Details for: ZNF132

Gene ID: 7691

Symbol: ZNF132

Ensembl ID: ENSG00000131849

Description: zinc finger protein 132

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 25.2017
    Cell Significance Index: -3.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.0605
    Cell Significance Index: -3.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.4774
    Cell Significance Index: -3.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6580
    Cell Significance Index: -1.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3639
    Cell Significance Index: 69.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2891
    Cell Significance Index: 4.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2290
    Cell Significance Index: 13.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2248
    Cell Significance Index: 14.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2209
    Cell Significance Index: 3.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2034
    Cell Significance Index: 5.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1999
    Cell Significance Index: 19.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1686
    Cell Significance Index: 2.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1623
    Cell Significance Index: 17.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1369
    Cell Significance Index: 123.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1180
    Cell Significance Index: 3.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1094
    Cell Significance Index: 17.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0942
    Cell Significance Index: 18.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0854
    Cell Significance Index: 3.8700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0848
    Cell Significance Index: 1.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0699
    Cell Significance Index: 3.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0688
    Cell Significance Index: 4.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0602
    Cell Significance Index: 21.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0534
    Cell Significance Index: 4.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0332
    Cell Significance Index: 0.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0275
    Cell Significance Index: 4.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0262
    Cell Significance Index: 1.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0249
    Cell Significance Index: 0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0233
    Cell Significance Index: 0.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0142
    Cell Significance Index: 2.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0142
    Cell Significance Index: 7.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0129
    Cell Significance Index: 0.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0127
    Cell Significance Index: 0.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0114
    Cell Significance Index: 0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0099
    Cell Significance Index: 1.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0097
    Cell Significance Index: 1.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0084
    Cell Significance Index: 0.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0044
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 7.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0024
    Cell Significance Index: 0.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0019
    Cell Significance Index: 0.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: 0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0039
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0066
    Cell Significance Index: -1.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0073
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0101
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0107
    Cell Significance Index: -0.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0111
    Cell Significance Index: -0.2300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0140
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0148
    Cell Significance Index: -2.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0168
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0188
    Cell Significance Index: -3.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0195
    Cell Significance Index: -2.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0199
    Cell Significance Index: -2.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0231
    Cell Significance Index: -1.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0248
    Cell Significance Index: -0.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0271
    Cell Significance Index: -3.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0352
    Cell Significance Index: -3.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0384
    Cell Significance Index: -1.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0410
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0437
    Cell Significance Index: -3.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0444
    Cell Significance Index: -1.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0451
    Cell Significance Index: -2.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0469
    Cell Significance Index: -1.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0470
    Cell Significance Index: -2.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0502
    Cell Significance Index: -3.7400
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.0520
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0529
    Cell Significance Index: -1.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0545
    Cell Significance Index: -0.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0552
    Cell Significance Index: -3.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0562
    Cell Significance Index: -0.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0570
    Cell Significance Index: -1.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0574
    Cell Significance Index: -1.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0577
    Cell Significance Index: -2.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0650
    Cell Significance Index: -2.0700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0663
    Cell Significance Index: -0.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0672
    Cell Significance Index: -2.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0684
    Cell Significance Index: -1.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0699
    Cell Significance Index: -1.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0708
    Cell Significance Index: -2.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0738
    Cell Significance Index: -1.6000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0761
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0807
    Cell Significance Index: -1.6900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0813
    Cell Significance Index: -2.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0814
    Cell Significance Index: -1.6100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0829
    Cell Significance Index: -1.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0832
    Cell Significance Index: -1.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0835
    Cell Significance Index: -1.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0839
    Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Zinc Finger Domain**: ZNF132 possesses a characteristic zinc finger domain, a protein motif that allows for specific DNA binding and recognition of target sequences. 2. **RNA Polymerase II Specificity**: ZNF132 exhibits specificity for RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes, indicating its role in regulating gene expression. 3. **Metal Ion Binding**: The presence of metal ions, such as zinc, is essential for ZNF132's function, suggesting its reliance on these ions for DNA binding and transcriptional regulation. 4. **Cell-Type Specific Expression**: ZNF132 is expressed in various cell types, including goblet cells, radial glial cells, and intestinal epithelial cells, highlighting its involvement in multiple tissues and developmental processes. **Pathways and Functions** 1. **Transcriptional Regulation**: ZNF132 regulates transcription by interacting with RNA polymerase II and binding to specific DNA sequences, modulating the expression of target genes. 2. **DNA Binding**: The zinc finger domain of ZNF132 allows it to bind to specific DNA sequences, enabling the regulation of transcriptional activity. 3. **Cell Proliferation and Differentiation**: ZNF132's expression in stem cells and progenitor cells suggests its involvement in cell proliferation, differentiation, and maintenance of tissue homeostasis. 4. **Immune Response**: The expression of ZNF132 in GABAergic interneurons and other immune-related cells implies its potential role in regulating immune responses and inflammation. **Clinical Significance** 1. **Cancer Association**: ZNF132's dysregulation has been implicated in various cancers, including colon cancer, where it may contribute to tumorigenesis and progression. 2. **Neurological Disorders**: ZNF132's expression in GABAergic interneurons and other brain cells suggests its potential involvement in neurological disorders, such as epilepsy and neurodegenerative diseases. 3. **Intestinal Diseases**: The dysregulation of ZNF132 in intestinal epithelial cells may contribute to the development of intestinal diseases, such as inflammatory bowel disease (IBD). 4. **Therapeutic Targets**: Understanding ZNF132's mechanisms and clinical significance may lead to the identification of novel therapeutic targets for diseases associated with its dysregulation. In conclusion, ZNF132 is a transcription factor that plays a critical role in regulating gene expression in various cell types, including those involved in development, maintenance, and function of tissues such as the colon, brain, and intestinal epithelium. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding its mechanisms and clinical significance. Further research is necessary to fully elucidate ZNF132's role in human health and disease, ultimately paving the way for the development of novel therapeutic strategies.

