Details for: ADAM7

Gene ID: 8756

Symbol: ADAM7

Ensembl ID: ENSG00000069206

Description: ADAM metallopeptidase domain 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.3769
    Cell Significance Index: 70.0100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5996
    Cell Significance Index: 8.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2273
    Cell Significance Index: 65.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1092
    Cell Significance Index: 2.3900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1059
    Cell Significance Index: 1.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0974
    Cell Significance Index: 3.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0973
    Cell Significance Index: 19.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0911
    Cell Significance Index: 2.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0789
    Cell Significance Index: 3.4900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0722
    Cell Significance Index: 0.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0543
    Cell Significance Index: 0.9300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0362
    Cell Significance Index: 0.4100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0349
    Cell Significance Index: 0.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0156
    Cell Significance Index: 10.8100
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0095
    Cell Significance Index: 0.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0015
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0011
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0036
    Cell Significance Index: -2.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0044
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0048
    Cell Significance Index: -0.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0080
    Cell Significance Index: -1.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0084
    Cell Significance Index: -0.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0097
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0102
    Cell Significance Index: -2.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0107
    Cell Significance Index: -1.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0116
    Cell Significance Index: -0.3700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0120
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0155
    Cell Significance Index: -1.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0160
    Cell Significance Index: -1.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0161
    Cell Significance Index: -1.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0168
    Cell Significance Index: -1.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0179
    Cell Significance Index: -1.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0180
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0190
    Cell Significance Index: -1.2800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0194
    Cell Significance Index: -0.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0227
    Cell Significance Index: -1.7400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0240
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0254
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0259
    Cell Significance Index: -0.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0260
    Cell Significance Index: -0.6300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0281
    Cell Significance Index: -0.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0297
    Cell Significance Index: -0.7400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0305
    Cell Significance Index: -0.4000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0329
    Cell Significance Index: -0.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0338
    Cell Significance Index: -1.5300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0360
    Cell Significance Index: -0.4800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0363
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0381
    Cell Significance Index: -1.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0417
    Cell Significance Index: -1.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0430
    Cell Significance Index: -1.3600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0447
    Cell Significance Index: -0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0475
    Cell Significance Index: -1.6700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0490
    Cell Significance Index: -0.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0503
    Cell Significance Index: -1.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0505
    Cell Significance Index: -0.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0555
    Cell Significance Index: -1.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0587
    Cell Significance Index: -1.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0588
    Cell Significance Index: -1.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0617
    Cell Significance Index: -1.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0621
    Cell Significance Index: -1.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0644
    Cell Significance Index: -1.6400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0653
    Cell Significance Index: -0.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0676
    Cell Significance Index: -1.8100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0683
    Cell Significance Index: -0.8800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0685
    Cell Significance Index: -1.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0697
    Cell Significance Index: -1.3600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0726
    Cell Significance Index: -0.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0727
    Cell Significance Index: -1.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0728
    Cell Significance Index: -1.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0758
    Cell Significance Index: -3.1100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0773
    Cell Significance Index: -1.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0779
    Cell Significance Index: -1.3100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0788
    Cell Significance Index: -1.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0796
    Cell Significance Index: -1.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0806
    Cell Significance Index: -4.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0832
    Cell Significance Index: -1.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0843
    Cell Significance Index: -1.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0848
    Cell Significance Index: -1.6700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0850
    Cell Significance Index: -1.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0856
    Cell Significance Index: -1.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0862
    Cell Significance Index: -1.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0883
    Cell Significance Index: -1.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0900
    Cell Significance Index: -1.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.0919
    Cell Significance Index: -0.9600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0921
    Cell Significance Index: -1.3200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0936
    Cell Significance Index: -1.4000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0949
    Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAM7 is a large transmembrane glycoprotein, consisting of a disintegrin domain, a metalloprotease domain, and a cytoplasmic tail. The disintegrin domain is responsible for cell-cell adhesion, while the metalloprotease domain is involved in the cleavage of various substrates, including growth factors and adhesion molecules. ADAM7 is expressed in a wide range of tissues, including epithelial cells, blood vessels, and the epididymis, suggesting its involvement in multiple biological processes. **Pathways and Functions:** ADAM7 is implicated in several key pathways, including: 1. **Epididymis development**: ADAM7 is expressed in the epididymis and plays a crucial role in the development and maturation of spermatozoa. 2. **Epithelial cell morphogenesis**: ADAM7 is involved in the regulation of epithelial cell morphology and movement, which is essential for various physiological processes, such as wound healing and tissue repair. 3. **Metalloendopeptidase activity**: ADAM7's metalloprotease domain is responsible for the cleavage of various substrates, including growth factors and adhesion molecules, which regulates cellular signaling and adhesion. 4. **Plasma membrane**: ADAM7 is a transmembrane glycoprotein, and its disintegrin domain is involved in cell-cell adhesion at the plasma membrane. 5. **Positive regulation of flagellated sperm motility**: ADAM7 is expressed in the epididymis and plays a crucial role in the regulation of sperm motility, which is essential for fertilization. **Clinical Significance:** ADAM7 has been implicated in various diseases and disorders, including: 1. **Epididymal dysgenesis**: ADAM7 mutations have been linked to epididymal dysgenesis, a condition characterized by impaired sperm development and fertility. 2. **Cancer**: ADAM7 is overexpressed in various types of cancer, including colon, breast, and lung cancer, suggesting its potential role as a tumor suppressor. 3. **Neurological disorders**: ADAM7 is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, such as autism and schizophrenia. In conclusion, ADAM7 is a multifaceted gene that plays a crucial role in various biological processes, including cell morphogenesis, motility, and development. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the mechanisms by which ADAM7 regulates cellular functions.

Genular Protein ID: 4206502130

Symbol: ADAM7_HUMAN

Name: Sperm maturation-related glycoprotein GP-83

UniProtKB Accession Codes:

Q9H2U9 A8K8X7 O75959 Q6PEJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21618342

Title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

PubMed ID: 21618342

DOI: 10.1002/humu.21477

Sequence Information:

  • Length: 754
  • Mass: 85669
  • Checksum: D9E9DF9B5812B0A7
  • Sequence:
    • MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD ILKTYEEELL 
YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH PQIMDHCFYQ GSIVHEYDSA 
ASISTCNGLR GFFRINDQRY LIEPVKYSDE GEHLVFKYNL RVPYGANYSC TELNFTRKTV 
PGDNESEEDS KIKGIHDEKY VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL 
NIHVTLVGIE IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV 
QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC TCPSGKCVMD 
SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH DFQFCGNKKL DEGEECDCGP 
AQECTNPCCD AHTCVLKPGF TCAEGECCES CQIKKAGSIC RPAKDECDFP EMCTGHSPAC 
PKDQFRVNGF PCKNSEGYCF MGKCPTREDQ CSELFDDEAI ESHDICYKMN TKGNKFGYCK 
NKENRFLPCE EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD 
IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH CEEGQAPVAC 
EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ VQSPPTETLG VENKGYFGDE 
QQIRTEPILP EIHFLNKPAS KDSRGIADPN QSAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.