Details for: UGT2B15

Gene ID: 7366

Symbol: UGT2B15

Ensembl ID: ENSG00000196620

Description: UDP glucuronosyltransferase family 2 member B15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 4.2341
    Cell Significance Index: 62.5000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 4.0544
    Cell Significance Index: 15.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8055
    Cell Significance Index: 60.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5312
    Cell Significance Index: 37.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2648
    Cell Significance Index: 21.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9074
    Cell Significance Index: 172.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.8768
    Cell Significance Index: 100.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8474
    Cell Significance Index: 98.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5514
    Cell Significance Index: 54.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5340
    Cell Significance Index: 32.0600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4489
    Cell Significance Index: 2.5900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.4151
    Cell Significance Index: 1.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4143
    Cell Significance Index: 45.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4054
    Cell Significance Index: 366.0200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3557
    Cell Significance Index: 5.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3301
    Cell Significance Index: 11.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3040
    Cell Significance Index: 49.4500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2469
    Cell Significance Index: 1.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2237
    Cell Significance Index: 15.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1736
    Cell Significance Index: 7.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1592
    Cell Significance Index: 3.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1482
    Cell Significance Index: 29.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1394
    Cell Significance Index: 10.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1354
    Cell Significance Index: 2.0400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1268
    Cell Significance Index: 2.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1238
    Cell Significance Index: 14.1900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1145
    Cell Significance Index: 1.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1127
    Cell Significance Index: 19.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0970
    Cell Significance Index: 5.0400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.0954
    Cell Significance Index: 0.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0910
    Cell Significance Index: 2.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0850
    Cell Significance Index: 53.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0611
    Cell Significance Index: 1.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0588
    Cell Significance Index: 1.2200
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.0567
    Cell Significance Index: 0.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0556
    Cell Significance Index: 1.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0554
    Cell Significance Index: 1.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0482
    Cell Significance Index: 0.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0325
    Cell Significance Index: 5.8600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0268
    Cell Significance Index: 0.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0076
    Cell Significance Index: 0.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0063
    Cell Significance Index: 0.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0016
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0028
    Cell Significance Index: -0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0032
    Cell Significance Index: -0.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0034
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0041
    Cell Significance Index: -2.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0051
    Cell Significance Index: -0.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0059
    Cell Significance Index: -2.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0134
    Cell Significance Index: -0.5500
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0158
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0162
    Cell Significance Index: -0.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0194
    Cell Significance Index: -2.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0207
    Cell Significance Index: -0.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0219
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0261
    Cell Significance Index: -3.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0263
    Cell Significance Index: -3.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0270
    Cell Significance Index: -2.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0296
    Cell Significance Index: -1.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0301
    Cell Significance Index: -2.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0307
    Cell Significance Index: -3.6200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0323
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0389
    Cell Significance Index: -0.4100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0397
    Cell Significance Index: -0.5500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0436
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0487
    Cell Significance Index: -1.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0530
    Cell Significance Index: -2.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0547
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0548
    Cell Significance Index: -1.9200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0567
    Cell Significance Index: -0.5900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0570
    Cell Significance Index: -0.5700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0596
    Cell Significance Index: -0.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0637
    Cell Significance Index: -2.0300
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0641
    Cell Significance Index: -0.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0652
    Cell Significance Index: -0.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0656
    Cell Significance Index: -2.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0663
    Cell Significance Index: -2.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0676
    Cell Significance Index: -3.1800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0694
    Cell Significance Index: -0.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0715
    Cell Significance Index: -0.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0726
    Cell Significance Index: -0.9900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0752
    Cell Significance Index: -1.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0753
    Cell Significance Index: -2.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0760
    Cell Significance Index: -2.7900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0761
    Cell Significance Index: -0.9800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0768
    Cell Significance Index: -0.4700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0775
    Cell Significance Index: -0.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0790
    Cell Significance Index: -1.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0813
    Cell Significance Index: -2.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0817
    Cell Significance Index: -0.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UGT2B15 is a type II UDP glucuronosyltransferase, which is distinct from type I enzymes that require NADPH as a cofactor. Unlike type I enzymes, type II enzymes, such as UGT2B15, utilize UDP-glucuronic acid as a substrate and do not require NADPH. This characteristic enables UGT2B15 to function in a variety of cellular environments, including the endoplasmic reticulum and the cytosol. The enzyme's substrate specificity is broad, with the ability to conjugate a wide range of compounds, including steroids, retinoids, and xenobiotics. **Pathways and Functions** UGT2B15 is involved in several key metabolic pathways, including glucuronidation, cellular oxidations, and xenobiotic metabolism. Glucuronidation is the primary function of UGT2B15, where the enzyme conjugates glucuronic acid to a substrate, making it more water-soluble and facilitating its excretion from the body. This process is crucial for the metabolism and detoxification of endogenous compounds, such as bilirubin and bile acids, as well as exogenous compounds, including drugs and environmental pollutants. In addition to glucuronidation, UGT2B15 is also involved in cellular oxidations, where it participates in the metabolism of retinoids and other oxidized compounds. The enzyme's role in xenobiotic metabolism is also significant, as it helps to detoxify and eliminate a wide range of environmental pollutants and pharmaceuticals. **Clinical Significance** UGT2B15 plays a critical role in maintaining human health and preventing disease. Deficiencies in UGT2B15 have been associated with various clinical conditions, including: 1. **Liver disease**: UGT2B15 is primarily expressed in the liver, where it plays a crucial role in the metabolism and detoxification of endogenous compounds. Deficiencies in UGT2B15 have been linked to liver disease, including liver cirrhosis and liver cancer. 2. **Cancer**: UGT2B15 has been implicated in the metabolism and detoxification of carcinogens, which can contribute to the development of cancer. Abnormal expression of UGT2B15 has been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Pharmacokinetics**: UGT2B15 plays a significant role in the metabolism and elimination of certain drugs, including aspirin and paracetamol. Abnormal expression of UGT2B15 can affect the pharmacokinetics of these drugs, leading to altered efficacy and toxicity. In conclusion, UGT2B15 is a critical enzyme in the glucuronidation pathway, playing a vital role in the metabolism and detoxification of endogenous and exogenous compounds. Its clinical significance is evident in the prevention and treatment of various diseases, including liver disease, cancer, and pharmacokinetic disorders. Further research is needed to fully understand the role of UGT2B15 in human health and disease, and to explore its potential as a therapeutic target for the treatment of various clinical conditions.

