Details for: DSPP

Gene ID: 1834

Symbol: DSPP

Ensembl ID: ENSG00000152591

Description: dentin sialophosphoprotein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32740
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.73
    Marker Score: 2747
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10812
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7531
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3656
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32729
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48061
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.87
    Marker Score: 1644
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 740
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1563.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 350
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 323
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.52
    Marker Score: 229
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7808
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 231.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.05
    Marker Score: 57.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 54
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 53
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.02
    Marker Score: 105
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 21.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 47
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 34
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.01
    Marker Score: 65
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.01
    Marker Score: 70
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 152
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 56
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 34
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 13

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Other Information

**Key characteristics** * DSPP is a glycoprotein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including progenitor cells, blood vessel endothelial cells, goblet cells, and neoplastic cells. * DSPP is found in the cytoplasm, extracellular matrix, and nucleus of cells. * It is involved in the regulation of odontoblast differentiation, which is the process by which dental tissue is formed. * DSPP is also involved in the regulation of calcium ion binding and collagen binding. **Pathways and functions** * DSPP is involved in the development of the dental tissue by promoting the migration and differentiation of progenitor cells. * It also plays a role in the maintenance of the dental tissue by regulating the turnover of cells in the tissue. * DSPP is also involved in the formation of the extracellular matrix, which provides structural support for the tissue. **Clinical significance** Mutations in the DSPP gene have been linked to a number of dental diseases, including dentinogenesis imperfecta, amelogenesis imperfecta, and dentin hypersensitivity. These diseases are caused by mutations in genes that are involved in the development and maintenance of the dental tissue.

Genular Protein ID: 3829196223

Symbol: DSPP_HUMAN

Name: Dentin sialophosphoprotein

UniProtKB Accession Codes:

Q9NZW4 A8MUI0 O95815

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 KEGG 1 MANE-Select 1 MIM 9 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10706475

Title: Molecular cloning of a human dentin sialophosphoprotein gene.

PubMed ID: 10706475

DOI: 10.1034/j.1600-0722.2000.00765.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 9879917

Title: Human dentin phosphophoryn nucleotide and amino acid sequence.

PubMed ID: 9879917

DOI: 10.1046/j.0909-8836..t01-9-.x

PubMed ID: 11175779

Title: DSPP mutation in dentinogenesis imperfecta Shields type II.

PubMed ID: 11175779

DOI: 10.1038/84765

PubMed ID: 18521831

Title: A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene.

PubMed ID: 18521831

DOI: 10.1002/humu.20783

PubMed ID: 11175790

Title: Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP.

PubMed ID: 11175790

DOI: 10.1038/84848

PubMed ID: 12354781

Title: Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization.

PubMed ID: 12354781

DOI: 10.1093/hmg/11.21.2559

PubMed ID: 14758537

Title: Clinical, histopathologic, and genetic investigation in two large families with dentinogenesis imperfecta type II.

PubMed ID: 14758537

DOI: 10.1007/s00439-004-1084-z

PubMed ID: 15592686

Title: Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II.

PubMed ID: 15592686

DOI: 10.1007/s00439-004-1223-6

PubMed ID: 17033625

Title: DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.

PubMed ID: 17033625

DOI: 10.1038/ng1868

PubMed ID: 17627120

Title: Disorders of human dentin.

PubMed ID: 17627120

DOI: 10.1159/000102682

PubMed ID: 21029264

Title: Identification of the DSPP mutation in a new kindred and phenotype-genotype correlation.

PubMed ID: 21029264

DOI: 10.1111/j.1601-0825.2010.01760.x

PubMed ID: 22392858

Title: Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP.

PubMed ID: 22392858

DOI: 10.1002/jbmr.1573

PubMed ID: 23509818

Title: A DSPP mutation causing dentinogenesis imperfecta and characterization of the mutational effect.

PubMed ID: 23509818

DOI: 10.1155/2013/948181

Sequence Information:

  • Length: 1301
  • Mass: 131151
  • Checksum: E0D86B52F5E53D05
  • Sequence:
    • MKIITYFCIW AVAWAIPVPQ SKPLERHVEK SMNLHLLARS NVSVQDELNA SGTIKESGVL 
VHEGDRGRQE NTQDGHKGEG NGSKWAEVGG KSFSTYSTLA NEEGNIEGWN GDTGKAETYG 
HDGIHGKEEN ITANGIQGQV SIIDNAGATN RSNTNGNTDK NTQNGDVGDA GHNEDVAVVQ 
EDGPQVAGSN NSTDNEDEII ENSCRNEGNT SEITPQINSK RNGTKEAEVT PGTGEDAGLD 
NSDGSPSGNG ADEDEDEGSG DDEDEEAGNG KDSSNNSKGQ EGQDHGKEDD HDSSIGQNSD 
SKEYYDPEGK EDPHNEVDGD KTSKSEENSA GIPEDNGSQR IEDTQKLNHR ESKRVENRIT 
KESETHAVGK SQDKGIEIKG PSSGNRNITK EVGKGNEGKE DKGQHGMILG KGNVKTQGEV 
VNIEGPGQKS EPGNKVGHSN TGSDSNSDGY DSYDFDDKSM QGDDPNSSDE SNGNDDANSE 
SDNNSSSRGD ASYNSDESKD NGNGSDSKGA EDDDSDSTSD TNNSDSNGNG NNGNDDNDKS 
DSGKGKSDSS DSDSSDSSNS SDSSDSSDSD SSDSNSSSDS DSSDSDSSDS SDSDSSDSSN 
SSDSSDSSDS SDSSDSSDSS DSKSDSSKSE SDSSDSDSKS DSSDSNSSDS SDNSDSSDSS 
NSSNSSDSSD SSDSSDSSSS SDSSNSSDSS DSSDSSNSSE SSDSSDSSDS DSSDSSDSSN 
SNSSDSDSSN SSDSSDSSNS SDSSDSSDSS NSSDSSDSSD SSNSSDSSDS SDSSDSSDSS 
NSSDSNDSSN SSDSSDSSNS SDSSNSSDSS DSSDSSDSDS SNSSDSSNSS DSSDSSNSSD 
SSDSSDSSDG SDSDSSNRSD SSNSSDSSDS SDSSNSSDSS DSSDSNESSN SSDSSDSSNS 
SDSDSSDSSN SSDSSDSSNS SDSSESSNSS DNSNSSDSSN SSDSSDSSDS SNSSDSSNSS 
DSSNSSDSSD SNSSDSSDSS NSSDSSDSSD SSDSSDSSDS SNSSDSSDSS DSSDSSNSSD 
SSNSSDSSNS SDSSDSSDSS DSSDSSDSSD SSDSSNSSDS SDSSDSSDSS DSSDSSDSSD 
SSESSDSSDS SNSSDSSDSS DSSDSSDSSD SSDSSDSSDS SNSSDSSDSS DSSDSSDSSN 
SSDSSDSSES SDSSDSSDSS DSSDSSDSSD SSDSSDSSNS SDSSDSSDSS DSSDSSDSSD 
SSDSSDSSDS SDSSDSSDSS DSSDSSDSSD SNESSDSSDS SDSSDSSNSS DSSDSSDSSD 
STSDSNDESD SQSKSGNGNN NGSDSDSDSE GSDSNHSTSD D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.