Details for: DSPP

Gene ID: 1834

Symbol: DSPP

Ensembl ID: ENSG00000152591

Description: dentin sialophosphoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 6.4211
    Cell Significance Index: 130.6600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.6763
    Cell Significance Index: 55.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.9577
    Cell Significance Index: 47.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3300
    Cell Significance Index: 4.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2758
    Cell Significance Index: 3.9500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2176
    Cell Significance Index: 2.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.1950
    Cell Significance Index: 4.0700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0387
    Cell Significance Index: 0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0296
    Cell Significance Index: 1.3800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.0187
    Cell Significance Index: 0.2200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0139
    Cell Significance Index: 0.1100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0087
    Cell Significance Index: 0.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0006
    Cell Significance Index: 0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0009
    Cell Significance Index: -0.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0023
    Cell Significance Index: -0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0032
    Cell Significance Index: -0.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0033
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0044
    Cell Significance Index: -0.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0055
    Cell Significance Index: -0.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0066
    Cell Significance Index: -0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0069
    Cell Significance Index: -0.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0071
    Cell Significance Index: -0.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0096
    Cell Significance Index: -0.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0105
    Cell Significance Index: -1.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0112
    Cell Significance Index: -0.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0120
    Cell Significance Index: -0.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0141
    Cell Significance Index: -0.4500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0145
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0160
    Cell Significance Index: -0.3200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0172
    Cell Significance Index: -0.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0180
    Cell Significance Index: -1.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0183
    Cell Significance Index: -0.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0190
    Cell Significance Index: -0.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0222
    Cell Significance Index: -0.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0226
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0227
    Cell Significance Index: -2.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0273
    Cell Significance Index: -0.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0284
    Cell Significance Index: -0.8100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0310
    Cell Significance Index: -0.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0313
    Cell Significance Index: -1.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0314
    Cell Significance Index: -0.6300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0316
    Cell Significance Index: -0.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0324
    Cell Significance Index: -0.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0328
    Cell Significance Index: -0.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0332
    Cell Significance Index: -0.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0332
    Cell Significance Index: -1.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0335
    Cell Significance Index: -0.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0343
    Cell Significance Index: -1.0100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0353
    Cell Significance Index: -0.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0359
    Cell Significance Index: -0.6200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0368
    Cell Significance Index: -0.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0386
    Cell Significance Index: -0.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0399
    Cell Significance Index: -0.7800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0430
    Cell Significance Index: -0.3600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0431
    Cell Significance Index: -0.6300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0457
    Cell Significance Index: -0.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0477
    Cell Significance Index: -0.5200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0485
    Cell Significance Index: -0.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0487
    Cell Significance Index: -0.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0488
    Cell Significance Index: -0.7900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0496
    Cell Significance Index: -0.4800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0498
    Cell Significance Index: -0.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0502
    Cell Significance Index: -1.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0508
    Cell Significance Index: -0.7300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0525
    Cell Significance Index: -0.7000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0532
    Cell Significance Index: -0.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0535
    Cell Significance Index: -0.7900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0540
    Cell Significance Index: -0.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0547
    Cell Significance Index: -0.9200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0549
    Cell Significance Index: -0.7900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0549
    Cell Significance Index: -0.7100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0552
    Cell Significance Index: -0.7200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0556
    Cell Significance Index: -0.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0566
    Cell Significance Index: -1.5100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0577
    Cell Significance Index: -0.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0582
    Cell Significance Index: -1.4200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0585
    Cell Significance Index: -0.7700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0588
    Cell Significance Index: -0.6000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0596
    Cell Significance Index: -0.7000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0597
    Cell Significance Index: -0.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0601
    Cell Significance Index: -0.5700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0606
    Cell Significance Index: -0.7500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0613
    Cell Significance Index: -0.7400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0623
    Cell Significance Index: -0.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0625
    Cell Significance Index: -1.5000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0636
    Cell Significance Index: -0.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0641
    Cell Significance Index: -1.4800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0642
    Cell Significance Index: -0.7700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0645
    Cell Significance Index: -0.8600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0647
    Cell Significance Index: -0.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DSPP is a gene that encodes a phosphoprotein essential for tooth development, particularly in the formation of dentin. It is characterized by: 1. **Phosphoprotein structure**: DSPP is a phosphoprotein, meaning it contains phosphate groups, which are crucial for its function. 2. **Calcium ion binding**: DSPP binds to calcium ions, facilitating the mineralization of dentin. 3. **Cell-type specificity**: DSPP expression is not limited to odontoblasts but is also found in other cell types, including progenitor cells, endothelial cells, and stem cells. 4. **Tissue specificity**: DSPP is specifically expressed in dental tissues, including dentin, enamel, and cementum. **Pathways and Functions:** DSPP is involved in various biological pathways, including: 1. **Biomineral tissue development**: DSPP plays a crucial role in the mineralization of dentin, facilitating the deposition of calcium and phosphate ions. 2. **Calcium ion binding**: DSPP binds to calcium ions, regulating the mineralization process. 3. **Collagen binding**: DSPP interacts with collagen, a key component of the extracellular matrix, to regulate the organization of dentin. 4. **Odontoblast differentiation**: DSPP expression is essential for the differentiation of odontoblasts, the cells responsible for dentin formation. 5. **Regulation of odontoblast differentiation**: DSPP regulates the differentiation of odontoblasts, ensuring proper dentin formation. **Clinical Significance:** The dysregulation of DSPP has been implicated in various dental anomalies, including: 1. **Tooth agenesis**: DSPP mutations have been associated with tooth agenesis, a condition characterized by the absence of one or more teeth. 2. **Dentinogenesis imperfecta**: DSPP mutations have been linked to dentinogenesis imperfecta, a condition characterized by discolored or translucent teeth. 3. **Cancer**: DSPP has been implicated in the development of certain cancers, including osteosarcoma and breast cancer. 4. **Other diseases**: DSPP has been linked to other diseases, including periodontal disease and osteoporosis. In conclusion, DSPP is a critical gene that plays a pivotal role in tooth development, particularly in the formation of dentin. Its dysregulation has been implicated in various dental anomalies and may have broader implications in cancer and other diseases. Further research is needed to fully understand the functions and clinical significance of DSPP.

