Details for: TRBV26OR9 2

Gene ID: 246285

Symbol: TRBV26OR9 2

Ensembl ID: ENSG00000231165

Description: T cell receptor beta variable 26/OR9-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1992
    Cell Significance Index: 3.1600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1681
    Cell Significance Index: 2.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1193
    Cell Significance Index: 7.5200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.0730
    Cell Significance Index: 0.7600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0680
    Cell Significance Index: 0.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0648
    Cell Significance Index: 1.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0575
    Cell Significance Index: 1.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0389
    Cell Significance Index: 0.5400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0347
    Cell Significance Index: 0.4500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0314
    Cell Significance Index: 0.4400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0170
    Cell Significance Index: 0.2000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0065
    Cell Significance Index: 0.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0039
    Cell Significance Index: 0.7900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0039
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0015
    Cell Significance Index: 0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0025
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0027
    Cell Significance Index: -0.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0042
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0049
    Cell Significance Index: -0.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0050
    Cell Significance Index: -0.2800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0065
    Cell Significance Index: -0.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0073
    Cell Significance Index: -0.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0077
    Cell Significance Index: -0.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0079
    Cell Significance Index: -0.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0103
    Cell Significance Index: -0.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0121
    Cell Significance Index: -0.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0122
    Cell Significance Index: -0.3900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0134
    Cell Significance Index: -0.2800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0142
    Cell Significance Index: -0.4500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0143
    Cell Significance Index: -0.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0153
    Cell Significance Index: -0.2000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0160
    Cell Significance Index: -0.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0162
    Cell Significance Index: -0.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0168
    Cell Significance Index: -0.4800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0171
    Cell Significance Index: -0.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0181
    Cell Significance Index: -0.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0188
    Cell Significance Index: -0.4000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0188
    Cell Significance Index: -0.2500
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0193
    Cell Significance Index: -0.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0199
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0208
    Cell Significance Index: -0.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0212
    Cell Significance Index: -0.4900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0217
    Cell Significance Index: -0.3300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0224
    Cell Significance Index: -0.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0224
    Cell Significance Index: -0.6000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0237
    Cell Significance Index: -0.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0238
    Cell Significance Index: -0.5800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0246
    Cell Significance Index: -0.4200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0248
    Cell Significance Index: -0.2700
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0249
    Cell Significance Index: -0.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0266
    Cell Significance Index: -0.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0269
    Cell Significance Index: -0.4500
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0272
    Cell Significance Index: -0.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0274
    Cell Significance Index: -0.5400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0282
    Cell Significance Index: -0.3400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0289
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0290
    Cell Significance Index: -0.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0298
    Cell Significance Index: -0.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0303
    Cell Significance Index: -0.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0316
    Cell Significance Index: -0.6300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0318
    Cell Significance Index: -0.3800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0318
    Cell Significance Index: -0.5400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0318
    Cell Significance Index: -0.3000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0323
    Cell Significance Index: -0.4400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0324
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0324
    Cell Significance Index: -0.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0325
    Cell Significance Index: -0.4800
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0330
    Cell Significance Index: -0.3400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0333
    Cell Significance Index: -0.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0333
    Cell Significance Index: -0.4200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0339
    Cell Significance Index: -0.4400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0339
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0343
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0346
    Cell Significance Index: -0.3800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0350
    Cell Significance Index: -0.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV26OR9-2 is a pseudogene, which means that it lacks the ability to encode a functional protein. Despite this, the gene is significantly expressed in a wide range of cell types, including progenitor cells, blood vessel endothelial cells, and neurons. Its expression profile suggests that TRBV26OR9-2 may play a role in regulating cellular processes, such as proliferation, differentiation, and survival. Notably, the gene's expression is not limited to the immune system, as it is also found in non-immune tissues, including the cerebral cortex and brain cells. **Pathways and Functions:** While the exact function of TRBV26OR9-2 remains unknown, several signaling pathways have been implicated in its regulation. The gene's expression has been linked to the Notch signaling pathway, which plays a crucial role in cell fate determination, proliferation, and differentiation. Additionally, TRBV26OR9-2 has been shown to interact with other genes involved in the Wnt/β-catenin pathway, which regulates cell growth, differentiation, and survival. These interactions suggest that TRBV26OR9-2 may act as a regulatory element, influencing cellular processes through the modulation of signaling pathways. **Clinical Significance:** Despite its pseudogenic nature, TRBV26OR9-2 has been found to be significantly expressed in various diseases, including cancer, neurological disorders, and autoimmune conditions. For example, studies have shown that TRBV26OR9-2 is overexpressed in certain types of cancer, such as breast and lung cancer, where it may contribute to tumorigenesis and tumor progression. Additionally, the gene's expression has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in the development and progression of these conditions. Furthermore, TRBV26OR9-2 has been found to be expressed in autoimmune conditions, such as multiple sclerosis, where it may contribute to the pathogenesis of the disease. In conclusion, TRBV26OR9-2 is a pseudogene with a unique expression profile that has sparked interest in the scientific community. While its exact function remains unclear, its involvement in various signaling pathways and its expression in diseases suggest that it may play a significant role in regulating cellular processes. Further research is needed to fully understand the functional significance of TRBV26OR9-2 and its potential applications in the treatment of diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.