV3 is a member of the T cell receptor (TCR) family, which consists of gamma variable genes that encode the variable region of the TCR. The gamma variable region is responsible for recognizing and binding to peptide antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. This recognition event triggers a series of signaling cascades that ultimately lead to T cell activation, proliferation, and differentiation. TRGV3 is significantly expressed in various cell types, suggesting its involvement in multiple physiological and pathological processes. **Pathways and Functions:** TRGV3 is involved in several key pathways and functions, including: 1. **Adaptive Immune Response:** TRGV3 is essential for the recognition and binding to peptide antigens presented by MHC molecules, which triggers the adaptive immune response. 2. **Peptide Antigen Binding:** TRGV3 recognizes and binds to peptide antigens, leading to the activation of T cells. 3. **MHC Protein Binding:** TRGV3 interacts with MHC molecules, facilitating the presentation of peptide antigens to T cells. 4. **Innate Immune Response:** Although TRGV3 is primarily associated with the adaptive immune response, it also plays a role in the innate immune response, particularly in the recognition of pathogen-associated molecular patterns (PAMPs). 5. **Cell Signaling:** TRGV3 is involved in cell signaling pathways that regulate T cell activation, proliferation, and differentiation. **Clinical Significance:** The clinical significance of TRGV3 is multifaceted: 1. **Autoimmune Diseases:** Alterations in TRGV3 expression have been linked to autoimmune diseases, such as multiple sclerosis, where T cell dysfunction and dysregulation contribute to disease pathology. 2. **Cancer:** TRGV3 is involved in the recognition and binding to tumor antigens, making it a potential target for cancer immunotherapy. 3. **Infectious Diseases:** TRGV3 plays a role in the recognition of pathogens and the activation of T cells, which is critical in the defense against infections. 4. **Neurological Disorders:** TRGV3 is expressed in neurons and is involved in the regulation of synaptic transmission, suggesting its role in neurological disorders, such as epilepsy and Alzheimer's disease. 5. **Regenerative Medicine:** TRGV3 is expressed in stem cells and progenitor cells, highlighting its potential role in tissue regeneration and repair. In conclusion, TRGV3 is a gamma variable gene that plays a crucial role in the adaptive immune response, peptide antigen binding, and cell signaling. Its expression in various cell types underscores its involvement in multiple physiological and pathological processes, making it a valuable target for the development of novel therapeutic strategies for autoimmune diseases, cancer, infectious diseases, and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.