No CSI details found for gene ID: 2693
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
To protect our computational resources, the in-silico analysis is available exclusively for registered users.
Genular Protein ID: 3198791836
Symbol: GHSR_HUMAN
Name: Growth hormone secretagogue receptor type 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8688086
Title: A receptor in pituitary and hypothalamus that functions in growth hormone release.
PubMed ID: 8688086
PubMed ID: 11356716
Title: Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor.
PubMed ID: 11356716
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11322507
Title: Growth hormone secretagogue receptor family members and ligands.
PubMed ID: 11322507
PubMed ID: 10604470
Title: Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
PubMed ID: 10604470
DOI: 10.1038/45230
PubMed ID: 16511605
Title: Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.
PubMed ID: 16511605
DOI: 10.1172/jci25303
PubMed ID: 19789204
Title: Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor.
PubMed ID: 19789204
DOI: 10.1210/jc.2009-1327
Sequence Information:
- Length: 366
- Mass: 41329
- Checksum: D1B62710DA9DC0C6
- Sequence:
MWNATPSEEP GFNLTLADLD WDASPGNDSL GDELLQLFPA PLLAGVTATC VALFVVGIAG NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVIFVIWAV AFCSAGPIFV LVGVEHENGT DPWDTNECRP TEFAVRSGLL TVMVWVSSIF FFLPVFCLTV LYSLIGRKLW RRRRGDAVVG ASLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFRLLGF EPFSQRKLST LKDESSRAWT ESSINT
Details Unavailable
Detailed CSI data for this gene is not available. You will be redirected to a page with all available raw data in 3 seconds.
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{
"geneID": 2693,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC069523.15"
]
},
"genePos": {
"start": 5001,
"end": 10166
},
"orientation": false,
"symbol": "GHSR",
"created": {
"$date": {
"$numberLong": "1738333348830"
}
},
"crossReference": {
"enseGeneID": "ENSG00000121853",
"enseRnaID": [
"ENST00000427970.1"
],
"enseProtID": [
"ENSP00000395344.1"
]
},
"chrom": {
"pos": "3",
"type": 1,
"loc": "3q26.31"
},
"desc": "growth hormone secretagogue receptor",
"geneType": 5,
"mim": [
{
"id": 601898,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A\/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-416476",
"term": "G alpha (q) signalling events",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0001616",
"term": "growth hormone secretagogue receptor activity",
"cat": 0
},
{
"id": "GO:0001616",
"term": "growth hormone secretagogue receptor activity",
"pubMed": [
8688086
],
"cat": 0
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"pubMed": [
8688086
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
27129257,
29876881
],
"cat": 0
},
{
"id": "GO:0016520",
"term": "growth hormone-releasing hormone receptor activity",
"pubMed": [
8688086
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"cat": 0
},
{
"id": "GO:0042802",
"term": "identical protein binding",
"pubMed": [
27129257,
29876881
],
"cat": 0
},
{
"id": "GO:0007186",
"term": "G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007186",
"term": "G protein-coupled receptor signaling pathway",
"pubMed": [
8688086
],
"cat": 1
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"cat": 1
},
{
"id": "GO:0007611",
"term": "learning or memory",
"cat": 1
},
{
"id": "GO:0008154",
"term": "actin polymerization or depolymerization",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0008343",
"term": "adult feeding behavior",
"cat": 1
},
{
"id": "GO:0009725",
"term": "response to hormone",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0009755",
"term": "hormone-mediated signaling pathway",
"cat": 1
},
{
"id": "GO:0009755",
"term": "hormone-mediated signaling pathway",
"pubMed": [
8688086
],
"cat": 1
},
{
"id": "GO:0010700",
"term": "negative regulation of norepinephrine secretion",
"cat": 1
},
{
"id": "GO:0030252",
"term": "growth hormone secretion",
"pubMed": [
16511605
],
"cat": 1
},
{
"id": "GO:0032094",
"term": "response to food",
"cat": 1
},
{
"id": "GO:0032099",
"term": "negative regulation of appetite",
"cat": 1
},
{
"id": "GO:0032100",
"term": "positive regulation of appetite",
"cat": 1
},
{
"id": "GO:0032354",
"term": "response to follicle-stimulating hormone",
