Details for: OR7E24

Gene ID: 26648

Symbol: OR7E24

Ensembl ID: ENSG00000237521

Description: olfactory receptor family 7 subfamily E member 24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7645
    Cell Significance Index: 42.7400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0260
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0012
    Cell Significance Index: -0.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0040
    Cell Significance Index: -0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0045
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0050
    Cell Significance Index: -0.8500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0073
    Cell Significance Index: -0.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0140
    Cell Significance Index: -0.1700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0148
    Cell Significance Index: -0.2100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0154
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0164
    Cell Significance Index: -1.1000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0196
    Cell Significance Index: -0.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0219
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0244
    Cell Significance Index: -0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0251
    Cell Significance Index: -0.9500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0260
    Cell Significance Index: -0.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0264
    Cell Significance Index: -0.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0289
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0290
    Cell Significance Index: -0.2700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0315
    Cell Significance Index: -0.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0331
    Cell Significance Index: -0.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0335
    Cell Significance Index: -1.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0341
    Cell Significance Index: -0.8500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0342
    Cell Significance Index: -0.5200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0343
    Cell Significance Index: -0.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0359
    Cell Significance Index: -0.7800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0362
    Cell Significance Index: -0.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0377
    Cell Significance Index: -0.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0391
    Cell Significance Index: -0.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0392
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0395
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0399
    Cell Significance Index: -0.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0400
    Cell Significance Index: -0.8500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0411
    Cell Significance Index: -0.7600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0416
    Cell Significance Index: -0.4800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0417
    Cell Significance Index: -0.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0419
    Cell Significance Index: -0.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0420
    Cell Significance Index: -1.0700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0421
    Cell Significance Index: -0.5500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0429
    Cell Significance Index: -0.4400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0440
    Cell Significance Index: -0.5100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0442
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0444
    Cell Significance Index: -0.6100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0457
    Cell Significance Index: -0.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0463
    Cell Significance Index: -0.9300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0469
    Cell Significance Index: -0.5100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0470
    Cell Significance Index: -0.3600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0472
    Cell Significance Index: -0.6900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0475
    Cell Significance Index: -0.6200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0477
    Cell Significance Index: -0.5100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0486
    Cell Significance Index: -0.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0488
    Cell Significance Index: -1.1900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0499
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0502
    Cell Significance Index: -0.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0509
    Cell Significance Index: -1.2200
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.0509
    Cell Significance Index: -0.4900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0512
    Cell Significance Index: -0.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0514
    Cell Significance Index: -0.8600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0519
    Cell Significance Index: -0.7200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0528
    Cell Significance Index: -0.7400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0533
    Cell Significance Index: -0.6900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0538
    Cell Significance Index: -0.6400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0551
    Cell Significance Index: -0.7000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0557
    Cell Significance Index: -0.4700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0560
    Cell Significance Index: -0.5200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0570
    Cell Significance Index: -0.7500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0576
    Cell Significance Index: -0.6200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0578
    Cell Significance Index: -0.6400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0593
    Cell Significance Index: -0.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0595
    Cell Significance Index: -0.7900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0599
    Cell Significance Index: -0.6200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0601
    Cell Significance Index: -0.4800
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0611
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0616
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0616
    Cell Significance Index: -0.6500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0626
    Cell Significance Index: -0.7200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0627
    Cell Significance Index: -0.6400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0627
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0633
    Cell Significance Index: -0.7700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0641
    Cell Significance Index: -0.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0642
    Cell Significance Index: -0.6200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0655
    Cell Significance Index: -0.7700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0661
    Cell Significance Index: -0.7400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0662
    Cell Significance Index: -0.5400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0667
    Cell Significance Index: -0.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0670
    Cell Significance Index: -0.7300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0671
    Cell Significance Index: -0.8100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0673
    Cell Significance Index: -0.8500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0677
    Cell Significance Index: -0.8000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0680
    Cell Significance Index: -0.6400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0682
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR7E24 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, which is responsible for detecting odorants in the air. This receptor is characterized by its unique ligand-binding properties, which allow it to recognize specific chemical stimuli. The OR7E24 receptor is specifically expressed in cells involved in olfactory processing, including glutamatergic neurons, progenitor cells, and microglial cells. Its expression is also detected in other cell types, such as blood vessel endothelial cells and cardiac endothelial cells, suggesting a broader role in sensory perception and signaling. **Pathways and Functions:** OR7E24 is involved in the detection of chemical stimuli involved in sensory perception of smell through its activation of G protein-coupled receptor signaling pathways. When activated by its ligand, OR7E24 triggers a signaling cascade that ultimately leads to the activation of downstream effectors, such as adenylyl cyclase and phospholipase C. This activation results in the production of second messengers, including cyclic AMP and inositol trisphosphate, which regulate various cellular processes, including ion channel activity, gene expression, and cell migration. In addition to its role in sensory perception, OR7E24 is also involved in the expression and translocation of olfactory receptors, suggesting a feedback mechanism that regulates the expression of these receptors. Furthermore, OR7E24 is part of the G protein-coupled receptor signaling pathway, which is a critical signaling mechanism involved in various physiological processes, including immune responses, cardiovascular regulation, and neuronal function. **Clinical Significance:** OR7E24 has been implicated in various diseases and disorders, including olfactory disorders, such as anosmia and hyposmia, which are characterized by the loss or reduction of olfactory function. Mutations in the OR7E24 gene have been associated with these disorders, highlighting its critical role in olfactory processing. Additionally, OR7E24 has been studied in the context of cancer, where its expression has been linked to tumor progression and metastasis. Furthermore, OR7E24 has been investigated as a potential therapeutic target for the treatment of various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Its role in modulating G protein-coupled receptor signaling pathways suggests that it may be involved in the regulation of various physiological processes, including immune responses and neuronal function. In conclusion, OR7E24 is a novel olfactory receptor that plays a critical role in the detection of chemical stimuli involved in sensory perception of smell. Its widespread expression in various cell types and its involvement in olfactory signaling pathways highlight its importance in olfactory processing. As an expert immunologist, I believe that further research on OR7E24 will provide valuable insights into the mechanisms of olfactory perception and the development of novel therapeutic strategies for various diseases and disorders.

Genular Protein ID: 50398597

Symbol: O7E24_HUMAN

Name: Olfactory receptor 7E24

UniProtKB Accession Codes:

Q6IFN5 B9EJD9 Q9UPJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 339
  • Mass: 38279
  • Checksum: 529D5BAB05301A24
  • Sequence:
    • MSYFPILFFF FLKRCPSYTE PQNLTGVSEF LLLGLSEDPE LQPVLAGLFL SMYLVTVLGN 
LLIILAVSSD SHLHTPMYFF LSNLSLADIG FTSTTVPKMI VDMQTHSRVI SYEGCLTQMS 
FFVLFACMDD MLLSVMAYDR FVAICHPLHY RIIMNPRLCG FLILLSFFIS LLDSQLHNLI 
MLQLTCFKDV DISNFFCDPS QLLHLRCSDT FINEMVIYFM GAIFGCLPIS GILFSYYKIV 
SPILRVPTSD GKYKAFSTCG SHLAVVCLFY GTGLVGYLSS AVLPSPRKSM VASVMYTVVT 
PMLNPFIYSL RNKDIQSALC RLHGRIIKSH HLHPFCYMG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.