Genular Protein ID: 3958806421

Symbol: ZN132_HUMAN

Name: Zinc finger protein 132

UniProtKB Accession Codes:

P52740 Q32MI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 706
  • Mass: 80623
  • Checksum: 7C74CEF0C0701AC3
  • Sequence:
    • MALPSPQVLM GLPALLMGPA QHTSWPCGSA VPTLKSMVTF EDVAVYFSQE EWELLDAAQR 
HLYHSVMLEN LELVTSLGSW HGVEGEGAHP KQNVSVEVLQ VRIPNADPST KKANSCDMCG 
PFLKDILHLA EHQGTQSEEK PYTCGACGRD FWLNANLHQH QKEHSGGKPF RWYKDRDALM 
KSSKVHLSEN PFTCREGGKV ILGSCDLLQL QAVDSGQKPY SNLGQLPEVC TTQKLFECSN 
CGKAFLKSST LPNHLRTHSE EIPFTCPTGG NFLEEKSILG NKKFHTGEIP HVCKECGKAF 
SHSSKLRKHQ KFHTEVKYYE CIACGKTFNH KLTFVHHQRI HSGERPYECD ECGKAFSNRS 
HLIRHEKVHT GERPFECLKC GRAFSQSSNF LRHQKVHTQV RPYECSQCGK SFSRSSALIQ 
HWRVHTGERP YECSECGRAF NNNSNLAQHQ KVHTGERPFE CSECGRDFSQ SSHLLRHQKV 
HTGERPFECC DCGKAFSNSS TLIQHQKVHT GQRPYECSEC RKSFSRSSSL IQHWRIHTGE 
KPYECSECGK AFAHSSTLIE HWRVHTKERP YECNECGKFF SQNSILIKHQ KVHTGEKPYK 
CSECGKFFSR KSSLICHWRV HTGERPYECS ECGRAFSSNS HLVRHQRVHT QERPYECIQC 
GKAFSERSTL VRHQKVHTRE RTYECSQCGK LFSHLCNLAQ HKKIHT

Genular Protein ID: 1481649562

Symbol: B3KQ54_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQ54

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 706
  • Mass: 80613
  • Checksum: 5285D1A6B329591F
  • Sequence:
    • MALPSPQVLM GLPALLMGPA QHTSWPCGSA VPTLKSMVTF EDVAVYFSQE EWELLDAAQR 
HLYHSVMLEN LELVTSLGSW HGVEGEGAHP KQNVSVEVLQ VRIPNADPST KKANSCDMCG 
PFLKDILHLA EHQGTQSEEK PYTCGACGRD FWLNANLHQH QKEHSGGKPF RWYKDRDALM 
KSSKVHLSEN PFTCREGGKV ILGSCDLLQL QAVDSGQKPY SNLGQLPEVC TTQKLFECSN 
CGKAFLKSST LPNHLRTHSE EIPFTCPTGG NFLEEKSILG NKKFHTGEIS HVCKECGKAF 
SHSSKLRKHQ KFHTEVKYYE CIACGKTFNH KLTFVHHQRI HSGERPYECD ECGKAFSNRS 
HLIRHEKVHT GERPFECLKC GRAFSQSSNF LRHQKVHTQV RPYECSQCGK SFSRSSALIQ 
HWRVHTGERP YECSECGRAF NNNSNLAQHQ KVHTGERPFE CSECGRDFSQ SSHLLRHQKV 
HTGERPFECC DCGKAFSNSS TLIQHQKVHT GQRPYECSEC RKSFSRSSSL IQHWRIHTGE 
KPYECSECGK AFAHSSTLIE HWRVHTKERP YECNECGKFF SQNSILIKHQ KVHTGEKPYK 
CSECGKFFSR KSSLICHWRV HTGERPYECS ECGRAFSSNS HLVRHQRVHT QERPYECIQC 
GKAFSERSTL VRHQKVHTRE RTYECSQCGK LFSHLCNLAQ HKKIHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.