Details for: IL36RN

Gene ID: 26525

Symbol: IL36RN

Ensembl ID: ENSG00000136695

Description: interleukin 36 receptor antagonist

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 10.4098
    Cell Significance Index: 69.1000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.1986
    Cell Significance Index: 8.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.8208
    Cell Significance Index: 30.1300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.5001
    Cell Significance Index: 6.3200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4923
    Cell Significance Index: 4.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0836
    Cell Significance Index: 1.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0205
    Cell Significance Index: 0.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0013
    Cell Significance Index: 0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0044
    Cell Significance Index: -2.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0054
    Cell Significance Index: -3.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0087
    Cell Significance Index: -1.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0129
    Cell Significance Index: -1.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0141
    Cell Significance Index: -2.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0160
    Cell Significance Index: -1.8700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0179
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0181
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0225
    Cell Significance Index: -2.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0243
    Cell Significance Index: -0.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0304
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0336
    Cell Significance Index: -0.3800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0352
    Cell Significance Index: -0.8800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0378
    Cell Significance Index: -0.4100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0381
    Cell Significance Index: -0.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0433
    Cell Significance Index: -0.7400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0516
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0671
    Cell Significance Index: -0.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0672
    Cell Significance Index: -0.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0687
    Cell Significance Index: -2.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0690
    Cell Significance Index: -1.7200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0695
    Cell Significance Index: -0.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0709
    Cell Significance Index: -2.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0715
    Cell Significance Index: -0.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0728
    Cell Significance Index: -2.3200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0740
    Cell Significance Index: -0.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0777
    Cell Significance Index: -3.6500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0778
    Cell Significance Index: -0.5600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0789
    Cell Significance Index: -1.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0799
    Cell Significance Index: -2.1400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0832
    Cell Significance Index: -1.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0877
    Cell Significance Index: -1.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0902
    Cell Significance Index: -2.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0939
    Cell Significance Index: -1.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0954
    Cell Significance Index: -2.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0992
    Cell Significance Index: -1.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1037
    Cell Significance Index: -2.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1055
    Cell Significance Index: -1.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1057
    Cell Significance Index: -3.0300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1100
    Cell Significance Index: -1.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1121
    Cell Significance Index: -2.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1134
    Cell Significance Index: -2.4500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1148
    Cell Significance Index: -2.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1180
    Cell Significance Index: -2.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1199
    Cell Significance Index: -2.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1239
    Cell Significance Index: -1.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1286
    Cell Significance Index: -3.5000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1316
    Cell Significance Index: -1.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1353
    Cell Significance Index: -2.3400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1361
    Cell Significance Index: -1.6200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1446
    Cell Significance Index: -2.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1453
    Cell Significance Index: -2.1100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1472
    Cell Significance Index: -1.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1492
    Cell Significance Index: -1.7000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1561
    Cell Significance Index: -1.6100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1569
    Cell Significance Index: -2.1600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1573
    Cell Significance Index: -1.6000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1580
    Cell Significance Index: -1.9100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1602
    Cell Significance Index: -2.0700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1611
    Cell Significance Index: -1.8000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1612
    Cell Significance Index: -2.2100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1626
    Cell Significance Index: -2.1400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1632
    Cell Significance Index: -2.1300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1641
    Cell Significance Index: -2.0500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1657
    Cell Significance Index: -1.7600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1661
    Cell Significance Index: -2.1800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1675
    Cell Significance Index: -2.1900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1706
    Cell Significance Index: -1.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1731
    Cell Significance Index: -2.6300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1739
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1771
    Cell Significance Index: -2.2300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1833
    Cell Significance Index: -1.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1841
    Cell Significance Index: -1.7000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1857
    Cell Significance Index: -1.9700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1861
    Cell Significance Index: -2.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1898
    Cell Significance Index: -2.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1918
    Cell Significance Index: -2.4600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1933
    Cell Significance Index: -2.1500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1940
    Cell Significance Index: -2.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1941
    Cell Significance Index: -1.9200
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.1959
    Cell Significance Index: -1.8600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1968
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1981
    Cell Significance Index: -4.1500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1983
    Cell Significance Index: -2.1600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2006
    Cell Significance Index: -2.3700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2023
    Cell Significance Index: -2.3500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2026
    Cell Significance Index: -2.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antagonistic function:** IL36RN acts as a decoy receptor for IL-36, a pro-inflammatory cytokine that plays a significant role in the regulation of inflammation and immune responses. 2. **Negative regulation:** IL36RN negatively regulates the production of various cytokines, including IL-6, IL-17, and type II interferons, thereby preventing excessive inflammation and immune responses. 3. **Tissue-specific expression:** IL36RN is significantly expressed in epithelial cells, including goblet cells, absorptive cells, and intestinal epithelial cells, underscoring its role in the intestinal immune system. 4. **Impaired function in disease:** Mutations or dysregulation of IL36RN have been linked to various inflammatory and autoimmune diseases, including psoriasis, inflammatory bowel disease, and Crohn's disease. **Pathways and Functions:** 1. **IL-36 pathway:** IL36RN negatively regulates the IL-36 pathway, which is involved in the production of pro-inflammatory cytokines. 2. **Cytokine activity:** IL36RN regulates the activity of various cytokines, including IL-6, IL-17, and type II interferons, thereby preventing excessive inflammation and immune responses. 3. **Innate immune response:** IL36RN plays a crucial role in the innate immune response, particularly in the regulation of the inflammatory response to antigenic stimuli. 4. **Negative regulation of cytokine-mediated signaling pathway:** IL36RN negatively regulates the signaling pathway of various cytokines, including IL-1, IL-6, and IL-17. **Clinical Significance:** 1. **Inflammatory diseases:** Mutations or dysregulation of IL36RN have been linked to various inflammatory and autoimmune diseases, including psoriasis, inflammatory bowel disease, and Crohn's disease. 2. **Inflammatory bowel disease:** IL36RN has been shown to play a critical role in the regulation of inflammation in the intestine, making it a potential therapeutic target for the treatment of inflammatory bowel disease. 3. **Psoriasis:** IL36RN has been implicated in the pathogenesis of psoriasis, a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes and excessive inflammation. 4. **Cancer:** IL36RN has been shown to have a tumor-suppressive role, and its dysregulation has been linked to the development of various cancers, including colorectal cancer. In conclusion, the IL36RN gene plays a critical role in regulating inflammation and immune responses, and its dysregulation has been linked to various inflammatory and autoimmune diseases. Further research is needed to fully understand the mechanisms of IL36RN and its potential therapeutic applications in the treatment of inflammatory and autoimmune diseases.

