Details for: GLRA3

Gene ID: 8001

Symbol: GLRA3

Ensembl ID: ENSG00000145451

Description: glycine receptor alpha 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.4413
    Cell Significance Index: -6.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.3054
    Cell Significance Index: 50.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.7749
    Cell Significance Index: 22.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9990
    Cell Significance Index: 200.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7768
    Cell Significance Index: -1.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7315
    Cell Significance Index: 49.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7076
    Cell Significance Index: 489.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6316
    Cell Significance Index: 15.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4475
    Cell Significance Index: 12.7700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3688
    Cell Significance Index: 4.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2144
    Cell Significance Index: 13.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1992
    Cell Significance Index: 8.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1676
    Cell Significance Index: 60.1300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1293
    Cell Significance Index: 1.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1080
    Cell Significance Index: 2.5900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0740
    Cell Significance Index: 0.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0518
    Cell Significance Index: 2.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0391
    Cell Significance Index: 1.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0370
    Cell Significance Index: 1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0068
    Cell Significance Index: -3.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0079
    Cell Significance Index: -5.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0101
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0119
    Cell Significance Index: -7.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0199
    Cell Significance Index: -0.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0209
    Cell Significance Index: -3.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0212
    Cell Significance Index: -0.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0233
    Cell Significance Index: -4.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0256
    Cell Significance Index: -5.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0289
    Cell Significance Index: -4.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0322
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0322
    Cell Significance Index: -5.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0402
    Cell Significance Index: -1.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0417
    Cell Significance Index: -4.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0435
    Cell Significance Index: -2.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0452
    Cell Significance Index: -6.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0497
    Cell Significance Index: -6.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0541
    Cell Significance Index: -4.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0544
    Cell Significance Index: -1.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0553
    Cell Significance Index: -5.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0570
    Cell Significance Index: -6.5300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0574
    Cell Significance Index: -0.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0603
    Cell Significance Index: -6.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0666
    Cell Significance Index: -1.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0742
    Cell Significance Index: -2.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0747
    Cell Significance Index: -5.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0770
    Cell Significance Index: -3.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0881
    Cell Significance Index: -1.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0888
    Cell Significance Index: -2.8100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0910
    Cell Significance Index: -1.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0961
    Cell Significance Index: -5.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1030
    Cell Significance Index: -1.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1033
    Cell Significance Index: -1.7700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1050
    Cell Significance Index: -1.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1071
    Cell Significance Index: -4.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1145
    Cell Significance Index: -5.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1225
    Cell Significance Index: -6.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1254
    Cell Significance Index: -2.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1259
    Cell Significance Index: -5.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1355
    Cell Significance Index: -6.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1471
    Cell Significance Index: -5.4000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1522
    Cell Significance Index: -1.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1670
    Cell Significance Index: -3.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1712
    Cell Significance Index: -4.2700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1733
    Cell Significance Index: -1.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1753
    Cell Significance Index: -6.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1790
    Cell Significance Index: -6.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1805
    Cell Significance Index: -3.6000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1832
    Cell Significance Index: -1.5900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1860
    Cell Significance Index: -2.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1900
    Cell Significance Index: -3.7100
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1933
    Cell Significance Index: -2.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2017
    Cell Significance Index: -4.2100
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2052
    Cell Significance Index: -2.1100
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2065
    Cell Significance Index: -2.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2103
    Cell Significance Index: -6.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2108
    Cell Significance Index: -4.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2122
    Cell Significance Index: -6.2500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2157
    Cell Significance Index: -4.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2179
    Cell Significance Index: -5.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2208
    Cell Significance Index: -6.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2229
    Cell Significance Index: -6.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2261
    Cell Significance Index: -3.9100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2330
    Cell Significance Index: -5.8200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2366
    Cell Significance Index: -2.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2375
    Cell Significance Index: -6.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2426
    Cell Significance Index: -6.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2447
    Cell Significance Index: -6.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2478
    Cell Significance Index: -6.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2504
    Cell Significance Index: -6.5900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2544
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit structure:** The GLRA3 gene encodes for a subunit of the glycine receptor, a ligand-gated chloride channel that plays a crucial role in inhibitory neurotransmission. 2. **Expression:** GLRA3 is widely expressed in various cell types, including neurons, glial cells, immune cells, and epithelial cells. 3. **Function:** The GLRA3 subunit is involved in the regulation of membrane potential, excitatory postsynaptic potential, and chloride channel activity. 4. **Signaling pathways:** GLRA3 is part of multiple signaling pathways, including chemical synaptic transmission, chloride channel activity, and neurotransmitter receptor activity. **Pathways and Functions:** 1. **Chemical synaptic transmission:** GLRA3 plays a crucial role in inhibitory neurotransmission, regulating the activity of neurons and modulating synaptic plasticity. 2. **Chloride channel activity:** The GLRA3 subunit is involved in the regulation of chloride channel activity, which is essential for the inhibition of neuronal activity. 3. **Excitatory postsynaptic potential:** GLRA3 modulates the excitatory postsynaptic potential, influencing the strength and duration of synaptic transmission. 4. **Regulation of membrane potential:** The GLRA3 subunit regulates the membrane potential of neurons, influencing their excitability and synaptic plasticity. 5. **Neurotransmitter receptor activity:** GLRA3 is involved in the regulation of neurotransmitter receptor activity, modulating the response to glycine and other neurotransmitters. **Clinical Significance:** 1. **Neurological disorders:** Dysregulation of GLRA3 has been implicated in various neurological disorders, including epilepsy, autism, and schizophrenia. 2. **Epilepsy:** GLRA3 mutations have been associated with epilepsy, highlighting the gene's role in the regulation of neuronal excitability. 3. **Autism:** GLRA3 dysregulation has been linked to autism, suggesting that the gene plays a crucial role in social behavior and communication. 4. **Schizophrenia:** GLRA3 mutations have been associated with schizophrenia, highlighting the gene's role in the regulation of neuronal excitability and synaptic plasticity. 5. **Immune system:** GLRA3 is expressed in immune cells, suggesting that the gene may play a role in immune function and disease. In conclusion, the GLRA3 gene is a crucial component of the glycine receptor complex, playing a pivotal role in neurotransmission and regulation of membrane potential. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the need for further research into the gene's mechanisms and functions.

