Details for: ADIRF

Gene ID: 10974

Symbol: ADIRF

Ensembl ID: ENSG00000148671

Description: adipogenesis regulatory factor

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.38
    Marker Score: 3,432
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.25
    Marker Score: 6,154
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 4.07
    Marker Score: 3,880
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.91
    Marker Score: 4,712
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.85
    Marker Score: 2,738
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.52
    Marker Score: 2,997
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.4
    Marker Score: 16,309
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.36
    Marker Score: 1,341
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.31
    Marker Score: 12,770
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.27
    Marker Score: 6,140
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.25
    Marker Score: 7,370
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.17
    Marker Score: 1,845
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.02
    Marker Score: 5,116
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.89
    Marker Score: 5,284
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.84
    Marker Score: 5,670
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.8
    Marker Score: 1,205
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.72
    Marker Score: 4,184
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.71
    Marker Score: 20,145
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.59
    Marker Score: 88,030
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.58
    Marker Score: 5,453
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.58
    Marker Score: 746
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.58
    Marker Score: 1,396
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.52
    Marker Score: 3,712
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.5
    Marker Score: 1,968
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.49
    Marker Score: 3,968
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.48
    Marker Score: 2,647
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.45
    Marker Score: 693
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.45
    Marker Score: 15,615
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.43
    Marker Score: 2,555
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.37
    Marker Score: 6,034
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.35
    Marker Score: 979
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.34
    Marker Score: 832
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.34
    Marker Score: 791
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.33
    Marker Score: 542
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.32
    Marker Score: 736
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.29
    Marker Score: 3,685
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.28
    Marker Score: 4,041
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.23
    Marker Score: 5,976
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.22
    Marker Score: 651
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.22
    Marker Score: 14,464
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.21
    Marker Score: 7,862
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.21
    Marker Score: 927
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.21
    Marker Score: 5,792
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.12
    Marker Score: 8,329
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.11
    Marker Score: 1,391
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.1
    Marker Score: 944
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.1
    Marker Score: 1,876
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.09
    Marker Score: 6,560
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.07
    Marker Score: 440
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.06
    Marker Score: 497
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.05
    Marker Score: 798
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.02
    Marker Score: 2,031
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.01
    Marker Score: 1,731
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.96
    Marker Score: 499
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.93
    Marker Score: 2,137
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.92
    Marker Score: 554
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 1.92
    Marker Score: 542
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.89
    Marker Score: 9,909
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.87
    Marker Score: 2,410
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.85
    Marker Score: 1,660
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.85
    Marker Score: 1,080
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.84
    Marker Score: 671
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.82
    Marker Score: 1,574
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.77
    Marker Score: 15,293
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.77
    Marker Score: 1,766
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.76
    Marker Score: 28,320
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.76
    Marker Score: 662
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.75
    Marker Score: 1,680
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.74
    Marker Score: 1,684
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.72
    Marker Score: 396
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.71
    Marker Score: 799
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.71
    Marker Score: 345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.69
    Marker Score: 5,050
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.66
    Marker Score: 3,940
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.66
    Marker Score: 3,771
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.65
    Marker Score: 1,491
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.64
    Marker Score: 408
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.63
    Marker Score: 414
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.6
    Marker Score: 1,625
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.6
    Marker Score: 385
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.6
    Marker Score: 1,865
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.56
    Marker Score: 389
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.55
    Marker Score: 389
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.55
    Marker Score: 407
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.54
    Marker Score: 3,389
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.54
    Marker Score: 1,046
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.53
    Marker Score: 857
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.51
    Marker Score: 485
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.5
    Marker Score: 546
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.49
    Marker Score: 1,248
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.47
    Marker Score: 772
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,117
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.43
    Marker Score: 1,987
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.41
    Marker Score: 944
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.38
    Marker Score: 713
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.33
    Marker Score: 292
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.33
    Marker Score: 843
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.32
    Marker Score: 321
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.31
    Marker Score: 544
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.29
    Marker Score: 2,113

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression**: ADIRF is expressed in a diverse range of cell types, including thyroid follicular cells, alveolar capillary type 2 endothelial cells, renal interstitial pericytes, and fibroblasts from connective tissue of the prostate. 2. **Transcriptional Regulation**: ADIRF acts as a transcriptional regulator, influencing the expression of genes involved in adipogenesis and other cellular processes. 3. **Positive Regulation of Fat Cell Differentiation**: ADIRF's role in promoting fat cell differentiation highlights its significance in adipogenesis, a critical process in energy storage and metabolism. 4. **Cell Differentiation**: ADIRF's involvement in the regulation of cell differentiation suggests its potential role in maintaining tissue homeostasis and responding to developmental cues. **Pathways and Functions:** 1. **Positive Regulation of Fat Cell Differentiation**: ADIRF's role in promoting fat cell differentiation is mediated through its interaction with transcriptional regulators and the transcriptional machinery. 2. **Transcriptional Regulation of White Adipocyte Differentiation**: ADIRF's influence on the transcriptional regulation of white adipocyte differentiation highlights its importance in regulating adipogenesis. 3. **Cell Differentiation**: ADIRF's involvement in cell differentiation processes underscores its role in maintaining tissue homeostasis and responding to developmental cues. 4. **Extracellular Exosome**: ADIRF's expression in various cell types, including those involved in intercellular communication, suggests its potential role in regulating extracellular exosome function. **Clinical Significance:** 1. **Adipogenesis Disorders**: Dysregulation of ADIRF's adipogenic function may contribute to adipogenesis disorders, such as obesity and metabolic syndrome. 2. **Cancer Metastasis**: ADIRF's expression in various cancer types, including thyroid and prostate cancer, suggests its potential role in cancer metastasis and progression. 3. **Regenerative Medicine**: ADIRF's involvement in cell differentiation and tissue homeostasis highlights its potential as a therapeutic target for regenerative medicine applications. 4. **Interdisciplinary Research**: The study of ADIRF's role in adipogenesis, cell differentiation, and extracellular exosome function underscores the need for interdisciplinary research collaborations to fully elucidate its mechanisms and functions. In conclusion, ADIRF's multifaceted role in adipogenesis, cell differentiation, and transcriptional regulation highlights its significance in maintaining tissue homeostasis. Further research is needed to fully elucidate its mechanisms and functions, with potential implications for the treatment of adipogenesis disorders, cancer metastasis, and regenerative medicine applications.

Genular Protein ID: 3837353830

Symbol: ADIRF_HUMAN

Name: Adipogenesis regulatory factor

UniProtKB Accession Codes:

Q15847

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19444912

Title: APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status.

PubMed ID: 19444912

DOI: 10.1002/ijc.24465

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23239344

Title: A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPARgamma and C/EBPalpha.

PubMed ID: 23239344

DOI: 10.1007/s10863-012-9492-6

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 76
  • Mass: 7855
  • Checksum: C95B41F13C4BA7B1
  • Sequence:
    • MASKGLQDLK QQVEGTAQEA VSAAGAAAQQ VVDQATEAGQ KAMDQLAKTT QETIDKTANQ 
ASDTFSGIGK KFGLLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.