Gene H4C14 - ENSG00000270882 | NCBI Gene ID: 8370

Details for: H4C14

Gene ID: 8370

Symbol: H4C14

Ensembl ID: ENSG00000270882

Description: H4 clustered histone 14

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 1.64
Marker Score: 4624
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1173
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 858
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7676
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 799
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5350
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 303
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2789
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 371
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 452
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.51
Marker Score: 607.5
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.47
Marker Score: 137
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.45
Marker Score: 142
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 247
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.43
Marker Score: 346
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.4
Marker Score: 758
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.39
Marker Score: 1073
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.39
Marker Score: 470
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.38
Marker Score: 464
Cell Name: mast cell (CL0000097)
Fold Change: 0.35
Marker Score: 205
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.35
Marker Score: 11982
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.27
Marker Score: 667
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.26
Marker Score: 262
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.24
Marker Score: 469.5
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.22
Marker Score: 136
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.22
Marker Score: 92
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.22
Marker Score: 55
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 72
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.21
Marker Score: 87
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2
Marker Score: 2239
Cell Name: malignant cell (CL0001064)
Fold Change: 0.2
Marker Score: 2640
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.19
Marker Score: 273.5
Cell Name: platelet (CL0000233)
Fold Change: 0.19
Marker Score: 84
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.18
Marker Score: 95
Cell Name: osteoblast (CL0000062)
Fold Change: 0.18
Marker Score: 98
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.18
Marker Score: 179
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.18
Marker Score: 98
Cell Name: mature B cell (CL0000785)
Fold Change: 0.18
Marker Score: 129
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.17
Marker Score: 353
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.16
Marker Score: 77
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.16
Marker Score: 86
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.15
Marker Score: 102
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.15
Marker Score: 1140
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.15
Marker Score: 39
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.14
Marker Score: 80
Cell Name: B cell (CL0000236)
Fold Change: 0.14
Marker Score: 136
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.14
Marker Score: 93
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.13
Marker Score: 61
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.13
Marker Score: 82
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.13
Marker Score: 32
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.12
Marker Score: 60
Cell Name: supporting cell (CL0000630)
Fold Change: 0.12
Marker Score: 225
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.12
Marker Score: 27
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.11
Marker Score: 56
Cell Name: T cell (CL0000084)
Fold Change: 0.11
Marker Score: 192
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.11
Marker Score: 219
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.11
Marker Score: 190
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.11
Marker Score: 45
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.1
Marker Score: 24
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1
Marker Score: 44
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.09
Marker Score: 90
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.09
Marker Score: 33
Cell Name: granulocyte (CL0000094)
Fold Change: 0.09
Marker Score: 41
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.09
Marker Score: 26
Cell Name: plasma cell (CL0000786)
Fold Change: 0.09
Marker Score: 97
Cell Name: melanocyte (CL0000148)
Fold Change: 0.09
Marker Score: 35
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.08
Marker Score: 220
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.08
Marker Score: 46
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.08
Marker Score: 64
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.07
Marker Score: 34
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.07
Marker Score: 636
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.07
Marker Score: 111
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.07
Marker Score: 49
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.07
Marker Score: 71
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.07
Marker Score: 16
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.07
Marker Score: 63
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.07
Marker Score: 17
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.07
Marker Score: 359
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.07
Marker Score: 24
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.07
Marker Score: 46
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.07
Marker Score: 24
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.07
Marker Score: 93
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.06
Marker Score: 25
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.06
Marker Score: 17
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.06
Marker Score: 52
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.06
Marker Score: 17
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.06
Marker Score: 104
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 14
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.06
Marker Score: 80

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Other Information

Description

**Key Characteristics** H4C14 is a histone gene that codes for a histone protein with a distinct C-terminal tail. This protein is involved in chromatin assembly and disassembly, and its modifications play a crucial role in regulating gene expression and cellular processes. H4C14 is part of the H4 family of histones, which are essential for DNA packaging and chromatin organization. The gene is highly conserved across species, suggesting its critical role in evolution. **Pathways and Functions** H4C14 is involved in various cellular processes, including: 1. **DNA Replication and Repair**: H4C14 is required for the assembly of the pre-replicative complex and the replication of DNA. It also plays a role in the repair of DNA damage, including base excision repair and homology-directed repair. 2. **Chromatin Modifications**: H4C14 is modified by various enzymes, including histone acetyltransferases (Hats) and histone deacetylases (Hdacs), which regulate chromatin structure and gene expression. 3. **Transcription and Gene Expression**: H4C14 is involved in the regulation of gene expression, including the assembly of the pre-initiation complex and the recruitment of RNA polymerase II. 4. **Development and Cell Cycle Regulation**: H4C14 is required for the development of various tissues, including the hindbrain and intestinal epithelium. It also plays a role in regulating the cell cycle, including the G2/M checkpoint and DNA damage response. 5. **Programmed Cell Death**: H4C14 is involved in the regulation of programmed cell death, including pyroptosis and senescence-associated secretory phenotype (SASP). **Clinical Significance** Dysregulation of H4C14 has been implicated in various diseases, including cancer, neurological disorders, and autoimmune diseases. For example: 1. **Cancer**: Alterations in H4C14 expression and function have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders**: H4C14 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Autoimmune Diseases**: H4C14 has been linked to autoimmune diseases, including rheumatoid arthritis and lupus. In conclusion, H4C14 is a critical gene involved in various cellular processes, including DNA replication, repair, and transcription, as well as development, cell cycle regulation, and programmed cell death. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.