Genular Protein ID: 3934752564

Symbol: I36RA_HUMAN

Name: Interleukin-36 receptor antagonist protein

UniProtKB Accession Codes:

Q9UBH0 A8K2I4 Q56AT9 Q7RTZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10625660

Title: Four new members expand the IL-1 superfamily.

PubMed ID: 10625660

DOI: 10.1074/jbc.275.2.1169

PubMed ID: 10512743

Title: IL1HY1: a novel interleukin-1 receptor antagonist gene.

PubMed ID: 10512743

DOI: 10.1006/bbrc.1999.1440

PubMed ID: 11093146

Title: A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.

PubMed ID: 11093146

DOI: 10.1002/1521-4141(200011)30:11<3299::aid-immu3299>3.0.co;2-s

PubMed ID: 11466363

Title: Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.

PubMed ID: 11466363

DOI: 10.4049/jimmunol.167.3.1440

PubMed ID: 10860666

Title: Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.

PubMed ID: 10860666

DOI: 10.1006/geno.2000.6184

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21965679

Title: Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity.

PubMed ID: 21965679

DOI: 10.1074/jbc.m111.267922

PubMed ID: 23147407

Title: The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses.

PubMed ID: 23147407

DOI: 10.1002/eji.201242711

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 21839423

Title: Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.

PubMed ID: 21839423

DOI: 10.1016/j.ajhg.2011.07.022

PubMed ID: 21848462

Title: Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.

PubMed ID: 21848462

DOI: 10.1056/nejmoa1013068

PubMed ID: 22903787

Title: Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis.

PubMed ID: 22903787

DOI: 10.1002/humu.22203

Sequence Information:

  • Length: 155
  • Mass: 16962
  • Checksum: B96DB5EFA2612E25
  • Sequence:
    • MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG 
VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF 
LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.