Details for: OR2H2

Gene ID: 7932

Symbol: OR2H2

Ensembl ID: ENSG00000204657

Description: olfactory receptor family 2 subfamily H member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.2694
    Cell Significance Index: 24.8200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3045
    Cell Significance Index: 9.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2768
    Cell Significance Index: 10.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2516
    Cell Significance Index: 11.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2075
    Cell Significance Index: 3.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1790
    Cell Significance Index: 3.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0980
    Cell Significance Index: 1.6800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.0502
    Cell Significance Index: 0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0497
    Cell Significance Index: 67.5200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0246
    Cell Significance Index: 0.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0227
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0119
    Cell Significance Index: 18.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0066
    Cell Significance Index: 0.3300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0041
    Cell Significance Index: 0.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0039
    Cell Significance Index: 0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0027
    Cell Significance Index: 5.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0023
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0007
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0016
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0018
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0034
    Cell Significance Index: -0.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0064
    Cell Significance Index: -1.8400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0077
    Cell Significance Index: -0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0105
    Cell Significance Index: -0.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0112
    Cell Significance Index: -1.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0127
    Cell Significance Index: -1.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0138
    Cell Significance Index: -0.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0153
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0160
    Cell Significance Index: -2.2000
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0230
    Cell Significance Index: -0.2300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0255
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0343
    Cell Significance Index: -1.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0348
    Cell Significance Index: -1.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0357
    Cell Significance Index: -1.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0363
    Cell Significance Index: -1.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0364
    Cell Significance Index: -0.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0368
    Cell Significance Index: -1.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0390
    Cell Significance Index: -0.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0412
    Cell Significance Index: -0.8600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0420
    Cell Significance Index: -0.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0436
    Cell Significance Index: -0.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0473
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0503
    Cell Significance Index: -0.8300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0512
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0533
    Cell Significance Index: -1.4500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0539
    Cell Significance Index: -0.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0583
    Cell Significance Index: -1.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0598
    Cell Significance Index: -1.2000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0600
    Cell Significance Index: -0.7200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0608
    Cell Significance Index: -0.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0613
    Cell Significance Index: -1.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0624
    Cell Significance Index: -0.8000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0626
    Cell Significance Index: -0.8900
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0648
    Cell Significance Index: -0.7000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0657
    Cell Significance Index: -0.6700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0666
    Cell Significance Index: -0.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0685
    Cell Significance Index: -1.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0694
    Cell Significance Index: -1.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0714
    Cell Significance Index: -1.3200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0725
    Cell Significance Index: -0.7500
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0738
    Cell Significance Index: -0.6900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0744
    Cell Significance Index: -0.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0754
    Cell Significance Index: -1.8400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0762
    Cell Significance Index: -1.5000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0789
    Cell Significance Index: -1.1800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0794
    Cell Significance Index: -0.8000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0796
    Cell Significance Index: -0.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0805
    Cell Significance Index: -2.1500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0821
    Cell Significance Index: -0.7800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0825
    Cell Significance Index: -1.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0827
    Cell Significance Index: -1.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0840
    Cell Significance Index: -1.4100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0941
    Cell Significance Index: -1.2700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0950
    Cell Significance Index: -1.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0950
    Cell Significance Index: -2.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0954
    Cell Significance Index: -1.3900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0959
    Cell Significance Index: -1.6400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0960
    Cell Significance Index: -1.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0963
    Cell Significance Index: -1.2000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0968
    Cell Significance Index: -1.3900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0985
    Cell Significance Index: -1.1100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0986
    Cell Significance Index: -1.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0989
    Cell Significance Index: -1.9300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0990
    Cell Significance Index: -1.2000
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1002
    Cell Significance Index: -1.2500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1003
    Cell Significance Index: -0.9700
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1009
    Cell Significance Index: -1.2200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1014
    Cell Significance Index: -0.6600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1021
    Cell Significance Index: -1.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1026
    Cell Significance Index: -1.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1038
    Cell Significance Index: -1.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR2H2 is a member of the olfactory receptor family, which consists of G protein-coupled receptors (GPCRs) responsible for detecting odorant molecules in the air. The OR2H2 receptor is specifically involved in detecting chemical stimuli involved in sensory perception of smell. 2. **Expression in Immune Cells:** OR2H2 is expressed in immune cells, such as B cells and goblet cells, suggesting its role in modulating immune responses and tissue homeostasis. 3. **Tissue Distribution:** OR2H2 is widely expressed in various tissues, including the olfactory epithelium, intestinal epithelium, and secondary lens fibers, highlighting its importance in maintaining tissue homeostasis and responsiveness to environmental cues. 4. **G-Protein Coupled Receptor Activity:** OR2H2 belongs to the GPCR family, which is characterized by its ability to activate G proteins, leading to various signaling pathways. **Pathways and Functions:** 1. **G-Protein Coupled Receptor Signaling Pathway:** OR2H2 activates G proteins, which in turn trigger a cascade of signaling events, leading to various cellular responses, including changes in gene expression, cell migration, and cell proliferation. 2. **Defense Response:** OR2H2 is involved in the defense response against pathogens and allergens, modulating immune responses and tissue homeostasis. 3. **Mating Behavior:** OR2H2 has been implicated in mating behavior, suggesting its role in reproductive functions and social behavior. 4. **Sensory Perception:** OR2H2 is essential for detecting chemical stimuli involved in sensory perception of smell, highlighting its importance in olfactory function. **Clinical Significance:** 1. **Olfactory Disorders:** Alterations in OR2H2 expression have been linked to olfactory disorders, such as anosmia and hyposmia, highlighting its importance in maintaining olfactory function. 2. **Immune-Related Disorders:** Dysregulation of OR2H2 has been implicated in immune-related disorders, such as asthma and allergies, suggesting its role in modulating immune responses. 3. **Cancer Research:** OR2H2 has been identified as a potential biomarker for cancer diagnosis and prognosis, particularly in epithelial cancers, such as colon cancer. 4. **Neurological Disorders:** OR2H2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in modulating neural function and tissue homeostasis. In conclusion, OR2H2 is a multifaceted gene that plays a crucial role in olfactory signaling, immune regulation, and tissue homeostasis. Its dysregulation has been implicated in various diseases, including olfactory disorders, immune-related disorders, and cancer. Further research is needed to fully elucidate the functions and clinical significance of OR2H2, but its importance in maintaining tissue homeostasis and responsiveness to environmental cues is undeniable.

Genular Protein ID: 859113290

Symbol: OR2H2_HUMAN

Name: Olfactory receptor 2H2

UniProtKB Accession Codes:

O95918 Q15062 Q2M1Y3 Q5STL8 Q5SUK1 Q6IFN7 Q6NTB7 Q96R14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 8 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7665158

Title: Olfactory receptor-like genes are located in the human major histocompatibility complex.

PubMed ID: 7665158

DOI: 10.1006/geno.1995.1013

PubMed ID: 10880742

Title: Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites.

PubMed ID: 10880742

DOI: 10.1016/s0198-8859(00)00132-4

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 34763
  • Checksum: 4E18B444768AAFC5
  • Sequence:
    • MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD PKLHSPMYFF 
LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF IFLSLGTTEC ILLTVMAFDR 
YVAVCQPLHY ATIIHPRLCW QLASVAWVIG LVESVVQTPS TLHLPFCPDR QVDDFVCEVP 
ALIRLSCEDT SYNEIQVAVA SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS 
SHLTVVTLFY SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR 
RLLGKEMGLT QS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.