Details for: GNAI3

Gene ID: 2773

Symbol: GNAI3

Ensembl ID: ENSG00000065135

Description: G protein subunit alpha i3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.23
    Marker Score: 19197
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2
    Marker Score: 2953
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.8
    Marker Score: 3760
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.8
    Marker Score: 14038
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.74
    Marker Score: 2954
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.7
    Marker Score: 1801
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.68
    Marker Score: 57148
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.66
    Marker Score: 21950
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.64
    Marker Score: 2914
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.62
    Marker Score: 7005
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.61
    Marker Score: 4009
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6
    Marker Score: 1687
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.58
    Marker Score: 1248
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.58
    Marker Score: 3816
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.57
    Marker Score: 1068
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.56
    Marker Score: 1662
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.56
    Marker Score: 2394.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.55
    Marker Score: 1559
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.55
    Marker Score: 86546
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.54
    Marker Score: 1448
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.54
    Marker Score: 9998
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.53
    Marker Score: 1441
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.53
    Marker Score: 3598
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.53
    Marker Score: 1622
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.53
    Marker Score: 1745.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.52
    Marker Score: 1624
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.52
    Marker Score: 529
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.52
    Marker Score: 362
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.51
    Marker Score: 17573
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91513
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.49
    Marker Score: 5845
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.48
    Marker Score: 501
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.47
    Marker Score: 13859
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.47
    Marker Score: 982
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.47
    Marker Score: 5672
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.47
    Marker Score: 5443
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.46
    Marker Score: 596
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.46
    Marker Score: 3563
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.46
    Marker Score: 13829
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.45
    Marker Score: 50327.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.45
    Marker Score: 2891
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.45
    Marker Score: 881
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.44
    Marker Score: 1619.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.44
    Marker Score: 2439
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.44
    Marker Score: 2805
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.44
    Marker Score: 12358
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.43
    Marker Score: 14384
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.42
    Marker Score: 5942
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.42
    Marker Score: 1189
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.42
    Marker Score: 1663
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.42
    Marker Score: 402
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.39
    Marker Score: 1395
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.39
    Marker Score: 768
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.39
    Marker Score: 732
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.39
    Marker Score: 949
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.39
    Marker Score: 3779.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.39
    Marker Score: 566
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.38
    Marker Score: 597
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.38
    Marker Score: 3816
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.38
    Marker Score: 522
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.38
    Marker Score: 509
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.37
    Marker Score: 1256
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.36
    Marker Score: 13517
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.36
    Marker Score: 994
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.36
    Marker Score: 859
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.36
    Marker Score: 5538
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.36
    Marker Score: 15284
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.35
    Marker Score: 34700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.35
    Marker Score: 49909
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.35
    Marker Score: 637.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.35
    Marker Score: 1301.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.34
    Marker Score: 714
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.34
    Marker Score: 3641
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.34
    Marker Score: 330
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.33
    Marker Score: 1763
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.33
    Marker Score: 382
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.32
    Marker Score: 2412
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.32
    Marker Score: 878.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.32
    Marker Score: 828
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.31
    Marker Score: 1171
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.31
    Marker Score: 5361
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.31
    Marker Score: 1408
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.31
    Marker Score: 256
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.31
    Marker Score: 1686
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.3
    Marker Score: 345.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.3
    Marker Score: 636.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.3
    Marker Score: 1634
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.3
    Marker Score: 742
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.3
    Marker Score: 885
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.29
    Marker Score: 4978
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.29
    Marker Score: 1984
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.28
    Marker Score: 28545
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.28
    Marker Score: 1153
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.28
    Marker Score: 769
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.28
    Marker Score: 580
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.27
    Marker Score: 1138
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.27
    Marker Score: 1822
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.27
    Marker Score: 48102
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.27
    Marker Score: 12826
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.26
    Marker Score: 5244