Genular Protein ID: 3829196223

Symbol: DSPP_HUMAN

Name: Dentin sialophosphoprotein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10706475

Title: Molecular cloning of a human dentin sialophosphoprotein gene.

PubMed ID: 10706475

DOI: 10.1034/j.1600-0722.2000.00765.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 9879917

Title: Human dentin phosphophoryn nucleotide and amino acid sequence.

PubMed ID: 9879917

DOI: 10.1046/j.0909-8836..t01-9-.x

PubMed ID: 11175779

Title: DSPP mutation in dentinogenesis imperfecta Shields type II.

PubMed ID: 11175779

DOI: 10.1038/84765

PubMed ID: 18521831

Title: A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene.

PubMed ID: 18521831

DOI: 10.1002/humu.20783

PubMed ID: 11175790

Title: Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP.

PubMed ID: 11175790

DOI: 10.1038/84848

PubMed ID: 12354781

Title: Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization.

PubMed ID: 12354781

DOI: 10.1093/hmg/11.21.2559

PubMed ID: 14758537

Title: Clinical, histopathologic, and genetic investigation in two large families with dentinogenesis imperfecta type II.

PubMed ID: 14758537

DOI: 10.1007/s00439-004-1084-z

PubMed ID: 15592686

Title: Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II.

PubMed ID: 15592686

DOI: 10.1007/s00439-004-1223-6

PubMed ID: 17033625

Title: DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.

PubMed ID: 17033625

DOI: 10.1038/ng1868

PubMed ID: 17627120

Title: Disorders of human dentin.

PubMed ID: 17627120

DOI: 10.1159/000102682

PubMed ID: 21029264

Title: Identification of the DSPP mutation in a new kindred and phenotype-genotype correlation.

