Details for: FAM187B

Gene ID: 148109

Symbol: FAM187B

Ensembl ID: ENSG00000177558

Description: family with sequence similarity 187 member B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.3561
    Cell Significance Index: 2.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2036
    Cell Significance Index: 3.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1006
    Cell Significance Index: 1.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0980
    Cell Significance Index: 1.4100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0925
    Cell Significance Index: 1.2100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0389
    Cell Significance Index: 0.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0324
    Cell Significance Index: 0.7100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0286
    Cell Significance Index: 0.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0237
    Cell Significance Index: 0.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0203
    Cell Significance Index: 0.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0180
    Cell Significance Index: 0.4900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0145
    Cell Significance Index: 0.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0062
    Cell Significance Index: 0.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0034
    Cell Significance Index: 0.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0033
    Cell Significance Index: 0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0009
    Cell Significance Index: 0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0009
    Cell Significance Index: 0.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0006
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0006
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0008
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0012
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0014
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0017
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0020
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0027
    Cell Significance Index: -0.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0031
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0031
    Cell Significance Index: -0.4200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0036
    Cell Significance Index: -0.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0036
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0037
    Cell Significance Index: -0.4500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0059
    Cell Significance Index: -0.1200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0065
    Cell Significance Index: -0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0085
    Cell Significance Index: -0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0086
    Cell Significance Index: -0.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0088
    Cell Significance Index: -0.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0089
    Cell Significance Index: -0.2300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0091
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0095
    Cell Significance Index: -0.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0104
    Cell Significance Index: -0.4600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0106
    Cell Significance Index: -0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0112
    Cell Significance Index: -0.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0114
    Cell Significance Index: -0.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0118
    Cell Significance Index: -0.2500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0123
    Cell Significance Index: -0.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0126
    Cell Significance Index: -0.4000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0137
    Cell Significance Index: -0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0139
    Cell Significance Index: -0.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0149
    Cell Significance Index: -0.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0157
    Cell Significance Index: -0.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0158
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0160
    Cell Significance Index: -0.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0160
    Cell Significance Index: -0.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0163
    Cell Significance Index: -0.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0165
    Cell Significance Index: -0.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0166
    Cell Significance Index: -0.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0171
    Cell Significance Index: -0.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0176
    Cell Significance Index: -0.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0188
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0198
    Cell Significance Index: -0.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0205
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0214
    Cell Significance Index: -0.3700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0222
    Cell Significance Index: -0.3000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0237
    Cell Significance Index: -0.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0237
    Cell Significance Index: -0.3500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0238
    Cell Significance Index: -0.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0240
    Cell Significance Index: -0.2800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0242
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0243
    Cell Significance Index: -0.4000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0248
    Cell Significance Index: -0.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0248
    Cell Significance Index: -0.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0253
    Cell Significance Index: -0.4100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0256
    Cell Significance Index: -0.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0258
    Cell Significance Index: -0.6300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0270
    Cell Significance Index: -0.3600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0272
    Cell Significance Index: -0.3800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0272
    Cell Significance Index: -0.2900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0274
    Cell Significance Index: -0.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0275
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAM187B is a non-coding gene, meaning it does not encode a protein. Instead, it is believed to play a regulatory role in gene expression, influencing the transcription of nearby genes. Its expression is widespread, with notable presence in progenitor cells, immature innate lymphoid cells, cardiac endothelial cells, goblet cells, and various other cell types. This unique expression profile suggests that FAM187B may be involved in the maintenance of cellular homeostasis and the regulation of cellular differentiation. **Pathways and Functions:** FAM187B is primarily associated with the membrane-related pathways, suggesting its involvement in cellular membrane dynamics and signaling. Its expression in progenitor cells and stem cells implies a role in cell fate determination and differentiation. Furthermore, its presence in immune cells, such as immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells, suggests a potential role in immune system development and function. The specific functions of FAM187B are not yet fully understood, but it is believed to modulate the expression of nearby genes, influencing cellular behavior and differentiation. This regulatory function may be crucial in maintaining tissue homeostasis and preventing disease. **Clinical Significance:** FAM187B's clinical significance is an area of active research, with potential implications in various diseases. Its expression in cardiac endothelial cells and goblet cells suggests a role in cardiovascular and gastrointestinal diseases, respectively. Furthermore, its presence in immune cells may be linked to autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. The identification of FAM187B as a regulator of gene expression has also sparked interest in its potential use as a therapeutic target. For instance, manipulating FAM187B expression may be beneficial in treating diseases characterized by dysregulated cellular differentiation and immune system dysfunction. In conclusion, FAM187B is a gene of increasing immunological significance, with a complex and multifaceted role in cellular regulation and immune system development. Further research is necessary to fully elucidate its functions and clinical implications, but its discovery has opened up new avenues for exploring the intricacies of gene regulation and immune system biology. **Future Directions:** To further explore the role of FAM187B in immunology, future studies should focus on: 1. Elucidating the specific mechanisms by which FAM187B regulates gene expression. 2. Investigating the functional consequences of FAM187B expression in different cell types and tissues. 3. Examining the clinical implications of FAM187B dysregulation in various diseases. 4. Developing therapeutic strategies that target FAM187B for the treatment of immunological disorders. By advancing our understanding of FAM187B, we may uncover new avenues for treating a range of diseases, from autoimmune disorders to cardiovascular and gastrointestinal diseases.

Genular Protein ID: 159320974

Symbol: F187B_HUMAN

Name: Protein FAM187B

UniProtKB Accession Codes:

Q17R55 Q8N7G6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 369
  • Mass: 42387
  • Checksum: 1EAD9CAC56D13E70
  • Sequence:
    • MPPMLWLLLH FAAPALGFYF SISCPSGKQC QQALLSGNDI LLYCNSSGAH WYYLFTQGKK 
GRLTSLTNIS NMEIMPEGSL LIKDPLPSQT GLYHCWNKNG RQVVQYEIDF QDVTTLHITH 
KDLGQRPLQN ETLHLGSKQL IFTWWEPWQD CNRCEEPGEC KRLGYRYIEE PLEEAMPCWL 
YLGEVLVWSS RLRPELQVEA CHVQCTNNTQ LRVDYVIFDN FRLDEKTEFV WLDCPLGSMY 
RPVNWRANDT PLTWESQLSG QDFTTFLDPS TGGRQLQVFQ PAVYKCFVQQ ELVAQFKPAA 
SLETLEAQWR ENDAQWREAR KALRGRADSV LKGLKLVLLV VTVLALLGAL LKCIHPSPGR 
RSTQVLVVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.