H4C14 | ENSG00000270882 | NCBI 8370

Details for: H4C14

Gene ID: 8370

Symbol: H4C14

Ensembl ID: ENSG00000270882

Description: H4 clustered histone 14

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9285
Cell Significance Index: 176.6900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7334
Cell Significance Index: 72.5500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5773
Cell Significance Index: 521.2200
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.3765
Cell Significance Index: 9.3900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3711
Cell Significance Index: 60.3600
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.3443
Cell Significance Index: 2.1300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3350
Cell Significance Index: 36.4400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2022
Cell Significance Index: 110.4200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1823
Cell Significance Index: 12.6100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1643
Cell Significance Index: 9.8700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1104
Cell Significance Index: 3.1800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0942
Cell Significance Index: 4.2700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0665
Cell Significance Index: 1.4400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0427
Cell Significance Index: 0.6400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0413
Cell Significance Index: 1.4500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0410
Cell Significance Index: 2.1300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0394
Cell Significance Index: 0.8400
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.0184
Cell Significance Index: 0.1900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0184
Cell Significance Index: 2.1100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0083
Cell Significance Index: 0.5100
Cell Name: helper T cell (CL0000912)
Fold Change: 0.0063
Cell Significance Index: 0.0900
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0031
Cell Significance Index: 0.3200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0016
Cell Significance Index: 0.0400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0014
Cell Significance Index: 0.2400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0010
Cell Significance Index: -0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0015
Cell Significance Index: -2.7400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0019
Cell Significance Index: -0.0900
Cell Name: keratocyte (CL0002363)
Fold Change: -0.0019
Cell Significance Index: -0.0300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0020
Cell Significance Index: -3.7300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0024
Cell Significance Index: -3.7300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0026
Cell Significance Index: -1.9600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0027
Cell Significance Index: -3.7300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0029
Cell Significance Index: -2.2300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0031
Cell Significance Index: -1.3500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0032
Cell Significance Index: -0.4400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0034
Cell Significance Index: -2.4800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0034
Cell Significance Index: -1.9200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0038
Cell Significance Index: -2.4100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0052
Cell Significance Index: -1.8800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0054
Cell Significance Index: -0.9700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0077
Cell Significance Index: -3.5200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0087
Cell Significance Index: -0.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0092
Cell Significance Index: -1.8500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0099
Cell Significance Index: -0.1700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0105
Cell Significance Index: -0.6800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0125
Cell Significance Index: -2.4800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0146
Cell Significance Index: -0.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0159
Cell Significance Index: -1.9500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0163
Cell Significance Index: -2.3700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0195
Cell Significance Index: -0.5300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0221
Cell Significance Index: -0.5900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0233
Cell Significance Index: -1.6500
Cell Name: decidual cell (CL2000002)
Fold Change: -0.0237
Cell Significance Index: -0.3800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0270
Cell Significance Index: -2.8100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0274
Cell Significance Index: -1.4400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0276
Cell Significance Index: -3.2500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0276
Cell Significance Index: -3.5700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0284
Cell Significance Index: -1.7900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0312
Cell Significance Index: -1.4700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0313
Cell Significance Index: -2.4800
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0350
Cell Significance Index: -1.5200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0358
Cell Significance Index: -2.7500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0373
Cell Significance Index: -1.1000
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: -0.0431
Cell Significance Index: -0.3100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0440
Cell Significance Index: -0.6000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0451
Cell Significance Index: -1.5800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0476
Cell Significance Index: -3.5500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0501
Cell Significance Index: -2.8100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0520
Cell Significance Index: -1.4500
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0540
Cell Significance Index: -0.7200
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.0545
Cell Significance Index: -0.6900
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.0563
Cell Significance Index: -0.6100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0600
Cell Significance Index: -0.7600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0637
Cell Significance Index: -1.6400
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0639
Cell Significance Index: -0.7000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0648
Cell Significance Index: -0.9100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0659
Cell Significance Index: -2.9200
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0663
Cell Significance Index: -0.4400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0672
Cell Significance Index: -2.2000
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0673
Cell Significance Index: -0.8800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0711
Cell Significance Index: -2.4700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0713
Cell Significance Index: -2.2700
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0737
Cell Significance Index: -1.8400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0753
Cell Significance Index: -2.7700
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.0771
Cell Significance Index: -0.7800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0772
Cell Significance Index: -2.9300
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0796
Cell Significance Index: -1.6200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0809
Cell Significance Index: -2.1600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0860
Cell Significance Index: -2.1900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0878
Cell Significance Index: -2.3100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0907
Cell Significance Index: -1.9600
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0932
Cell Significance Index: -2.3300
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0966
Cell Significance Index: -1.3400
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0980
Cell Significance Index: -1.0500
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1016
Cell Significance Index: -2.1200
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1035
Cell Significance Index: -1.7900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1037
Cell Significance Index: -2.2000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1051
Cell Significance Index: -2.2000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1076
Cell Significance Index: -2.7500
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.1108
Cell Significance Index: -1.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H4C14 is a histone gene that codes for a histone protein with a distinct C-terminal tail. This protein is involved in chromatin assembly and disassembly, and its modifications play a crucial role in regulating gene expression and cellular processes. H4C14 is part of the H4 family of histones, which are essential for DNA packaging and chromatin organization. The gene is highly conserved across species, suggesting its critical role in evolution. **Pathways and Functions** H4C14 is involved in various cellular processes, including: 1. **DNA Replication and Repair**: H4C14 is required for the assembly of the pre-replicative complex and the replication of DNA. It also plays a role in the repair of DNA damage, including base excision repair and homology-directed repair. 2. **Chromatin Modifications**: H4C14 is modified by various enzymes, including histone acetyltransferases (Hats) and histone deacetylases (Hdacs), which regulate chromatin structure and gene expression. 3. **Transcription and Gene Expression**: H4C14 is involved in the regulation of gene expression, including the assembly of the pre-initiation complex and the recruitment of RNA polymerase II. 4. **Development and Cell Cycle Regulation**: H4C14 is required for the development of various tissues, including the hindbrain and intestinal epithelium. It also plays a role in regulating the cell cycle, including the G2/M checkpoint and DNA damage response. 5. **Programmed Cell Death**: H4C14 is involved in the regulation of programmed cell death, including pyroptosis and senescence-associated secretory phenotype (SASP). **Clinical Significance** Dysregulation of H4C14 has been implicated in various diseases, including cancer, neurological disorders, and autoimmune diseases. For example: 1. **Cancer**: Alterations in H4C14 expression and function have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders**: H4C14 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Autoimmune Diseases**: H4C14 has been linked to autoimmune diseases, including rheumatoid arthritis and lupus. In conclusion, H4C14 is a critical gene involved in various cellular processes, including DNA replication, repair, and transcription, as well as development, cell cycle regulation, and programmed cell death. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.