Details for: GMFB

Gene ID: 2764

Symbol: GMFB

Ensembl ID: ENSG00000197045

Description: glia maturation factor beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.43
    Marker Score: 80173
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.28
    Marker Score: 12839
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.24
    Marker Score: 1329
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.23
    Marker Score: 41824
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.22
    Marker Score: 3328
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.22
    Marker Score: 10466
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.15
    Marker Score: 2829
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.14
    Marker Score: 1214
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.12
    Marker Score: 1982
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63166
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.02
    Marker Score: 9723
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1
    Marker Score: 6082
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71682
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47906
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.99
    Marker Score: 1528
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.98
    Marker Score: 34100
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1964
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.95
    Marker Score: 3740
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.95
    Marker Score: 1393
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.94
    Marker Score: 49823
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.93
    Marker Score: 4582
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.92
    Marker Score: 8684
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14405
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.92
    Marker Score: 845.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.91
    Marker Score: 259
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.91
    Marker Score: 2699
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5184
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.91
    Marker Score: 2286
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.9
    Marker Score: 887
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2697
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.89
    Marker Score: 3436
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.89
    Marker Score: 4258
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.88
    Marker Score: 22567
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.88
    Marker Score: 354
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1626.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.86
    Marker Score: 1421
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.86
    Marker Score: 2687
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.85
    Marker Score: 904
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.85
    Marker Score: 534
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.84
    Marker Score: 940
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.84
    Marker Score: 417
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.83
    Marker Score: 558
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.81
    Marker Score: 2892
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.8
    Marker Score: 1890
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.79
    Marker Score: 503
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.78
    Marker Score: 1643
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.78
    Marker Score: 694
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.77
    Marker Score: 2987
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.77
    Marker Score: 766
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.77
    Marker Score: 273
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.77
    Marker Score: 6596
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.76
    Marker Score: 4526
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.76
    Marker Score: 773
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.75
    Marker Score: 1571
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.75
    Marker Score: 453
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.75
    Marker Score: 940
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.75
    Marker Score: 360
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.74
    Marker Score: 772
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.74
    Marker Score: 1992
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.74
    Marker Score: 408
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.74
    Marker Score: 262
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.73
    Marker Score: 792
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.73
    Marker Score: 248
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.73
    Marker Score: 275
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 496
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.73
    Marker Score: 1773.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.72
    Marker Score: 170
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.72
    Marker Score: 2801
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.72
    Marker Score: 7425
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.72
    Marker Score: 2268
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.71
    Marker Score: 350
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.7
    Marker Score: 799
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7
    Marker Score: 466
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.7
    Marker Score: 739.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.7
    Marker Score: 986
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.7
    Marker Score: 148
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2911
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.69
    Marker Score: 996
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.69
    Marker Score: 391
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.69
    Marker Score: 150
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.68
    Marker Score: 905
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.68
    Marker Score: 169
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.68
    Marker Score: 10147
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.68
    Marker Score: 2913
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 458
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.67
    Marker Score: 720
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.67
    Marker Score: 169
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.67
    Marker Score: 673

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Other Information

**Key characteristics:** - GMFB is a secreted protein that is produced by epithelial cells. - It is a type of scaffolding protein that helps to assemble the actin cytoskeleton. - GMFB binds to the actin filament barbed domain of the Arp2/3 complex, which is a key regulator of the actin cytoskeleton. - GMFB also binds to the EF-hand domain of actin, which is another key regulator of the actin cytoskeleton. - GMFB is a negative regulator of the Arp2/3 complex-mediated actin nucleation pathway. **Pathways and functions:** - GMFB binds to the Arp2/3 complex and inhibits its activity. - This prevents the assembly of the actin filament barbed domain of the Arp2/3 complex, which leads to the inhibition of actin nucleation. - GMFB also binds to the EF-hand domain of actin, which is another key regulator of the actin cytoskeleton. - This binding inhibits the interaction between actin and the EF-hand domain, which leads to the inhibition of actin polymerization. - As a result of these effects, GMFB helps to regulate the assembly and activity of the actin cytoskeleton. **Clinical significance:** - Mutations in the GMFB gene have been linked to a number of human diseases, including cancer and cardiovascular disease. - GMFB is a potential target for therapy in these diseases.

Genular Protein ID: 3933868169

Symbol: GMFB_HUMAN

Name: Glia maturation factor beta

UniProtKB Accession Codes:

P60983 B2R499 P17774 Q9BS35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1712830

Title: Molecular cloning and expression of biologically active human glia maturation factor-beta.

PubMed ID: 1712830

DOI: 10.1111/j.1471-4159.1991.tb03777.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7598724

Title: Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.

PubMed ID: 7598724

DOI: 10.1006/bbrc.1995.1901

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 142
  • Mass: 16713
  • Checksum: CF2D4A8CB1F37B1F
  • Sequence:
    • MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE 
LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV 
FEIRNTEDLT EEWLREKLGF FH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.