Details for: OR4E2

Gene ID: 26686

Symbol: OR4E2

Ensembl ID: ENSG00000221977

Description: olfactory receptor family 4 subfamily E member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.1098
    Cell Significance Index: 28.2800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.8319
    Cell Significance Index: 14.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7037
    Cell Significance Index: 17.0500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5070
    Cell Significance Index: 7.3900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3941
    Cell Significance Index: 5.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3143
    Cell Significance Index: 4.3100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.2287
    Cell Significance Index: 2.4300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0595
    Cell Significance Index: 0.6700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0179
    Cell Significance Index: 0.2400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0177
    Cell Significance Index: 0.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0116
    Cell Significance Index: 0.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0083
    Cell Significance Index: 0.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0013
    Cell Significance Index: 0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0008
    Cell Significance Index: 0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0003
    Cell Significance Index: 0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0015
    Cell Significance Index: -0.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0016
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0025
    Cell Significance Index: -0.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0028
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0030
    Cell Significance Index: -0.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0032
    Cell Significance Index: -0.0600
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0034
    Cell Significance Index: -0.2100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0044
    Cell Significance Index: -0.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0045
    Cell Significance Index: -0.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0049
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0051
    Cell Significance Index: -0.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0054
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0057
    Cell Significance Index: -0.3200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0066
    Cell Significance Index: -0.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0072
    Cell Significance Index: -0.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0079
    Cell Significance Index: -0.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0079
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0079
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0084
    Cell Significance Index: -0.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0093
    Cell Significance Index: -0.2000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0105
    Cell Significance Index: -0.1700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0107
    Cell Significance Index: -0.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0108
    Cell Significance Index: -0.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0115
    Cell Significance Index: -0.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0118
    Cell Significance Index: -0.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0120
    Cell Significance Index: -0.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0134
    Cell Significance Index: -0.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0134
    Cell Significance Index: -0.2700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0135
    Cell Significance Index: -0.2700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0139
    Cell Significance Index: -0.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0148
    Cell Significance Index: -0.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0149
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0152
    Cell Significance Index: -0.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0154
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0162
    Cell Significance Index: -0.2800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0163
    Cell Significance Index: -0.2100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0164
    Cell Significance Index: -0.2500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0165
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0167
    Cell Significance Index: -0.2400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0168
    Cell Significance Index: -0.2900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0177
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0178
    Cell Significance Index: -0.2700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0179
    Cell Significance Index: -0.2100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0187
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0190
    Cell Significance Index: -0.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0191
    Cell Significance Index: -0.2500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0192
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0193
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0200
    Cell Significance Index: -0.2800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0202
    Cell Significance Index: -0.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0203
    Cell Significance Index: -0.2700
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0204
    Cell Significance Index: -0.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0213
    Cell Significance Index: -0.2000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0214
    Cell Significance Index: -0.2600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0214
    Cell Significance Index: -0.2400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0214
    Cell Significance Index: -0.2900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0215
    Cell Significance Index: -0.2900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0217
    Cell Significance Index: -0.2600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0217
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR4E2 is a G protein-coupled receptor (GPCR) that binds to odorants, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Cell Type-Specific Expression:** OR4E2 is expressed in various cell types, including erythrocytes, goblet cells, intestinal epithelial cells, and neoplastic cells, suggesting its involvement in multiple physiological processes. 3. **Signaling Pathways:** OR4E2 is involved in the detection of chemical stimuli, G protein-coupled receptor activity, and G protein-coupled receptor signaling pathway, highlighting its role in sensory perception and cellular signaling. 4. **Metal Ion Binding:** OR4E2 exhibits metal ion binding capabilities, which may contribute to its ligand-binding properties and receptor activity. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR4E2 is involved in the detection of chemical stimuli involved in sensory perception of smell, which is essential for navigating the environment and responding to odors. 2. **G Protein-Coupled Receptor Activity:** OR4E2 is a GPCR that activates a signaling cascade upon binding to odorants, leading to the perception of smell and potentially other physiological responses. 3. **G Protein-Coupled Receptor Signaling Pathway:** OR4E2 is part of the G protein-coupled receptor signaling pathway, which regulates various cellular processes, including gene expression, cellular proliferation, and differentiation. 4. **Metal Ion Binding:** OR4E2's metal ion binding capabilities may contribute to its ligand-binding properties and receptor activity, potentially influencing its function in sensory perception and cellular signaling. **Clinical Significance:** 1. **Olfactory Disorders:** Alterations in OR4E2 expression or function may contribute to olfactory disorders, such as anosmia or hyposmia, which can have significant impacts on quality of life. 2. **Cancer Research:** OR4E2's expression in neoplastic cells suggests its potential role in cancer development and progression, highlighting the need for further investigation into its involvement in oncogenesis. 3. **Intestinal Health:** OR4E2's expression in intestinal epithelial cells suggests its potential role in maintaining intestinal health and homeostasis, which may be relevant to the development of intestinal disorders, such as inflammatory bowel disease. 4. **Neurological Disorders:** OR4E2's involvement in sensory perception and signaling pathways may also have implications for neurological disorders, such as Alzheimer's disease, where olfactory dysfunction is a common feature. In conclusion, the OR4E2 gene is a multifunctional gene with significant implications for our understanding of olfactory perception, sensory processing, and cellular signaling. Further research is needed to fully elucidate its role in various physiological and pathological processes, including cancer development, intestinal health, and neurological disorders.

Genular Protein ID: 3902821524

Symbol: A0A126GVR8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A126GVR8

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 5 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 2 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 313
  • Mass: 35526
  • Checksum: 7DF3AD6AA85E7EEF
  • Sequence:
    • MDSLNQTRVT EFVFLGLTDN RVLEMLFFMA FSAIYMLTLS GNILIIIATV FTPSLHTPMY 
FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCITQ LFFLHLFACA EIFLLIIMAY 
DRYVAICTPL HYPNVMNMRV CIQLVFALWL GGTVHSLGQT FLTIRLPYCG PNIIDSYFCD 
VPLVIKLACT DTYLTGILIV TNSGTISLSC FLAVVTSYMV ILVSLRKHSA EGRRKALSTC 
SAHFMVVALF FGPCIFIYTR PDTSFSIDKV VSVFYTVVTP LLNPFIYTLR NEEVKSAMKQ 
LRQRQVFFTK SYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.