Details for: PIP4K2B

Gene ID: 8396

Symbol: PIP4K2B

Ensembl ID: ENSG00000276293

Description: phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.5898
    Cell Significance Index: -22.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.1950
    Cell Significance Index: -23.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2664
    Cell Significance Index: -25.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9849
    Cell Significance Index: -10.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5126
    Cell Significance Index: 303.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1515
    Cell Significance Index: 59.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0374
    Cell Significance Index: 102.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8187
    Cell Significance Index: 95.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7518
    Cell Significance Index: 149.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7151
    Cell Significance Index: 256.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5511
    Cell Significance Index: 89.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5225
    Cell Significance Index: 56.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4778
    Cell Significance Index: 13.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4557
    Cell Significance Index: 315.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3453
    Cell Significance Index: 9.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3129
    Cell Significance Index: 13.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2748
    Cell Significance Index: 37.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2460
    Cell Significance Index: 5.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2415
    Cell Significance Index: 9.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2386
    Cell Significance Index: 13.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2062
    Cell Significance Index: 14.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2046
    Cell Significance Index: 36.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1825
    Cell Significance Index: 2.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1744
    Cell Significance Index: 10.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1723
    Cell Significance Index: 7.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1633
    Cell Significance Index: 2.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1476
    Cell Significance Index: 80.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1383
    Cell Significance Index: 61.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1215
    Cell Significance Index: 6.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1100
    Cell Significance Index: 8.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1078
    Cell Significance Index: 13.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0723
    Cell Significance Index: 2.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0652
    Cell Significance Index: 3.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0514
    Cell Significance Index: 0.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0439
    Cell Significance Index: 5.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0406
    Cell Significance Index: 7.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0391
    Cell Significance Index: 35.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0227
    Cell Significance Index: 3.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0226
    Cell Significance Index: 42.4600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0211
    Cell Significance Index: 0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0096
    Cell Significance Index: 17.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 1.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0019
    Cell Significance Index: -1.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0055
    Cell Significance Index: -0.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0067
    Cell Significance Index: -0.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0225
    Cell Significance Index: -10.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0246
    Cell Significance Index: -18.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0262
    Cell Significance Index: -14.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0270
    Cell Significance Index: -2.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0459
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0475
    Cell Significance Index: -10.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0480
    Cell Significance Index: -1.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0594
    Cell Significance Index: -8.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0731
    Cell Significance Index: -3.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0744
    Cell Significance Index: -1.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0903
    Cell Significance Index: -25.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0920
    Cell Significance Index: -5.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1137
    Cell Significance Index: -12.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1311
    Cell Significance Index: -9.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1372
    Cell Significance Index: -16.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1728
    Cell Significance Index: -3.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1837
    Cell Significance Index: -23.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2186
    Cell Significance Index: -22.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2597
    Cell Significance Index: -6.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2660
    Cell Significance Index: -12.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2781
    Cell Significance Index: -5.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2844
    Cell Significance Index: -9.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2893
    Cell Significance Index: -22.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3040
    Cell Significance Index: -22.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3174
    Cell Significance Index: -10.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3272
    Cell Significance Index: -8.9100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3280
    Cell Significance Index: -4.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3296
    Cell Significance Index: -20.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3297
    Cell Significance Index: -6.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3496
    Cell Significance Index: -7.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3506
    Cell Significance Index: -11.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3555
    Cell Significance Index: -7.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4011
    Cell Significance Index: -10.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4167
    Cell Significance Index: -4.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4392
    Cell Significance Index: -7.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4521
    Cell Significance Index: -4.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4678
    Cell Significance Index: -16.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4818
    Cell Significance Index: -16.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4886
    Cell Significance Index: -9.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5008
    Cell Significance Index: -10.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5087
    Cell Significance Index: -12.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5836
    Cell Significance Index: -12.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6333
    Cell Significance Index: -10.9500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6338
    Cell Significance Index: -8.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6390
    Cell Significance Index: -16.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6393
    Cell Significance Index: -23.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6401
    Cell Significance Index: -9.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6481
    Cell Significance Index: -12.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6621
    Cell Significance Index: -17.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6630
    Cell Significance Index: -9.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6670
    Cell Significance Index: -15.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PIP4K2B is a type II phosphatidylinositol 4-kinase enzyme that exhibits substrate specificity for PIP2. The enzyme is highly specific, with a low Km value, indicating a strong affinity for its substrate. PIP4K2B is also highly regulated, with negative regulation of the PI3K/AKT network and insulin receptor signaling pathway, suggesting a role in modulating cellular metabolism. The enzyme is also involved in the regulation of autophagy, with positive regulation of autophagosome assembly and negative regulation of autophagosome-lysosome fusion. **Pathways and Functions:** PIP4K2B is involved in various cellular pathways, including: 1. **Autophagy**: PIP4K2B regulates autophagy by modulating the activity of key autophagy-related proteins, such as PI3K/AKT and TP53. 2. **Lipid Metabolism**: PIP4K2B is involved in the synthesis of PIP5, a key phospholipid involved in lipid metabolism. 3. **Cell Signaling**: PIP4K2B regulates cell signaling by modulating the activity of key signaling molecules, such as PI3K/AKT and TP53. 4. **Transcriptional Regulation**: PIP4K2B regulates transcriptional activity by modulating the activity of key transcription factors, such as TP53. **Clinical Significance:** Dysregulation of PIP4K2B has been implicated in various diseases, including: 1. **Autophagy Disorders**: Mutations in PIP4K2B have been associated with autophagy disorders, such as Ataxia with Oculomotor-Related Neurodegeneration (AORN). 2. **Cancer**: PIP4K2B has been shown to regulate TP53 activity, suggesting a role in cancer development and progression. 3. **Neurological Disorders**: PIP4K2B has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, PIP4K2B is a critical enzyme involved in the regulation of autophagy and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis. Further research is needed to fully understand the role of PIP4K2B in human disease and to develop therapeutic strategies for the treatment of PIP4K2B-related disorders.

Genular Protein ID: 796186840

Symbol: PI42B_HUMAN

Name: 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta

UniProtKB Accession Codes:

P78356 Q5U0E8 Q8TBP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9038203

Title: A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.

PubMed ID: 9038203

DOI: 10.1074/jbc.272.9.5861

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20583997

Title: PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.

PubMed ID: 20583997

DOI: 10.1042/bj20100341

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 31091439

Title: PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

PubMed ID: 31091439

DOI: 10.1016/j.celrep.2019.04.070

PubMed ID: 9753329

Title: Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.

PubMed ID: 9753329

DOI: 10.1016/s0092-8674(00)81741-9

PubMed ID: 26774281

Title: The Lipid Kinase PI5P4Kbeta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

PubMed ID: 26774281

DOI: 10.1016/j.molcel.2015.12.011

Sequence Information:

  • Length: 416
  • Mass: 47378
  • Checksum: 2288CD2883EACEBE
  • Sequence:
    • MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV NHTINELSNV 
PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP MVFRNLRERF GIDDQDYQNS 
VTRSAPINSD SQGRCGTRFL TTYDRRFVIK TVSSEDVAEM HNILKKYHQF IVECHGNTLL 
PQFLGMYRLT VDGVETYMVV TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD 
NDFLNEGQKL HVGEESKKNF LEKLKRDVEF LAQLKIMDYS LLVGIHDVDR AEQEEMEVEE 
RAEDEECEND GVGGNLLCSY GTPPDSPGNL LSFPRFFGPG EFDPSVDVYA MKSHESSPKK 
EVYFMAIIDI LTPYDTKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFNEF MSNILT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.