Details for: OR7A5

Gene ID: 26659

Symbol: OR7A5

Ensembl ID: ENSG00000188269

Description: olfactory receptor family 7 subfamily A member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.0131
    Cell Significance Index: 17.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1880
    Cell Significance Index: -2.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9720
    Cell Significance Index: 26.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.8673
    Cell Significance Index: 12.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.4481
    Cell Significance Index: 5.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.4054
    Cell Significance Index: 10.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2743
    Cell Significance Index: 2.8400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.2215
    Cell Significance Index: 0.2900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1233
    Cell Significance Index: 1.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0863
    Cell Significance Index: 2.1500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0605
    Cell Significance Index: 0.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0444
    Cell Significance Index: 12.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0174
    Cell Significance Index: 0.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0146
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0112
    Cell Significance Index: 1.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0031
    Cell Significance Index: -1.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0037
    Cell Significance Index: -1.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0081
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0085
    Cell Significance Index: -1.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0106
    Cell Significance Index: -1.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0120
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0139
    Cell Significance Index: -0.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0149
    Cell Significance Index: -1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0149
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0152
    Cell Significance Index: -1.7400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0181
    Cell Significance Index: -0.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0200
    Cell Significance Index: -0.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0205
    Cell Significance Index: -1.4500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0266
    Cell Significance Index: -0.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0275
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0275
    Cell Significance Index: -0.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0290
    Cell Significance Index: -1.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0296
    Cell Significance Index: -0.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0315
    Cell Significance Index: -2.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0400
    Cell Significance Index: -1.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0400
    Cell Significance Index: -1.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0416
    Cell Significance Index: -1.0700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0437
    Cell Significance Index: -0.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0488
    Cell Significance Index: -0.8200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0502
    Cell Significance Index: -0.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0531
    Cell Significance Index: -1.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0542
    Cell Significance Index: -0.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0574
    Cell Significance Index: -1.0600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0608
    Cell Significance Index: -0.7700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0676
    Cell Significance Index: -0.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0709
    Cell Significance Index: -0.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0717
    Cell Significance Index: -1.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0730
    Cell Significance Index: -1.8200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0732
    Cell Significance Index: -0.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0735
    Cell Significance Index: -1.4800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0748
    Cell Significance Index: -0.7100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0749
    Cell Significance Index: -1.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0771
    Cell Significance Index: -2.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0780
    Cell Significance Index: -1.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0798
    Cell Significance Index: -1.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0799
    Cell Significance Index: -1.7000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0819
    Cell Significance Index: -1.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0848
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0851
    Cell Significance Index: -2.4400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0898
    Cell Significance Index: -1.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0907
    Cell Significance Index: -1.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0920
    Cell Significance Index: -1.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0930
    Cell Significance Index: -2.2300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0935
    Cell Significance Index: -1.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0936
    Cell Significance Index: -2.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0939
    Cell Significance Index: -1.9100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0947
    Cell Significance Index: -1.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0963
    Cell Significance Index: -1.9200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0969
    Cell Significance Index: -1.5700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0976
    Cell Significance Index: -1.0300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0979
    Cell Significance Index: -1.5700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0980
    Cell Significance Index: -1.2900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0992
    Cell Significance Index: -1.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0996
    Cell Significance Index: -1.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1001
    Cell Significance Index: -1.7300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1019
    Cell Significance Index: -0.9600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1038
    Cell Significance Index: -1.3100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1038
    Cell Significance Index: -1.2200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1061
    Cell Significance Index: -1.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1065
    Cell Significance Index: -1.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1123
    Cell Significance Index: -1.8800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1127
    Cell Significance Index: -1.2900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1144
    Cell Significance Index: -1.5200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1153
    Cell Significance Index: -1.4600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1160
    Cell Significance Index: -2.4200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1168
    Cell Significance Index: -1.6400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1169
    Cell Significance Index: -1.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1172
    Cell Significance Index: -1.6300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1172
    Cell Significance Index: -1.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1174
    Cell Significance Index: -1.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1175
    Cell Significance Index: -1.9800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1178
    Cell Significance Index: -1.4800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1213
    Cell Significance Index: -1.4100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1218
    Cell Significance Index: -1.2400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1219
    Cell Significance Index: -1.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1237
    Cell Significance Index: -1.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR7A5 exhibits several distinct characteristics that set it apart from other olfactory receptors. Firstly, its unique ligand specificity allows it to detect a wide range of odorant molecules, including those that are not typically associated with traditional olfactory perception. Additionally, OR7A5 has been shown to be expressed in various cell types, including blood vessel endothelial cells, T cells, and goblet cells, suggesting its involvement in multiple physiological processes. Furthermore, OR7A5 has been found to be significantly upregulated in certain tissues, such as the cerebral cortex and intestinal crypt stem cells, indicating its potential role in regulating sensory perception and immune responses. **Pathways and Functions:** OR7A5 is embedded in the plasma membrane and activates G protein-coupled receptor activity, triggering a signaling cascade that ultimately leads to the detection of chemical stimuli. This process involves the binding of odorant molecules to OR7A5, which activates a G protein and initiates a signaling pathway that transduces the signal to downstream effectors. The OR7A5 signaling pathway is also linked to other cellular processes, including expression and translocation of olfactory receptors, G protein-coupled receptor activity, and sensory perception of smell. Moreover, OR7A5 has been implicated in regulating immune responses, with its expression in T cells and plasma cells suggesting its involvement in modulating immune cell function. **Clinical Significance:** The discovery of OR7A5 has significant implications for our understanding of human health and disease. Given its involvement in sensory perception and immune responses, OR7A5 may play a role in the development of various disorders, including olfactory disorders, autoimmune diseases, and immune-related cancers. Furthermore, OR7A5 may serve as a potential therapeutic target for the treatment of these conditions. For instance, modulation of OR7A5 activity could potentially improve olfactory perception in individuals with olfactory disorders or modulate immune responses in autoimmune diseases. Additionally, OR7A5 may be used as a biomarker for detecting early stages of disease, as its expression levels can be altered in response to disease-related stimuli. In conclusion, OR7A5 is a unique olfactory receptor with distinct characteristics and functions that make it an attractive subject for further research. Its involvement in sensory perception, immune responses, and various cellular processes highlights its potential significance in human health and disease. As we continue to unravel the mysteries of OR7A5, we may uncover new avenues for therapeutic intervention and improved understanding of human health and disease.

Genular Protein ID: 1380468796

Symbol: OR7A5_HUMAN

Name: Olfactory receptor 7A5

UniProtKB Accession Codes:

Q15622 B2R682 Q6IFP1 Q96R96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9268701

Title: Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome.

PubMed ID: 9268701

DOI: 10.1006/bbrc.1997.7043

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9119360

Title: Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

PubMed ID: 9119360

DOI: 10.1006/geno.1996.4490

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 319
  • Mass: 35579
  • Checksum: B024A0B6E703189A
  • Sequence:
    • MEPGNDTQIS EFLLLGFSQE PGLQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY 
FFLSNLSFAD ICVTSTTIPK MLMNIQTQNK VITYIACLMQ MYFFILFAGF ENFLLSVMAY 
DRFVAICHPL HYMVIMNPHL CGLLVLASWT MSALYSLLQI LMVVRLSFCT ALEIPHFFCE 
LNQVIQLACS DSFLNHMVIY FTVALLGGGP LTGILYSYSK IISSIHAISS AQGKYKAFST 
CASHLSVVSL FYGAILGVYL SSAATRNSHS SATASVMYTV VTPMLNPFIY SLRNKDIKRA 
LGIHLLWGTM KGQFFKKCP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.