Details for: GHSR

Gene ID: 2693

Symbol: GHSR

Ensembl ID: ENSG00000121853

Description: growth hormone secretagogue receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.61
    Marker Score: 2630.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.26
    Marker Score: 4116
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.15
    Marker Score: 671
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1
    Marker Score: 2092
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 529
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1344
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9461
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 328
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2710
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.41
    Marker Score: 401
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.27
    Marker Score: 92
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 536
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 119
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.23
    Marker Score: 240
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 85.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.19
    Marker Score: 204
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.15
    Marker Score: 116
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 154
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 144
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 144
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 188
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1
    Marker Score: 213
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1
    Marker Score: 649
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 379
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.09
    Marker Score: 229
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.05
    Marker Score: 73
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 105
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 54
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.04
    Marker Score: 110
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 105
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 25.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 19.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 89
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 14

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Other Information

## Summary The GHSR gene encodes a protein that is a receptor for growth hormone. It is expressed in a variety of cell types, including blood vessel endothelial cells, microglial cells, goblet cells, pericytes, cardiac endothelial cells, cerebral cortex GABAergic interneurons, intestinal crypt stem cells of colon, forebrain radial glial cells, and absorptive cells. ## Key characteristics * The GHSR is a G protein-coupled receptor (GPCR). * It is a member of the GHSR family of GPCRs. * The GHSR is expressed in high levels in the pituitary gland. * It is a key regulator of growth hormone secretion. * It is involved in a variety of physiological processes, including reproduction, metabolism, and inflammation. ## Pathways and functions The GHSR is involved in a variety of signaling pathways, including: * The G alpha (q) signaling pathway * The Gpcr downstream signaling pathway * The growth hormone-releasing hormone receptor activity * The peptide hormone binding pathway * The signaling by gpcr pathway The GHSR is a key regulator of growth hormone secretion. It is thought to be responsible for feedback inhibition of growth hormone secretion. When growth hormone levels are high, the GHSR is stimulated, which leads to the release of growth hormone. This feedback mechanism helps to maintain growth hormone levels within a narrow range. ## Clinical significance The GHSR gene has been linked to a number of human diseases, including: * Growth hormone deficiency * Pseudohypothyroidism * Obesity * Cancer The GHSR is a promising target for the treatment of these diseases. Inhibitors of the GHSR have been shown to be effective in promoting growth hormone secretion and reversing the effects of growth hormone deficiency.

Genular Protein ID: 3198791836

Symbol: GHSR_HUMAN

Name: Growth hormone secretagogue receptor type 1

UniProtKB Accession Codes:

Q92847 Q14D12 Q6ISR8 Q92848 Q96RJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 10 EMDB 4 Ensembl 2 GO 60 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8688086

Title: A receptor in pituitary and hypothalamus that functions in growth hormone release.

PubMed ID: 8688086

DOI: 10.1126/science.273.5277.974

PubMed ID: 11356716

Title: Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor.

PubMed ID: 11356716

DOI: 10.1210/endo.142.6.8184

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11322507

Title: Growth hormone secretagogue receptor family members and ligands.

PubMed ID: 11322507

DOI: 10.1385/endo:14:1:009

PubMed ID: 10604470

Title: Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

PubMed ID: 10604470

DOI: 10.1038/45230

PubMed ID: 16511605

Title: Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.

PubMed ID: 16511605

DOI: 10.1172/jci25303

PubMed ID: 19789204

Title: Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor.

PubMed ID: 19789204

DOI: 10.1210/jc.2009-1327

Sequence Information:

  • Length: 366
  • Mass: 41329
  • Checksum: D1B62710DA9DC0C6
  • Sequence:
    • MWNATPSEEP GFNLTLADLD WDASPGNDSL GDELLQLFPA PLLAGVTATC VALFVVGIAG 
NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ 
FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVIFVIWAV AFCSAGPIFV 
LVGVEHENGT DPWDTNECRP TEFAVRSGLL TVMVWVSSIF FFLPVFCLTV LYSLIGRKLW 
RRRRGDAVVG ASLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI 
SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFRLLGF EPFSQRKLST LKDESSRAWT 
ESSINT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.