Details for: TRGV8

Gene ID: 6982

Symbol: TRGV8

Ensembl ID: ENSG00000211696

Description: T cell receptor gamma variable 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.8926
    Cell Significance Index: 5.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.6454
    Cell Significance Index: 8.1600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3731
    Cell Significance Index: 4.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1415
    Cell Significance Index: 3.7900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0098
    Cell Significance Index: -1.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0099
    Cell Significance Index: -2.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0148
    Cell Significance Index: -2.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0157
    Cell Significance Index: -2.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0209
    Cell Significance Index: -0.5500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0225
    Cell Significance Index: -0.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0230
    Cell Significance Index: -2.3500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0323
    Cell Significance Index: -0.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0357
    Cell Significance Index: -1.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0358
    Cell Significance Index: -1.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0372
    Cell Significance Index: -0.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0375
    Cell Significance Index: -2.4200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0377
    Cell Significance Index: -0.6400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0394
    Cell Significance Index: -0.4400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0444
    Cell Significance Index: -0.6500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0521
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0581
    Cell Significance Index: -0.5900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0618
    Cell Significance Index: -0.8000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0625
    Cell Significance Index: -0.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0642
    Cell Significance Index: -1.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0648
    Cell Significance Index: -1.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0723
    Cell Significance Index: -0.7500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0725
    Cell Significance Index: -1.8100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0746
    Cell Significance Index: -1.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0759
    Cell Significance Index: -1.9400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0791
    Cell Significance Index: -0.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0805
    Cell Significance Index: -2.1500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0807
    Cell Significance Index: -0.4400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0842
    Cell Significance Index: -0.8400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0882
    Cell Significance Index: -0.8600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0904
    Cell Significance Index: -0.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0909
    Cell Significance Index: -2.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0926
    Cell Significance Index: -1.2700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0938
    Cell Significance Index: -0.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0963
    Cell Significance Index: -1.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1028
    Cell Significance Index: -2.0100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1062
    Cell Significance Index: -1.2500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1074
    Cell Significance Index: -1.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1093
    Cell Significance Index: -1.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1098
    Cell Significance Index: -2.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1110
    Cell Significance Index: -1.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1117
    Cell Significance Index: -1.9100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1173
    Cell Significance Index: -0.9900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1173
    Cell Significance Index: -0.9500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1192
    Cell Significance Index: -1.5100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1193
    Cell Significance Index: -1.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1207
    Cell Significance Index: -2.0200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1260
    Cell Significance Index: -1.4200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1262
    Cell Significance Index: -2.0300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1269
    Cell Significance Index: -1.8500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1295
    Cell Significance Index: -1.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1312
    Cell Significance Index: -2.5600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1318
    Cell Significance Index: -1.7300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1320
    Cell Significance Index: -1.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1328
    Cell Significance Index: -1.9600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1349
    Cell Significance Index: -1.3700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1354
    Cell Significance Index: -1.9000
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.1356
    Cell Significance Index: -1.2000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1368
    Cell Significance Index: -1.8000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1369
    Cell Significance Index: -1.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1370
    Cell Significance Index: -2.0800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1399
    Cell Significance Index: -1.6100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1406
    Cell Significance Index: -1.9500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1408
    Cell Significance Index: -2.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1410
    Cell Significance Index: -2.4300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1423
    Cell Significance Index: -1.5300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1442
    Cell Significance Index: -1.5400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1484
    Cell Significance Index: -1.9000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1485
    Cell Significance Index: -1.9800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1494
    Cell Significance Index: -1.3300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1535
    Cell Significance Index: -1.7000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1536
    Cell Significance Index: -1.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1541
    Cell Significance Index: -2.1600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1551
    Cell Significance Index: -1.8600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1555
    Cell Significance Index: -2.0300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1557
    Cell Significance Index: -2.0000
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1560
    Cell Significance Index: -1.2800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1579
    Cell Significance Index: -1.9200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1587
    Cell Significance Index: -2.1800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1609
    Cell Significance Index: -1.6300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1624
    Cell Significance Index: -1.9300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1663
    Cell Significance Index: -1.8300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1667
    Cell Significance Index: -1.2400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1667
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1670
    Cell Significance Index: -1.9400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1676
    Cell Significance Index: -1.9800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1676
    Cell Significance Index: -1.7800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1676
    Cell Significance Index: -2.2600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1686
    Cell Significance Index: -2.0300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1688
    Cell Significance Index: -1.8200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1703
    Cell Significance Index: -1.9600
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1703
    Cell Significance Index: -1.8600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1704
    Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGV8 belongs to the T cell receptor gamma (TRG) family, which is a crucial component of the adaptive immune response. The gamma chains of the T cell receptor (TCR) are responsible for recognizing and binding to major histocompatibility complex (MHC) molecules on antigen-presenting cells. TRGV8 is one of the 25 gamma chain variants, each with distinct properties and expression profiles. The TRGV8 gene is localized on the X chromosome and has been associated with various immune-related disorders. Its expression is tightly regulated, with a high level of variability observed among different cell types and individuals. **Pathways and Functions:** TRGV8 is involved in several key pathways, including: 1. **Adaptive Immune Response**: TRGV8 plays a critical role in the adaptive immune response by recognizing and binding to MHC molecules on antigen-presenting cells. This interaction triggers the activation of T cells, leading to the production of cytokines and the initiation of an immune response. 2. **T Cell Receptor Complex**: TRGV8 is a component of the T cell receptor complex, which is essential for the recognition and binding of antigens. The TCR complex is composed of two alpha chains, two beta chains, and one gamma chain, with each chain contributing to the overall binding specificity. 3. **Innate Immune Response**: TRGV8 has been shown to interact with pattern recognition receptors (PRRs) on innate immune cells, such as dendritic cells and macrophages. This interaction can lead to the activation of innate immune responses and the production of pro-inflammatory cytokines. **Clinical Significance:** TRGV8 has been associated with several immune-related disorders, including: 1. **Autoimmune Diseases**: Variations in the TRGV8 gene have been linked to autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. 2. **Cancer**: TRGV8 has been implicated in the development and progression of various cancers, including leukemia, lymphoma, and breast cancer. 3. **Infectious Diseases**: TRGV8 has been shown to play a role in the immune response to infections, including tuberculosis and HIV. In conclusion, TRGV8 is a complex gene that plays a critical role in the adaptive and innate immune responses. Its involvement in immune-related disorders highlights the importance of understanding its function and regulation. Further research is necessary to elucidate the mechanisms by which TRGV8 contributes to immune homeostasis and disease. **Recommendations:** 1. **Immunogenetic Studies**: Further immunogenetic studies should be conducted to investigate the relationship between TRGV8 variants and immune-related disorders. 2. **Functional Studies**: Functional studies should be performed to elucidate the mechanisms by which TRGV8 contributes to immune responses and disease. 3. **Therapeutic Applications**: TRGV8-targeted therapies should be explored as a potential treatment for immune-related disorders. By advancing our understanding of TRGV8, we can gain insights into the complex interplay between the immune system and disease, ultimately leading to the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.