Details for: GPR15

Gene ID: 2838

Symbol: GPR15

Ensembl ID: ENSG00000154165

Description: G protein-coupled receptor 15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.91
    Marker Score: 1254
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.43
    Marker Score: 755
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.11
    Marker Score: 465.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 465
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1177
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 460.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.62
    Marker Score: 3986
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.59
    Marker Score: 431.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 497
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5
    Marker Score: 1024
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.41
    Marker Score: 240.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.41
    Marker Score: 783
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 337.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.27
    Marker Score: 4238
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 145.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.23
    Marker Score: 371
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.21
    Marker Score: 175
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.19
    Marker Score: 1158
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.18
    Marker Score: 197
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 164
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.14
    Marker Score: 121
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.14
    Marker Score: 107
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.12
    Marker Score: 162
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.12
    Marker Score: 95
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.11
    Marker Score: 264
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.09
    Marker Score: 98
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 58
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.07
    Marker Score: 315
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 96
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 143
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.07
    Marker Score: 3514
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.06
    Marker Score: 91
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.06
    Marker Score: 114
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.06
    Marker Score: 83
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 118
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.04
    Marker Score: 80
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.04
    Marker Score: 124
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.04
    Marker Score: 508
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.04
    Marker Score: 74
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 257
  • Cell Name: T-helper 2 cell (CL0000546)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 18.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 61
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 35

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Other Information

**Key characteristics:** * GPR15 is a type I GPCR, which is known for its ability to activate intracellular signaling pathways upon binding to its ligand. * It is a single-pass membrane protein with a molecular weight of approximately 130 kDa. * It is expressed in high levels in immune cells, particularly in lymphoid tissues and cell types. * It is a key receptor for the cytokine interleukin-21 (IL-21), which is a potent cytokine that promotes immune responses. **Pathways and functions:** * GPR15 is a key receptor for IL-21, a cytokine that plays a critical role in regulating immune responses. * It is involved in the regulation of T cell responses, including the differentiation and survival of effector T cells. * It also plays a role in the regulation of B cell development and differentiation. * It is involved in the regulation of inflammation and tissue remodeling. **Clinical significance:** * Mutations in GPR15 have been linked to several autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. * Targeting GPR15 has emerged as a potential therapeutic strategy for these diseases. * Small molecule inhibitors of GPR15 have been shown to be effective in reducing inflammation and disease activity in animal models of autoimmune diseases. **Additional notes:** * GPR15 is a highly conserved GPCR, with similar sequences found in organisms from humans to mice. * It is a promising target for the development of novel therapeutic interventions for autoimmune diseases.

Genular Protein ID: 3372293658

Symbol: GPR15_HUMAN

Name: G-protein coupled receptor 15

UniProtKB Accession Codes:

P49685 Q3MIL4 Q6ISN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8838812

Title: A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.

PubMed ID: 8838812

DOI: 10.1006/geno.1996.0143

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 360
  • Mass: 40787
  • Checksum: F781F28B7E312390
  • Sequence:
    • MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF 
KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS 
VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK 
PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI 
KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF 
IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL

Genular Protein ID: 4012107238

Symbol: B2R8H6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R8H6

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 360
  • Mass: 40821
  • Checksum: 1A347BDA13804BB2
  • Sequence:
    • MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGAFHF 
KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS 
VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK 
PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI 
KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF 
IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.