PubMed ID: 21029264

DOI: 10.1111/j.1601-0825.2010.01760.x

PubMed ID: 22392858

Title: Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP.

PubMed ID: 22392858

DOI: 10.1002/jbmr.1573

PubMed ID: 23509818

Title: A DSPP mutation causing dentinogenesis imperfecta and characterization of the mutational effect.

PubMed ID: 23509818

DOI: 10.1155/2013/948181

Sequence Information:

  • Length: 1301
  • Mass: 131151
  • Checksum: E0D86B52F5E53D05
  • Sequence:
  • MKIITYFCIW AVAWAIPVPQ SKPLERHVEK SMNLHLLARS NVSVQDELNA SGTIKESGVL 
    VHEGDRGRQE NTQDGHKGEG NGSKWAEVGG KSFSTYSTLA NEEGNIEGWN GDTGKAETYG 
    HDGIHGKEEN ITANGIQGQV SIIDNAGATN RSNTNGNTDK NTQNGDVGDA GHNEDVAVVQ 
    EDGPQVAGSN NSTDNEDEII ENSCRNEGNT SEITPQINSK RNGTKEAEVT PGTGEDAGLD 
    NSDGSPSGNG ADEDEDEGSG DDEDEEAGNG KDSSNNSKGQ EGQDHGKEDD HDSSIGQNSD 
    SKEYYDPEGK EDPHNEVDGD KTSKSEENSA GIPEDNGSQR IEDTQKLNHR ESKRVENRIT 
    KESETHAVGK SQDKGIEIKG PSSGNRNITK EVGKGNEGKE DKGQHGMILG KGNVKTQGEV 
    VNIEGPGQKS EPGNKVGHSN TGSDSNSDGY DSYDFDDKSM QGDDPNSSDE SNGNDDANSE 
    SDNNSSSRGD ASYNSDESKD NGNGSDSKGA EDDDSDSTSD TNNSDSNGNG NNGNDDNDKS 
    DSGKGKSDSS DSDSSDSSNS SDSSDSSDSD SSDSNSSSDS DSSDSDSSDS SDSDSSDSSN 
    SSDSSDSSDS SDSSDSSDSS DSKSDSSKSE SDSSDSDSKS DSSDSNSSDS SDNSDSSDSS 
    NSSNSSDSSD SSDSSDSSSS SDSSNSSDSS DSSDSSNSSE SSDSSDSSDS DSSDSSDSSN 
    SNSSDSDSSN SSDSSDSSNS SDSSDSSDSS NSSDSSDSSD SSNSSDSSDS SDSSDSSDSS 
    NSSDSNDSSN SSDSSDSSNS SDSSNSSDSS DSSDSSDSDS SNSSDSSNSS DSSDSSNSSD 
    SSDSSDSSDG SDSDSSNRSD SSNSSDSSDS SDSSNSSDSS DSSDSNESSN SSDSSDSSNS 
    SDSDSSDSSN SSDSSDSSNS SDSSESSNSS DNSNSSDSSN SSDSSDSSDS SNSSDSSNSS 
    DSSNSSDSSD SNSSDSSDSS NSSDSSDSSD SSDSSDSSDS SNSSDSSDSS DSSDSSNSSD 
    SSNSSDSSNS SDSSDSSDSS DSSDSSDSSD SSDSSNSSDS SDSSDSSDSS DSSDSSDSSD 
    SSESSDSSDS SNSSDSSDSS DSSDSSDSSD SSDSSDSSDS SNSSDSSDSS DSSDSSDSSN 
    SSDSSDSSES SDSSDSSDSS DSSDSSDSSD SSDSSDSSNS SDSSDSSDSS DSSDSSDSSD 
    SSDSSDSSDS SDSSDSSDSS DSSDSSDSSD SNESSDSSDS SDSSDSSNSS DSSDSSDSSD 
    STSDSNDESD SQSKSGNGNN NGSDSDSDSE GSDSNHSTSD D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.