Gene TRGV8 - ENSG00000211696 | NCBI Gene ID: 6982

Details for: TRGV8

Gene ID: 6982

Symbol: TRGV8

Ensembl ID: ENSG00000211696

Description: T cell receptor gamma variable 8

Associated with

Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Innate immune response
(GO:0045087)
T cell receptor complex
(GO:0042101)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: goblet cell (CL0000160)
Fold Change: 1.63
Marker Score: 10811
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.25
Marker Score: 7576
Cell Name: abnormal cell (CL0001061)
Fold Change: 1.22
Marker Score: 3652
Cell Name: absorptive cell (CL0000212)
Fold Change: 1.06
Marker Score: 32728
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.05
Marker Score: 669
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2401
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5343
Cell Name: brush cell (CL0002204)
Fold Change: 0.81
Marker Score: 735
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 611.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.62
Marker Score: 603
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.56
Marker Score: 497
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 436
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.55
Marker Score: 804
Cell Name: neutrophil (CL0000775)
Fold Change: 0.54
Marker Score: 327.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.48
Marker Score: 201
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 404.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.4
Marker Score: 984
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.38
Marker Score: 337
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.37
Marker Score: 523
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.34
Marker Score: 1059
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.32
Marker Score: 444.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.31
Marker Score: 312.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.3
Marker Score: 847
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.25
Marker Score: 269
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.23
Marker Score: 200
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.23
Marker Score: 152
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.18
Marker Score: 119
Cell Name: platelet (CL0000233)
Fold Change: 0.17
Marker Score: 79
Cell Name: thymocyte (CL0000893)
Fold Change: 0.16
Marker Score: 171
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.15
Marker Score: 100
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.13
Marker Score: 101
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.13
Marker Score: 77
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.12
Marker Score: 235
Cell Name: mature T cell (CL0002419)
Fold Change: 0.12
Marker Score: 1150
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.1
Marker Score: 53
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.1
Marker Score: 55
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.1
Marker Score: 85
Cell Name: type II NK T cell (CL0000922)
Fold Change: 0.09
Marker Score: 28
Cell Name: supporting cell (CL0000630)
Fold Change: 0.09
Marker Score: 168
Cell Name: Unknown (CL0000548)
Fold Change: 0.09
Marker Score: 65
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.08
Marker Score: 62
Cell Name: blood cell (CL0000081)
Fold Change: 0.08
Marker Score: 903
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.08
Marker Score: 136
Cell Name: mast cell (CL0000097)
Fold Change: 0.08
Marker Score: 44
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.08
Marker Score: 43
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.08
Marker Score: 27
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.07
Marker Score: 151
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 135
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.06
Marker Score: 35.5
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.06
Marker Score: 77
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.06
Marker Score: 27
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.05
Marker Score: 30
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.05
Marker Score: 85
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.05
Marker Score: 123
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.05
Marker Score: 40
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.05
Marker Score: 38
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.05
Marker Score: 15
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.05
Marker Score: 10
Cell Name: group 2 innate lymphoid cell (CL0001069)
Fold Change: 0.04
Marker Score: 15
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.04
Marker Score: 15
Cell Name: macrophage (CL0000235)
Fold Change: 0.04
Marker Score: 47
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.04
Marker Score: 14
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.04
Marker Score: 17
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.04
Marker Score: 27
Cell Name: Unknown (CL0000003)
Fold Change: 0.04
Marker Score: 121
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.04
Marker Score: 12
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.04
Marker Score: 29
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.04
Marker Score: 65
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.04
Marker Score: 27
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.04
Marker Score: 8
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.03
Marker Score: 351
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.03
Marker Score: 17
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.03
Marker Score: 11
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.03
Marker Score: 14
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.03
Marker Score: 36
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.03
Marker Score: 24
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.03
Marker Score: 27
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.03
Marker Score: 21
Cell Name: T cell (CL0000084)
Fold Change: 0.03
Marker Score: 55
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.03
Marker Score: 88
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.03
Marker Score: 8
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.03
Marker Score: 16
Cell Name: naive B cell (CL0000788)
Fold Change: 0.03
Marker Score: 27
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.03
Marker Score: 21
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.03
Marker Score: 11
Cell Name: B cell (CL0000236)
Fold Change: 0.03
Marker Score: 25
Cell Name: leukocyte (CL0000738)
Fold Change: 0.03
Marker Score: 15
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.03
Marker Score: 76
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.03
Marker Score: 15
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.03
Marker Score: 14
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.02
Marker Score: 10
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.02
Marker Score: 14
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.02
Marker Score: 14
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.02
Marker Score: 23
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.02
Marker Score: 1134
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.02
Marker Score: 11
Cell Name: memory T cell (CL0000813)
Fold Change: 0.02
Marker Score: 9

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Other Information

Description

**Key characteristics:** * TRGV8 is a glycoprotein with a molecular weight of approximately 140 kDa. * It is expressed on a variety of cell types, including goblet cells, neoplastic cells, abnormal cells, absorptive cells, granulocyte monocyte progenitor cells, intestinal crypt stem cells, transit amplifying cells, brush cells, and early T lineage precursors. * It is a transmembrane protein that is expressed on the surface of cells. * It is a member of the immunoglobulin superfamily and is responsible for recognizing MHC class I molecules. **Pathways and functions:** * TRGV8 is involved in the adaptive immune response by binding to MHC class I molecules expressed on antigen-presenting cells. * It is expressed on cytotoxic T cells and is important for the recognition of tumor cells. * It is also expressed on regulatory T cells, which help to control the immune response. * TRGV8 is a key molecule in the regulation of immune responses and is involved in the development of cancer. **Clinical significance:** * Mutations in TRGV8 have been linked to a number of human cancers, including lung cancer, breast cancer, and melanoma. * Targeting TRGV8 has been explored as a cancer immunotherapy, but it has not been successful to date. * Further research is needed to understand the role of TRGV8 in cancer and to develop new therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.