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Other Information

**Key characteristics:** * The GNAI3 gene is located on chromosome 15q26.1. * It is a large gene, encoding a protein of 1,274 amino acids. * GNAI3 is a member of the G protein-coupled receptor (GPCR) family of proteins. * It is a key regulator of cell growth, differentiation, and migration. **Pathways and functions:** * GNAI3 is a key regulator of the adp-mediated p2y purinoceptor 12 signaling pathway. * It is also involved in the disease, esr-mediated signaling pathway, and extra-nuclear estrogen signaling pathways. * GNAI3 is a regulator of G alpha (i) signaling events, G alpha (s) signaling events, and G alpha (z) signaling events. * It is involved in the regulation of platelet activation, signaling, and aggregation. * GNAI3 is also involved in the regulation of the hemostasis, infectious disease, and leishmaniasis pathways. * It is a key regulator of neuronal system, neurotransmitter receptors, and postsynaptic signal transmission. * GNAI3 is also involved in the regulation of parasitic infection pathways and the regulation of the menstrual cycle. **Clinical significance:** * Mutations in the GNAI3 gene have been linked to several human diseases, including cancer, heart disease, and stroke. * Targeting GNAI3 has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 4029771227

Symbol: GNAI3_HUMAN

Name: Guanine nucleotide-binding protein G(i) subunit alpha-3

UniProtKB Accession Codes:

P08754 P17539 Q5TZX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EMDB 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 15 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3109953

Title: Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families.

PubMed ID: 3109953

DOI: 10.1016/0014-5793(87)81228-0

PubMed ID: 3120178

Title: A small multigene family encodes Gi signal-transduction proteins.

PubMed ID: 3120178

DOI: 10.1073/pnas.84.22.7886

PubMed ID: 2834384

Title: Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.

PubMed ID: 2834384

DOI: 10.1016/s0021-9258(18)68692-2

PubMed ID: 2452165

Title: Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.

PubMed ID: 2452165

DOI: 10.1016/s0021-9258(18)68706-x

PubMed ID: 3132707

Title: Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines.

PubMed ID: 3132707

DOI: 10.1073/pnas.85.12.4153

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2440724

Title: The human genome encodes at least three non-allelic G proteins with alpha i-type subunits.

PubMed ID: 2440724

DOI: 10.1016/0014-5793(87)80900-6

PubMed ID: 2535845

Title: Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels.

PubMed ID: 2535845

DOI: 10.1016/s0021-9258(17)31281-4

PubMed ID: 8774883

Title: RGS10 is a selective activator of G alpha i GTPase activity.

PubMed ID: 8774883

DOI: 10.1038/383175a0

PubMed ID: 16870394

Title: Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization.

PubMed ID: 16870394

DOI: 10.1016/j.cellsig.2006.06.002

PubMed ID: 17635935

Title: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

PubMed ID: 17635935

DOI: 10.1083/jcb.200604114

PubMed ID: 19211784

Title: GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.

PubMed ID: 19211784

DOI: 10.1073/pnas.0900294106

PubMed ID: 20462955

Title: A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.

PubMed ID: 20462955

DOI: 10.1091/mbc.e10-01-0028

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 25187647

Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

PubMed ID: 25187647

DOI: 10.1091/mbc.e14-05-0978

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 26126266

Title: Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

PubMed ID: 26126266

DOI: 10.7554/elife.07091

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27864364

Title: Membrane recruitment of the non-receptor protein GIV/Girdin (Galpha-interacting, Vesicle-associated Protein/Girdin) is sufficient for activating heterotrimeric G protein signaling.

PubMed ID: 27864364

DOI: 10.1074/jbc.m116.764431

PubMed ID: 30194280

Title: A biochemical and genetic discovery pipeline identifies PLCdelta4b as a nonreceptor activator of heterotrimeric G-proteins.

PubMed ID: 30194280

DOI: 10.1074/jbc.ra118.003580

PubMed ID: 18434541

Title: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

PubMed ID: 18434541

DOI: 10.1073/pnas.0801508105

PubMed ID: 19478087

Title: Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

PubMed ID: 19478087

DOI: 10.1074/jbc.m109.024711

PubMed ID: 22952234

Title: Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai.

PubMed ID: 22952234

DOI: 10.1074/jbc.m112.391607

PubMed ID: 22560091

Title: A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome.

PubMed ID: 22560091

DOI: 10.1016/j.ajhg.2012.04.002

Sequence Information:

  • Length: 354
  • Mass: 40532
  • Checksum: EAB6B4DD3646BC01
  • Sequence:
    • MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG 
YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR ADDARQLFVL AGSAEEGVMT 
PELAGVIKRL WRDGGVQACF SRSREYQLND SASYYLNDLD RISQSNYIPT QQDVLRTRVK 
TTGIVETHFT FKDLYFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM 
NRMHESMKLF DSICNNKWFT ETSIILFLNK KDLFEEKIKR SPLTICYPEY TGSNTYEEAA 
AYIQCQFEDL NRRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKE CGLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.