Gene FGF10 - ENSG00000070193 | NCBI Gene ID: 2255

Details for: FGF10

Gene ID: 2255

Symbol: FGF10

Ensembl ID: ENSG00000070193

Description: fibroblast growth factor 10

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1b ligand binding and activation
(R-HSA-190370)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in early pancreatic precursor cells
(R-HSA-210747)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton organization
(GO:0030036)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Blood vessel remodeling
(GO:0001974)
Cell differentiation
(GO:0030154)
Chemoattractant activity
(GO:0042056)
Determination of left/right symmetry
(GO:0007368)
Embryonic camera-type eye development
(GO:0031076)
Embryonic genitalia morphogenesis
(GO:0030538)
Embryonic pattern specification
(GO:0009880)
Endothelial cell proliferation
(GO:0001935)
Establishment of mitotic spindle orientation
(GO:0000132)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Hair follicle morphogenesis
(GO:0031069)
Heparin binding
(GO:0008201)
Lacrimal gland development
(GO:0032808)
Mesonephros development
(GO:0001823)
Metanephros development
(GO:0001656)
Metanephros morphogenesis
(GO:0003338)
Muscle cell fate commitment
(GO:0042693)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Organ induction
(GO:0001759)
Otic vesicle formation
(GO:0030916)
Pancreas development
(GO:0031016)
Pituitary gland development
(GO:0021983)
Positive regulation of atp-dependent activity
(GO:0032781)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Regulation of activin receptor signaling pathway
(GO:0032925)
Regulation of smoothened signaling pathway
(GO:0008589)
Response to estradiol
(GO:0032355)
Response to lipopolysaccharide
(GO:0032496)
Salivary gland development
(GO:0007431)
Somatic stem cell population maintenance
(GO:0035019)
Thyroid gland development
(GO:0030878)
Tissue regeneration
(GO:0042246)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)
Wnt signaling pathway
(GO:0016055)
Wound healing
(GO:0042060)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.93
Marker Score: 1704
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168725.5
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.14
Marker Score: 2160
Cell Name: goblet cell (CL0000160)
Fold Change: 1.11
Marker Score: 7393
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71818
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48042
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5343
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.85
Marker Score: 1727
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.82
Marker Score: 202
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.79
Marker Score: 475
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.67
Marker Score: 1034
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.67
Marker Score: 2593
Cell Name: mast cell (CL0000097)
Fold Change: 0.64
Marker Score: 369
Cell Name: stromal cell (CL0000499)
Fold Change: 0.61
Marker Score: 719
Cell Name: keratocyte (CL0002363)
Fold Change: 0.61
Marker Score: 140
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.6
Marker Score: 156
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.6
Marker Score: 1147.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 467
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.58
Marker Score: 700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.57
Marker Score: 3402
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.57
Marker Score: 8844
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.55
Marker Score: 185
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.53
Marker Score: 292
Cell Name: fat cell (CL0000136)
Fold Change: 0.5
Marker Score: 281
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.5
Marker Score: 1102
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.47
Marker Score: 5257
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.46
Marker Score: 267
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.44
Marker Score: 111
Cell Name: decidual cell (CL2000002)
Fold Change: 0.43
Marker Score: 1836
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.41
Marker Score: 853
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.38
Marker Score: 121.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.36
Marker Score: 174
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.36
Marker Score: 1508
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.35
Marker Score: 172
Cell Name: fibroblast (CL0000057)
Fold Change: 0.34
Marker Score: 332
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.34
Marker Score: 290
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.34
Marker Score: 578
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.34
Marker Score: 2871
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.33
Marker Score: 11219
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.29
Marker Score: 127
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.28
Marker Score: 132
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.28
Marker Score: 1156
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.28
Marker Score: 342
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.27
Marker Score: 572
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.27
Marker Score: 300
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.25
Marker Score: 149
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.24
Marker Score: 70
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.24
Marker Score: 99
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.24
Marker Score: 62
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.23
Marker Score: 178
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.22
Marker Score: 78
Cell Name: Unknown (CL0000003)
Fold Change: 0.22
Marker Score: 689
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.22
Marker Score: 71
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.22
Marker Score: 117
Cell Name: astrocyte (CL0000127)
Fold Change: 0.22
Marker Score: 190
Cell Name: neuron (CL0000540)
Fold Change: 0.21
Marker Score: 865
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.21
Marker Score: 77
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.21
Marker Score: 252
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.2
Marker Score: 92
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.2
Marker Score: 50
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.2
Marker Score: 50
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.19
Marker Score: 87
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.19
Marker Score: 1647
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.19
Marker Score: 60
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.18
Marker Score: 283
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.18
Marker Score: 431
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.18
Marker Score: 1403
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.18
Marker Score: 60
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.18
Marker Score: 413
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.17
Marker Score: 34
Cell Name: melanocyte (CL0000148)
Fold Change: 0.17
Marker Score: 69
Cell Name: neural cell (CL0002319)
Fold Change: 0.17
Marker Score: 82
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.17
Marker Score: 43
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.16
Marker Score: 1678
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.16
Marker Score: 163
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.16
Marker Score: 106
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.15
Marker Score: 324
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.15
Marker Score: 190
Cell Name: podocyte (CL0000653)
Fold Change: 0.15
Marker Score: 56
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.15
Marker Score: 33
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.15
Marker Score: 47
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.15
Marker Score: 93
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.15
Marker Score: 46
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.15
Marker Score: 33
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.14
Marker Score: 99.5
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.14
Marker Score: 194
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.14
Marker Score: 56
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.14
Marker Score: 172
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.14
Marker Score: 63
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.13
Marker Score: 30
Cell Name: pericyte (CL0000669)
Fold Change: 0.13
Marker Score: 77
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.13
Marker Score: 34
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.13
Marker Score: 1712

