Details for: DSPP
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 6.4211
Cell Significance Index: 130.6600 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.6763
Cell Significance Index: 55.0000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.9577
Cell Significance Index: 47.4200 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.3300
Cell Significance Index: 4.8100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2758
Cell Significance Index: 3.9500 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.2176
Cell Significance Index: 2.8600 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.1950
Cell Significance Index: 4.0700 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.0387
Cell Significance Index: 0.5000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0296
Cell Significance Index: 1.3800 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.0187
Cell Significance Index: 0.2200 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.0139
Cell Significance Index: 0.1100 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.0087
Cell Significance Index: 0.1100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0045
Cell Significance Index: 0.1200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0006
Cell Significance Index: 0.1200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0004
Cell Significance Index: 0.7800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0004
Cell Significance Index: -0.7600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0007
Cell Significance Index: -0.2000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.1200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0009
Cell Significance Index: -0.3100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0009
Cell Significance Index: -0.4700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0010
Cell Significance Index: -1.3400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0023
Cell Significance Index: -0.1100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0028
Cell Significance Index: -0.5600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0032
Cell Significance Index: -0.1300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0033
Cell Significance Index: -0.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0034
Cell Significance Index: -2.4800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0044
Cell Significance Index: -0.7900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0055
Cell Significance Index: -0.7500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0066
Cell Significance Index: -0.0900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0069
Cell Significance Index: -0.2400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0071
Cell Significance Index: -0.7400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0096
Cell Significance Index: -0.2100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0105
Cell Significance Index: -1.3400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0112
Cell Significance Index: -0.8600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0120
Cell Significance Index: -0.8100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0141
Cell Significance Index: -0.4500 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0145
Cell Significance Index: -0.2000 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0160
Cell Significance Index: -0.3200 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0172
Cell Significance Index: -0.2900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0180
Cell Significance Index: -1.0100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0183
Cell Significance Index: -0.6000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0190
Cell Significance Index: -0.8400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0222
Cell Significance Index: -0.8400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0226
Cell Significance Index: -1.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0227
Cell Significance Index: -2.6100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0273
Cell Significance Index: -0.6800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0284
Cell Significance Index: -0.8100 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0310
Cell Significance Index: -0.4100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0313
Cell Significance Index: -1.4700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0314
Cell Significance Index: -0.6300 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0316
Cell Significance Index: -0.4200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0324
Cell Significance Index: -0.7000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0324
Cell Significance Index: -0.6400 - Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.0328
Cell Significance Index: -0.3700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0332
Cell Significance Index: -0.7100 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0332
Cell Significance Index: -1.0500 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0335
Cell Significance Index: -0.6600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0343
Cell Significance Index: -1.0100 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0353
Cell Significance Index: -0.9000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0359
Cell Significance Index: -0.6200 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0368
Cell Significance Index: -0.4700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0386
Cell Significance Index: -0.5700 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0399
Cell Significance Index: -0.7800 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0430
Cell Significance Index: -0.3600 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0431
Cell Significance Index: -0.6300 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0457
Cell Significance Index: -0.6500 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0477
Cell Significance Index: -0.5200 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.0485
Cell Significance Index: -0.5700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0487
Cell Significance Index: -0.8200 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0488
Cell Significance Index: -0.7900 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0496
Cell Significance Index: -0.4800 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0498
Cell Significance Index: -0.6900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0502
Cell Significance Index: -1.4400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0508
Cell Significance Index: -0.7300 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0525
Cell Significance Index: -0.7000 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0532
Cell Significance Index: -0.9100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0535
Cell Significance Index: -0.7900 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0540
Cell Significance Index: -0.7400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0547
Cell Significance Index: -0.9200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0549
Cell Significance Index: -0.7900 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0549
Cell Significance Index: -0.7100 - Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0552
Cell Significance Index: -0.7200 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0556
Cell Significance Index: -0.7500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0566
Cell Significance Index: -1.5100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0577
Cell Significance Index: -0.7700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0582
Cell Significance Index: -1.4200 - Cell Name: mast cell (CL0000097)
Fold Change: -0.0585
Cell Significance Index: -0.7700 - Cell Name: macrophage (CL0000235)
Fold Change: -0.0588
Cell Significance Index: -0.6000 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0596
Cell Significance Index: -0.7000 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0597
Cell Significance Index: -0.6300 - Cell Name: neuron (CL0000540)
Fold Change: -0.0601
Cell Significance Index: -0.5700 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0606
Cell Significance Index: -0.7500 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0613
Cell Significance Index: -0.7400 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0623
Cell Significance Index: -0.7900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0625
Cell Significance Index: -1.5000 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.0636
Cell Significance Index: -0.8300 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0641
Cell Significance Index: -1.4800 - Cell Name: pericyte (CL0000669)
Fold Change: -0.0642
Cell Significance Index: -0.7700 - Cell Name: adipocyte (CL0000136)
Fold Change: -0.0645
Cell Significance Index: -0.8600 - Cell Name: basal cell (CL0000646)
Fold Change: -0.0647
Cell Significance Index: -0.7700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3829196223
Symbol: DSPP_HUMAN
Name: Dentin sialophosphoprotein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10706475
Title: Molecular cloning of a human dentin sialophosphoprotein gene.
