Gene TRGV3 - ENSG00000211699 | NCBI Gene ID: 6976

Details for: TRGV3

Gene ID: 6976

Symbol: TRGV3

Ensembl ID: ENSG00000211699

Description: T cell receptor gamma variable 3

Associated with

Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Mhc protein binding
(GO:0042287)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
T cell receptor complex
(GO:0042101)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.99
Marker Score: 162075
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.69
Marker Score: 8269
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.16
Marker Score: 2173.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.16
Marker Score: 2959
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7669
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71824
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48049
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 1
Marker Score: 5682
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30384
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.96
Marker Score: 1554
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2722.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5271
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.79
Marker Score: 696
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 586
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.68
Marker Score: 541
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.61
Marker Score: 897
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.59
Marker Score: 519
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.58
Marker Score: 1425
Cell Name: neutrophil (CL0000775)
Fold Change: 0.52
Marker Score: 317.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.46
Marker Score: 411
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 275
Cell Name: Unknown (CL0000548)
Fold Change: 0.45
Marker Score: 331.5
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.4
Marker Score: 389
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.36
Marker Score: 301
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.36
Marker Score: 507
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.34
Marker Score: 229
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.32
Marker Score: 322
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.3
Marker Score: 185
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.3
Marker Score: 350
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.28
Marker Score: 878
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.27
Marker Score: 477
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.26
Marker Score: 724
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.26
Marker Score: 503
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.25
Marker Score: 66
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.23
Marker Score: 153
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.23
Marker Score: 129
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.22
Marker Score: 372
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.21
Marker Score: 206
Cell Name: plasmablast (CL0000980)
Fold Change: 0.2
Marker Score: 272
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.18
Marker Score: 450
Cell Name: mature T cell (CL0002419)
Fold Change: 0.18
Marker Score: 1750
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.17
Marker Score: 390
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.17
Marker Score: 105
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.15
Marker Score: 97
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.15
Marker Score: 152
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.15
Marker Score: 112
Cell Name: blood cell (CL0000081)
Fold Change: 0.15
Marker Score: 1718
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.14
Marker Score: 123
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.14
Marker Score: 155
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.14
Marker Score: 62
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.14
Marker Score: 69
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.14
Marker Score: 7349
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.13
Marker Score: 172
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.13
Marker Score: 100
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.13
Marker Score: 206.5
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.12
Marker Score: 514
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.12
Marker Score: 50
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.12
Marker Score: 28
Cell Name: naive B cell (CL0000788)
Fold Change: 0.12
Marker Score: 103
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.11
Marker Score: 26
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.11
Marker Score: 83
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.11
Marker Score: 61
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.11
Marker Score: 55
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.1
Marker Score: 82
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.1
Marker Score: 67
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.1
Marker Score: 23
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.1
Marker Score: 68
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.1
Marker Score: 26
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.09
Marker Score: 63
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.09
Marker Score: 41
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.09
Marker Score: 44
Cell Name: platelet (CL0000233)
Fold Change: 0.09
Marker Score: 40
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.09
Marker Score: 20
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.09
Marker Score: 23
Cell Name: naive T cell (CL0000898)
Fold Change: 0.09
Marker Score: 55.5
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.09
Marker Score: 22
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.08
Marker Score: 104
Cell Name: macrophage (CL0000235)
Fold Change: 0.08
Marker Score: 93
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.08
Marker Score: 21
Cell Name: memory B cell (CL0000787)
Fold Change: 0.08
Marker Score: 62
Cell Name: eosinophil (CL0000771)
Fold Change: 0.08
Marker Score: 26
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.08
Marker Score: 19
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.08
Marker Score: 57
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.08
Marker Score: 18
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.08
Marker Score: 65
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.08
Marker Score: 27
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.08
Marker Score: 44
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.07
Marker Score: 61
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.07
Marker Score: 26
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.07
Marker Score: 16
Cell Name: macrophage dendritic cell progenitor (CL0002009)
Fold Change: 0.07
Marker Score: 25
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.07
Marker Score: 37
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.07
Marker Score: 76
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.07
Marker Score: 24
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.07
Marker Score: 23
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 133
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.07
Marker Score: 55

Hover over a box to see details here...

Other Information

Description

**Key characteristics:** * TRGV3 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed on a variety of cell types, including glutamatergic neuron, oligodendrocyte precursor cell, blood vessel endothelial cell, intestinal crypt stem cell of colon, goblet cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, transit amplifying cell, absorptive cell, and intestinal epithelial cell. * It is a transmembrane protein that is expressed on the cell surface. * It is a member of the TGR family of cell surface receptors, which are involved in the recognition of peptide antigens. **Pathways and functions:** * TRGV3 is expressed on the surface of T cells, natural killer (NK) cells, and other immune cells. * It is a ligand for CD28, a co-stimulatory molecule expressed on the surface of T cells. * When TRGV3 binds to CD28, it triggers the activation of the T cell. * Activation of the T cell leads to the expression of cytokines and chemokines, which can recruit other immune cells to the site of inflammation. **Clinical significance:** * Mutations in the TRGV3 gene have been linked to several human diseases, including multiple sclerosis, autoimmune disorders, and cancer. * TRGV3 is a potential target for therapy in autoimmune disorders that are characterized by excessive immune responses. * Monoclonal antibodies against TRGV3 have been shown to be effective in inhibiting autoimmune responses in animal models.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.