Hover over a box to see details here...

**Key characteristics:** - FGF10 is a secreted protein that is produced by various cell types. - It is known to be a potent activator of the PI3K/Akt signaling pathway. - It is also involved in the regulation of beta-cell development, gene expression in early pancreatic cells, and signaling by the insulin receptor. **Pathways and functions:** - FGF10 signaling primarily occurs through the PI3K/Akt pathway. - It promotes cell proliferation, survival, and migration by activating the PI3K/Akt pathway. - It also regulates the expression of various genes involved in cell growth and metabolism. - In cancer, FGF10 signaling can promote tumor growth, invasion, and metastasis. **Clinical significance:** - FGF10 is a protein that is frequently overexpressed in cancer cells. - High FGF10 levels are associated with poor prognosis and increased risk of cancer development and progression. - Targeting FGF10 signaling has emerged as a promising therapeutic strategy for cancer treatment. **Additional points:** - FGF10 is also involved in wound healing and tissue regeneration. - It is a key factor in maintaining the integrity and function of the cardiovascular system. - Dysregulation of FGF10 signaling has been linked to various diseases, including cancer, diabetes, and cardiovascular disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 10

Genular Protein ID: 2629450378

Symbol: FGF10_HUMAN

Name: Fibroblast growth factor 10

UniProtKB Accession Codes:

O15520 C7FDY0 Q6FHR3 Q6FHT6 Q96P59

Database IDs:

Citations:

PubMed ID: 9287324

Title: Structure and expression of human fibroblast growth factor-10.

PubMed ID: 9287324

DOI: 10.1074/jbc.272.37.23191

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15806171

Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.

PubMed ID: 15806171

DOI: 10.1038/sj.onc.1208560

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 12591959

Title: Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.

PubMed ID: 12591959

DOI: 10.1073/pnas.0436500100

PubMed ID: 15654336

Title: Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.

PubMed ID: 15654336

DOI: 10.1038/ng1507

PubMed ID: 16630169

Title: LADD syndrome is caused by FGF10 mutations.

PubMed ID: 16630169

DOI: 10.1111/j.1399-0004.2006.00597.x

PubMed ID: 16501574

Title: Mutations in different components of FGF signaling in LADD syndrome.

PubMed ID: 16501574

DOI: 10.1038/ng1757

Sequence Information:

Length: 208
Mass: 23436
Checksum: C0A0705C108680B3
Sequence:

MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP 
SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV 
VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL 
NGKGAPRRGQ KTRRKNTSAH FLPMVVHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FGF10

Associated with

Cells (max top 100)

Other Information

Structure and expression of human fibroblast growth factor-10. PubMed ID: 9287324

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. PubMed ID: 15806171

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. PubMed ID: 12591959

Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. PubMed ID: 15654336

LADD syndrome is caused by FGF10 mutations. PubMed ID: 16630169

Mutations in different components of FGF signaling in LADD syndrome. PubMed ID: 16501574