Details for: NR2E1

Gene ID: 7101

Symbol: NR2E1

Ensembl ID: ENSG00000112333

Description: nuclear receptor subfamily 2 group E member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.4700
    Cell Significance Index: 17.0200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1142
    Cell Significance Index: 26.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9076
    Cell Significance Index: 50.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4509
    Cell Significance Index: 161.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1117
    Cell Significance Index: 3.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0909
    Cell Significance Index: 5.5900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0403
    Cell Significance Index: 0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0086
    Cell Significance Index: -0.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0104
    Cell Significance Index: -15.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0164
    Cell Significance Index: -7.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0166
    Cell Significance Index: -10.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0292
    Cell Significance Index: -13.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0432
    Cell Significance Index: -12.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0493
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0564
    Cell Significance Index: -11.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0609
    Cell Significance Index: -12.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0630
    Cell Significance Index: -1.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0633
    Cell Significance Index: -12.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0655
    Cell Significance Index: -11.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0706
    Cell Significance Index: -12.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0841
    Cell Significance Index: -12.2300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0934
    Cell Significance Index: -1.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0987
    Cell Significance Index: -6.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1007
    Cell Significance Index: -12.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1018
    Cell Significance Index: -2.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1069
    Cell Significance Index: -2.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1088
    Cell Significance Index: -11.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1208
    Cell Significance Index: -13.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1658
    Cell Significance Index: -10.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1810
    Cell Significance Index: -3.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1950
    Cell Significance Index: -13.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2287
    Cell Significance Index: -12.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2894
    Cell Significance Index: -12.8000
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2924
    Cell Significance Index: -2.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2977
    Cell Significance Index: -13.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3085
    Cell Significance Index: -7.6900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3147
    Cell Significance Index: -4.4200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3184
    Cell Significance Index: -2.8800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3235
    Cell Significance Index: -1.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3243
    Cell Significance Index: -15.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3376
    Cell Significance Index: -12.7900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3485
    Cell Significance Index: -6.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3503
    Cell Significance Index: -12.2700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3576
    Cell Significance Index: -5.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3760
    Cell Significance Index: -12.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3777
    Cell Significance Index: -19.6200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3961
    Cell Significance Index: -2.8800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3971
    Cell Significance Index: -2.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4008
    Cell Significance Index: -12.7700
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.4039
    Cell Significance Index: -3.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4137
    Cell Significance Index: -11.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4173
    Cell Significance Index: -15.3200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4211
    Cell Significance Index: -4.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4258
    Cell Significance Index: -9.2000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4472
    Cell Significance Index: -5.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4563
    Cell Significance Index: -9.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4608
    Cell Significance Index: -13.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4805
    Cell Significance Index: -12.8300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4821
    Cell Significance Index: -6.8500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4825
    Cell Significance Index: -3.0300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4973
    Cell Significance Index: -15.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5038
    Cell Significance Index: -13.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5052
    Cell Significance Index: -13.2900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.5058
    Cell Significance Index: -5.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5111
    Cell Significance Index: -12.7500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5313
    Cell Significance Index: -10.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5340
    Cell Significance Index: -13.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5344
