Details for: GHSR

Gene ID: 2693

Symbol: GHSR

Ensembl ID: ENSG00000121853

Description: growth hormone secretagogue receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.2608
    Cell Significance Index: 2.7700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.1878
    Cell Significance Index: 2.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1024
    Cell Significance Index: 1.0600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.1004
    Cell Significance Index: 0.9300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0994
    Cell Significance Index: 1.3100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0884
    Cell Significance Index: 0.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0841
    Cell Significance Index: 1.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0730
    Cell Significance Index: 45.6000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0658
    Cell Significance Index: 0.8300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0537
    Cell Significance Index: 0.5200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0357
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0291
    Cell Significance Index: 3.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0270
    Cell Significance Index: 0.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0229
    Cell Significance Index: 1.5400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0181
    Cell Significance Index: 0.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0155
    Cell Significance Index: 0.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0032
    Cell Significance Index: 1.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0004
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0008
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0013
    Cell Significance Index: -0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0024
    Cell Significance Index: -0.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0028
    Cell Significance Index: -0.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0029
    Cell Significance Index: -0.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0054
    Cell Significance Index: -0.6600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0062
    Cell Significance Index: -0.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0090
    Cell Significance Index: -0.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0091
    Cell Significance Index: -0.5100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0096
    Cell Significance Index: -0.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0117
    Cell Significance Index: -0.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0124
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0126
    Cell Significance Index: -0.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0137
    Cell Significance Index: -0.1400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0143
    Cell Significance Index: -0.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0148
    Cell Significance Index: -0.3600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0152
    Cell Significance Index: -0.2000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0165
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0169
    Cell Significance Index: -0.4300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0170
    Cell Significance Index: -0.2300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0174
    Cell Significance Index: -0.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0177
    Cell Significance Index: -0.3700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0183
    Cell Significance Index: -0.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0186
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0190
    Cell Significance Index: -0.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0194
    Cell Significance Index: -0.4700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0201
    Cell Significance Index: -0.2200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0203
    Cell Significance Index: -0.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0207
    Cell Significance Index: -0.3000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0211
    Cell Significance Index: -0.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0213
    Cell Significance Index: -0.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0218
    Cell Significance Index: -0.5200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0222
    Cell Significance Index: -0.2500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0224
    Cell Significance Index: -0.3000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0230
    Cell Significance Index: -0.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0230
    Cell Significance Index: -0.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0234
    Cell Significance Index: -0.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0236
    Cell Significance Index: -0.5000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0240
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0243
    Cell Significance Index: -0.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0243
    Cell Significance Index: -0.4800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0245
    Cell Significance Index: -0.3300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0248
    Cell Significance Index: -0.3300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0267
    Cell Significance Index: -0.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0273
    Cell Significance Index: -0.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0276
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0278
    Cell Significance Index: -0.3500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0286
    Cell Significance Index: -0.3600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0287
    Cell Significance Index: -0.3700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0289
    Cell Significance Index: -0.3400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0294
    Cell Significance Index: -0.3100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0296
    Cell Significance Index: -0.3600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0296
    Cell Significance Index: -0.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0300
    Cell Significance Index: -0.4000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0300
    Cell Significance Index: -0.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0301
    Cell Significance Index: -0.3900
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0306
    Cell Significance Index: -0.3300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0309
    Cell Significance Index: -0.5000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0310
    Cell Significance Index: -0.2800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0313
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The GHSR is a transmembrane receptor composed of seven transmembrane alpha-helices, with an extracellular N-terminus and an intracellular C-terminus. 2. **Activation:** The GHSR is activated by ghrelin, a 29-amino acid peptide hormone produced in the gastrointestinal tract. 3. **Signaling:** Activation of the GHSR triggers a G-protein coupled signaling cascade, which modulates various downstream pathways, including those involved in energy homeostasis, appetite regulation, and growth hormone secretion. 4. **Expression:** The GHSR is widely expressed in various tissues, including the brain, pituitary gland, liver, and adipose tissue. **Pathways and Functions:** 1. **Energy Homeostasis:** The GHSR plays a crucial role in regulating energy homeostasis by modulating appetite and energy expenditure. 2. **Growth Hormone Secretion:** The GHSR is involved in the regulation of growth hormone secretion from the pituitary gland. 3. **Insulin-Like Growth Factor (IGF) Signaling:** The GHSR is also implicated in the regulation of IGF signaling, which is involved in cell growth and differentiation. 4. **Neurotransmission:** The GHSR is expressed in the brain and plays a role in modulating neurotransmission, particularly in the regulation of appetite and satiety. 5. **Inflammation:** The GHSR has anti-inflammatory properties, and its activation has been shown to reduce inflammation in various tissues. **Clinical Significance:** 1. **Obesity:** The GHSR has been implicated in the pathophysiology of obesity, and its dysregulation has been linked to increased body weight and metabolic disorders. 2. **Diabetes:** The GHSR has been shown to play a role in the regulation of glucose metabolism, and its dysregulation has been linked to the development of type 2 diabetes. 3. **Cancer:** The GHSR has been implicated in the regulation of tumor growth and metastasis, and its dysregulation has been linked to the development of certain types of cancer. 4. **Neurological Disorders:** The GHSR has been implicated in the regulation of neurotransmission and has been shown to play a role in the pathophysiology of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the growth hormone secretagogue receptor (GHSR) is a key player in regulating energy homeostasis, appetite, and growth hormone secretion. Its dysregulation has been implicated in various diseases, including obesity, diabetes, and certain types of cancer. Further research is needed to fully understand the mechanisms by which the GHSR regulates various physiological processes and to explore its therapeutic potential in the treatment of these diseases.

Genular Protein ID: 3198791836

Symbol: GHSR_HUMAN

Name: Growth hormone secretagogue receptor type 1

UniProtKB Accession Codes:

Q92847 Q14D12 Q6ISR8 Q92848 Q96RJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 10 EMDB 4 Ensembl 2 GO 60 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8688086

Title: A receptor in pituitary and hypothalamus that functions in growth hormone release.

PubMed ID: 8688086

DOI: 10.1126/science.273.5277.974

PubMed ID: 11356716

Title: Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor.

PubMed ID: 11356716

DOI: 10.1210/endo.142.6.8184

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11322507

Title: Growth hormone secretagogue receptor family members and ligands.

PubMed ID: 11322507

DOI: 10.1385/endo:14:1:009

PubMed ID: 10604470

Title: Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

PubMed ID: 10604470

DOI: 10.1038/45230

PubMed ID: 16511605

Title: Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.

PubMed ID: 16511605

DOI: 10.1172/jci25303

PubMed ID: 19789204

Title: Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor.

PubMed ID: 19789204

DOI: 10.1210/jc.2009-1327

Sequence Information:

  • Length: 366
  • Mass: 41329
  • Checksum: D1B62710DA9DC0C6
  • Sequence:
    • MWNATPSEEP GFNLTLADLD WDASPGNDSL GDELLQLFPA PLLAGVTATC VALFVVGIAG 
NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ 
FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVIFVIWAV AFCSAGPIFV 
LVGVEHENGT DPWDTNECRP TEFAVRSGLL TVMVWVSSIF FFLPVFCLTV LYSLIGRKLW 
RRRRGDAVVG ASLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI 
SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFRLLGF EPFSQRKLST LKDESSRAWT 
ESSINT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.