Details for: WNT8B

Gene ID: 7479

Symbol: WNT8B

Ensembl ID: ENSG00000075290

Description: Wnt family member 8B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5540
    Cell Significance Index: 13.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5430
    Cell Significance Index: 7.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0937
    Cell Significance Index: 2.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0224
    Cell Significance Index: 0.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0085
    Cell Significance Index: 5.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0067
    Cell Significance Index: 1.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0013
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0006
    Cell Significance Index: 0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0023
    Cell Significance Index: -0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0042
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0050
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0080
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0103
    Cell Significance Index: -2.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0112
    Cell Significance Index: -0.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0113
    Cell Significance Index: -0.1900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0126
    Cell Significance Index: -1.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0147
    Cell Significance Index: -1.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0172
    Cell Significance Index: -0.8000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0172
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0180
    Cell Significance Index: -2.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0193
    Cell Significance Index: -1.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0228
    Cell Significance Index: -1.4000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0234
    Cell Significance Index: -0.8200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0248
    Cell Significance Index: -1.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0262
    Cell Significance Index: -0.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0267
    Cell Significance Index: -1.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0287
    Cell Significance Index: -1.1800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0292
    Cell Significance Index: -0.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0293
    Cell Significance Index: -1.4800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0301
    Cell Significance Index: -0.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0310
    Cell Significance Index: -1.7400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0320
    Cell Significance Index: -0.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0326
    Cell Significance Index: -1.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0327
    Cell Significance Index: -0.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0328
    Cell Significance Index: -0.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0341
    Cell Significance Index: -1.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0344
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0354
    Cell Significance Index: -0.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0358
    Cell Significance Index: -1.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0378
    Cell Significance Index: -1.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0386
    Cell Significance Index: -0.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0433
    Cell Significance Index: -0.4100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0456
    Cell Significance Index: -0.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0469
    Cell Significance Index: -1.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0489
    Cell Significance Index: -1.3100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0495
    Cell Significance Index: -0.6100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0495
    Cell Significance Index: -0.6900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0501
    Cell Significance Index: -0.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0505
    Cell Significance Index: -1.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0505
    Cell Significance Index: -0.8500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0509
    Cell Significance Index: -0.3700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0513
    Cell Significance Index: -0.7100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0523
    Cell Significance Index: -0.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0529
    Cell Significance Index: -1.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0532
    Cell Significance Index: -1.1300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0547
    Cell Significance Index: -0.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0564
    Cell Significance Index: -1.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0568
    Cell Significance Index: -0.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0569
    Cell Significance Index: -0.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0570
    Cell Significance Index: -1.1900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0587
    Cell Significance Index: -0.6900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0594
    Cell Significance Index: -0.7600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0606
    Cell Significance Index: -0.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0625
    Cell Significance Index: -1.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0627
    Cell Significance Index: -1.2400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0630
    Cell Significance Index: -0.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0633
    Cell Significance Index: -1.2700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0654
    Cell Significance Index: -0.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0656
    Cell Significance Index: -1.8900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0668
    Cell Significance Index: -0.6900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0675
    Cell Significance Index: -0.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0689
    Cell Significance Index: -2.0300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0689
    Cell Significance Index: -0.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0694
    Cell Significance Index: -1.2000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0696
    Cell Significance Index: -0.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0706
    Cell Significance Index: -1.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0707
    Cell Significance Index: -1.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0724
    Cell Significance Index: -1.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0728
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0729
    Cell Significance Index: -2.0800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0735
    Cell Significance Index: -0.9300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0752
    Cell Significance Index: -1.4800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0760
    Cell Significance Index: -0.7200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0763
    Cell Significance Index: -0.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WNT8B is a secreted protein belonging to the Wnt family, which consists of a group of related proteins that play key roles in development, tissue homeostasis, and disease. WNT8B is specifically characterized by its high expression in endothelial cells, plasma cells, and stem cells, highlighting its importance in vascular development and tissue regeneration. Its expression is also observed in neurons, particularly in GABAergic interneurons, suggesting a role in neural development and function. **Pathways and Functions:** WNT8B's signaling pathway is primarily mediated through the Frizzled receptors, which form complexes with co-receptors and ligand-binding proteins to activate downstream signaling cascades. The canonical Wnt signaling pathway, which involves the stabilization of β-catenin and its translocation to the nucleus, is a key downstream effector of WNT8B signaling. This pathway regulates cell fate commitment, differentiation, and proliferation, as well as the determination of dorsal identity during embryonic development. WNT8B also interacts with other signaling pathways, including the TCF-dependent signaling pathway, which is involved in the regulation of transcriptional responses to Wnt ligands. In addition to its role in developmental processes, WNT8B is also involved in maintaining tissue homeostasis and responding to external stimuli. Its expression is induced by retinoic acid, a derivative of vitamin A, and it plays a role in regulating cellular responses to estradiol and other hormones. WNT8B also interacts with other signaling molecules, including GPCRs, to regulate cell signaling and response to external cues. **Clinical Significance:** Dysregulation of WNT8B signaling has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. For example, aberrant WNT8B expression has been observed in colorectal cancer, where it contributes to tumor progression and metastasis. In cardiovascular disease, WNT8B signaling has been implicated in the regulation of vascular development and maintenance. In neurological disorders, WNT8B has been shown to play a role in regulating neural development and function. Mutations in the WNT8B gene have been associated with neurodevelopmental disorders, such as intellectual disability and autism spectrum disorder. Furthermore, WNT8B signaling has been implicated in the regulation of neuronal differentiation and survival, highlighting its potential as a therapeutic target for neurological disorders. In conclusion, WNT8B is a critical regulator of developmental and cellular processes, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the mechanisms by which WNT8B signaling regulates cellular processes and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 1408312816

Symbol: WNT8B_HUMAN

Name: Protein Wnt-8b

UniProtKB Accession Codes:

Q93098 O00771 Q5VX55 Q8WYK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9536085

Title: A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain.

PubMed ID: 9536085

DOI: 10.1093/hmg/7.5.813

PubMed ID: 11788899

Title: Up-regulation of WNT8B mRNA in human gastric cancer.

PubMed ID: 11788899

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 8661156

Title: Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24.

PubMed ID: 8661156

DOI: 10.1006/geno.1996.0374

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 351
  • Mass: 38721
  • Checksum: DD242070948813F8
  • Sequence:
    • MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG IEECKYQFAW 
DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL TRNCSLGDFD NCGCDDSRNG 
QLGGQGWLWG GCSDNVGFGE AISKQFVDAL ETGQDARAAM NLHNNEAGRK AVKGTMKRTC 
KCHGVSGSCT TQTCWLQLPE FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS 
ISTRELVHLE DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE 
RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.