PubMed ID: 10706475
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 9879917
Title: Human dentin phosphophoryn nucleotide and amino acid sequence.
PubMed ID: 9879917
PubMed ID: 11175779
Title: DSPP mutation in dentinogenesis imperfecta Shields type II.
PubMed ID: 11175779
DOI: 10.1038/84765
PubMed ID: 18521831
Title: A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene.
PubMed ID: 18521831
DOI: 10.1002/humu.20783
PubMed ID: 11175790
Title: Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP.
PubMed ID: 11175790
DOI: 10.1038/84848
PubMed ID: 12354781
Title: Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization.
PubMed ID: 12354781
PubMed ID: 14758537
Title: Clinical, histopathologic, and genetic investigation in two large families with dentinogenesis imperfecta type II.
PubMed ID: 14758537
PubMed ID: 15592686
Title: Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II.
PubMed ID: 15592686
PubMed ID: 17033625
Title: DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.
PubMed ID: 17033625
DOI: 10.1038/ng1868
PubMed ID: 17627120
PubMed ID: 21029264
Title: Identification of the DSPP mutation in a new kindred and phenotype-genotype correlation.
PubMed ID: 21029264
PubMed ID: 22392858
Title: Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP.
PubMed ID: 22392858
DOI: 10.1002/jbmr.1573
PubMed ID: 23509818
Title: A DSPP mutation causing dentinogenesis imperfecta and characterization of the mutational effect.
PubMed ID: 23509818
DOI: 10.1155/2013/948181
Sequence Information:
- Length: 1301
- Mass: 131151
- Checksum: E0D86B52F5E53D05
- Sequence:
MKIITYFCIW AVAWAIPVPQ SKPLERHVEK SMNLHLLARS NVSVQDELNA SGTIKESGVL VHEGDRGRQE NTQDGHKGEG NGSKWAEVGG KSFSTYSTLA NEEGNIEGWN GDTGKAETYG HDGIHGKEEN ITANGIQGQV SIIDNAGATN RSNTNGNTDK NTQNGDVGDA GHNEDVAVVQ EDGPQVAGSN NSTDNEDEII ENSCRNEGNT SEITPQINSK RNGTKEAEVT PGTGEDAGLD NSDGSPSGNG ADEDEDEGSG DDEDEEAGNG KDSSNNSKGQ EGQDHGKEDD HDSSIGQNSD SKEYYDPEGK EDPHNEVDGD KTSKSEENSA GIPEDNGSQR IEDTQKLNHR ESKRVENRIT KESETHAVGK SQDKGIEIKG PSSGNRNITK EVGKGNEGKE DKGQHGMILG KGNVKTQGEV VNIEGPGQKS EPGNKVGHSN TGSDSNSDGY DSYDFDDKSM QGDDPNSSDE SNGNDDANSE SDNNSSSRGD ASYNSDESKD NGNGSDSKGA EDDDSDSTSD TNNSDSNGNG NNGNDDNDKS DSGKGKSDSS DSDSSDSSNS SDSSDSSDSD SSDSNSSSDS DSSDSDSSDS SDSDSSDSSN SSDSSDSSDS SDSSDSSDSS DSKSDSSKSE SDSSDSDSKS DSSDSNSSDS SDNSDSSDSS NSSNSSDSSD SSDSSDSSSS SDSSNSSDSS DSSDSSNSSE SSDSSDSSDS DSSDSSDSSN SNSSDSDSSN SSDSSDSSNS SDSSDSSDSS NSSDSSDSSD SSNSSDSSDS SDSSDSSDSS NSSDSNDSSN SSDSSDSSNS SDSSNSSDSS DSSDSSDSDS SNSSDSSNSS DSSDSSNSSD SSDSSDSSDG SDSDSSNRSD SSNSSDSSDS SDSSNSSDSS DSSDSNESSN SSDSSDSSNS SDSDSSDSSN SSDSSDSSNS SDSSESSNSS DNSNSSDSSN SSDSSDSSDS SNSSDSSNSS DSSNSSDSSD SNSSDSSDSS NSSDSSDSSD SSDSSDSSDS SNSSDSSDSS DSSDSSNSSD SSNSSDSSNS SDSSDSSDSS DSSDSSDSSD SSDSSNSSDS SDSSDSSDSS DSSDSSDSSD SSESSDSSDS SNSSDSSDSS DSSDSSDSSD SSDSSDSSDS SNSSDSSDSS DSSDSSDSSN SSDSSDSSES SDSSDSSDSS DSSDSSDSSD SSDSSDSSNS SDSSDSSDSS DSSDSSDSSD SSDSSDSSDS SDSSDSSDSS DSSDSSDSSD SNESSDSSDS SDSSDSSNSS DSSDSSDSSD STSDSNDESD SQSKSGNGNN NGSDSDSDSE GSDSNHSTSD D
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.