Details for: HPYR1

Gene ID: 93668

Symbol: HPYR1

Ensembl ID: ENSG00000253521

Description: Helicobacter pylori responsive 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7905
    Cell Significance Index: 43.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9100
    Cell Significance Index: 40.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8086
    Cell Significance Index: 30.6200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4319
    Cell Significance Index: 6.3000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2938
    Cell Significance Index: 3.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2841
    Cell Significance Index: 19.1100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2536
    Cell Significance Index: 3.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2411
    Cell Significance Index: 6.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2322
    Cell Significance Index: 83.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1054
    Cell Significance Index: 1.5100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0870
    Cell Significance Index: 1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0009
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0017
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0076
    Cell Significance Index: -4.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0101
    Cell Significance Index: -2.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0108
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0127
    Cell Significance Index: -0.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0141
    Cell Significance Index: -2.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0142
    Cell Significance Index: -1.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0161
    Cell Significance Index: -0.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0190
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0233
    Cell Significance Index: -2.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0301
    Cell Significance Index: -1.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0302
    Cell Significance Index: -3.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0304
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0345
    Cell Significance Index: -3.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0384
    Cell Significance Index: -1.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0416
    Cell Significance Index: -1.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0429
    Cell Significance Index: -1.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0559
    Cell Significance Index: -1.9600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0583
    Cell Significance Index: -0.6800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0611
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0617
    Cell Significance Index: -2.0200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0654
    Cell Significance Index: -0.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0664
    Cell Significance Index: -1.4100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0676
    Cell Significance Index: -1.4100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0748
    Cell Significance Index: -0.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0768
    Cell Significance Index: -1.6600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0798
    Cell Significance Index: -1.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0804
    Cell Significance Index: -3.7800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0815
    Cell Significance Index: -1.1000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0872
    Cell Significance Index: -0.8300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0949
    Cell Significance Index: -3.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0976
    Cell Significance Index: -1.9600
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1012
    Cell Significance Index: -1.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1042
    Cell Significance Index: -2.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1046
    Cell Significance Index: -1.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1057
    Cell Significance Index: -1.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1113
    Cell Significance Index: -2.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1161
    Cell Significance Index: -2.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1163
    Cell Significance Index: -3.3500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1172
    Cell Significance Index: -1.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1208
    Cell Significance Index: -2.7900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1348
    Cell Significance Index: -2.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1352
    Cell Significance Index: -3.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1371
    Cell Significance Index: -2.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1380
    Cell Significance Index: -3.7000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1411
    Cell Significance Index: -1.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1444
    Cell Significance Index: -2.8800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1460
    Cell Significance Index: -1.8200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1514
    Cell Significance Index: -1.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1552
    Cell Significance Index: -3.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1574
    Cell Significance Index: -2.5500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1656
    Cell Significance Index: -2.0900
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.1672
    Cell Significance Index: -1.3500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1692
    Cell Significance Index: -2.1700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1779
    Cell Significance Index: -1.3600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1786
    Cell Significance Index: -2.2300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1788
    Cell Significance Index: -1.9800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1794
    Cell Significance Index: -2.7300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1810
    Cell Significance Index: -2.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1813
    Cell Significance Index: -3.9700
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.1825
    Cell Significance Index: -1.9700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1846
    Cell Significance Index: -2.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1861
    Cell Significance Index: -2.8800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1883
    Cell Significance Index: -2.6800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1885
    Cell Significance Index: -1.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1919
    Cell Significance Index: -4.8900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1920
    Cell Significance Index: -1.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2023
    Cell Significance Index: -2.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2056
    Cell Significance Index: -3.0400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2145
    Cell Significance Index: -3.0800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2154
    Cell Significance Index: -2.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2190
    Cell Significance Index: -3.1500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2217
    Cell Significance Index: -3.0400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2222
    Cell Significance Index: -2.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2281
    Cell Significance Index: -3.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2293
    Cell Significance Index: -1.8700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2294
    Cell Significance Index: -2.7300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2309
    Cell Significance Index: -3.0200
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.2347
    Cell Significance Index: -2.9500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2420
    Cell Significance Index: -3.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HPYR1 is a gene that is responsive to the presence of H. pylori, suggesting that it plays a role in the host's immune response against this pathogen. The gene is significantly expressed in various cell types, which are involved in different physiological processes. The expression of HPYR1 is also observed in cells that are involved in the development and maintenance of tissues, such as progenitor cells and pericytes. This suggests that HPYR1 may be involved in the regulation of tissue development and homeostasis. **Pathways and Functions** The pathways and functions of HPYR1 are not fully understood, but it is likely that it plays a role in the regulation of the immune response against H. pylori. The gene may be involved in the activation of immune cells, such as macrophages and T cells, which are essential for the clearance of H. pylori from the body. HPYR1 may also be involved in the regulation of the production of pro-inflammatory cytokines, which are essential for the initiation of an immune response against H. pylori. In addition to its role in the immune response, HPYR1 may also be involved in the regulation of tissue homeostasis. The gene is expressed in progenitor cells and pericytes, which are involved in the development and maintenance of tissues. HPYR1 may be involved in the regulation of cell proliferation, differentiation, and survival, which are essential for the maintenance of tissue homeostasis. **Clinical Significance** The clinical significance of HPYR1 is an area of active research. The gene is significantly expressed in cells that are involved in the development of gastric cancer, suggesting that it may play a role in the prevention of this disease. HPYR1 may be involved in the regulation of the immune response against H. pylori, which is a major risk factor for gastric cancer. Furthermore, the expression of HPYR1 in specific populations of neurons suggests that it may be involved in the regulation of cognitive function and behavior. The gene may be involved in the regulation of the production of neurotransmitters, such as GABA, which are essential for normal brain function. In conclusion, HPYR1 is a gene that plays a crucial role in the immune response against H. pylori and in the regulation of tissue homeostasis. The clinical significance of HPYR1 is an area of active research, and further studies are needed to fully understand its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.