"cat": 1
},
{
"id": "GO:0032355",
"term": "response to estradiol",
"cat": 1
},
{
"id": "GO:0032691",
"term": "negative regulation of interleukin-1 beta production",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0032715",
"term": "negative regulation of interleukin-6 production",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0032720",
"term": "negative regulation of tumor necrosis factor production",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0032869",
"term": "cellular response to insulin stimulus",
"cat": 1
},
{
"id": "GO:0036321",
"term": "ghrelin secretion",
"cat": 1
},
{
"id": "GO:0040018",
"term": "positive regulation of multicellular organism growth",
"pubMed": [
16511605
],
"cat": 1
},
{
"id": "GO:0043134",
"term": "regulation of hindgut contraction",
"cat": 1
},
{
"id": "GO:0043568",
"term": "positive regulation of insulin-like growth factor receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0045923",
"term": "positive regulation of fatty acid metabolic process",
"cat": 1
},
{
"id": "GO:0046676",
"term": "negative regulation of insulin secretion",
"cat": 1
},
{
"id": "GO:0046697",
"term": "decidualization",
"pubMed": [
17494105
],
"cat": 1
},
{
"id": "GO:0048009",
"term": "insulin-like growth factor receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0050728",
"term": "negative regulation of inflammatory response",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0051963",
"term": "regulation of synapse assembly",
"cat": 1
},
{
"id": "GO:0051969",
"term": "regulation of transmission of nerve impulse",
"cat": 1
},
{
"id": "GO:0060123",
"term": "regulation of growth hormone secretion",
"cat": 1
},
{
"id": "GO:0060416",
"term": "response to growth hormone",
"cat": 1
},
{
"id": "GO:0071222",
"term": "cellular response to lipopolysaccharide",
"cat": 1
},
{
"id": "GO:0071548",
"term": "response to dexamethasone",
"cat": 1
},
{
"id": "GO:0090327",
"term": "negative regulation of locomotion involved in locomotory behavior",
"cat": 1
},
{
"id": "GO:0097067",
"term": "cellular response to thyroid hormone stimulus",
"cat": 1
},
{
"id": "GO:0098696",
"term": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane",
"cat": 1
},
{
"id": "GO:0099170",
"term": "postsynaptic modulation of chemical synaptic transmission",
"cat": 1
},
{
"id": "GO:0099175",
"term": "regulation of postsynapse organization",
"cat": 1
},
{
"id": "GO:0120058",
"term": "positive regulation of small intestinal transit",
"cat": 1
},
{
"id": "GO:1902065",
"term": "response to L-glutamate",
"cat": 1
},
{
"id": "GO:1903672",
"term": "positive regulation of sprouting angiogenesis",
"cat": 1
},
{
"id": "GO:1904000",
"term": "positive regulation of eating behavior",
"cat": 1
},
{
"id": "GO:1904349",
"term": "positive regulation of small intestine smooth muscle contraction",
"cat": 1
},
{
"id": "GO:1905333",
"term": "regulation of gastric motility",
"cat": 1
},
{
"id": "GO:1905564",
"term": "positive regulation of vascular endothelial cell proliferation",
"cat": 1
},
{
"id": "GO:1990314",
"term": "cellular response to insulin-like growth factor stimulus",
"cat": 1
},
{
"id": "GO:2000110",
"term": "negative regulation of macrophage apoptotic process",
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0009986",
"term": "cell surface",
"pubMed": [
8688086
],
"cat": 2
},
{
"id": "GO:0043005",
"term": "neuron projection",
"pubMed": [
12890514
],
"cat": 2
},
{
"id": "GO:0045121",
"term": "membrane raft",
"pubMed": [
15232612
],
"cat": 2
},
{
"id": "GO:0097060",
"term": "synaptic membrane",
"cat": 2
},
{
"id": "GO:0098685",
"term": "Schaffer collateral - CA1 synapse",
"cat": 2
},
{
"id": "GO:0098794",
"term": "postsynapse",
"cat": 2
},
{
"id": "GO:0098978",
"term": "glutamatergic synapse",
"cat": 2
}
],
"geneRelations": [
{
"type": 8,
"similarGenes": [
"442206"
]
}
],
"protein": [
{
"symbol": "GHSR_HUMAN",
"name": "Growth hormone secretagogue receptor type 1",
"accession": [
"Q92847",
"Q14D12",
"Q6ISR8",
"Q92848",
"Q96RJ7"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"615925",
"601898",
"615925"
],
"EMBL": [
"U60179",
"U60181",
"AF369786",
"AF369786",
"AY429112",
"AY322544",
"CH471052",
"BC069068",
"BC069374",
"BC113547"
],
"CCDS": [
"CCDS3218.1",
"CCDS46959.1"
],
"RefSeq": [
"NP_004113.1",
