Details for: PIP4K2B

Gene ID: 8396

Symbol: PIP4K2B

Ensembl ID: ENSG00000276293

Description: phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.24
    Marker Score: 4634
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.56
    Marker Score: 95955
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.53
    Marker Score: 14495
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.52
    Marker Score: 13069
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.48
    Marker Score: 13919
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.33
    Marker Score: 50381
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2042
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.32
    Marker Score: 5112
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.32
    Marker Score: 3729
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.3
    Marker Score: 19418
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.29
    Marker Score: 25608
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.28
    Marker Score: 5933
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.25
    Marker Score: 46272
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.22
    Marker Score: 9341
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.16
    Marker Score: 925
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.12
    Marker Score: 9816
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.08
    Marker Score: 4495
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.05
    Marker Score: 13952
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.96
    Marker Score: 6407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.91
    Marker Score: 978
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.89
    Marker Score: 18958
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4986
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.87
    Marker Score: 942
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.86
    Marker Score: 914
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.84
    Marker Score: 972
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.83
    Marker Score: 1599
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.79
    Marker Score: 1866
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.75
    Marker Score: 1889
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.74
    Marker Score: 417
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.74
    Marker Score: 1048
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.73
    Marker Score: 1478
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.72
    Marker Score: 1191
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2981
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 340
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7
    Marker Score: 269
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.66
    Marker Score: 624
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.65
    Marker Score: 599
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.64
    Marker Score: 341
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 421.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.62
    Marker Score: 373
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.62
    Marker Score: 260
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.61
    Marker Score: 206
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 191
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.61
    Marker Score: 6098.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.6
    Marker Score: 3575
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.6
    Marker Score: 242
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 190
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.59
    Marker Score: 610
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.58
    Marker Score: 549
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.57
    Marker Score: 200
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.57
    Marker Score: 333
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.56
    Marker Score: 2057
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.56
    Marker Score: 160
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.55
    Marker Score: 641.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.54
    Marker Score: 575
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.53
    Marker Score: 3468
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.53
    Marker Score: 293
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.53
    Marker Score: 1414
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.52
    Marker Score: 148
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.52
    Marker Score: 180
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.51
    Marker Score: 2094
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.51
    Marker Score: 5765
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5
    Marker Score: 2076
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5
    Marker Score: 114
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.49
    Marker Score: 181
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.49
    Marker Score: 334
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.49
    Marker Score: 1065
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.47
    Marker Score: 268
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.47
    Marker Score: 226
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.47
    Marker Score: 231.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.46
    Marker Score: 1057
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.46
    Marker Score: 229
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.46
    Marker Score: 6216
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.46
    Marker Score: 309
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.46
    Marker Score: 464
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.46
    Marker Score: 518
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.45
    Marker Score: 906
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.45
    Marker Score: 131
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.45
    Marker Score: 602
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.45
    Marker Score: 478
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.45
    Marker Score: 168
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.44
    Marker Score: 256
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.44
    Marker Score: 546
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.44
    Marker Score: 549.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.43
    Marker Score: 472

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Other Information

**Key Characteristics:** PIP4K2B is a type II phosphatidylinositol 4-kinase enzyme that exhibits substrate specificity for PIP2. The enzyme is highly specific, with a low Km value, indicating a strong affinity for its substrate. PIP4K2B is also highly regulated, with negative regulation of the PI3K/AKT network and insulin receptor signaling pathway, suggesting a role in modulating cellular metabolism. The enzyme is also involved in the regulation of autophagy, with positive regulation of autophagosome assembly and negative regulation of autophagosome-lysosome fusion. **Pathways and Functions:** PIP4K2B is involved in various cellular pathways, including: 1. **Autophagy**: PIP4K2B regulates autophagy by modulating the activity of key autophagy-related proteins, such as PI3K/AKT and TP53. 2. **Lipid Metabolism**: PIP4K2B is involved in the synthesis of PIP5, a key phospholipid involved in lipid metabolism. 3. **Cell Signaling**: PIP4K2B regulates cell signaling by modulating the activity of key signaling molecules, such as PI3K/AKT and TP53. 4. **Transcriptional Regulation**: PIP4K2B regulates transcriptional activity by modulating the activity of key transcription factors, such as TP53. **Clinical Significance:** Dysregulation of PIP4K2B has been implicated in various diseases, including: 1. **Autophagy Disorders**: Mutations in PIP4K2B have been associated with autophagy disorders, such as Ataxia with Oculomotor-Related Neurodegeneration (AORN). 2. **Cancer**: PIP4K2B has been shown to regulate TP53 activity, suggesting a role in cancer development and progression. 3. **Neurological Disorders**: PIP4K2B has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, PIP4K2B is a critical enzyme involved in the regulation of autophagy and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis. Further research is needed to fully understand the role of PIP4K2B in human disease and to develop therapeutic strategies for the treatment of PIP4K2B-related disorders.

Genular Protein ID: 796186840

Symbol: PI42B_HUMAN

Name: 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta

UniProtKB Accession Codes:

P78356 Q5U0E8 Q8TBP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 43 PDBsum 26 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9038203

Title: A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.

PubMed ID: 9038203

DOI: 10.1074/jbc.272.9.5861

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20583997

Title: PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.

PubMed ID: 20583997

DOI: 10.1042/bj20100341

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 31091439

Title: PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

PubMed ID: 31091439

DOI: 10.1016/j.celrep.2019.04.070

PubMed ID: 9753329

Title: Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.

PubMed ID: 9753329

DOI: 10.1016/s0092-8674(00)81741-9

PubMed ID: 26774281

Title: The Lipid Kinase PI5P4Kbeta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

PubMed ID: 26774281

DOI: 10.1016/j.molcel.2015.12.011

Sequence Information:

  • Length: 416
  • Mass: 47378
  • Checksum: 2288CD2883EACEBE
  • Sequence:
    • MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV NHTINELSNV 
PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP MVFRNLRERF GIDDQDYQNS 
VTRSAPINSD SQGRCGTRFL TTYDRRFVIK TVSSEDVAEM HNILKKYHQF IVECHGNTLL 
PQFLGMYRLT VDGVETYMVV TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD 
NDFLNEGQKL HVGEESKKNF LEKLKRDVEF LAQLKIMDYS LLVGIHDVDR AEQEEMEVEE 
RAEDEECEND GVGGNLLCSY GTPPDSPGNL LSFPRFFGPG EFDPSVDVYA MKSHESSPKK 
EVYFMAIIDI LTPYDTKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFNEF MSNILT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.