Details for: ADAM7

Gene ID: 8756

Symbol: ADAM7

Ensembl ID: ENSG00000069206

Description: ADAM metallopeptidase domain 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53065
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3179
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.14
    Marker Score: 4433
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10808
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7501
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3639
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32725
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1586
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 736
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1239
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.71
    Marker Score: 2266
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.69
    Marker Score: 1058
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.68
    Marker Score: 396
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1351
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 8038
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 308
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.46
    Marker Score: 125
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.32
    Marker Score: 3255
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.31
    Marker Score: 729
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 309
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.25
    Marker Score: 91
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.22
    Marker Score: 904
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 66
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2
    Marker Score: 12119
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.17
    Marker Score: 1662
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.17
    Marker Score: 1420
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.13
    Marker Score: 141
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.11
    Marker Score: 990
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.1
    Marker Score: 3634
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.06
    Marker Score: 19.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.05
    Marker Score: 650.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.05
    Marker Score: 197
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 56
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.04
    Marker Score: 166
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 17.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 19.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.03
    Marker Score: 57
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.03
    Marker Score: 81
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 87
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 51
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.03
    Marker Score: 59
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.03
    Marker Score: 36

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Other Information

**Key characteristics:** * ADAM7 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a secreted protein that is found in both spermatozoa and somatic cells. * ADAM7 is a key regulator of sperm motility, capacitation, and fertilization. **Pathways and functions:** * ADAM7 is involved in the regulation of epididymis development and function. * It is essential for the maturation of sperm and the maintenance of male fertility. * ADAM7 is also involved in the regulation of epithelial cell morphogenesis and the development of the male reproductive tract. * It is a key regulator of flagellated sperm motility, promoting their migration and penetration into the egg. * ADAM7 also plays a role in positive regulation of sperm capacitation, ensuring that sperm are properly activated for fertilization. * It is involved in the proteolytic regulation of plasma membrane components and cellular signaling pathways. **Clinical significance:** * Mutations in the ADAM7 gene have been linked to male infertility and sterility in humans. * Targeting ADAM7 has been explored as a therapeutic strategy for male infertility. * In animal models, inhibition of ADAM7 has been shown to improve fertility and prevent infertility. **Additional information:** * ADAM7 is a member of the ADAM (a disintegrin and metallopeptidase) family of metallopeptidases. * It is expressed in high levels in germ cells and continues to be expressed in differentiated sperm and seminal vesicles. * ADAM7 is a highly conserved protein with homologs in other species.

Genular Protein ID: 4206502130

Symbol: ADAM7_HUMAN

Name: Sperm maturation-related glycoprotein GP-83

UniProtKB Accession Codes:

Q9H2U9 A8K8X7 O75959 Q6PEJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21618342

Title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

PubMed ID: 21618342

DOI: 10.1002/humu.21477

Sequence Information:

  • Length: 754
  • Mass: 85669
  • Checksum: D9E9DF9B5812B0A7
  • Sequence:
    • MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD ILKTYEEELL 
YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH PQIMDHCFYQ GSIVHEYDSA 
ASISTCNGLR GFFRINDQRY LIEPVKYSDE GEHLVFKYNL RVPYGANYSC TELNFTRKTV 
PGDNESEEDS KIKGIHDEKY VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL 
NIHVTLVGIE IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV 
QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC TCPSGKCVMD 
SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH DFQFCGNKKL DEGEECDCGP 
AQECTNPCCD AHTCVLKPGF TCAEGECCES CQIKKAGSIC RPAKDECDFP EMCTGHSPAC 
PKDQFRVNGF PCKNSEGYCF MGKCPTREDQ CSELFDDEAI ESHDICYKMN TKGNKFGYCK 
NKENRFLPCE EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD 
IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH CEEGQAPVAC 
EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ VQSPPTETLG VENKGYFGDE 
QQIRTEPILP EIHFLNKPAS KDSRGIADPN QSAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.