    Cell Significance Index: -15.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5479
    Cell Significance Index: -13.9600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5675
    Cell Significance Index: -7.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5693
    Cell Significance Index: -11.8100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5741
    Cell Significance Index: -6.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5841
    Cell Significance Index: -12.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5855
    Cell Significance Index: -12.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5871
    Cell Significance Index: -12.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5914
    Cell Significance Index: -12.9500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.6132
    Cell Significance Index: -6.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6134
    Cell Significance Index: -8.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6236
    Cell Significance Index: -12.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6247
    Cell Significance Index: -9.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6308
    Cell Significance Index: -7.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6818
    Cell Significance Index: -13.3300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.6820
    Cell Significance Index: -6.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7091
    Cell Significance Index: -17.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7255
    Cell Significance Index: -13.4100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.7338
    Cell Significance Index: -7.2600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.7447
    Cell Significance Index: -7.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.7683
    Cell Significance Index: -13.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7768
    Cell Significance Index: -13.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7780
    Cell Significance Index: -13.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7875
    Cell Significance Index: -15.3700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7919
    Cell Significance Index: -11.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7996
    Cell Significance Index: -40.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8064
    Cell Significance Index: -13.0600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.8076
    Cell Significance Index: -13.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ligand-activated transcription factor**: NR2E1 is a ligand-activated transcription factor that regulates gene expression in response to specific ligands. 2. **Highly expressed in various cell types**: NR2E1 is expressed in a wide range of cell types, including blood vessel endothelial cells, plasma cells, and neurons. 3. **Involved in angiogenesis**: NR2E1 plays a role in the regulation of angiogenesis, the process of new blood vessel formation. 4. **Regulates cell differentiation**: NR2E1 is involved in the regulation of cell differentiation, including the differentiation of neurons and astrocytes. 5. **Involvement in neural development**: NR2E1 is essential for the development of the nervous system, including the formation of the cerebral cortex and the development of neurons. **Pathways and Functions** 1. **PI3K/AKT signaling pathway**: NR2E1 is involved in the regulation of the PI3K/AKT signaling pathway, which is critical for cell survival and proliferation. 2. **Transcriptional regulation**: NR2E1 regulates gene expression by binding to specific DNA sequences and recruiting coactivators or corepressors. 3. **Angiogenesis**: NR2E1 promotes angiogenesis by regulating the expression of genes involved in blood vessel formation. 4. **Cell differentiation**: NR2E1 regulates cell differentiation by controlling the expression of genes involved in the development of specific cell types. 5. **Neural development**: NR2E1 is essential for the development of the nervous system, including the formation of the cerebral cortex and the development of neurons. **Clinical Significance** 1. **Cancer**: NR2E1 has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. 2. **Neurological disorders**: NR2E1 has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Angiogenesis-related disorders**: NR2E1 plays a role in angiogenesis, which is involved in various disorders, including cancer, atherosclerosis, and diabetic retinopathy. 4. **Neurodevelopmental disorders**: NR2E1 is involved in the development of the nervous system, and dysregulation of this gene has been implicated in neurodevelopmental disorders, including autism spectrum disorder and attention deficit hyperactivity disorder. In conclusion, NR2E1 is a critical transcription factor that plays a key role in various developmental and physiological processes, including angiogenesis, cell differentiation, and neural development. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and angiogenesis-related disorders. Further research is needed to fully understand the functions of NR2E1 and its role in human disease.

Genular Protein ID: 3150651018

Symbol: NR2E1_HUMAN

Name: Nuclear receptor subfamily 2 group E member 1

UniProtKB Accession Codes:

Q9Y466 Q6ZMP8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9628820

Title: The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21.

PubMed ID: 9628820

DOI: 10.1006/geno.1998.5270

PubMed ID: 11073974

Title: Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX.

PubMed ID: 11073974

DOI: 10.1128/mcb.20.23.8731-8739.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 385
  • Mass: 42589
  • Checksum: 39181A42A2FB79C2
  • Sequence:
    • MSKPAGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRTY VCKSGNQGGC 
PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR KQVALYFRGH KEENGAAAHF 
PSAALPAPAF FTAVTQLEPH GLELAAVSTT PERQTLVSLA QPTPKYPHEV NGTPMYLYEV 
ATESVCESAA RLLFMSIKWA KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAN 
TLLAVSGMNG DNTDSQKLNK IISEIQALQE VVARFRQLRL DATEFACLKC IVTFKAVPTH 
SGSELRSFRN AAAIAALQDE AQLTLNSYIH TRYPTQPCRF GKLLLLLPAL RSISPSTIEE 
VFFKKTIGNV PITRLLSDMY KSSDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.