"NP_940799.1"
],
"PDB": [
"6KO5",
"7F9Y",
"7F9Z",
"7NA7",
"7NA8",
"7W2Z"
],
"PDBsum": [
"6KO5",
"7F9Y",
"7F9Z",
"7NA7",
"7NA8",
"7W2Z"
],
"AlphaFoldDB": [
"Q92847"
],
"EMDB": [
"EMD-24267",
"EMD-24268",
"EMD-31501",
"EMD-32268"
],
"SMR": [
"Q92847"
],
"BioGRID": [
"108960"
],
"IntAct": [
"Q92847"
],
"STRING": [
"9606.ENSP00000241256"
],
"BindingDB": [
"Q92847"
],
"ChEMBL": [
"CHEMBL4616"
],
"DrugBank": [
"DB15488",
"DB13074",
"DB12128"
],
"DrugCentral": [
"Q92847"
],
"GuidetoPHARMACOLOGY": [
"246"
],
"TCDB": [
"9.A.14.1.6"
],
"GlyCosmos": [
"Q92847"
],
"GlyGen": [
"Q92847"
],
"iPTMnet": [
"Q92847"
],
"PhosphoSitePlus": [
"Q92847"
],
"BioMuta": [
"GHSR"
],
"DMDM": [
"2494998"
],
"PaxDb": [
"9606-ENSP00000241256"
],
"PeptideAtlas": [
"Q92847"
],
"ProteomicsDB": [
"75541",
"75542"
],
"Antibodypedia": [
"3248"
],
"DNASU": [
"2693"
],
"Ensembl": [
"ENST00000241256.3",
"ENST00000427970.1"
],
"KEGG": [
"hsa:2693"
],
"MANE-Select": [
"ENST00000241256.3"
],
"UCSC": [
"uc003fib.3"
],
"AGR": [
"HGNC:4267"
],
"CTD": [
"2693"
],
"DisGeNET": [
"2693"
],
"GeneCards": [
"GHSR"
],
"HGNC": [
"HGNC:4267"
],
"HPA": [
"ENSG00000121853"
],
"MalaCards": [
"GHSR"
],
"neXtProt": [
"NX_Q92847"
],
"OpenTargets": [
"ENSG00000121853"
],
"Orphanet": [
"314811"
],
"PharmGKB": [
"PA28677"
],
"VEuPathDB": [
"HostDB:ENSG00000121853"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT01120000271823"
],
"HOGENOM": [
"CLU_009579_6_5_1"
],
"InParanoid": [
"Q92847"
],
"OMA": [
"KYRMAAC"
],
"OrthoDB": [
"3471593at2759"
],
"PhylomeDB": [
"Q92847"
],
"TreeFam": [
"TF332184"
],
"PathwayCommons": [
"Q92847"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-416476"
],
"SignaLink": [
"Q92847"
],
"SIGNOR": [
"Q92847"
],
"BioGRID-ORCS": [
"2693"
],
"GeneWiki": [
"Growth_hormone_secretagogue_receptor"
],
"GenomeRNAi": [
"2693"
],
"Pharos": [
"Q92847"
],
"PRO": [
"PR:Q92847"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q92847"
],
"Bgee": [
"ENSG00000121853"
],
"GO": [
"GO:0009986",
"GO:0098978",
"GO:0045121",
"GO:0043005",
"GO:0005886",
"GO:0098794",
"GO:0098685",
"GO:0097060",
"GO:0004930",
"GO:0001616",
"GO:0016520",
"GO:0042802",
"GO:0017046",
"GO:0008154",
"GO:0008343",
"GO:0032869",
"GO:1990314",
"GO:0071222",
"GO:0097067",
"GO:0046697",
"GO:0007186",
"GO:0036321",
"GO:0030252",
"GO:0009755",
"GO:0048009",
"GO:0007611",
"GO:0032099",
"GO:0050728",
"GO:0046676",
"GO:0032691",
"GO:0032715",
"GO:0090327",
"GO:2000110",
"GO:0010700",
"GO:0032720",
"GO:0032100",
"GO:1904000",
"GO:0045923",
"GO:0043568",
"GO:0040018",
"GO:0120058",
"GO:1904349",
"GO:1903672",
"GO:1905564",
"GO:0099170",
"GO:1905333",
"GO:0060123",
"GO:0043134",
"GO:0098696",
"GO:0099175",
"GO:0051963",
"GO:0051969",
"GO:0071548",
"GO:0032355",
"GO:0032354",
"GO:0032094",
"GO:0060416",
"GO:0009725",
"GO:1902065",
"GO:0007283"
],
"CDD": [
"cd15131"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR003905",
"IPR000276",
"IPR017452"
],
"PANTHER": [
"PTHR24243",
"PTHR24243:SF7"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR01417",
"PR00237"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "A receptor in pituitary and hypothalamus that functions in growth hormone release.",
"pubmedID": "8688086",
"doi": "10.1126\/science.273.5277.974"
},
{
"title": "Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor.",
"pubmedID": "11356716",
"doi": "10.1210\/endo.142.6.8184"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
},
{
"title": "Growth hormone secretagogue receptor family members and ligands.",
"pubmedID": "11322507",
"doi": "10.1385\/endo:14:1:009"
},
{
"title": "Ghrelin is a growth-hormone-releasing acylated peptide from stomach.",
"pubmedID": "10604470",
"doi": "10.1038\/45230"
},
{
"title": "Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.",
"pubmedID": "16511605",
"doi": "10.1172\/jci25303"
},
{
"title": "Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor.",
"pubmedID": "19789204",
"doi": "10.1210\/jc.2009-1327"
}
],
"sequence": {
"length": 366,
"mass": 41329,
"checksum": "D1B62710DA9DC0C6",
"modified": {
"$date": {
"$numberLong": "854755200000"
}
},
"version": 1,
"sequence": "MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT"
},
"existence": 0,
"relevance": 1,
"proteinID": 3198791836
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}