Genular Protein ID: 110659518

Symbol: UDB15_HUMAN

Name: HLUG4

UniProtKB Accession Codes:

P54855 A6NDX0 A6NNJ4 A8K054 P23765 Q9UK63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 28 EC 1 EMBL 8 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8399210

Title: Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms.

PubMed ID: 8399210

DOI: 10.1021/bi00091a015

PubMed ID: 7835232

Title: Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

PubMed ID: 7835232

PubMed ID: 9295060

Title: Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene.

PubMed ID: 9295060

DOI: 10.1097/00008571-199708000-00007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 2116769

Title: Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase.

PubMed ID: 2116769

DOI: 10.1016/0003-9861(90)90428-2

PubMed ID: 16595710

Title: Human UDP-glucuronosyltransferase, UGT1A8, glucuronidates dihydrotestosterone to a monoglucuronide and further to a structurally novel diglucuronide.

PubMed ID: 16595710

DOI: 10.1124/dmd.106.009621

PubMed ID: 18719240

Title: The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

PubMed ID: 18719240

DOI: 10.1124/dmd.108.022731

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 23288867

Title: Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

PubMed ID: 23288867

DOI: 10.1124/dmd.112.049072

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15618667

Title: A major genotype in UDP-glucuronosyltransferase 2B15.

PubMed ID: 15618667

DOI: 10.2133/dmpk.17.164

Sequence Information:

  • Length: 530
  • Mass: 61036
  • Checksum: EB2DAE838769C955
  • Sequence:
    • MSLKWTSVFL LIQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG HEVTVLTSSA 
STLVNASKSS AIKLEVYPTS LTKNYLEDSL LKILDRWIYG VSKNTFWSYF SQLQELCWEY 
YDYSNKLCKD AVLNKKLMMK LQESKFDVIL ADALNPCGEL LAELFNIPFL YSLRFSVGYT 
FEKNGGGFLF PPSYVPVVMS ELSDQMIFME RIKNMIHMLY FDFWFQIYDL KKWDQFYSEV 
LGRPTTLFET MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS 
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS NTRLYKWLPQ 
NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ HDNIAHMKAK GAALSVDIRT 
MSSRDLLNAL KSVINDPVYK ENVMKLSRIH HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA 
AHNLTWIQYH SLDVIAFLLA CVATVIFIIT KFCLFCFRKL AKKGKKKKRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.