Genular Protein ID: 9893938

Symbol: GLRA3_HUMAN

Name: Glycine receptor subunit alpha-3

UniProtKB Accession Codes:

O75311 D3DP44 O75816 Q5D0E3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9677400

Title: The human glycine receptor subunit alpha3. GLRA3 gene structure, chromosomal localization, and functional characterization of alternative transcripts.

PubMed ID: 9677400

DOI: 10.1074/jbc.273.31.19708

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26416729

Title: Crystal structure of human glycine receptor-alpha3 bound to antagonist strychnine.

PubMed ID: 26416729

DOI: 10.1038/nature14972

Sequence Information:

  • Length: 464
  • Mass: 53800
  • Checksum: 8E17A30B3C6E648D
  • Sequence:
    • MAHVRHFRTL VSGFYFWEAA LLLSLVATKE TDSARSRSAP MSPSDFLDKL MGRTSGYDAR 
IRPNFKGPPV NVTCNIFINS FGSIAETTMD YRVNIFLRQK WNDPRLAYSE YPDDSLDLDP 
SMLDSIWKPD LFFANEKGAN FHEVTTDNKL LRIFKNGNVL YSIRLTLTLS CPMDLKNFPM 
DVQTCIMQLE SFGYTMNDLI FEWQDEAPVQ VAEGLTLPQF LLKEEKDLRY CTKHYNTGKF 
TCIEVRFHLE RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI TTVLTMTTQS 
SGSRASLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRF RRKRKNKTEA 
FALEKFYRFS DMDDEVRESR FSFTAYGMGP CLQAKDGMTP KGPNHPVQVM PKSPDEMRKV 
FIDRAKKIDT ISRACFPLAF LIFNIFYWVI YKILRHEDIH QQQD

Genular Protein ID: 134454918

Symbol: Q9UPF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UPF3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 9677400

Title: The human glycine receptor subunit alpha3. GLRA3 gene structure, chromosomal localization, and functional characterization of alternative transcripts.

PubMed ID: 9677400

DOI: 10.1074/jbc.273.31.19708

Sequence Information:

  • Length: 219
  • Mass: 25581
  • Checksum: 25DA2F28D80B8EFF
  • Sequence:
    • RFHLERQMGY YLIQMYIPSL LIVILSWVSF WINMDAAPAR VALGITTVLT MTTQSSGSRA 
SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRK NKTEAFALEK 
FYRFSDMDDE VRESRFSFTA YGMGPCLQAK DGMTPKGPNH PVQVMPKSPD EMRKVFIDRA 
KKIDTISRAC FPLAFLIFNI FYWVIYKILR HEDIHQQQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.